Update README.md

README.md

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----
-license: mit
----
+---
+license: mit
+language:
+- en
+pretty_name: ABX-RM-012 Cell Wall Modification Progression
+tags:
+- antibiotics
+- resistance
+- cell-wall
+- remodeling
+- tabular
+task_categories:
+- tabular-classification
+size_categories:
+- n<1k
+---
+
+ABX-RM-012 Cell Wall Modification Progression
+
+Purpose
+
+Detect accumulating cell wall modification before MIC crosses a resistant cutoff and before treatment failure.
+
+Core pattern
+
+- stress_index high
+- cw_mod_index climbs and continues climbing
+- growth_rate_rel rebounds while MIC stays below cutoff
+- later MIC crosses resistant_mic_cutoff_mg_L
+
+Files
+
+- data/train.csv
+- data/test.csv
+- scorer.py
+
+Schema
+
+Each row is one timepoint in a within strain series.
+
+Required columns
+
+- row_id
+- series_id
+- timepoint_h
+- organism
+- strain_id
+- drug_name
+- stress_index
+- cw_mod_index
+- wall_thickness_nm
+- growth_rate_rel
+- mic_drug_mg_L
+- resistant_mic_cutoff_mg_L
+- media
+- assay_method
+- source_type
+- cw_progression_signal
+- earliest_cw_progression
+
+Labels
+
+- cw_progression_signal
+  - 1 for rows at or after the first confirmed progression point
+
+- earliest_cw_progression
+  - 1 only for the first detected progression row in that series
+
+Scorer logic in v1
+
+- baseline is timepoint 0
+- candidate progression point
+  - stress_index at least 0.80
+  - cw_mod_index at least 0.30
+  - next timepoint cw_mod_index increases by 0.10 or more
+  - growth_rate_rel rebound of at least 0.20 vs previous timepoint
+  - MIC below cutoff and at most 2x baseline
+  - exclude cw_mod_index spike then reversal artifacts
+- confirmation
+  - later MIC crosses resistant cutoff
+
+Evaluation
+
+Run
+
+- python scorer.py --path data/test.csv