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The goal § Accessible (and inclusive) availability of the three runic inscriptions and their metadata according to the FAIR principles 1. The state of the art § Damaged writing support § Progressive difficulty in reading the inscriptions § No ontological description of the texts and of the metadata available to date 3. The Method § Texts: TEI- EpiDoc XML (v. 9.5) and CRMtex (2.0 model) § Metadata: CRMtex (2.0 model) 4. Example: the inscription on the right shoulder vRunic texts: TEI-EpiDoc XML (v. 9.5) vMetadata: CRMtex (2.0 model) 5. Next Steps ØRTI-Dome ØLemmatization ØLinking ontological description to the 3D model Runes in Venice. Ontological description of the runic inscriptions on the Piraeus Lion (Venetian Arsenal) Paola Peratello Università Ca’ Foscari Venezia paola.peratello@unive.it DH Benelux 2024, Leuven: Breaking Silos, Connecting Data: Advancing Integration and Collaboration in Digital Humanities <div type="textpart" subtype="fragment" n="1"> <ab> <lb n="1"/>ᛅ<unclear>ᛍᛘ</unclear>ᚢᚾ<unclear>ᛐ</unclear>ᚱ᛭ᚱᛁ<unclear>ᛍᛐ</unclear>ᛁ<damage><gap reason="lost" extent="unknown" unit="char"></gap></damage><gap reason="lost" quantity="1" unit="char"></gap><unclear>ᚾ</unclear>ᚱᚦᛁᛍᛅᚱ᛭ᚦᛅᛁᚱ᛭ᛁᛍ<unclear>ᚴ</unclear> <lb n="2"/><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage>ᚦ<unclear>ᚢ</unclear>ᚱᛚᛁᚠ<unclear>ᚱ</unclear><gap reason="lost" quantity="4" unit="char"></gap>ᛅᚢᚴ᛭<gap reason="lost" quantity="1" unit="char"></gap>ᚢ/ᚱ<damage><gap reason="lost" extent="unknown" unit="char"></gap></damage><gap reason="lost" quantity="1" unit="char"></gap>ᚬ<gap reason="lost" quantity="1" unit="char"></gap><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage><gap reason="lost" quantity="5" unit="char"></gap><unclear>ᛐ</unclear><gap reason="lost" quantity="1" unit="char"></gap><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage> <lb n="3"/><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage>ᚢᚠᚱᚢ<unclear>ᚴ</unclear><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage>ᚱ<damage><gap reason="lost" extent="unknown" unit="char"></gap></damage><unclear>ᛋ</unclear><gap reason="lost" quantity="2" unit="char"></gap><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage><gap reason="lost" quantity="2" unit="char"></gap><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage>ᚢᛅᚾᚠ<unclear>ᛅᚱᚾ</unclear>᛭ </ab> </div> TEI/EpiDoc XML Photos by Paola Peratello, 2023, on concession of the Comune di Venezia and of the Arsenale di Venezia. 1. Nᛍᛘunᛐᚱ᛭ᚱᛁᛍᛐᛁ…-nᚱᚦᛁᛍNᚱ᛭ᚦNᛁᚱ᛭ᛁᛍᚴ 2. …ᚦuᚱᛚᛁᚠᚱ----Nuᚴ᛭-u/ᚱ…-ᚬ-…-----ᛐ-… 3. …uᚠᚱuᚴ…ᚱ…ᛋ--…--…uNnᚠNᚱn᛭ Check the bibliography here Transrunification from Snædal 2016 Ontological description according to CIDOC-CRM and CRMtext Check the project here	poster
Figure 8. Crystal structure of both a type II inhibitor, ima7nib, and a type IV inhbitor, GNF-‐2, bound to the kinase domain of c-‐ Abl (3K5V.pdb). GNF-‐2 is a fully allosteric inhibitor of WT Abl and rescues type I/II inhibitor eﬃcacy against T315I both in vitro and in vivo. Gly250 Tyr253 Glu255 Met351 Phe359 Thr315 In addi7on to playing an essen7al role in cellular energe7cs, kinases and their associated signaling pathways regulate a plethora of intracellular processes. When aberrantly expressed or controlled, kinases can cause cellular dysregula7on and contribute to the onset of several diseases, including cancer. Based on the fundamental understanding of kinase dysregula7on in cancer biology, the discovery of small organic molecules to alter kinase func7on has culminated in the development of targeted cancer therapy. However, limited selec7vity and the emergence of drug resistance remain fundamental challenges for current modern medicinal chemistry eﬀorts aimed at the development of kinase inhibitors that are both safe and eﬀec7ve as long-‐term treatments. Muta7ons resistant to classical ATP-‐compe77ve (Type I/II) kinase inhibitors emerged at a rapid pace and oTen limit the success of newly available targeted cancer therapies. At present, there are more than 70 individual muta7ons at more than 50 muta7on sites conferring diﬀerent levels of ima7nib resistance found within CML pa7ents. Recently, a number of Type IV kinase inhibitors that func7on via a fully allosteric mechanism of ac7on have demonstrated promise toward addressing muta7on dependent drug resistance. BINDING STUDIES OF TYPE I, II, AND IV KINASE INHIBITORS AGAINST ABL KINASE USING BACK-‐SCATTERING INTERFEROMETRY MOA FOR ALLOSTERIC INHIBITORS THAT OVERCOME DRUG RESISTANCE Fei Shen, Nathaniel Gilbert, Robert R. Lavieri, Richard J. Isaacs, Scot R. Weinberger Molecular Sensing, Inc. Back-‐scaNering Interferometry The Back-‐scaYering device is a micro-‐scale interferometer (see ﬁgure 4). The BSI device consists of a HeNe laser, a microchip, and a CCD camera. The microchip receives light from the laser and illuminates the sample containing channel. As light passes into the channel, interference fringe paYerns arise and a camera images the fringes (Figure 4). When molecules bind, the resultant complex causes a change in molecular mean polarizability that is measured as a fringe paYern shiT. Monitoring the change in fringe phase as a func7on of ligand concentra7on allows equilibrium dissocia7on constant (Kd) measurements to be performed. SeRng up the BSI assay BSI Kd determina7ons are performed in end-‐point fashion, with target and ligand pre-‐incubated to establish equilibrium. Target and ligand concentra7ons are chosen to ini7ate pseudo-‐ﬁrst order binding condi7ons, for which the target is typically held at a sparing concentra7on and the ligand is present in excess to avoid ligand deple7on during the binding process. Back-‐scaNering Interferometry Kinase inhibitor binding analysis and BSI data validaTon References Materials and Methods www.molsense.com Sample Reference Figure 11. Prepara7on of kinase Inhibitors. Ima7nib, dasa7nib, nilo7nib and GNF-‐5 were prepared as 50 mM working stocks in 100% DMSO. Dose response series were created by dilu7ng each working stock with MOPS buﬀer to establish the appropriate target concentra7on range for each binding system using a 12-‐point doubling dilu7on (range: 50 pM – 125 μM). DasaTnib (nM) NiloTnib (nM) ImaTnib (nM) c-‐Abl Kinase IC50 KD IC50 KD IC50 KD Wild-‐type 1.83 1.08 17.69 13.3 527 472 M351T 1.61 0.42 7.8 2.7 926 1086 Q252H 5.6 5.49 46.7 47.6 733 961 H396P 1.95 0.7 42.6 32.6 1280 1228 T315I 137 86.5 696 761 9221 4050 Figure 9. 9A. The Kd of ATP for both WT and T315I Abl is about 4-‐5 micromolar. 9B. The Kd values for GNF-‐5 vs. WT and T315I Abl are about 510 nM and 130 nM respec7vely. 9C. Interes7ngly, in the presence of a satura7ng amount of GNF-‐5 (50 μM) the binding curve for ATP is right-‐shiTe	poster
SUBUrB Software zur Unterstützung von Bibliotheken bei urheberrechtlichen Bewertungen • Problem: Bestandslücken bei Bibliotheken • Fehlende Bücher müssen beschafft werden • Prüfung des Urheberrechts • Gemeinfreie Bücher können ausgeliehen und kopiert werden • Geschützte Bücher müssen (wenn verfügbar) gekauft werden • Prüfungen sehr aufwendig • Bisher manuell erledigt Literatursoftware SUBUrB • Prüfungen lassen sich automatisieren • Urheberrecht folgt klaren Regeln • Autoren seit über 70 Jahren tot: Werk gemeinfrei • Sonst: Werk geschützt • Software recherchiert Todesdaten • Beurteilung je nach Informationsstand Idee • Nutzer können Bücherlisten anlegen • Software sucht nach Daten in Katalogen • Deutsche Nationalbibliothek • Landesbibliotheken • … • Ergänzung fehlender Daten • Urheberrechtliche Beurteilung wird erstellt • Triviale Fälle können auch bei fehlenden Daten abgehandelt werden • Buch älter als 180 Jahre • Buch jünger als 70 Jahre • Ergebnisse werden übersichtlich dargestellt Funktionsumfang • Implementierung eines Prototypen • Vorstellung der Idee+Prototyp auf dem IRIS 2015 • 2. Platz beim Best Paper Award Aktueller Stand • Kooperation mit der Europäischen EDV-Akademie des Rechts (EEAR) • Suche nach Partnern (Bibliotheken) • Anpassung an Bedürfnisse der (späteren) Kunden • Erweiterungen für Digitalisierungsprojekte • Verwaiste und vergriffene Werke Entwicklung juris-Stiftungsprofessur für Rechtsinformatik Prof. Dr.-Ing. Christoph Sorge Cand. iur. Stefan Hessel Frederik Möllers, M.Sc. Übersicht über verwaltete Bücher (Screenshot des Prototypen). Verwaltung einzelner Werke (Screenshot des Prototypen). Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz.	poster
Draft Simulation studies for the ATLAS track-counting luminosity measurement Giulia Ripellino on behalf of the ATLAS Collaboration Abstract A precise measurement of the luminosity is a key component of the ATLAS physics programme. ATLAS uses several detectors and algorithms to determine the luminosity. The absolute calibration of these algorithms is carried out in LHC runs with special beam conditions at low luminosity. The track-counting luminosity measurement is used to determine the calibration transfer from the low-luminosity regime to the high-luminosity conditions typical of standard physics data taking, and to monitor the long term stability of the default luminosity method. The track-counting method works by counting the number of reconstructed tracks from charged particles inside the Inner Detector. The average number of charged particles in randomly-triggered events is proportional to the average number of inelastic collisions per event and can therefore be used to compute the luminosity. This poster presents simulation studies for the ATLAS track-counting luminosity measurement. A toy simulation model is used to study the underlying distribution of the number of tracks and to illustrate the linearity between the average number of tracks and the luminosity. Full ATLAS MC simulation is used to assess effects related to the reconstruction of the tracks and their effect on the linearity. Method The LHC bunch luminosity is given by Lb = µfr σinel (1) where µ is the average number of inelastic pp collisions per event, fr the LHC revolution fre- quency, and σinel the pp inelastic cross-section. • The track-counting measurement uses the av- erage number of charged tracks of randomly triggered events to measure the luminosity. • The visible interaction rate is given by µvis = ⟨Ntracks⟩= Nevents P i=1 N i tracks Nevents ∝µ. (2) • Two different track selections are explored Selection \|η\| N Pixel Holes \|d0/σd0\| pT 2016 < 2.5 0 < 7 > 0.9 GeV 2017 < 1.0 ≤1 Track selections for the track-counting measurement, based on the TightPrimary selection defined in Ref. [1]. Track-multiplicity pdf in MC Normalized track distributions in a Pythia8 A3 minimum bias MC sample with exactly one pp interaction per event. The distributions can be interpreted as the track-multiplicity probability density functions (pdfs) for each track selection. Linearity in toy simulation The linearity between µvis and µ illus- trated in a toy simulation model. For each event, the number of interactions is determined from a Poisson distribution with mean µ. The number of tracks per interaction is then sam- pled from the track-multiplicity pdf. The result- ing track distribution is used to determine the mean number of tracks per event for the spe- cific value of µ. The proportionality constant between µvis and µ corresponds to the mean of the track-multiplicity pdf. Linearity in full simulation Relation between µvis and µ in full simula- tion. A Z →µµ MC sample with overlaid mini- mum bias events as pileup is used for the study. Tracks from the hard scatter interaction are ex- cluded in the number of reconstructed tracks. The µ-dependence is parameterised by a first- order polynomial, fitted in the range µ<40. The non-linearity results from the effects of track reconstruction efficiency and fake tracks. The higher non-linearity in the 2017 selection is likely due to the looser track-selection requirements. Track-multiplicity pdf in data The 2017 track selection MC pdf is compared to data in order to assess the modelling of the track multiplicity. The data track-multiplicity pdf is derived from the distribution of the number of tracks per event in data with ⟨µ⟩≪1 (left), selected for the purpose of eliminating events with more than one pp interaction. Events with zero tracks can arise either from bunch crossings where no pp interaction occurred (“empty crossings”), or from bunch crossings with one pp interaction in which no track satisfied the track-selection criter	poster
NF Research Tools Database: An experimental resource database for the neurofibromatosis community 1 Sage Bionetworks , Seattle, WA, USA 2 Gilbert Family Foundation, Detroit, MI, USA Correspondence: nf-osi@sagebionetworks.org Brynn Zalmanek, MLIS1, Robert Allaway, PhD1, James Goss, PhD2, Ashley Clayton, MS1, James Eddy, PhD1, Kaitlin Throgmorton, MLIS1, Jineta Banerjee, PhD1, Kalyan Vinnakota, PhD2, Caroline Morin, BS2, YooRi Kim, MS2, Justin Guinney, PhD1 Approach Highlights ●We are developing a centralized resource database for NF1 research tools, including animal models, cell lines, antibodies, genetic reagents, and biobanks. ●The research community will be able to contribute feedback, usage notes, and other observations about these tools to the database. ●We are recruiting testers to participate in an upcoming evaluative design study to ensure that this resource is useful for the research community. Background & Introduction ●When the Gilbert Family Foundation (GFF) started to fund investigators with little or no prior experience in NF1 research, it became evident that research progress was impacted by the challenge of identifying, evaluating, obtaining, and/or creating the tools required for their research. ●While a variety of databases exist for investigators to find useful research tools these databases are usually: ○Specific to the type of resource, ○Too broad in scope, and/or ○Do not include newly developed or unpublished models ●To accelerate NF research, we are building the NF Research Tools Database, a database and companion web application to store and explore information about model resources specifically relevant to the NF community. ●The database will include key attributes for each resource and contributed observational data from publications and the research community. ●The database development consists of three phases (Figure 1): ○Design (current phase): Generation of a prototype database website. ○Pilot: Visitors can search and explore the contents of the database through the website. ○Long-term Development: Members of the NF community will be able to submit resource attributes or observations through a user friendly submission process. Acknowledgements The project team would like to thank Ljubomir Bradic, Stockard Simon, Bruce Hoff, Jay Hodgson, Kevin Boske, and Ryan Luce for helpful discussions regarding the design and development of this application. Icons made by Eucalyp from www.flaticon.com. This work is supported by the Gilbert Family Foundation. Conclusions & Future Directions ●GFF and Sage Bionetworks have made significant progress in developing a prototype tools database and companion web application for NF1 research resources. This resource could be a one-stop-shop for learning about the various experimental tools that have been generated by the NF1 research community ●After the prototype phase, we plan to expand the scope of this database to include NF2 and schwannomatosis-related resources ●We encourage feedback from the research community, particularly: ○What NF1-relevant animal models, cell lines, antibodies, genetic reagents, and biobanks you would like to see listed in the database. ○What types of research resource attributes you consider when, for example, selecting a cell line for an experiment. ○Whether you would be likely to contribute observational information about a research resource to a database like this. ●We are recruiting testers to participate in an upcoming evaluative design study. Please contact nf-osi@sagebionetworks.org if you are interested in participating in this study (Q4 2021) or contributing information about an NF1 research resource! Evaluating External Data Sources & Prior Work Designing a Data Model Identifying Use-Cases Prototype Design & Evaluation ●GFF developed an alpha version of the database, incorporating tools utilized within GFF research programs and soliciting feedback from their awardees on how to best classify and characterize each tool. ●Sage then condu	poster
