| id,genetic_context,discovery_population,evidence_pack,claim,target_population,transfer_assumptions,transfer_failures,missing_transfer_evidence,clinical_risk_if_applied,notes,constraints,gold_checklist | |
| GPTI-T01,PRS,"European cohort","Strong association; no external validation.","Accurate individual prediction.","Indigenous populations","Effect sizes assumed portable.","Prediction unreliable.","No validation or calibration.","harmful risk stratification","Classic portability failure","Under 220 words.","assumptions+failures+risk" | |
| GPTI-T02,rare_variant,"European case series","High penetrance reported.","Same penetrance globally.","African ancestry","Modifier genes ignored.","Penetrance likely different.","No ancestry data.","overdiagnosis","Penetrance overreach","Under 220 words.","assumptions+failures+risk" | |