In Situ Origins of Hot Jupiter Isolation Brandon Radzom1, Songhu Wang1, Bonan Pu2 1Indiana University, 2Cornell University • Outstanding issue: Hot Jupiters are more observed to be more isolated than warm Jupiters • Context: • Widespread prevalence of super-Earths in compact multiple-planet systems • Super-Earth pairs packed near the boundary of Hill instability (Pu & Wu 2015) • Most exhibit “peas in a pod” structure (Weiss et al. 2018) • Many are sufficiently massive to trigger runaway accretion (Lee et al. 2014; Batygin et al. 2016) • Our work: Use N-body simulations of mass-boosted super-Earths to demonstrate that in situ formation naturally produces observationally isolated hot Jupiters and warm Jupiters with nearby low-mass companions Introduction N-body Simulation Set-up References: Batygin, K., Bodenheimer, P. H., & Laughlin, G. P. 2016, ApJ, 829, 114; Lee, E. J., Chiang, E., & Ormel, C. W. 2014, ApJ, 797, 95; Millholland, S. C., He, M. Y., & Zink, J. K. 2022, arXiv e-prints, arXiv:2207.10068.; Pu, B., & Wu, Y. 2015, ApJ, 807, 44; Weiss, L. M., Marcy, G.W., Petigura, E. A., et al. 2018, AJ, 155, 48, Main Results Our final systems exhibit three key properties (Figure 1): 1. Hot Jupiter Isolation. Period ratios of our hottest Jupiters (𝑃< 5 days) relative to their nearest companions are typically larger than those of warm Jupiters (by a factor of ~2). Thus, a large fraction of hot Jupiters' companions would not yet be detectable through transit timing variations or transit searches. 2. Dynamical Sweet Spot. Inner companions rarely survive for the hottest Jupiters but are seldom destroyed for hot Jupiters in the dynamical “sweet spot” (5 < 𝑃< 7 days). This sweet spot marks a dramatic drop in the average period ratio and a transition to inner companion configurations. 3. Mirrored Architectures. Our hot and warm Jupiter systems mirror each other— inner companion period ratios steadily increase with giant period while outer ratios tend to decrease. Step 1: Generate Stable Peas-in-a-Pod Systems We generate 200 peas-in-a pod systems, each with eight super-Earths orbiting a solar mass star. We then boost the mass of one planet per system to 1 Jupiter mass (MJ), driving instability, and integrate to 𝑡= 10 Myr. Step 2: Provide Mass Boost Dynamics: The giant’s position chiefly determines the final configuration since companion-companion collisions dominate (Figure 2). Hot Jupiter Isolation Dynamical Sweet Spot Mirrored Architectures Figure 2. Fraction of companions that avoid collisions & ejections (black squares; left axes) and average timescale for such events (blue shading; right axes) as a function of planet position, stacked for each giant’s position. Giant positions are shown schematically at the top of each panel (large black circles). Figure 1. Final giant period ratios with their nearest neighbor as a function of giant period, with orientations indicated (red rightward and blue leftward triangles). The mirror effect between our red and blue triangles may be astrophysical so long as peas-in-a-pod systems become truncated (see Millholland et al. 2022). A long planet chain exists outside the hot Jupiter, resulting in collisional cascade once two adjacent planets reach 𝑒≈𝑒𝑐/2. The hot Jupiter also merges with its nearest inner companion, leaving it isolated. The hot Jupiter has two inner companions which quickly merge and are then Hill stable for all time, since the Jupiter will “filter” 𝑒excitation. The number of companions on either side of the giant dictates the system’s fate, causing a mirrored effect for hot and warm Jupiter configurations. Sweet spot Innermost period @ 3-day pile- up Orbital eccentricities are bound by orbit-crossing value 𝑒𝑐 25 simulations run for each planet boosting position (25 × 8 = 200) Spacing based on the Equal Mutual Separation scheme— pairs initially Hill stable but pushed near 𝐾= 3.5 threshold after mass-boosting 𝑃~6 d 𝑃~4 d 𝑃~30 d	poster
sdfsafdsa Using digital tools and methods for a systematic literature review Representing social media interactions and meanings as knowledge graphs Creating a curation-enabled social media research archive The Connective project A three-year EU-funded research project (2020-2023) aiming to: Reveal how memory practices on social network sites inside and outside Lithuania, mediated by contested heritage, enable the construction of multiple collective identities. Advance digital curation approaches to social media data and its future preservation and access for research. 2. Based on the ontology, we established a property graph schema using the Cypher query language to design and implement a Neo4j database of social media conversations on Lithuanian heritage, memory and identity. We adopted Open Archives Information System (OAIS) definitions of Submission, Archival, and Dissemination Information Packages, to ensure integrity and authenticity of research data collected from social media platforms, while also ensuring their intelligibility in the research process. Digital resources, methods and tools in the research lifecycle The Connective Digital Memory in the Borderlands project We used the Publish or Perish reference collection software to conduct 20 faceted queries on Google Scholar, based on combinations of Boolean query expressions for difficult heritage and social media platforms. The queries yielded 1,201 documents. Costis Dallas, Ingrida Kelpšienė, Rimvydas Laužikas Connective Research Group, Faculty of Communication, Vilnius University This poster reports on research conducted as part of “Connective digital memory in borderlands: a mixed-methods study of cultural identity, heritage communication and digital curation on social networks”. The Connective project was funded by the European Social Fund under grant agreement 09.3.3-LMT-K-712-17-0027 with the Research Council of Lithuania (LMT-LT). 11 researchers 9 themes 72 topics 4 languages 25,455 Facebook threads 264,954 messages 93,551 users 75 interviews Investigating the semiotic circulation of agency through knowledge graphs Extending nexus theory to show how attitudes on Soviet heritage move across social media, users and references to the dissonant past Investigating propagation across Neo4j person and message nodes Analyzing digital memories and perceptions of the past through qualitative content analysis Examining how Lithuanian everyday life and culture during the 1990s is represented on social media through identifications and memes Using MaxQDA and Neo4j for content and critical discourse analysis Comparing discourse constructs in actual and ChatGPT-produced social media content Investigating the use of ChatGPT to analyze and produce speculative SNS conversations on Lithuanian contested heritage Kelpšienė, Ingrida, Donata Armakauskaitė, Viktor Denisenko, Kęstas Kirtiklis, Rimvydas Laužikas, Renata Stonytė, Lina Murinienė, and Costis Dallas. 2023. ‘Difficult Heritage on Social Network Sites: An Integrative Review’. New Media & Society 25 (11): 3137–64. https://doi.org/10.1177/14614448221122186. Kirtiklis, Kęstas, Rimvydas Laužikas, Ingrida Kelpšienė, and Costis Dallas. 2023. ‘An Ontology of Semiotic Activity and Epistemic Figuration of Heritage, Memory and Identity Practices on Social Network Sites’. SAGE Open 13 (3): 1–25. https://doi.org/10.1177/21582440231187367. Laužikas, Rimvydas, and Costis Dallas. 2024. ‘The Message Is the Agent: Nexus and Semiosphere in Social Media Communication’. In Semiotics and Visual Communication IV: Myths of Today, edited by Evripides Zantides and Sonia Andreou. Cambridge: Cambridge Scholars Publishing. Publications https://doi.org/10.5281/zenodo.10886535 Entities Relationships Deposit Thread Message Agent Topic PART_OF SHARED_FROM RESPONDED_TO FOLLOWED_BY REACTED_TO POSTED DISPLAYS CONNECTED_AS IN_CONTEXT REFERS_TO 1. We built a theory-laden CIDOC CRM-compatible ontology to represent how social media users belonging	poster
An Analysis of Disabled Accessibility Transportation in the City of Chicago Manuel Luna Jr, Industrial Design, University of Illinois Chicago Dr. Joseph Hoereth, UIC — Institute for Policy & Civic Engagement (IPCE) According to the Regional Transportation Authority (RTA), all CTA and Pace buses are 100 percent accessible (RTA, 2023). The Americans with Disabilities Act holds these transportation systems to provide accessible features such as wheelchair securement areas, ramps, priority seating, and visual displays. In reality, 76% of stations are actually functional. The city of Chicago is constantly expanding their stations, not focusing this effort on the already established stations. Funding is going towards new station projects when some of the funding should be used for fixing the old stations that need it. Chicago Accessibility Compliance Program (CACP): The CACP focuses on ensuring that public spaces, transportation systems, and municipal buildings comply with accessibility standards outlined in the Americans with Disabilities Act (ADA). This initiative involves conducting audits, implementing necessary renovations, and providing resources to enhance accessibility for individuals with disabilities throughout the city. Chicago Business Leadership Network (CBLN): The CBLN collaborates with local businesses to promote inclusive hiring practices and provide support to employees with disabilities. Through education, training, and advocacy, the CBLN aims to increase workforce diversity and create employment opportunities for individuals with disabilities. Home Accessibility Program: This program provides financial assistance and incentives to property owners for retrofitting existing housing units to meet accessibility standards. By offering grants and resources, the city encourages the creation of accessible living environments for individuals with disabilities, thereby enhancing housing options and accommodation. These policies and initiatives reflect the City of Chicago's commitment to promoting inclusivity, accessibility, and empowerment for individuals with disabilities. By addressing various aspects such as infrastructure, employment, housing, and community support, Chicago strives to create a more inclusive and equitable environment for all its residents. BACKGROUND POLICY INITATIVES RECOMMENDATIONS RESEARCH OBJECTIVE METHODOLOGY FINDINGS • Increased funding for advocacy efforts from disability rights groups would significantly enhance their capacity to promote accessibility and inclusivity for individuals with disabilities. This funding could support initiatives such as grassroots organizing, public awareness campaigns, legal advocacy, and lobbying efforts aimed at influencing policymakers and stakeholders. • Implementing and upholding inclusive design standards and infrastructure would greatly bolster advocacy efforts for accessibility from disability rights groups. By ensuring that public spaces, buildings, transportation systems, and digital platforms are universally accessible, these standards not only remove physical barriers but also validate the rights and dignity of individuals with disabilities. This research seeks to examine the way the City of Chicago addresses issues of accessibility when it comes to people with disabilities and means of transportation. By analyzing existing policies, infrastructure improvements, and community engagement initiatives, this study aims to shed light on the effectiveness of current strategies in enhancing mobility and inclusivity for individuals with disabilities within the city's transportation network. Additionally, it seeks to identify potential areas for improvement and recommendations for fostering a more accessible and equitable transportation system for all residents of Chicago, regardless of ability. Introduction: The rights and well-being of individuals with disabilities have increasingly gained attention in policy circles and societal discourse. In urban environments	poster
www.postersession.com g Remote sensing has been used in many environmental studies because of its capacity to provide information rapidly on large and hard-to-reach areas. Recently, many programmes such as ASTER, Landsat and Copernicus Sentinels have provided satellite imagery of both high temporal and spatial resolutions free of charge. These data, combined with fieldworks and geophysical measurement , can lead to the finding of solutions for modern challenges such as climate change, natural hazards and increasing population growth. We used these technologies in a region which is both sensitive to and vulnerable to these phenomena, the karst environment of the Tabular Middle Atlas (TMA) of Morocco, in order to study the vulnerability of its natural water reserves . The TMA of Morocco contains an important water reservoir, located in Liassic carbonate rocks (dolomite and limestone), and used for everyday activities in cities such as Agourai, Fez, El Hajeb, Ifrane and Meknes. Because of its importance and the value it holds in the economy of the region it has been described as château d’eau. The most recent studies conducted in this region show that water quality is deteriorating due to anthropologic activities and natural processes. The present study proposes the use of earth observation, geophysical methods and free available data to map various forms of karst (avens, dolines, poljes...) and fault systems; these are the most fragile hotspots where the water reservoir can be easily penetrated in this karst system, with pollutants infiltrating and reaching groundwater and eventually identify most vulnerable areas. We intend to answer the question related to the part played by each fracture system, in order to find out which one is responsible for the infiltration of surface water and consequently is contributing to the development of sinkholes, and also to find out which system is draining water from the Causse to the basin. The aim of this study is to enhance the understanding of the hydrogeological system of the TMA, to improve the fracture database, to explore the profitability of new methodology combining space technology, applied geophysics and ground-based field work, and to establish a complete picture of vulnerable areas where sinkholes and human activities are degrading the quality of groundwater. There are three priority questions to be answered: -What is the direction of the fault systems involved in water infiltration, and probably led to the development of different karst landforms? -What is the predominant location of the sinkholes responsible for the turbidity and chemicals observed in water springs? -Where are water-soluble substances such as fertilizers, pesticides and herbicides accelerating carbonate dissolution due to human activities? Methods and materials Conclusions A.Muzirafuti1, M. Boualoul 1, G.Randazzo 2 , A. Allaoui1, S. Lanza 2, H. El Ouardi3, H. Habibi3, H. Ouhaddach3 1 Team of applied geophysics, Nat Ress. and Heritage, Dept. of Geology, Fac. of Sciences, University of Moualy Ismail, BP. 11201 Zitoune, Meknes, Morocco 2 Section of Earth Sciences, Dept. of Math and Computer Science, Physical Sciences and Earth Sciences, Univ. of Messina. Via F. Stagno d'Alcontres, 31 98166 - Sant'Agata di Messina, Messina, Italy – 3 Team of tec mapping, Dept. of Geology, Fac. of Sciences, University of Moualy Ismail, BP. 11201 Zitoune, Meknes, Morocco - Synthetic map of various karst landform location Fieldworks conducted in numerous locations around major faults, water springs and on different karst landforms helped us validate remote sensing results. We noticed that a big number of sinkholes are located in fractured carbonate rocks in low laying areas, some of them were identified in agricultural areas filled with basalts or clay sediments. Structural study conducted on carbonate fractures revealed that 37 % represent NE-SW fault system while 22% and 30 % represent Sub-meridian and NW-SE Fault faults systems resp	poster
SST CCI Phase-II Requirements for Sea Surface Temperature data sets for Climate Research and Services Nick Rayner, Met Office Hadley Centre, UK SST information is needed by almost all applications in climate research and by many climate service activities. The needs of these diverse fields are varied and can seem confusing without undertaking a systematic user requirements gathering exercise. The ESA Climate Change Initiative SST project has recently reviewed requirements for climate SST data sets from a wide range of applications in climate science and services; this updates its assessment undertaken over five years ago. Responses were received from scientists in 20 countries in North and South America, Europe, Asia, Africa and Australasia. A selected, preliminary analysis of responses is presented here; the final analysis will be presented in the updated User Requirements Document (see http://www.esa-sst-cci.org/ over the coming months). On what kind of grid would you like the data? Other here included: cubed sphere; ORCA (NEMO) grid; and equal area. Please classify this application into one or more of the following applications/interests. Other here included: climate feedbacks; Combined historical, near real-time, and seasonal applications; air quality modelling; comparison with in-situ; interpretation and analysis of hydrographic data; fisheries; for assessing processes; atmospheric chemistry; analysis of relationship between SST and crop productivity and drought; responses of marine top predators to climate change; global numerical weather prediction and high-resolution numerical weather prediction; climate impact model evaluation; ocean heat content comparison; and calibration of proxy data. On what data level does the application require observations? For your application, is it more useful to have all SSTs for the same local time or the same universal time? What spatial coverage is required? What is the temporal coverage needed for your application? How quickly you need data: Is the concept of an interim climate record important to your application? Here respondents gave responses between less than one day and 30 days. SST depth. Providers of satellite SST products variously aim to report temperatures for either the radiometric skin depth they observe or for sub-suface depths. For your application, which type(s) of SST is (are) most relevant? Other included SST1m. The SST CCI project will make Level 2 and Level 3C products available in a flexible format containing information enabling users to derive the SST and its uncertainty adjusted to different depths and times appropriate to their needs. We also propose to make available a standard product file which provides information in a simpler-to-use form. This standard file would contain SSTskin at the observation time, plus one other adjusted SST If you would use this, which combination of adjustments is most relevant to your application? Other here gave no specific alternatives Is your application sensitive to locally-correlated errors (correlated within synoptic scales and uncorrelated beyond)? If SST uncertainty information were to be provided as a parametrised covariance matrix, would you use this? If SST uncertainty information were to be represented by an ensemble (a set of plausible realizations of each SST field which span the uncertainties in the data), what size of ensemble would you need for your application (how many members)? not applicable 3 to 10 10 to 50 50 to 100 100 need guidance How would you like quality/confidence information to be communicated? Other here included requests for uncertainty information or an ensemble only and not to include flags as well. What information would you like to be within the data files? Other here included: gap filled or no gap filled / how?; info on anomalously cold data; data points that may contain extreme upwelling; and information about difference w.r.t. adjacent pixels. What other ancillary data from external sources	poster
www.rethinkaction.eu This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101037104 A platform to support local land-use decision making. Objective The main objective of RethinkAction is to engage citizens and decision-makers to participate in the energy transition and actively support climate adaptation and mitigation. Six representative case studies form the backbone of the RethinkAction project, covering the main regional differences related to climate change. Together with our End-User-Community we create an Integrated Assessment Platform. The user-friendly platform will empower citizens, stakeholders, and decision-makers to analyse climate change and incorporate climate action into the decisions that will affect our lives in the coming decades. Analysis at EU / global level Analysis at local level Land use-based Adaptation and Mitigation Solutions (LAMS) catalogue High-resolution climate data and land use maps. Climate change impacts and risks in each case study Land use-based Adaptation and Mitigation Solutions catalogued at local, EU and global scales Multiscale evaluation framework: 1) Future scenarios consistent across scales 2) Local system dynamic mo- dels for the integrated assessment of solutions 3) An upscaling function for solutions to EU and global scales (WILIAM IAM). • • • 1 Diagnosis 2 LAMS feasibility 3 Simulati on Interested? Engage! Help to make high-level information on land-use and climate change more accessible to people’s lives. Join our End-User-Community: Help to shape the direction in which RethinkAction is to be further developed. Expand and internationalise your professional network. Receive exclusive invitations to work meetings, training sessions and conferences organised by the project consortium. • • • What would happen if the LAMS assessed at local level…. …would be applied at EU / global level in all feasible locations? Upscaling solutions Simulati on with system dynamics integrated assessment model [WILIAM] An impression of the platform	poster
1 INTRODUCTION Depuis des décennies, la Station Biologique de Roscoff suit la diversité de s communauté s planctonique s a u larg e de Roscoff, avec des prélèvements bimensuels sur les si tes "Estaca de" et "SOMLIT-Asta n" , au Nord -Es t de l 'Îl e de B atz. Plusi eurs mét hodes sont utilisées pour dénombrer les cellules , d ont la micro scopie o ptiqu e po ur les e sp èc es > 20 µm , et la cyt omé trie en fl ux p our les esp èces <20 µm. La cy tom étrie en flu x permet de distinguer les groupes fonctionnels suivants : (i) les cyanobactéries du genre Synechococcus, (ii) les picoeucaryotes photosynthétiques, (iii) les nanoeucaryotes photosynthétiques (iv) les algues Cryptophytes (v) les bactéries et (vi) les virus marins Les données de diversité phytoplanctonique de Roscoff obtenues par microscopie optique on t déjà été bien étudiées par le laboratoire et ont m is en éviden ce u ne dynamiq ue saisonniè re t rès marquée avec des successions d’espèces au c ours de l’année (Caracciolo et al. 2022). Ce projet, focalisé sur les données obtenues par cytométrie en flux avait pour objectif : (1) d e fair e u n inventair e de s donnée s disponible s et d es protocol es utilis és po ur l es collecte r, ( 2) de détermi ner les dynamiq ues saisonniè res des principaux groupes fonctionnels distingués po ur le site SOMLIT- Ast an e t ( 3) de déter min er si les blooms saiso nni ers de Synecho coccus avaient changé de date au cours des deux dernières 20 ans de données Échantillonnage et analyse de la mer à la cellule Actuel Protocole 2 Anciens FACSCanto, FACSCan Flash frozen Sans Pluronic + Glutaraldéhyde (fixateur) + Pluronic (surfactant) Echantillonnage (Neomysis) Congélation (-20°C) Congélation (-80°C) Conservation Niskin bottle Picoeucaryotes Analyse des abondance s des group es taxonomiques Cytogramme Fluorescence Side Scatter (SSC) Synechococcus Bactéries Nanoeucaryotes + 5µl billes Polysciences fluoresbrite® Analyse (laboratoire) Microgouttelette chargée contenan t 1 seule cellule FACSort Détecteur et photomultiplicateur SSC : taille Fluorescence : naturelle ou fluorochrome Cytométrie en flux : Dynamique saisonnière au site SOMLIT-Astan 7 Trait de filet (eau de Roscoff) diatomées Synechococcus ? nanoeucaryotes photosynthétiques ? picoeucaryote photosynthétique ? © SBR 6 Cyanophage et Synechoccocus infectée © Sophie Le Panse, Plateforme MERIMAGE (SBR) 48°46'40.1"N 3°56'15.0"W 48°43'55.9"N 3°58'58.0"W 3 4 OUI Fig. 5. Variations saisonnières des abondances des 5 groupes fonctionnels sur la période d u 12/01/200 7 a u 18/12/201 9 (1 2 an s e t 1 1 mois ). Donné es issu es de la ba se PELAGO S, s ite SOMLIT-Astan surface. (d) Picoeucaryotes (e) Nanoeucaryotes (b) Bactéries (c) Cryptophytes (a) Synechococcus Pico : 0.2-2 µm Nano : 2 – 20 µm Micro : 20-200 µm Phytoplancton → diversité de taille : 500 nm 5 8 Fig. 9. Variations saisonnières des abondances de virus HNA (2013- 2020), site SOMLIT-Astan surface. Intéractions virales Abondance virale (cellules/mL) Synechococcus est la cible de certains virus marins. Au site Astan, en surface, l'abondance des virus HNA (High Nucleic Acid content) qui ciblent Synechococcus, mais aussi des picoeucaryote s photosynthétiqu es (communicati on personnel le de AC Baudo ux) va rie de f açon saisonni ère, ave c un pi c en juin-juil let, pér iod e de développ ement des pico- et nanoeucaryotes. 500 nm 200 nm LIMITES & PERSPECTIVES → Biais potentiels dus au changement de protocole des données PELAGOS → Série temporelle courte : description possible, mais conclusions limitées → Échantillonnage tous les 15 jours insuffisant pour suivre les blooms d’organismes unicellulaires à cycle de vie court (de quelques heures à quelque s jours) De nombreuses pistes sont possibles pour explorer davantage cette communauté. Par exemple, des données de fluorescence et de PA R (Rayonnemen t Photosynthétiquemen t Actif ) son t disponible s su r l a ba se SOMLIT. Ces données pourraient révéler des changements physiologiques c hez	poster
Resolving Surface Features on M Dwarfs that Host Transient Corotating Material Ben Tofflemire1,†, Adam Kraus1, Andrew Mann2, Greg Mace1 1The University of Texas at Austin, 2UNC Chapel Hill †51 Pegasi b Fellow RIK 12 Toy Model Complex Periodic Variables Complex periodic variables (CPVs) exhibit narrow dimming events with variable morphologies and depths that are periodic with the stellar rotation. Dimming events emerge and disappear stochastically. CPVs are predominantly young (<~200 Myr), low- mass (M<0.4 M⨀), and rapidly rotating (P<1 d). The most likely explanation for this behavior is magnetically confined material orbiting in co-rotation with the star [1,2,3]. Monitoring with IGRINS We have monitored four CPVs in Upper Sco using the IGRINS spectrograph ([4,5], simultaneous H and K at R~45,000). Here, we showcase the results for RIK 12 ([6], M2.5 SpT, 5-10 Myr, Prot = 0.49 d, G mag = 13.8, K mag = 9.7) We reconstruct the stellar absorption profiles by computing spectral-line broadening functions using the saphires package [7]. We find: • Large rotational velocities (vsini>150 km/s), consistent with edge on viewing angles • Evidence for large and evolving spot features • No significant radial-velocity variability Modeling Surface Features The cadence and baseline of our observations do not allow for a full surface reconstruction. Still, we can use a toy model to investigate characteristics of surface features that are consistent with our observations. We find the amplitude of the line-profile deviations are challenging to reproduce with typical spot- photosphere surface brightness ratios in the NIR (~0.5). The depth and bread of the deviations are improved when incorporating polar spots. Our most extreme cases likely require obscuring dust. In summary, our spectra suggest the presence of: • Large, high-contrast (dark) spots near equator • Large polar spots • Potentially, obscuring dust Our sparsely sampled spectra highlight CPVs as prime candidates for future Doppler tomographic studies to fully reconstruct the stellar surface, and to measure the orientation and size of the transiting material. Resolution Element Rotational Phase Rotation Periods since K2 Signature of Dark Spots (or Obscuring Material) No evidence for RV variability Flux compared to a homogeneous surface Typical Residual Depth vsini Acknowledgements & References BMT acknowledges the Heising-Simons Foundation, and TESS Cycle 3 & 4 Guest Investigator Grants (80NSSC21K0780, 80NSSC22K0302) [1] – Bouma et al. 2024, AJ, 167, 38 [2] – Stauffer et al. 2017, AJ, 151,60 [3] – Zhan et al. 2019, ApJ 876, 127 [4] – Mace et al. 2016, SPIE, Vol. 9908 [5] – Mace et al. 2018, SPIE, Vol. 10702 [6] – Rizzuto et al. 2015 MNRAS,448, 2737 [7] – Tofflemire et al. 2019, AJ, 148, 245	poster
1 2 3 4 5 6 7 8 BTSA 1 et 2 Licence de biologie générale 2 et 3 Master 1 et 2 en Microbiologie Doctorat Nutrition animale, parasitisme et environnement BTSA 1 et 2 Classe préparatoire ATS* École d’ingénieur Agroalimentaire- Agronomie Doctorat Nutrition animale et qualité des produits laitiers Doctorat Microbiologie et santé animale Doctorat Nutrition animale et qualité des produits laitiers École d’ingénieur en Agriculture avec classes préparatoires intégrées Master 1 et 2 en Sciences Animales Licence de biologie générale 1, 2 et 3 Master 1 et 2 en Microbiologie Doctorat Sélection génétique et santé animale École d’ingénieur en Agriculture avec classes préparatoires intégrées Lucie Laurianne Valentin Blandine Des parcours variés vers le doctorat (bac+8), à toi de créer le tien ! Bac ATS : Adaptation de Technicien Supérieur *BTSA : Brevet de Technicien Supérieu r Agricole Clément Centre Auvergne Rhône Alpes - Theix Route de Theix 63122 Saint-Genès-Champanelle, France Tel.: +33 (0)4 73 62 40 00	poster
Tolerance of DNA Replication Stress Is Promoted by Fumarate Through Modulation of Histone Demethylation in Saccharomyces cerevisiae Faeze Saatchi1, Ann L. Kirchmaier1 1 Department of Biochemistry and Purdue Center for Cancer Research , Purdue University, West Lafayette, IN 47907 Current address: Department of Internal Medicine, Kidney Cancer Research Program, UT Southwestern Medical Center, Dallas, TX 75235 Abstract Conclusions Introduction me me Ku70/80 me me FH Ku70/80 H2A H2A H2A.Z H2A.ZH3K36H3K36 FH H2A H2A.Z H2A H2A.Z Malate Fumarate KDM2B Malate Fumarate Figure 1. Upon DNA damage, fumarase (FH) is recruited to sites of double stranded break (DSB) through interaction with the histone variant H2A.Z. Fumarate generated by DSB-associated FH acts as an inhibitor of α- ketoglutarate-dependent histone demethylase KDM2B causing an increase of H3 K36 methylation at DSBs. This, in turn, promotes binding of Ku70/80 to DSB ends and enhances DSB repair by NHEJ. Sensitivity of htz1Δ mutants to DNA replication stress caused by HU is suppressed by high cellular levels of the metabolite fumarate (achieved by addition of exogenous fumarate or deletion of Fumarase, Fum1p) Figure 3. Cells with genotypes as indicated were grown overnight in rich (YPD) medium, then 3 ul of 10-fold serial dilutions were spotted onto YPD medium containing the indicated concentrations of fumarate and/or HU, and incubated at 30°C for 2 days prior to imaging. Loss of JmjC domain-containing histone demethylase Jhd2p suppresses the sensitivity to DNA replication stress of htz1Δ mutants. Results Our study uncovers links between the metabolic enzyme fumarase plus the metabolite fumarate and chromatin modifications during DNA damage response in Saccharomyces cerevisiae. In mammalian cells, fumarase becomes enriched at sites of double stranded break (DSB) through interaction with the histone variant H2A.Z. At DSBs, fumarase promotes DNA repair by nonhomologous end joining (NHEJ) by local production of fumarate which in turn acts as an inhibitor of KDM2B, a H3 K36-specific histone demethylase. We have demonstrated that treatment with hydroxyurea (HU), which creates stalled replication forks by depletion of nucleotides, leads to upregulation as well as nuclear enrichment of Fum1p. We have also shown that increased cellular levels of fumarate (upon deletion of FUM1 or addition of exogenous fumarate) suppresses the sensitivity to HU in htz1Δ mutants in a manner that is independent of modulating nucleotide levels. In fact, fumarate confers resistance to HU in htz1Δ mutants by inhibition of the H3 K4-specific histone demethylase Jhd2p, and increasing H3 K4 methylation levels. Sensors and mediators of the DNA replication checkpoint were required for fumarate- dependent resistance to HU in htz1Δ whereas factors involved in processing of regressed replication forks were dispensable. Together, our findings imply that high cellular levels of fumarate support processing of replicative intermediates by regulation of histone methylation, thereby promoting genome integrity. Fumarase is induced and becomes enriched in the nuclear fraction upon exposure to hydroxyurea (HU) Fumarate modulates levels of JDH2-dependent H3 K4 methylation. Figure 4. Strains with indicated genotypes were analyzed in serial dilution growth assays as described in Figure 3 YKu70p is not required for suppression of sensitivity of htz1Δ mutants to DNA replication stress by fumarate. Figure 2. Yeast expressing Fum1-GFPp were incubated in the absence or presence of 200 mM HU at 30°C for 3 hr. Whole cell extracts (A), or nuclear fractions (B) were analyzed by immunoblotting using anti-GFP, and anti-PCNA antibodies. A representative immunoblot and fold enrichment of Fum1p from two independent experiments is shown. Levels of Fum1-GFPp were normalized to levels of PCNA (loading control), then expressed relative to signal that was observed in the absence of HU, which was set to 1. Figure 5. (A) Enhancing histone methyl	poster
NuSTARConstrainstheOriginofGammaRays inRSOph Marina Orio1,2, G. Juan M. Luna3 1. U Wisconsin and INAF-Padova, 2. orio@astro.wisc.edu, 3. CONICET, Buenos Aires and Hurlingham Universities Introduction RS Oph is arguably the best known recurrent symbiotic nova. Classical and recurrent novae occur in white dwarf binaries. The outbursts are attributed to a thermonuclear runaway on the surface of the WD, that has accreted ma- terial from the binary companion. A radiation- driven wind follows, depleting the accreted enve- lope [1, 2]. The designation “recurrent” implies that the outburst is observed more than once over human life timescales, and in RS Oph case outbursts were recorded in 1898, 1933, 1958, 1967, 1985, and 2006. RS Oph is also a sym- biotic system, hosting a red giant M0-2 III mass donor companion [3, 4] in a binary with a 453.6 day orbital period [5]. The NuSTAR observation We obtained a Director Discretionary Time NuSTAR 40 ks exposure in the 3-79 keV range on 2021 August 17, day 10 of the outburst ( it was impossible to schedule the exposure earlier, when the source may have been harder). The X-ray ﬂux was expected from colliding winds, presumably the high velocity ejecta impacting the slow red giant wind. One of the most in- teresting facts of this phase is the gamma-ray ﬂux, measured with Fermi in the GeV range and with HESS up to tens of GeV [6]. During the NuSTAR observation, several short exposures were done with NICER. Most important, for the ﬁrst time, a nova was observed at the same time also in gamma rays with Fermi and with Cherenkov telescopes [6]. References [1] S. Starrﬁeld, F. X. Timmes, C. Iliadis, W. R. Hix, W. D. Arnett, C. Meakin, and W. M. Sparks. Hy- drodynamic Studies of the Evolution of Recurrent, Symbiotic and Dwarf Novae: the White Dwarf Com- ponents are Growing in Mass. Baltic Astronomy, 21:76–87, January 2012. [2] William M. Wolf, Lars Bildsten, Jared Brooks, and Bill Paxton. Hydrogen Burning on Accreting White Dwarfs: Stability, Recurrent Novae, and the Post- nova Supersoft Phase. ApJ, 777(2):136, November 2013. [3] Danuta Dobrzycka, Scott J. Kenyon, Daniel Proga, Joanna Mikolajewska, and Richard A. Wade. The Hot Component of RS Ophiuchi. AJ, 111:2090, May 1996. [4] G. C. Anupama and J. Mikołajewska. Recurrent no- vae at quiescence: systems with giant secondaries. A&A, 344:177–187, April 1999. [5] E. Brandi, C. Quiroga, J. Mikołajewska, O. E. Ferrer, and L. G. García. Spectroscopic orbits and variations of RS Ophiuchi. A&A, 497(3):815–825, April 2009. [6] H. E. S. S. Collaboration. Time-resolved hadronic particle acceleration in the recurrent nova RS Ophi- uchi. Science, 376(6588):77–80, April 2022. [7] Indrek Vurm and Brian D. Metzger. High-energy Emission from Nonrelativistic Radiative Shocks: Ap- plication to Gamma-Ray Novae. ApJ, 852(1):62, Jan- uary 2018. [8] Gary Wegner, Joseph P. Cassinelli, and George Wallerstein. Shockwave Models for the Outburst of the Repeating Nova, RS Ophiuchi. In Bulletin of the American Astronomical Society, volume 1, page 209, March 1969. [9] S. Orlando, J. J. Drake, and J. M. Laming. Three- dimensional modeling of the asymmetric blast wave from the 2006 outburst of RS Ophiuchi: Early X-ray emission. ApJ, 493(3):1049–1059, January 2009. Conclusions The low maximum temperature measured with NICER rules out that the site of the X-ray emission is the same as the site of the gamma-ray emission. In fact, the energetics of novae are such that the shock temperature may be in the hard X-ray range, but gamma rays due either to inverse Compton eﬀect (leptonic mechanism) or to particle acceleration in the shock (causing pion decay; hadronic mechanism) are only associated with a very hard X-ray spectrum, with conspicuous ﬂux up to 80 keV. The site of the gamma-ray emission was thus optically thick even to very hard X-rays. In the 40-79 keV range, we have upper limits of 3 ×10−4 cts s−1 in NuSTAR. Assuming an initial X-ray ﬂux above 10−9 erg cm−2, consistent with Fermi	poster
RESEARCH POSTER PRESENTATION DESIGN © 2012 www.PosterPresentations.com In developing countries, Clinical Research is considered a luxurious interest with lower priority. Ongoing studies show considerable gap in responses between developed countries where most research is conducted and developing countries where most of needy population is located. Background and Significance Purpose This process proved effective and necessitated developing tools for providing more comprehensive treatment roadmaps and tracking patients’ treatment milestones. Another advantage of applying the system is the improvement of medical team conduct knowing that their performance is being reviewed in what’s known as Hawthorne Effect. With the establishment of first research informatics unit in the region Monitoring process became live web-based activity where performance and survival can be monitored instantaneously. Method Within five years we’ve developed a model example for developing countries to improve clinical practice through integrating research methods and informatics. Dealing with all treatment regimens as research protocol with the integration of audit and feedback approach in the treatment process definitely improves treatment outcome most specifically at poorly established settings. Conclusion We demonstrate a case where practice was improved in a multi-disciplinary cancer center through setting the institution vision and objectives to be patient centered, research focused and outcome oriented. Research Clinical 2008 • Starting Protocol development and Monitoring Unit • Data collection using MS Excel 2008-2009 • Access databases (local) • Databases shared over network. 2009 • In-House development of Web-based application for electronic data capture. Each protocol is digitized. 2010 • Development of Web-based plug-in for mobile / handheld devices and real-time analysis. • Task manager • Cancer Registry 2011 • Violation Reporting / Patient safety 2012 • Joining RedCap open source Consortium • IRB submission and review online system • Research Online Training Management System. • Research and Clinical Pharmacy eLearning module 2007 • RIS: Radiology Information System. • PACS: Picture archiving and communicatio n system • LIS: Lab Information System 2007-2009 • Paper based patient charts. 2009 • Implementing Electronic medical Record System. Research Department, Children's Cancer Hospital 57357 - Egypt. Research Department, Children's Cancer Hospital 57357 - Egypt. A.S. Alfaar, M. Kamal, O. Hassanain, M. Sabry, S. Ezzat, S. Abouelnaga Advancing Clinical Oncology Practice in Developing Countries: Integrating Research Informatics for Continuous Process Improvement. Advancing Clinical Oncology Practice in Developing Countries: Integrating Research Informatics for Continuous Process Improvement. Since the development of the Protocol Monitoring unit and the Research Department, a monitoring process has been established which identified violations and deviations from the developed clinical protocols with a continuous feedback to the attending treatment and research teams i.e. treating each treatment regimen as a research protocol. 2008 Paper File 2011 Electronic research systems Pictures are graphically manipulated for protecting patients’ privacy No Conflict Of Interest To Be Declared By Authors Telemedicine Live Stat’s The customized treatment protocols were developed through identifying key evidence-based practices, integrating it with research questions and local clinical expertise. Cooperation with international centers like St. Jude Children’s Research hospital and Dana Farber Cancer Institute as well as Children’s Hospital-Boston has supported our transition into an international center through benchmarking and training. Acknowledgement This Poster is Supported by Travel Grant From ESMO Contact Us: mohamedkamalpharm@gmail.com asamir@57357research.com msabrybakry@gmail.com N.B. The team is all MDs and Pharmacists No IT members. Portal Dashboar	poster
Eingangsformel Der Parlamentarische Rat hat am 23. Mai 1949 in Bonn am Rhein in öffentlicher Sitzung festgestellt, daß das am 8. Mai des Jahres 1949 vom Parlamentarischen Rat beschlossene Grundgesetz für die Bundesrepublik Deutschland in der Woche vom 16. bis 22. Mai 1949 durch die Volksvertretungen von mehr als Zweidritteln der beteiligten deutschen Länder angenommen worden ist. Auf Grund dieser Feststellung hat der Parlamentarische Rat, vertreten durch seine Präsidenten, das Grundgesetz ausgefertigt und verkündet. Das Grundgesetz wird hiermit gemäß Artikel 145 Abs. 3 im Bundesgesetzblatt veröffentlicht: Präambel Im Bewußtsein seiner Verantwortung vor Gott und den Menschen, von dem Willen beseelt, seine nationale und staatliche Einheit zu wahren und als gleichberechtigtes Glied in einem vereinten Europa dem Frieden der Welt zu dienen, hat sich das Deutsche Volk in den Ländern Baden, Bayern, Bremen, Hamburg, Hessen, Niedersachsen, Nordrhein-Westfalen, Rheinland-Pfalz, Schleswig-Holstein, Württem- berg-Baden und Württemberg-Hohenzollern, um dem staatlichen Leben für eine Übergangs- zeit eine neue Ordnung zu geben, kraft seiner verfassungsgebenden Gewalt dieses Grund- gesetz der Bundesrepublik Deutschland beschlossen. gegeben. Es hat auch für jene Deutschen gehandelt, denen mitzuwirken versagt war. Das gesamte Deutsche Volk bleibt aufgefordert, Die Deutschen in den Ländern Baden- Württemberg, Bayern, Berlin, Brandenburg, Bremen, Hamburg, Hessen, Mecklenburg- Vorpommern, Niedersachsen, Nordrhein- Westfalen, Rheinland-Pfalz, Saarland, Sachsen, Sachsen-Anhalt, Schleswig-Holstein und Thüringen haben in freier Selbstbestimmung die Einheit und Freiheit Deutschlands zu vollenden vollendet. Damit gilt dieses Grundgesetz für das gesamte Deutsche Volk. I. Die Grundrechte Artikel 1 (1) Die Würde des Menschen ist unantastbar. Sie zu achten und zu schützen ist Verpflichtung aller staatlichen Gewalt. (2) Das Deutsche Volk bekennt sich darum zu unverletzlichen und unveräußerlichen Men- schenrechten als Grundlage jeder menschlichen Gemeinschaft, des Friedens und der Gerech- tigkeit in der Welt. (3) Die nachfolgenden Grundrechte binden Gesetzgebung, Verwaltung vollziehende Gewalt und Rechtsprechung als unmittelbar geltendes Recht. Artikel 2 (1) Jeder hat das Recht auf die freie Entfaltung seiner Persönlichkeit, soweit er nicht die Rechte anderer verletzt und nicht gegen die verfassungs- mäßige Ordnung oder das Sittengesetz verstößt. (2) Jeder hat das Recht auf Leben und körperliche Unversehrtheit. Die Freiheit der Person ist unverletzlich. In diese Rechte darf nur auf Grund eines Gesetzes eingegriffen werden. Artikel 3 (1) Alle Menschen sind vor dem Gesetz gleich. (2) Männer und Frauen sind gleichberechtigt. Der Staat fördert die tatsächliche Durchsetzung der Gleichberechtigung von Frauen und Män- nern und wirkt auf die Beseitigung bestehender Nachteile hin. (3) Niemand darf wegen seines Geschlechtes, seiner Abstammung, seiner Rasse, seiner Sprache, seiner Heimat und Herkunft, seines Glaubens, seiner religiösen oder politischen An- schauungen benachteiligt oder bevorzugt wer- den. Niemand darf wegen seiner Behinderung benachteiligt werden. Artikel 4 (1) Die Freiheit des Glaubens, des Gewissens und die Freiheit des religiösen und weltan- schaulichen Bekenntnisses sind unverletzlich. (2) Die ungestörte Religionsausübung wird ge- währleistet. (3) Niemand darf gegen sein Gewissen zum Kriegsdienst mit der Waffe gezwungen werden. Das Nähere regelt ein Bundesgesetz. Artikel 5 (1) Jeder hat das Recht, seine Meinung in Wort, Schrift und Bild frei zu äußern und zu verbreiten und sich aus allgemein zugänglichen Quellen ungehindert zu unterrichten. Die Pressefreiheit und die Freiheit der Berichterstattung durch Rundfunk und Film werden gewährleistet. Eine Zensur findet nicht statt. (2) Diese Rechte finden ihre Schranken in den Vorschriften der allgemeinen Gesetze, den gesetzlichen Bestimmungen zum Schutze der Jugend und in dem Recht der persönlichen Ehre. (	poster
DIE STORY IN DEN DATEN Robert Köpke IfL Leipzig Unser Use Case Im Projekt arbeitet das IfL an der Entwicklung von Visualisierungsformaten und der kritischen Analyse von Biodiversitätsdatensätzen. Das IfL entwickelt (raumbezogene) Visualisierungen sowie Methoden des visuellen Storytellings, um komplexe Datensätze verständlich darzustellen und unterschiedleiche Zielgruppen zu adressieren. Girlitz im Blick Seit vielen Jahren führt der DDA das Monitoring häufiger Brutvögel durch, unterstützt von zahlreichen geschulten Freiwilligen. Diese Story beleuchtet, wie die gesammelten Daten verarbeitet werden und welche Schlüsse daraus gezogen werden können, insbesondere im Hinblick auf den rückläufigen Brutbestand des Girlitz. Sie erzählt von den langfristigen Erkenntnissen aus Jahrzehnten der Datenerhebung und zeigt, wie Technik die Arbeit erleichtert. Von Ruf und Realität Die Süßwasserfische Brachse und Äsche, obwohl häufig vorkommend, erleben einen Bestandsrückgang. Die länderübergreifende Auswertung von Bestandsdaten, wie sie das Projekt NFDI4Biodiversity vornimmt, ermöglicht es, solche Entwicklungen frühzeitig zu erkennen und Schutzmaßnahmen einzuleiten. Diese Story zeigt am Beispiel dieser Fischarten das Potenzial der einheitlichen Datenverarbeitung für den Biodiversitätsschutz. DATENGRUNDLAGE - Harmonisierter Fischmonitoring- Datensatz ZIELGRUPPE - Wissenschaftler :innen - Fachpublikum FORSCHUNGSFRAGE Kartographische Methoden zur Visua- lisierung von Unsi- cherheiten in Vorkom- mensdaten und deren Einfluss auf Interpretation und Entscheidungsfindung. DATENGRUNDLAGE - Testflächen Monitoring häufiger Brutvögel ZIELGRUPPE - Ausgebildete Helfer:innen - Breite Öffentlichkeit FORSCHUNGSFRAGE Wie können räumliche Analysemethoden ein- gesetzt werden, um Muster und Trends zu identifizieren? Data Storys Die Verwendung von digitalem Storytelling, das Karten, Infografiken und Bilder einsetzt, ist eine effektive Methode, um Inhalte für verschiedene Zielgruppen ansprechend zu gestalten. Möglichkeiten Verbesserte Entscheidungsfindung: Erleichtern das Verständnis komplexer Daten, unterstützen so umweltpolitische und wissenschaftliche Entscheidungen. Interaktive Lernerfahrung: Multimedia-Elemente wie Videos, interaktiven Karten und Animationen können Nutzer die Daten erfahren lassen. Forschung und wissenschaftliche Analyse: Kann neue Muster und Zusammenhänge in Biodiversitätsdaten kommunizieren. Herausforderungen Zeitliche Dynamik: Darstellung von zeitlichen Veränderungen und Aktualität Interdisziplinäre Integration: Zusammenführung von Expertenwissen Darstellung von Unsicherheiten: Um Fehlinterpretationen zu vermeiden und ein realistisches Bild zu vermitteln. Dateninterpretation und -verfügbarkeit: Sicherstellung der Genauigkeit, Aktualität und Vollständigkeit der Daten.	poster
Seminar für Ägyptologie und Koptologie (Re-)Konstruktion der Lübecker Aegyptiaca – Didaktische Perspektiven auf gegenständliche Quellen in der Ägyptologie Nina Wagenknecht, M.A. E-Mail: nina.wagenknecht@stud.uni-goettingen.de Erstbetreuung: apl. Prof. Dr. Heike Sternberg-el Hotabi, Seminar für Ägyptologie und Koptologie Zweitbetreuung: Prof. Dr. Michael Sauer, Seminar für Mittlere und Neuere Geschichte •Thema und Zielgruppe festlegen •Vermittlungsziele des Themas formulieren •Objekte auf Basis des Themas auswählen Thema und Zielgruppe der Ausstellung •Kontextualisierung von Verwendungsweisen und Datierung der Objekte •Rekonstruktion der Erwerbsumstände der Objekte Fachwissenschaftliche Sachanalyse •Erarbeitung der Umsetzungsformate unter Einbezug von Medienwahl, - wechsel und Barrierefreiheit •Ausarbeitung der digitalen Präsentation der Objekte in Microsoft Access Didaktische Analyse Methodisches Vorgehen Thema und Ziele der Arbeit Im Rahmen des Dissertationsvorhabens wird ein Online- Vermittlungskonzept für die nicht physisch ausgestellten Aegyptiaca der Völkerkundesammlung der Lübecker Museen erarbeitet. Zentrale Ziele dabei sind: • Die Übertragung methodischer Schritte zur Vermittlung gegenständlicher Quellen aus der Geschichtsdidaktik zur Erarbeitung zusammenhängender Lernmaterialien. • Erstellung eines Vermittlungskonzeptes thematisch ausgewählter Aegyptiaca unter Einbezug einer kritischen Reflexion der Sammlungsgeschichte. Materialbasis Inhalt der Sammlung: 338 Aegyptiaca (415 Objekte einschließlich Verluste). Erwartete Ergebnisse 1. Inhaltliches Ergebnis: Ein Online-Konzept, das einen ausgewählten Teil des Bestandes der Lübecker Aegyptiaca der Öffentlichkeit thematisch aufbereitet zugänglich macht und dabei die Verbindung der Objekte zur Sammlungsgeschichte der Völkerkundesammlung kritisch einordnet. 2. Methodisches Ergebnis: Systematische Erschließung neuer Formate der Wissensvermittlung auf Basis der Struktur von Bestandskatalogen, die auf weitere Sammlungen übertragen werden kann. Zeitphase Anzahl Beispiele für Objekte Paläolithische Zeit 49 Flint- und Hornsteinobjekte Prädynastische Zeit 40 Tonkrüge, Haarnadel, Schminkpalette Frühdynastische Zeit 9 Flintwerkzeuge Altes Reich 8 Modell-Opferteller Mittleres Reich 3 Koḥl-Gefäß Neues Reich 11 Grabziegel, Umschlagtuch, Wandbruchstück Spätzeit 96 Gewichtsteine, Kaurischnecken, Figur-Sockel Ptolemäische Zeit 20 Amulette, Öllampen, Ostrakon, Vogelmumie Römische Zeit 61 Würfel, Spinnwirtel, Schreibtafel, Brotstempel Frühislamische Zeit 6 Koptische Textilien Unklare Datierung 12 Skarabäen, Torso einer Königs-Statuette 19./20./21. Jahrhundert 23 Fälschungen, Repliken Literatur Falck, Martin von. 2011. „Museologischer Anspruch und museumsägyptologische Wirklichkeit“. In: Verbovsek, Alexandra, Burkhard Backes und Catherine Jones, Hrsgg. Methodik und Didaktik in der Ägyptologie. Herausforderungen eines kulturwissenschaftlichen Paradigmenwechsels in den Altertumswissenschaften. Ägyptologie und Kulturwissenschaft IV. München: Fink, 405–422. Germer, Renate. 2018. Die altägyptischen Objekte der Völkerkundesammlung der Hansestadt Lübeck: Ein Kurzkatalog zusammengestellt von Renate Germer, <https://vks.die-luebecker-museen.de/file/die_altaegyptischen_objekte__kompl_zusammengefasst.pdf> (Zugriff: Juli 2020). Röttele, Hannah. 2020. „Objektbegegnungen“ im historischen Museum: eine empirische Studie zum Wahrnehmungs- und Rezeptionsverhalten von Schüler_innen. München: kopaed.	poster
APPROACH The textile sector is undergoing a set of transformations to shift to a circular model. Within the framework of the TRICK project, an innovative approach to traceability and sustainability in textile supply chains has been developed. BACKGROUND OUTCOMES INDUSTRIAL PILOTS – CIRCULAR APPROACH The data model validation has been done through two pilots, one for the classical fashion segment and the other for the technical work-wear segment aiming to get the necessary data from a fragmented supply chain. The pilots began with the production of the goods made from virgin raw materials; the obtained garments, which usage was simulated, then were mechanically recycled. The obtained secondary raw materials include a percentage of the recycled goods; they were used to obtain garments of the same model whose characteristics were analyzed. The pilots started by an initial data gathering from the industrial users' internal system, a data validation and the mapping to the data model for its refinement. Then traceability reports were created by modeling data and reporting the product’s history. The collected data was also used to perform a PEF study across the whole supply chain. CONCLUSIONS AND NEXT STEPS The holistic approach to data collection covering traceability and sustainability data allows to easily meet the requirements from new normative: it is the case of ESPR and Digital Product Passport (DPP) enforcing a sustainable approach to production and, in parallel, more efficacy of the market surveillance authorities. The next steps will be to validate TRICK efficacy in collecting faithful data to fuel the creation of digital product passport contents from the fragmented textile supply chains. On this purpose a CEN Workshop process will be launched to share and improve such contents and contribute with a public pre- standardization activity to the establishment of a framework for collecting faithful data to support the DPP statements of the fashion firms. A Traceability Report for the data collections on the events is the TRICK response to the requirements emerged from the pilot supply chains to overcome the barriers, criticalities and needs highlighted by industrial partners involved in the project. In respect of the EPCGlobal EPCIS and UNECE event models, its Enriched Event-based Model: - offers a plurality of product and lot identification methods and a more detailed process step description with a shared taxonomy of manufacturing operations - supports the collection of the events from a wide range of heterogeneous systems, covering the many tiers of the supply chain - enforces a triangle of synergies among usual daily operations, blockchain technology and business services of a traceability platform and its disclosure policies. Enhancing Traceability and Faithfulness of Sustainability Data in the Textile and Clothing Supply Chain through Blockchain and a Standard Based Enriched Event Model Gessica Ciaccio (1), Carla Fité Galan (2), Piero De Sabbata (1), Arianna Brutti (1) (1) Italian National Agency for New Technology, Energy and Sustainable Economic Development, ENEA, TERIN-SEN-CROSS Laboratory, via dei Mille 21, 40121, Bologna, Italy (2) Polytechnic University of Catalonia (UPC), Systems and Processes lab of the Textile Research Institute of Terrassa (INTEXTER), Carrer Colom 15, 08222, Terrassa, Spain This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 958352 Fig. 5 Representation of a circular approach of the textile pilots in the TRICK project CONTACTS Gessica Ciaccio, gessica.ciaccio@gmail.com Carla Fité Galan, Carla.fite@upc.edu Piero De Sabbata, piero.desabbata@gmail.com In parallel the Transparency and Sustainability Report is the core of the Transparency and Sustainability data collection. It collects all the available non- operational data about Product and Organization and shares the data groups related to sustainability with specific	poster
Protect Bees, Save the Future I. Madaleno1, S. Branco1, students from 10th Grade Mechatronics1 1Externato Cooperativo da Benedita, Benedita, Portugal Abstract In this project students built a hive by adapting remote control systems for its internal environment (temperature and humidity) and external environment (door, fire, location). The solution was aimed at beekeepers, and anyone interested in getting started in the beekeeping industry. The main goals of the project were to facilitate the work of beekeepers and to improve the management, control and monitoring of hives. The solution created is feasible and satisfies the project's objectives. Keywords Automation; bees; electronics; robotics; sustainability.	poster
Direct Dark Matter Search with the CRESST-III Experiment Michael Willers on behalf of the CRESST collaboration Physik-Department and Excellence Cluster Universe, Technische Universität München, 85748 Garching The CRESST-III Experiment The CRESST (Cryogenic Rare Event Search with Superconducting Thermometers) [1, 2] experiment aims for the direct detection of Dark Matter (DM) particles via elastic scattering off nuclei in CaWO4. CRESST-III, the current stage of the experiment, searches for low-mass (M ≲10 GeV/c2) DM particles and ultimately aims to probe the parameter space down to the neutrino ﬂoor. The experiment is located in the Gran Sasso National Laboratory (LNGS), Italy, shielded against cosmic rays by ∼3600 m.w.e. of rock overburden. CRESST uses a multi-element target: scintillating CaWO4 single crystals operated as cryogenic detectors. Requirements for probing low-mass DM particles: • sub-keV energy threshold due to low momentum transfer to target crystal. • Low background rate in region of interest and good background suppression capabilities. CaWO4 target crystal: • Block-shaped CaWO4 crystal (20 × 20 × 10) mm3, Mass 25g. • Sensitivity gain due to reduced heat capacity and adapted TES design. Silicon-On-Sapphire light detector: simultaneous measurement of phonon- and light-signal enables particle identiﬁcation and background suppression. plain CaWO4 stick holding light detector Copper housing with reﬂective and scintillating inner surface (3M® Vikuiti foil [3]). Tungsten (W) TES Instrumented CaWO4 sticks (iStick) holding the CaWO4 target crystal: • events within the CaWO4 sticks are a potential back- ground for low-mass DM search. • instrumentation enables ef- ﬁcient veto of these events. • 3 iStick per module (1 read- out channel). Recent results from CRESST III phase 1 CRESST-III phase 1 started in summer of 2016 with an initial campaign to set-up and calibrate the detectors. The physics run of phase 1 started in September of 2016. • 10 detector modules installed. • 8 modules with TUM-grown crystals, 2 with commercial crystals. • 5 modules reached / exceeded design goal of 100eV nu- clear recoil energy threshold. • Detector A has lowest threshold in CRESST-III phase 1. First analysis of detector A • Data taking period: Oct. 2016 - May 2017 • Gross exposure (before cuts): 2.39 kg days • Blind analysis with non-blind training set (20% randomly selected, excluded from DM data set). Training set data used to deﬁne cuts. • Conservative analysis threshold of 100 eV. • Data quality (rate, stability, unphysical events) and coincidence (µ- veto and iStick) cuts applied. 79.5% survival probability at 100eV. • Limit on DM-nucleon cross-section calculated using Yellin’s optimal interval method [4] →sensitivity extended to lower DM masses (lim- ited by non-ﬂat background at low energies). The analysis of the full dataset as well as a low-threshold analysis are currently ongoing. Furthermore, the application of optimum ﬁltering to a stream of continuously acquired data is investigated with the goal of improving the trigger threshold of the detectors [5]. Data taken with detector A in the light yield - energy plane e−/γ-band recoils off oxygen recoils off tungsten dark matter acceptance region Low-energy spectrum of all events recorded with detector A CaWO4 crystal growth at TUM A high radio-purity of the CaWO4 crystals is es- sential for CRESST. In order to have full control of all crystal growth parameters, TUM has estab- lished a complete in-house CaWO4 crystal growth process [6]: • Powder production via solid state reaction or precipitation including chemical puriﬁcation (net reaction: CaCO3 + WO3 →CaWO4 + CO2). • Crystal growth in dedicated Czochralski fur- nace. • Annealing of grown ingots in pure O2 atmo- sphere. • Cutting and polishing of target crystals. In addition, recrystallisation of grown crystals is investigated as a measure to further improve the radio-purity of the CaWO4 crystals [7, 8]. Czochralski Furnace & raw	poster
Are You Catching Cosmic Rays or Just Checking Messages? Towards an Extremely Distributed Mobile Phone Cosmic Ray Observatory Carlyn Lee and Harvey Newman Division of Physics, Mathematics and Astronomy, California Institute of Technology, CA, USA Contact: Carlyn Lee Email: cblee@caltech.edu https://github.com/carlynlee/credo-api-tools/tree/playground/ References 1. Martın Abadi, et al., TensorFlow: Large-scale machine learning on heterogeneous systems, 2015. Software available from tensorflow.org. 2. Piotr Homola, et al., Cosmic-ray extremely dis- tributed observatory. Symmetry, 2020. 3. Jennifer Ngadiuba, et al., Compressing deep neural networks on fpgas to binary and ternary precision with hls4ml. Machine Learning: Science and Technology, 2(1):015001, Dec 2020. 4. Daniel Whiteson, et al., Searching for ultra-high energy cosmic rays with smartphones, Astroparticle Physics, Volume 79, 2016, Pages 1-9, ISSN 0927-6505. This project aims to design an architecture for applying Federated Learning (FL) to the analysis of cosmic ray event data collected through the Cosmic Ray Extremely Distributed Observatory (CREDO) project. CREDO gathers data from a global network of smartphones, enabling a large-scale citizen science initiative to study cosmic rays. The traditional approach of centralizing this data raises concerns about privacy and data ownership. We explore as a potential solution, allowing decentralized training of machine learning models directly on participants’ devices. We explore how FL can accommodate CREDO's requirements, such as handling heterogeneous data and robust model aggregation. We present our initial steps in designing an FL architecture tailored to the needs of the CREDO project, outline our architectural proposal, and discussing the potential benefits and the technical challenges. This sets the stage for future implementation and evaluation, aiming to enhance accountability and collaboration in scientific data analysis. Abstract Cluster Identification: Identified and visualized ten distinct clusters, each representing different events triggering the CREDO app. Device Comparison: Analysis reveals variance in detection patterns across devices, possibly indicating differences in device sensitivity or environmental conditions. Data Retrieval: Elasticsearch for query and image retrieval. Data stored as base64 encoded strings, corresponding to different devices and time frames. Image Processing: Decoded images from base64 format and resized to uniform dimensions for consistent analysis. Performed clustering based on extracted features using a pre-trained model, adapted to identify distinct patterns within the data. Cluster Visualization: Python scripts to compute and display the mean image for each cluster across multiple devices, enhancing interpretability of clustering results. Tools: Python (NumPy, Matplotlib, Pillow), ResNet50 deep learning model. q Visual analysis leveraged clustering and image processing techniques to dissect cosmic ray detection data. This approach highlighted variations across different devices and conditions, revealing possible patterns through visual data exploration. Such insights can be critical for refining detection strategies and enhancing the overall understanding of cosmic ray distributions. Future Work q Enhance Model Accuracy: Improve machine learning models and clustering precision. q Dataset Expansion: Enlarge dataset scope and integrate real-time data analysis for dynamic insights. q Federated Learning Implementation: q Local Model Training: Enable devices to train locally, sharing only model updates to minimize bandwidth use and enhance privacy. q Scalability: Use federated learning to keep data on local devices, addressing privacy concerns and managing large data volumes. q Collaborative Advancements: Combine insights across diverse devices, enhancing detection pattern accuracy and variety. q Managing asynchronous updates to models Discussion and Conclusions Objective: To analy	poster
RESULTS REFERENCES Geiser, E., Walker, K. M., & Bendor, D. (2014). Global timing: a conceptual framework to investigate the neural basis of rhythm perception in humans and non-human species. Front Psychol, 5. Gorgolewski, K., Burns, C. D., Madison, C., Clark, D., Halchenko, Y. O., Waskom, M. L., & Ghosh, S. S. (2011). Nipype: a flexible, lightweight and extensible neuroimaging data processing framework in python. Front Neuroinform, 5(3). Hanke, M., Halchenko, Y. O., Sederberg, P. B., Olivetti, E., Fründ, I., Rieger, J. W., ... & Pollmann, S. (2015). PyMVPA: a unifying approach to the analysis of neuroscientific data. Python in Neuroscience, 157. Kriegeskorte, N., Goebel, R., & Bandettini, P. (2006). Information-based functional brain mapping. Proc Natl Acad Sci USA, 103(10), 3863-3868. Stelzer, J., Chen, Y., & Turner, R. (2013). Statistical inference and multiple testing correction in classification-based multi-voxel pattern analysis (MVPA): random permutations and cluster size control. Neuroimage, 65, 69-82. INTRODUCTION • Humans are able to recognize a familiar rhythm, for example the rhythm of a song, independently of the tempo at which it is played. This is exemplary of the fact that auditory experiences comprise percepts of auditory Gestalt based on the rhythmic structure of sounds. • The pattern resulting from the relative temporal relationship between acoustic events is the basis for the perceptual emergence of temporal Gestalt. This Gestalt percept is invariant to the absolute temporal relationship between constituent acoustic events (Hulse et al. 1992). • It is unknown, where in the brain percepts of temporal Gestalt are generated. • A linear support vector machine (SVM) classifier was trained to differentiate activation patterns in functional Magnetic Resonance Imaging (fMRI) data to two different percepts, across different sensory constituents. • A searchlight analysis localized activation patterns specific to the temporal Gestalt. CONCLUSIONS →Based on brain activation patterns, a linear SVM classifier identified which relative temporal pattern had been presented. The classifier was trained across absolute temporal patterns (tempi) of sequences. -> The classifier had identified the neural activation pattern associated with the Gestalt percept. →Based on a searchlight analysis, activation patterns in the temporo-parietal junction (TPJ) (left and right hemisphere) and the inferior frontal gyrus (right hemisphere) discriminated between the two different temporally grouped percepts of temporal Gestalt. →Our findings reveal for the first time that both sensory and higher cortical areas encode temporal Gestalt. →The study provides an example of how we can tackle the neural basis of perceptual invariance using neuroimaging. METHODS EXPERIMENTAL SETUP • 19 volunteers underwent functional neuroimaging (fMRI). Where the rhythm plays: Machine learning decodes rhythm-sensitive cortices Michael P. Notter1,2, Michael Hanke3, Micah M. Murray1,2,4,5, Eveline Geiser1,6 1The Laboratory for Investigative Neurophysiology (The LINE), Department of Radiology and Department of Clinical Neurosciences, Vaudois University Hospital Center and University of Lausanne, Lausanne, Switzerland 2Electroencephalography Brain Mapping Core, Center for Biomedical Imaging of Lausanne and Geneva, Switzerland 3Psychoinformatics lab, Institute of Psychology II, Otto-von-Guericke-University and the Center for Behavioral Brain Sciences, Magdeburg, Germany 4Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Lausanne, Switzerland 5Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, TN, USA 6McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA, USA SCANNER SETUP • 3T Siemens scanner; 64-channel head coil (coverage shown on the right) • TR of 2s; 365 volumes x 5 sessions; 33 slices (ascending order) PREPROCESSING • Pre-processing was done with Nipype (Gorgolewski et al., 2011): despiking (A	poster
CONTACT: =ichaelOWagenpfeil IrlangenOHentreOforOUstroparticleO+hysics michaelTwagenpfeilBfauTde SEEgALSO: StudyOofO+hotonOtransportOandOSi+= inOexternalOelectricalOfieldOinOnIX; &rTO+inO°Vi)OidqOV2?6 CharacterizationgofgVUV@ sensitivegSiPMsgforgnEXO MichaelgWagenpfeilO0forOtheOnIX;Ocollaboration5 id:g#439 PhysicsgbeyondgStandardgModel? •OTheOneutrinolessOdoubleObetaOdecayO 05opensOwindowOtoOphysicsObeyondOS= •OUreOneutrinosO=ajoranaOparticlesN •OHurrentO?νββOsearchesOareOsensitiveO 05toOaOhalf•lifeOofOaboutOv?-[OyearsO[v)O-] •OnIX;OplansOtoOincreaseOsensitivityO[1] ThegnEXOgdetectorO[1)O2] •OTime•projection•chamberO0T+H5OfilledOwithO~O6 tonsOOO 05ofOliquidOXenonO0°Xe5O–OenrichedOtoO~? :OinOv1[Xe •OHylindricObarrelOwithOaOdiameterOandOheightOofOvT1 m •O&etectorOsetOupOinOundergroundOlabOtoOshieldOfromO 05cosmicOraysO0likelyOS/;°UG)O[??? mweT5 •OSignalOdetectionOviaOchargeOreadoutOtilesO0endOcap5O 05andOVUV•sensitiveOSi+=sO0innerOcylinderOsurface5 •OHathodeOsetOtoO•6? kVOtoOproduceOaxialOdriftOfieldOO •OIxtensiveOradiopurityOscreeningOtoOconstrainOG8 •OQomogeneousOdetectorO#Omulti•parameterOanalysis Lightgdetection •OnIX;OsensitivityOdependsOonOphotonOtransportO 05efficiencyOandOphotonOdetectionOefficiency •ORnsideOwallOcoveredOwithO2 m-OofOVUV•sensitiveOSi+=s •O&etectionOofOv]3 nmOscintillationOlightOinO°Xe •O8oalqOv :OenergyOresolutionOatOµ•valueO0-263 keV5 •OStrongOrequirementsOonOSi+=OparametersO SiPMgcharacterizationgtestgsetups •OIHU+)OIrlangenO0&arkOnoise)O+&I)OVUVOreflectance5 •ORQI+)OGeijingO0QVObehaviour)OVUVOreflectance5 •OTzRU=7)OVancouverO0&arkOnoise)O+&I5 •OUU)OUlabamaO0VUVOreflectance5 •OStanfordO0+&I)OSi+=Otiles5 •OU=assO0+&I)O°Xe5 VariousgSiPMs •OQamamatsuOVUV1)OVUV2 •O7GKO/UVO-?v[O°7O#OST& 7romOleftOtoOrightq TestOsetupOatOIHU+)OtestOsetup atOStanford)OQVOsetupOatORQI+ •OzecordOSi+=OdarkO 05pulsesOatO•v??°H •O7itOpulseOtemplateO 05toOwaveforms •OUseOamplitude)O 05timestamp)OriseO#O 05fallOtimeOforOanalysis Afterpulsing •O&elayedOavalanchesOcorre• 05latedOtoOtheOprimaryOpulse •ORmportantOnuisanceOchargeO 05contribution PDE •OIfficiencyOtoOdetectOsingleO 05photons •OUngle•)Owavelength•OandO 05biasOvoltage•dependent •OnIX;OrequirementsOmet nEXOgenergygresolution •O&ependsOonO+&IO#OphotonO 05transportOefficiencyO0+TI5 •O+lotOshowsOcaseOofO+TI%?T-OOOOO 050electronicOnoiseOneglected5 •OzesolutionOgoalOachievable SiPMgHVgrobustness •OSi+=sOwillObeOexposedOtoOexternalOelectricO 05fieldsOupOtoO-? kVjcmOinOnIX;OaccordingOtoO 05H;=S;°Osimulations •O&etectorsOfoundOtoObeOoperationalOinOhighO 05electricOfieldsOatOcryogenicOtemperatures •OGasicOparametersOunaffected–O/oOdischarge •O/oOdamageO•OevenOonOaOmicroscopicOlevel Measuringgprocedureg@gECAP Measuringgprocedureg@gStanford •OzecordO+=TOandOSi+=OpulsesOfromO-6-Hf •OHalibrationOofOsingleOphotonOresponses •OIxtractOchargeOratioOofOtheOdecayO 05spectrumOpeaks •OTranslateOinto 05absoluteO+&I 05usingOtheO+=T 05referenceOµI •OUccountOfor5cor• 05relatedOnoise [v]OUgostiniOetTOalT)Ov]?6T?-~~[ [-]OIX;•-??•HollT)OarXivqv]?]T?3]?] [1]qOnIX;•HollT)OarXivqv]v?T?6?]6 [-]qOnIX;•HollT)OarXivqv3?6Tvvv2- Wb Wb e e ? 6 v? v6 -? -6 1? ? ?T- ?T2 ?T[ ?T3 v vT- +hoton detection eﬃciency [:] Udditional avalanches within vµs °7 Sv °7 S- ST& S ?T] ?T3 ?T~ v vTv vT- vT1 vT2 ? v - 1 2 6 [ Inergy resolution [:] ;vervoltage [V] °7 Sv °7 S- ST& S ? v - 1 v?? v?v v?- v?1 v?2 prompt crosstalk prompt delayed crosstalk afterpulsesOand darkOnoise 0afterpulsesOand darkOnoise5Osuffering promptOcrosstalk afterpulsesOsuffering promptOcrosstalk afterpulses Hharge [pTeT] Time after trigger [ns] ? v - 1 v?? v?v v?- v?1 v?2 v?? v?v v?- /umber of events v?? v?v v?- v?1 v?2 v?6 v?[ v?] v?? v?v v?- v?1 v?2 v?6 v?[ v?] v?3 v?~ +ulse rate [Qz] Time to next pulse [ns] ]Tv V 2T[ V 1T[ V [kVjcm] I ? 6 v? v6 -? -6 1? 8ain η ?T3 ?T36 ?T~ ?T~6 v vT?6 vTv vTv6 vT- 7GK•z8G 7GK•lowOfield QamamatsuOVUV1 relativeOSi+=O8ain [kVjcm] I ? 6 v? v6 -? -6 1? H/ + η ?T3 ?T36 ?T~ ?T~6 v vT?6 vTv vTv6 vT- 7GK•z8G 7GK•lowOfield QamamatsuOVU	poster
Materials and Methods Sarah K . Morris1†; Oscar A. Pérez-Escobar1,2†; Bente B. Klitgård1; Alexandre Antonelli1,2; Alejandro Zuluaga3; Monica Carlsen4; Eve J. Lucas1; Simon Mayo1; Anna Haigh1; Steven Dodsworth5; Olivier Maurin1; Grace Brewer1; Robyn Cowan1; Ilia J. Leitch1; Felix Forest1; William J. Baker1 The origin and diversification of the hyper-diverse flora in the Chocó biogeographic region Objectives Anthurium obtusilobum Silica-gel dried leaf fragments 13 outgroup 27 Anthurium DNA extraction, shearing, library preparation, pooling, hybridization and sequencing as described in Johnson et al. (2018) with Angiosperm353 bait kit HybPiper v 1.3.1 (with Spathiphyllum kochii reference) skimmed plastid genome data (39 Anthurium) multiple sequence alignment use full genomic alignment to constrain combined alignment for Maximum Likelihood tree Secondary calibration age of Pothoideae13 Petrocardium cerrejonense (55.8 Myr)8 divergence time estimation with BEAST v2.0 geographic occurrence data from GBIF ancestral range estimation comparing biogeographical models with R-package BioGeoBEARS v0.2.1 1Royal Botanic Gardens, Kew. TW9 3AE, London, UK 2Gothenburg Global Biodiversity Centre, Sweden 3Universidad del Valle, Colombia 4Missouri Botanical Garden, USA 5University of Bedfordshire, Luton, UK †these authors contributed equally to this study *corresponding authors: o.perez-escobar@kew.org, s.morris@kew.org Alwyn H. Gentry (Annals of the Missouri Botanical Garden, 1996) Geographic extension of the Chocó biogeographical region in Central and South America12 and its compound geological origin14 Extract loci from genomic alignments that match Sanger sequences from Carlsen & Croat (2013) Angiosperm 353 kit successfully enriched 50-333 nuclear genes (& recovered 93 plastid genes) species-tree coalescence analyses revealed extensive incongruence near the MRCA of Anthurium the timing and origin of the MRCA of Anthurium remains unclear multiple migrations into Chocó: 3 at ~9 Mya from Central America 1 at ~5 Mya from Amazonia multiple recent migrations within 1 My from Central America and northern Andes Were Gentry’s ideas about the mode and tempo of plant evolution into the Chocó correct? Chocoan flora is likely older than Gentry assumed (perhaps late Miocene) migrations occurred after rapid mountain building had begun in the northern Andes allopatric speciation due to Andean uplift unlikely origin of Chocoan flora from Central America and northern Andes is supported migrations split between 9 Mya and < 1 Mya, suggesting a burst of migration after the closure of the CAS and again more recently Gentry believed the habit type, dispersal system and pollination syndrome of the Chocoan flora allowed for rapid speciation of endemics7: shorter generation time of shrubby and herbaceous groups bird and mammal (more localized) dispersal specific pollinator relationships To investigate these biotic factors, we are conducting similar genomic studies of other representative groups, including Blakea (Melastomataceae) and Neotropical orchids14 key geologic events in mid-late Miocene: 1. accretion of the Chocó Block4 2. Northern Andean orogeny9 3. closure of the Central American Seaway (CAS)10 The Chocó Introduction Gentry from available floristic, geological and palynological data in the 80s: Chocoan flora originated in the mid- Pleistocene from Amazonian lineages which migrated around the northern Andes, through southern Central America 6 “the historical accident of the Andean uplift, with the concomitant opportunity for explosive speciation among certain taxa … may largely explain the “excess” plant species diversity of the Neotropics” 5 Test Gentry’s hypothesis with genomic data of Anthurium using phylogeny reconstruction, molecular dating and ancestral area estimation We expect to see: a MRCA for the Anthurium lineage in Amazonia a MRCA of Chocoan clades in the northern Andes and Central America migration into the Chocó in the Pleis	poster
State-independent wind Wind-related features Observing a black hole transient Javier Sánchez-Sierras E-mail: javisansie@gmail.com Instituto de Astrofísica de Canarias Wind-type outflows from the black hole X-ray binary MAXI J1820+070: the near infrared view SOFT HARD X-ray winds (expected) Optical winds Near-infrared winds MAXI J1820+070 is a low-mass X-ray binary (LMXB) with a black hole of ~8M☉located very nearby, at only 3kpc. It was discovered during a bright outburst of the source in 2018, which showed a standard evolution in the Hardness-Intensity Diagram (see image below), passing through the main accretion states: hard and soft. THE SPECTRA We obtained 8 spectra using VLT/X-shooter, a spectrograph with a wide spectral range from optical to near-infrared (3000 Å – 24750 Å). These observations cover the different accretion states (soft, red; intermediate, green; hard, blue). Optical winds have been observed during the bright-hard state, which is consistent with previous studies in other LMXBs, such as V404Cyg, V4641Sgr or GRS 1716-249. The optical winds discovered during the hard state were observed in some optical lines, such as Ha or HeI-5876Å. The wind-related features observed include P-Cygni profiles and broad emission line wings, and they showed velocities of 1200-1800 km/s. NEAR-INFRARED SPECTRAL RANGE We analysed several near-infrared lines during the hard state and found wind-related features such as blue- shifted absorptions and broad emission line wings (see image above). These features showed similar kinetic properties to the optical ones. During the soft state, these wind features disappear in optical lines but remain visible in the near-infrared spectra. The presence of wind-related features in near-infrared lines during both hard and soft accretion states, with similar kinetic properties to the hard state optical ones, suggests that they are tracing the same wind. This state-independent wind changes its visibility depending on the conditions of the material (i.e. temperature, ionization level, ...). This idea can be seen in the sketch above, which shows the presence of the wind during the 2018 outburst of MAXI J1820+070. This represents one more step to complete the picture of winds in X-ray binary outbursts. Sánchez-Sierras J. 1,2, Muñoz-Darias T. 1,2 1 Instituto de Astrofísica de Canarias (Tenerife, Spain), 2 Universidad de La Laguna (Tenerife, Spain) Based on paper: Sánchez-Sierras & Muñoz-Darias, 2020, A&A 640 L3	poster
SAW 2024 – Seeing and AcƟng Workshop: FuncƟonal and Neural PerspecƟves Poster Session 1 — September 27, Friday 1 – Visually guided acƟons survive bilateral lesions of the occipitotemporal cortex: evidence from behavioural and tractography Authors: Ana C. Torres Cresto, Marine Keime, Alessandro Vinciarelli, Melvyn A Goodale, Jody C. Culham, Cassandra Sampaio-BapƟsta, Monika Harvey 2 – EvoluƟonary approaches for audio-visual associaƟons Authors: Ana Rodrigues, Amílcar Cardoso, Penousal Machado 3 – Seeing speech: Probing the cerebral mechanisms of Cued Speech percepƟon Authors: Annahita Sarré, Laurent Cohen 4 – Using ultra-high resoluƟon MRI to uncover the underlying microstructural mechanisms of structural plasƟcity in blind humans Authors: Anna-Lena Stroh, Daniel Haenelt, Luke J. Edwards, Fakhereh Movahedian AƩar, Kerrin J. Pine, Robert Trampel, Marcin Szwed, Nikolaus Weiskopf 5 – DiﬀerenƟal modulaƟon of serial dependence by acƟon percepƟon integraƟon in auƟsm spectrum traits in a dynamic VR task Authors: Antonella Pomè, Michael Wiesing, Rebecca Süther, Eckart Zimmermann 6 – Does Observing Bodily Movement Contribute to Developing Goal Comprehension? Authors: Ben-Ami Shlomit, Verma Dhun, Lall Naviya, Ganesh Suma Ralekar Chetan, Gilad- Gutnick Sharon, Sinha Pawan 7 – Touch localizaƟon aŌer nerve repair: Longitudinal measures reveal high individual variability Authors: Benjamin Govier, MarƟn Weber, Andrew Marshall, Obi Onyekwelu, Louise Booth, Edwin Jesudason, Vivien Lees, Ken Valyear 8 – FuncƟonal organisaƟon of sensorimotor regions in people with congenital facial paralysis (Moebius Syndrome) Authors: Ceren BaƩal, Emmanuelle Bellot, Benoit Herman, Iqra Shahzad, Moritz Wurm, Olivier Collignon, Gilles Vannuscorps 9 – Can the dimensionality crossing phenomenon partly explain the large sex diﬀerence in the mental rotaƟon test? Authors: Daniela E. Aguilar Ramirez, Stephanie Chu, Claudia L. Gonzalez 10 – Reach adjustment and target selecƟon begin within 80ms Authors: David Y. Mekhaiel, Melvyn A. Goodale, Brian D. Corneil 11 – Comparing object topography in visual cortex and arƟﬁcial neural networks Authors: Davide CorƟnovis, Bracci Stefania 12 – Reward as a facet of word meaning Authors: Doina-Irina Giurgea, Penny M. Pexman, Richard J. Binney 13 – Distributed high-level processing supports the emoƟonal assessment of complex social scenes (human brain and AI) Authors: Elahe Yargholi, Laurent Mertens, Joost Vennekens, Jan Van den Stock, Hans Op de Beeck 14 – Changes in connecƟvity between ‘higher order’ perceptual areas in apraxia aŌer stroke Authors: Elisabeth Rounis Zuo Zhang, Ajay Halai, Gloria Pizzamiglio, MaƩ Lambon Ralph 15 – Localising touch on the hand: Revealing systemaƟc variaƟons in performance and context-dependent direcƟonal biases. Authors: Elsie Harvey Pearce, Ronan Timircan, MarƟn Weber, Kenneth Valyear 16 – InvesƟgaƟng the funcƟons underlying short-term memory conjuncƟve binding through the study of aphantasia Authors: Emma Delhaye, Pauline Fritz, CharloƩe MarƟal, ChrisƟne BasƟn 17 – TesƟng humans and machines on the animate-inanimate disƟncƟon for ambiguous visual objects Authors: Farzad Rostami-Ghahfarokhi, Céline Spriet, Hans Op De Beeck, Jean-Remy Hochmann, Liuba Papeo 18 – AƩenƟon to AcƟons Authors: Federica Danaj, Lena Gessele, Jens Schwarzbach, Paul Downing, Angelika Lingnau 19 – ConnecƟng the dots: similar visual reading acquisiƟon for Braille or line juncƟons Authors: Filippo Cerpelloni, Olivier Collignon, Hans Op de Beeck 20 – ReweighƟng of Visual Depth Cues through Dynamic InteracƟon with ConﬂicƟng SƟmuli Authors: Francesca Peveri, Andrea Canessa, Silvio P. SabaƟni 21 – Does unisensory object categorisaƟon improve following mulƟsensory category training? Authors: Grace A. Gabriel, Fiona N. Newell 22 – InteracƟons of Visual and Motor PlasƟcity in Adults Authors: Izel D. Sari, Claudia Lunghi 23 – A specialized mental resource for intuiƟve physics Authors: Jason Fischer, Alex Mitko 24 – Ultrafast RS fMRI unveils	poster
Health-related quality of life of people attending screening for diabetic retinopathy within a trial setting CJ Sampson,1† M James,1 D Van Eker,2 D Szmyt,2 SP Harding3 †chris.sampson@nottingham.ac.uk 1University of Nottingham \| 2Royal Liverpool University Hospital \| 3University of Liverpool Introduction Background • DR associated with lower health-related quality of life (HRQoL) • Economic evaluations tend to base outcomes on visual acuity. Aims • Estimate generic HRQoL for a cross-section of attenders within the UK screening programme • Inform calculation of quality-adjusted life years (QALYs) for model-based economic evaluation. Methods: the sample ▶874 people from 7 screening centres in Liverpool, UK ▶Baseline trial data from the ISDR study ▶Matched screening outcome data R0 No retinopathy R1 Background retinopathy (in at least one eye) Methods: outcome measures ▶Two widely-used generic descriptors of HRQoL. ▶Both can be used to calculate QALYs. ▶Together provide 5 ways to measure HRQoL. EQ-5D-5L Dimensions 5 dimensions reported from 1 (no problems) to 5 (extreme problems) Index score Weighted score based on health state preferences elicited from the UK general public, used to calculate QALYs EQ-VAS A visual analogue scale from 0 (“The worst health you can imagine”) to 100 (“The best health you can imagine”) HUI3 Dimensions 8 dimensions (including ‘vision’) scored from 1 (no problems) to 5 or 6 (severe functional limitations) Index score Multi-attribute utility function, to calculate QALYs Results: full sample ▶840 (96%) fully completed EQ-5D-5L ▶738 (84%) fully completed HUI3 ▶Mean EQ-5D-5L index score was 0.777 ▶Mean HUI3 index score was 0.707 Table: EQ-5D-5L: distribution of responses 1 2 3 4 5 Mobility 52% 15% 17% 15% 0% Self-care 76% 10% 10% 4% 1% Usual activities 57% 15% 15% 10% 3% Pain/discomfort 43% 20% 20% 14% 4% Anxiety/depression 67% 14% 12% 5% 1% Table: HUI3: distribution of responses 1 2 3 4 5 6 Vision 31% 63% 3% 2% 2% 1% Hearing 78% 11% 7% 3% 1% 0% Speech 93% 4% 2% 0% 0% — Ambulation 63% 18% 11% 5% 2% 0% Dexterity 81% 14% 2% 2% 1% 0% Emotion 66% 21% 9% 3% 1% — Cognition 68% 8% 18% 4% 2% 0% Pain 40% 26% 15% 12% 7% — ▶Dimensions with ≥20% of responses are highlighted Results: R1 vs R0 ▶R1 screening outcome associated with lower HRQoL on average than R0 EQ-5D-5L 0.762 vs 0.776 HUI3 0.660 vs 0.713 (p=0.03) EQ-VAS: How do EASDec delegates compare? ▶The left side of the scale shows the distribution in our sample. ▶Place a sticker on the right according to how good or bad your health is TODAY. The best health you can imagine 100 0 The worst health you can imagine Discussion ▶HUI3 recognised as being more sensitive to visual impairment, but may require trade-off with data quality • Lower mean HUI3 index score may reflect inclusion of sensory domains ▶Economic modelling studies that treat R1 and R0 as homogeneous may give biased results ▶We cannot determine whether the difference in HRQoL between R1 and R0 is because of retinopathy level Conclusions ▶DR screening attendees have an impaired HRQoL compared with the general population ▶People with background retinopathy have lower health-related quality of life than people with no retinopathy • Statistically significant difference of 0.053 in mean HUI3 index score ▶HUI3 is associated with poorer completion rates • Greatest missingness on ‘vision’ domain ▶www.isdrproject.co.uk ▶Twitter @ISDRstudy Download this poster DOI: 10.6084/m9.figshare.3443705 This poster presents independent research funded by the NIHR under the Programme Grants for Applied Research programme (RP-PG-1210-12016). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Heath.	poster
Altered Physiological Conditions Lead To Antibiotic Persistence In Vibrio Cholerae. Shridhar Paranjape*, Shashidhar R. Bhabha Atomic Research Centre, Mumbai, India. shridharsonda@gmail.com Introduction The physiological heterogeneity of a bacterial population is a complex phenomenon. The asymmetric cell division and asynchronous metabolic activities result in the population with age gradients. The persister cells are the transiently dormant cells which survive prolonged exposure to bactericidal antibiotics. We hypothesized that the changes in nutrient levels, which are common in the environment, can cause significant changes in tolerance to antibiotics. Here, an attempt has been made to disturb the cell physiology using different strategies to alter the antibiotic persistence. Methods • Antibiotics used: Ciprofloxacin, Ampicillin, Carbinicillin, Kanamycin, Erythromycin, Gentamycin and Chloramphenicol. Data 1. Mulcahy LR, Burns JL, Lory S, Lewis K. 2010 Dec;192(23):6191–9. 2. Harms A, Maisonneuve E, Gerdes K. Science. 2016 Dec 16;354(6318). pii: aaf4268. 3. Sharma B, Brown AV, Matluck NE, Hu LT, Lewis K. 2015 May 26;AAC.00864-15. 4. Balaban NQ, Merrin J, Chait R, Kowalik L, Leibler S. 2004 Sep 10;305(5690):1622– 5. 5. Fauvart, Maarten & De Groote, Valerie & Michiels, Jan. (2011). 60. 699-709. 10.1099/jmm.0.030932-0. Results 1. The V. cholerae forms persister subpopulations , when challenged with ampicillin and ciprofloxacin. (Fig. 1) 2. The persistence varies with the media type, in the order of decreasing persistence: TSB > LB > M9 > APW. (Table 1) 3. The reduced respiration is key to successful persistence. (Table 2) 4. The V. cholerae was sensitive to inhibition of protein synthesis with no persistence formation. (Table 3) • The present study reveals the complex responses of cell population under antibiotic treatment. • This research could be the beginning of phylogenic clad specific studies of persister cell formation with respect to cell physiology. • The persistence may represent a unique physiological state amongst the various physiological states in a bacterial population. – Single cell based studies may reveal more about the molecular mechanisms underlying persister physiological states. References Fig. 1.Effect of different antibiotics on exponential culture of V. cholerae Table 1. Persistence as a function of media type and nutrient. Table 2. Persistence as a function of respiration Table 3. Persistence as a function of protein synthesis Discussion Fauvart et al.(2011) 0 1 2 3 4 5 6 7 8 9 10 0 2 4 6 8 10 Log CFU ml-1 Time (hours) V. cholerae Ciprofloxacin Kanamycin Ampicillin Persister frequency Media V. Cholerae E. coli Luria Bertani broth 0.1 0.1 Tryptone soya broth 10 0.1 Alkaline peptone water 0.001 NA M9 minimal media 0.01 0.01 Antibiotic V. cholerae E. coli Aerobic An- aerobic ATP - uncoupler Aerobic An- aerobic ATP- uncoupler Ampicillin 1 10 10 0.01 100 100 Ciprofloxacin 0.1 100 10 0.01 10 100 Kanamycin 0 0.01 0 0.1 10 10 Antibiotic V. cholerae E. coli Kanamycin 0 0.1 Chloramphenicol 0 1.0 Erythromycin 0 0.1 Gentamycin 0 0.1	poster
the problem methodology findings on the one hand 1st possible consequence To assess the evaluation process of professional doctorate proposals, three types of analysis were performed: Even though they were not clear before, CAPES had some expectations from proposals. From the evaluation reports of the 105 projects which were not approved, we see examples of such unfulﬁlled expectations: According to CAPES, without previously establishing the criteria and indicators for the accreditation of professional doctorates, they expected: In spite of the lack of pre-established criteria and indicators for the accreditation process, this research showed that CAPES’ evaluation was well conducted and that expectations for the approval of PrD courses are consistent throughout ﬁelds. Expectations Reality on the other hand • Without criteria or indicators for PrD, proposals were: • Too conservative and did not innovate from this “freedom”; • Inspired by academic doctorates (without the required professional nature) or professional master’s (not advanced enough). • Without ground-breaking proposals at hand, the accreditation process could only focus on the viability of the proposed courses, resulting in low approval rates. • The lack of pre-established criteria and indicators did not mean a lack of expectations. Several proposals were weakened because of that. André Brasil a.l.brasil@cwts.leidenuniv.nl Centre for Science and Technology Studies Leiden University, The Netherlands September, 2019 Accreditation of Graduate Courses in Brazil Analysing the Evaluation of the First Proposals of Professional Doctorates in the Country http://bit.ly/2Z6KqJp Approval rates are strikingly different between academic and professional proposals, with fewer accredited courses in the second modality. Proposals Approved Not approved 43.9% 60.0% 77.8% 78.2% Academic Doctorate (PhD) Academic Master’s Professional Doctorate (PrD) Professional Master’s 56,1% 40.0% 22.2% 21.8% Graduate education is responsible for over 80% of S&T research in Brazil Professional Master’s were authorised in 1998 and Doctorates in 2017/2018 135 professional doctorate (PrD) proposals were submitted in the ﬁrst evaluation cycle There are over 6500 graduate courses in the country today Course accreditation is compulsory, conducted by a federal agency (CAPES) No criteria or indicators were stablished before submissions Could an evaluation process without previously defined criteria and indicators work? NOT WITHOUT CONSEQUENCES! http://bit.ly/2M9awpk Get the full paper, this poster, and more at: Regulations and guideline documents related to the accreditation of graduate courses were investigated. Documental The evaluation results of 1404 accreditation proposals were analysed across distinct ﬁelds, levels and modalities. Statistical The reports on the assessment of the 135 professional doctorate proposals were individually analysed in order to identify the existence of coherent criteria and indicators. Qualitative 1 2 3 4 5 6 UNRESTRICTED Proponents would not be limited by pre-established concepts of what a professional doctorate should be. INNOVATION They would innovate, designing ground-breaking graduate programs, which could inspire evaluators. INSPIRATION Evaluation committees would build criteria and indicators based on proposals and previous experience. GUIDELINES The evaluation effort would lead to proper guideline documents to support future submissions. 1 2 3 4 INSTITUTIONAL SUPPORT Expected: projects should include evidence of integration with productive sector. Reality: most projects were successful in that, but some failed to show these partnerships. 73% positive PROPOSAL Expected: projects should have an applied science design at a doctoral level. Reality: most proposals were either too academic or were closer to a master’s level. FACULTY (Profile) Expected: faculty could include experienced professionals from the productive sector. Reality: faculty proﬁle was almost exclusively	poster
Cuscuta campestris Cuscută mare Familia Convolvulaceae, Clasa Magnoliopsida Plantă erbacee anuală, parazită, lipsită de cloroﬁlă, fără frunze, cu tulpini volubile, foarte ramiﬁcate, galbene-portocalii, ce formează prin împletire și răsucire plase laxe ce se întind ca o pânză pe suprafețe de mai mulți metri pătrați. Florile sunt nemirositoare, dispuse câte 10-30 într-un glomerul. Corolă campanulată, cu lobii triunghiulari, acuți. Fructul este capsulă globuloasă, ușor turtită, cu 2-4 semințe brune, ovoidale, cu suprafața neregulată. Foto credit: https://www.invasive.org/search/action.cfm?q=cuscuta+campestris Flori Fruct 1 Semințe	poster
SITool (v1.0) An evaluation tool for large-scale sea ice model simulation Xia Lin, François Massonnet, Thierry Fichefet, and Martin Vancoppenolle 1) Absolute errors at each grid cell (1980-2007) Mean: ->monthly mean over 12 months (Meandiff) Interannual variability/trend: monthly anomalies -> standard deviation (SDdiff)/linear regression (Trenddiff) 2) Average spatially weighted by grid cell areas 3) Scaled by typical errors (absolute difference between two observations) Meandiff = ∑!"# !"#$ ∑&"# &"' ()* !,& ,(#* !,& ×.& ∑&"# &"' .& × #! ∑!"# !"#$ #! (1) SDdiff = ∑&"# &"' $%(')&(')* & )($%('#&('#* & ) ×& ∑&"# &"' & (2) Trenddiff = ∑!"# !"$ "#$%&((%!)(%& ! ))"#$%&((#!)(#& ! ) ×,! ∑!"# !"$ ,! (3) 𝑛(months); 𝑖(grid cells); 𝐶/0, 𝐶10/ 𝐶/, 𝐶1(two monthly mean/monthly ice concentration); A (grid cell area); D (days in each month). Sea ice plays a fundamental role in the polar environment, by influencing air–ice and ice–sea exchange, atmospheric and oceanic processes, and climate change. Large inter-model spread exists in the performance of sea ice simulations. Systematic projections and evaluations on sea ice simulations are needed. Want to quantify the bias in sea ice simulations? Want to track performance across different model versions? Try SITool released on the GitHub (open-access): https://github.com/XiaLinUCL/Sea-Ice-Evaluation-Tool A performance metrics and diagnostics tool developed to evaluate the skill of Arctic and Antarctic model reconstructions of sea ice concentration, extent, edge location, drift, thickness, and snow depth. 1 The concept of the SITool 3 Application to CMIP6 OMIP 2 The methods in SITool Find more information on the sea ice edge location, drift, thickness and snow depth in Lin et al. (2021). Xia Lin, François Massonnet, Thierry Fichefet and Martin Vancoppenolle, SITool (v1.0) – a new evaluation tool for large-scale sea ice simulations: application to CMIP6 OMIP. Geosci. Model Dev., 14, 1–24, 2021. SITool provides metrics and diagnostic maps 3.1 Sea ice concentration 3.2 Sea ice extent Any comments/questions? Get in touch! xia.lin@uclouvain.be Metrics: Lower values -> better skill 1) Model errors >> observational uncertainty 2) Improved simulations from OMIP1 (CORE-II) to OMIP2 (JRA55-do) 3) Lower skill on the ice concentration variability Ice extent: total area of grid cells with the ice concentration above 15% -negative ice extent biases in the summer reduced in OMIP2 Model mean ice extent monthly anomalies; -large bias reduced under OMIP2 Diagnostic maps: Reduced negative bias of summer Arctic ice concentration in OMIP2	poster
1) Background • Many people struggle to manage indulgences in our current ‘obesogenic’ environment (Kruger et al. 2004) • Results of our previous qualitative study showed that one of the strategies to reduce intake of tempting foods is to plan meals in advance (Gatzemeier et al. under review) • Planned indulgences increase motivation to continue with goal pursuit (e.g. following a diet to lose weight) (Coelho do Vale et al. 2016) • High restrained eating is associated with lower food intake (Olea López et al. 2016) Jennifer Gatzemeier, Menna Price, Laura Wilkinson, Michelle Lee Department of Psychology, Swansea University, UK. Rigid and flexible restraint moderates a relationship between a future eating prime and food intake Rigid and flexible restraint moderates a relationship between a future eating prime and food intake Coelho do Vale, R., et al. (2016). "The benefits of behaving badly on occasion: Successful regulation by planned hedonic deviations." Journal of Consumer Psychology 26(1): 17-28. Gatzemeier, J., et al. (2018). “Understanding everyday strategies used to manage indulgent food consumption: a mixed-methods design.” Manuscript submitted for publication. Kruger, J., et al. (2004). "Attempting to lose weight: Specific practices among U.S. adults." American Journal of Preventive Medicine 26(5): 402-406. Olea López, A. L. and L. Johnson (2016). "Associations between Restrained Eating and the Size and Frequency of Overall Intake, Meal, Snack and Drink Occasions in the UK Adult National Diet and Nutrition Survey." PLoS One 11(5): e0156320. Van Strien, T., et al. (1986). "The Dutch Eating Behavior Questionnaire (DEBQ) for Assessment of Restrained Emotional, and External Eating Behavior." International Journal of Eating Disorders 5(2): 295-315. Westenhoefer, J., et al. (1999). "Validation of the flexible and rigid control dimensions of dietary restraint." Int J Eat Disord 26(1): 53-64. 3) Methods 3) Methods • Procedure a) Priming: Intervention: writing down near future eating plans Control: writing down near future non-eating plans (e.g. going to the cinema) b) Presentation of taste test: c) Questionnaires: DEBQ (Van Strien, Frijters et al. 1986) Rigid and flexible restraint (Westenhoefer, Stunkard et al. 1999) Question about trait tendency to plan indulgences • Analysis: Moderation analysis with SPSS PROCESS macro • Registered at OSF (https://osf.io/pydvz) 5) Conclusions 5) Conclusions • Flexible and rigid restraint is indeed moderating the association between condition and intake: The intervention condition had a significantly higher consumption compared to the control condition, but only in low rigid and flexible restraint • For low restrained eaters thinking about future eating plans might have enhanced attention to the snacks and therefore increased wanting • High restraint eaters exert a high level of cognitive control to maintain restraint. This might have led to an insensitivity to the priming • Further research is needed to understand the underlying mechanism of the observed interactions and the difference between low and high restrained eaters 2) Research Questions 2) Research Questions • We hypothesis that the trait tendencies to plan indulgences moderate the association between a future eating prime and food intake. Participants with the trait tendencies to plan indulgences consume less after a future eating prime • We are interested if restraint is moderating the relationship between the priming and intake. Contact: Jennifer Gatzemeier jennifer.gatzemeier@swansea.ac.uk Department of Psychology, Swansea University, Singleton Park, Swansea, SA2 8PP, UK Tel: +44 (0) 1792 295279 Swansea Nutrition, Appetite and Cognition group a) Priming b) Taste test c) Questionnaires 1. Minstrels (Mars, UK) 2. Bitsa Wispa (Cadbury, Mondelez, Birmingham, UK) 3. Haribo Star Mix (HARIBO Dunhills, Pontefract, UK) 4. Pringles Original (Wimble Manufacturing Belgium, Mechelen, Belgium) 5. Salted Popcorn (Tesco Stores Ltd., Cheshunt, U	poster
Reactor Neutrino Anomalies and Possible Solutions Yu-Feng Li* Institute of High Energy Physics, Beijing, China *corresponding author: liyufeng@ihep.ac.cn Reactor neutrinos (electron antineutrinos) are produced from beta decays of the neutron-rich fission products, and are detected via the inverse beta decay (IBD) process. Reactor experiments have shown anomalous results for both IBD rate (left plot) and spectrum (right plot) measurements Reactor rate anomaly: measured IBD yields are smaller than model predictions by around 6%. Reactor spectrum anomaly: there is a bump at around 5 MeV when comparing the measured and predicted spectra. How to solve these reactor anomalies is an intensively discussed topic in nuclear and particle physics community. 1. Reactor neutrino anomalies 3. Ab initial method Using the reactor rates data and fuel evolution data: 2. Data-driven method Reactor rates tend to favor equal suppression of the 235U and 239Pu fluxes (oscillation), while (DYB & RENO) fuel evolution data favor the suppression of 235U. Regarding all hybrid hypotheses: a) a deficit for the 235U flux is always obtained; b) oscillation-including hypothesis is favored over the oscillation-excluding one: moderately at 1-2σ 5. Conversion method Giunti et al., JHEP 10 (2017) 143 4. Beta decay at KATRIN 6. Conclusion Reactor rate/spectrum anomalies are interesting topics in particle and nuclear physics, and awaiting satisfactory solutions. Data-driven method always favors a suppression of the 235U flux, while KATRIN can provide independent tests. Both the ab initial and conversion calculations need to be improved in many aspects (database, fission yield and single spectrum, etc.). Accurate reactor rate and spectrum predictions are important for future reactor experiments (i.e., JUNO). Giunti et al., Phys. Rev.D 99 (2019) 073005 Ab initial model for the reactor neutrino flux: summation of each beta decay branches using the nuclear database for the fission and decay information Possible problems: the nuclear database (e.g., pandemonium effect), fission yield, single beta decay spectrum, etc. We discuss the effects of the single beta decay spectrum by using a fully numerical calculation of lepton wave functions, compared to previous ones using the famous Fermi function. Fang, et al., arXiv: 2001.01689 ENDF VIII.0, for fission yield data, and ENSDF for the decay data. 2% and 4% deviations for the neutrino and electron spectra. Beta decay is a model-independent way to probe the absolute neutrino masses. KATRIN published its first data in 2019, with a limit on the effective neutrino mass as mν< 1.1 eV (95% C.L.). We test the reactor rate anomaly using the beta decay data at KATRIN by assuming the 3+1 active-sterile mixing. KATRIN improves the exclusion of the large-Δm2 41 solution of the Huber-Muller reactor rate anomaly. RSR: the reactor spectra ratio data test a large part of the small-Δm2 41 region. Tritium: KATRIN + Mainz + Troitsk RSR and Tritium limits are complementary, and rule out most of the parameter space. Giunti et al., JHEP 05 (2020) 061 Conversion model for the reactor neutrino flux: using dozens of virtual beta decay branches to fit the aggregate electron spectra of 235U, 239Pu, and 241Pu at ILL. We propose a new realization of the conversion calculation by including the contribution of forbidden decay branches. Using data of ILL U235 beta spectrum Li, et. al., Phys. Rev. D 100 (2019), 053005 7. Reference [1] G. Mention et al., Phys. Rev. D 83 (2011) 073006. [2] T.A. Mueller et al., Phys. Rev. C 832011) 054615. [3] P. Huber, Phys. Rev. C 84 (2011) 024617. [4] KATRIN, Phys. Rev. Lett. 123 (2019) 221802. [5] C. Giunti et al., Phys. Rev. D 99 (2019) 073005. [6] Y.F. Li, D. Zhang, Phys. Rev. D 100 (2019) 053005. [7] D.L. Fang et al., arXiv: 2001.01689. [8] C. Giunti et al., JHEP 05 (2020) 061.	poster
LATEX TikZposter ANALYTICAL HALO MODEL OF GALACTIC CONFORMITY Isha Pahwa and Aseem Paranjape Inter-University Centre for Astronomy and Astrophysics, Pune University Campus-Ganeshkhind, Pune - 411007 ipahwa@iucaa.in ANALYTICAL HALO MODEL OF GALACTIC CONFORMITY Isha Pahwa and Aseem Paranjape Inter-University Centre for Astronomy and Astrophysics, Pune University Campus-Ganeshkhind, Pune - 411007 ipahwa@iucaa.in Galactic Conformity is the observation that satellite galaxies in groups whose central galaxy is quenched (or red) are preferentially quenched, even when the groups are restricted to reside in dark matter halos of the same mass. We develop a model to include the effects of ‘Galactic conformity’ within halo occupation distribution (HOD) framework. This effect has been modelled via the correlation of galaxy colors in a group with the concentration of the common parent dark matter halo. Standard HOD Framework • fcen(> L\|m) - The fraction of m-halos (i.e., halos with masses in the range (m, m + dm)) that have a central galaxy brighter than the luminosity threshold L. • Nsat(> L\|m) - The number of satellites brighter than L in each m-halo with a central brighter than L (assumed to be Poisson distributed with mean). fcen(> L\|m) = 1 2 1 + erf log(m/Mmin) σlog m , Nsat(> L\|m) = m −M0 M1 α , [Zehavi et al 2011] with {Mmin, σlog m, α, M1, M0} being functions of the threshold L. We deﬁne the following quantities that are ﬁxed by the HOD: Nsat(> L\|m) ≡fcen(> L\|m)¯Nsat(> L\|m) ; fcen(L\|m) ≡−∂fcen(> L\|m)/∂L , Nsat(Lm) ≡−∂Nsat(> L\|m)/∂L ; ¯Nsat(L\|m) ≡Nsat(L\|m)/fcen(> L\|m) . Color-selcted HOD •Given p(red\|Mr) = 0.423 −0.175 (Mr + 19.5) and [Paranjape et al 2015] p(red\|sat, Mr) = 1.0 −0.33 1 + tanh Mr+20.25 2.1 , one can calculate p(red\|cen) from equation p(red\|L) = p(red\|cen, L) ¯p(cen\|L) + p(red\|sat, L) ¯p(sat\|L) , where ¯p(sat\|L) = R dm n(m) Nsat(L\|m) R dm n(m) [fcen(L\|m) + Nsat(L\|m)] • The HOD split by galaxy colour - frcen(L\|m) ≡p(red\|cen, L)fcen(L\|m) , Nrsat(L\|m) ≡p(red\|sat, L)Nsat(L\|m) , ¯Nrsat(L\|m) ≡Nrsat(L\|m)/fcen(> L\|m) = p(red\|sat, L)¯Nsat(L\|m) . frcen(L\|m)dL is the differential fraction of m-halos with red L-centrals and ¯Nrsat(L\|m)dL is the mean differential number of red L-satellites in m-halos with centrals (of any colour) brighter than L. Red fractions as a function of luminosity −22.0 −21.5 −21.0 −20.5 −20.0 −19.5 −19.0 Mr 0.0 0.2 0.4 0.6 0.8 1.0 red fraction satellites all centrals psat HOD with galactic conformity • We introduce conformity between the central and satellite colors in a group using the model of Paranjape et al 2015 which correlates the red fraction of a given galaxy type with the parent halo concentration, i.e., a concentration-dependence of the red fraction of satel- lites/centrals at ﬁxed luminosity and halo mass by making galaxies in high (low) concentration halos preferentially red (blue). • Given the fact that distribution of halo concentration c at ﬁxed halo mass is approximately Lognormal with mean ¯c(m) ≡e⟨ln c\|m ⟩and logarithmic scatter σln c, we deﬁne s ≡ln(c/¯c)/σln c . The distribution of s is approximately a standard Gaussian (zero mean and unit variance), independent of halo mass. The conditional red fraction now depends on the parent halo concentration and is given as p(red\|sat/cen, s) = (1 −ρ) p(red\|sat/cen) + ρ Θ(s −sr,sat/cen) , where sr,sat/cen gives the dividing line between high and low concentrations in each case as sr,sat/cen = √ 2 erfc−1 [2 p(red\|sat/cen)] . • “group quenching efﬁciency", ρ ∈[0, 1]. • The color selected HOD with conformity - frcen(L\|m, s) ≡p(red\|cen, s)fcen(L\|m) , Nrsat(L\|m, s) ≡p(red\|sat, s)Nsat(L\|m) and ¯Nrsat(L\|m, s) ≡Nrsat(L\|m, s)/fcen(> L\|m) = p(red\|sat, s)¯Nsat(L\|m) . 1-halo conformity • Difference in the red fractions of satellites with red and blue centrals of similar halo mass represented by red and blue colors. −22.0 −21.5 −21.0 −20.5 −20.0 −19.5 −19.0 Mr 0.0 0.2 0.4 0.6 0.8 1.0 satellite red fraction ½ =0:01 ½ =0:65 ½ =0:90 Correlation funct	poster
A Key Actor in EMI METU English Proficiency Exam: Design, Implementation & Validation Aim The School of Foreign Languages (SFL) initiated a Program Evaluation and Renewal study to investigate the effectiveness of the English Language education curricula at its two departments based on a large scale needs analysis of all relevant stakeholders which involved the evaluation and validation of METU English Proficiency Exam, integral to EMI at METU. Design This research was designed as a mixed methods study. Our approach towards the qualitative / quantitative dilemma was pragmatic. Pragmatism views these two methods as compatible (Howe, 1988, in Teddlie & Tashakkori, 2009), and therefore finds it productive to combine these methods to study phenomena especially in social sciences. Hence, the pragmatic paradigm was the framework of this study. Needs Analysis Data Analysis English Proficiency Examination EPE Revisited- OPERATIONS Design Identifying Target Language Use tasks, task characteristics, theoretical constructs Operationalization Developing test task specifications & test blueprint Administration Alpha & Beta testing Piloting Field-testing Final revision First official version of new EPE Results: Communicative Needs of EMI students Benchmarking, Piloting & External Validity To validate EPE, an experimental pretest-posttest design (N=211) was used to compare EPE scores with an international standardized test, TOEFL IBT, a gatekeeper in many EMI universities. There was a significant positive correlation between EPE and the pretest (r = 0,89, n = 102, p = 0.070); between the two versions of the TOEFL IBT (r = 0,89, n = 102, p = 0.00); and between EPE and the posttest (r = 0.85, n = 115, p = 0.044). EPE cut scores were based on this study. Listening: Field, 2012 Reading: Urqhart & Weir, !998; Khalifa & Weir, 2009 Writing: Shaw & Weir, 2008 Reliability & Internal Validity Predictive Validity & Stakeholder Perception Stakeholders Qualitative / Quantitative Instr. 2612 DBE Ss Surveys / Focus- group interviews 2205 MLD Ss Surveys / Focus- group interviews 133 SFL Instructors Surveys / Interviews 66 Faculty Members Interviews 40 Graduates in 19 Firms Interviews 14 Employers in 12 Firms Interviews Document Analysis of student essays, exams, lab reports from all faculties Communicative Activity Required Skill Listening -listening in-class -assigned listening Very deep attention understanding instructions Medium to deep attention following lectures /discussions Reading -background reading -intensive reading search reading reading longer texts careful reading understanding instructions analytical/critical reading interpreting visuals Writing -writing in -class -assigned writing note-taking writing responses to exam projects, reports, papers fluency & coherence Speaking -spontaneous speech -planned speech communicating with instructors asking & answering Q’s delivering presentations fluency in speech Grammar & Vocabulary basic structures - wide range academic lexis • For quantitative data, descriptive and inferential statistics were employed. Depending on the results of tests of normality, either ANOVA/ t-Test or Kruskall- Wallis and Mann-Whitney U tests were used. • As for qualitative data, the recordings of interviews were analyzed by MaxQDA 11. Miles and Hubermann Qualitative Data Analysis Framework was used (1994). Theoretical Framework of Test Design Sociocognitive Framework, Weir, 2005 The relationship between, TOEFL Pre-and Po EPEsttests Reliability: Cronbach’s alpha, which measures the internal consistency of a group of items was found to be (α= .81). This alpha coefficient is high (≥70 ) in terms of testing. Item Discrimination: The Rpbi mean for the MC items was found to be Rpbi .33, meaning that the exam discriminated well between higher and lower proficiency levels. Items with Rpbi in the .30 - .49 range are considered strong discriminators. Item difficulty: P values for the scored items show a desired distribution of the P (.4	poster
Figura 1. Intervalos para la Varianza aditiva estimada, para los grupos de años. Figura 2. Intervalos para la Heredabilidad estimada, para los grupos de años. 0.0021 0.0060 0.0054 0.0113 0.0000 0.0050 0.0100 0.0150 0 1 2 3 Grupos Va Ln 0.09 0.25 0.16 0.31 0.00 0.10 0.20 0.30 0.40 0 1 2 3 Grupos Heredabilidad Ln Figura 3. Intervalos para la Varianza aditiva estimada, para los grupos de años. Datos en Ln. Figura 4. Intervalos para la Heredabilidad estimada, para los grupos de años. Datos en Ln. Cva Cva Ln Grupo 1 0.055 0.023 Grupo 2 0.080 0.036 Cuadro 1. Coeficientes de variación aditivos para cada uno de los grupos de años, con datos originales y en LN. Evolución de la Variabilidad Genética para peso a edad comercial en una población seleccionada de camarón blanco del Pacífico [Penaeus (Litopenaeus) vannamei]. Cala N¹*, Montaldo HH¹, Castillo-Juárez H², Campos-Montes GR², Ruiz-López FJ³. Universidad Nacional Autónoma de México¹, Universidad Autónoma Metropolitana- Xochimilco², Centro Nacional de Investigación en Fisiología y Mejoramiento Animal, INIFAP³. necamo4@comunidad.unam.mx Introducción En una población de tamaño efectivo limitado bajo selección, se pueden producir cambios en las varianzas genéticas y ambientales a través de las generaciones, que pueden reflejarse en cambios en la variabilidad genética. Estos cambios manifiestan una disminución en la variación genética a través de las generaciones para la población en selección. Objetivo Estimar cambios los componentes de variabilidad genética y ambiental para P130 en 8 generaciones de una población núcleo de camarón blanco del Pacífico bajo selección. Material y Métodos Se usaron datos de ocho generaciones (2003-2010) de una población Mexicana de camarón blanco del Pacifico seleccionada para peso a los 130 días, con su respectivo pedigrí. Se analizaron 123,561 registros, procedentes de la progenie de 1043 madres y 746 padres. La estructura es por familias, provenientes de apareamientos de un macho con dos hembras mediante inseminación artificial. Se utilizó un modelo lineal mixto en ASReml. Los efectos fijos fueron año-estanque-sexo y los efectos lineal y cuadrático de la edad a la cosecha como covariables. Los efectos aleatorios, el efecto genético aditivo, el efecto de ambiente común de familia de hermanos y el error. En el modelo se consideraron varianzas heterogéneas por generación (año). Resultados y Discusión Los parámetros usados para evaluar los cambios fueron la heredabilidad “ ( )”, la varianza aditiva “ ” y el coeficiente de variación aditivo “ (√ ̂)”. Se estimaron las tendencias con las ecuaciones de regresión lineal y polinomiales de segundo y tercer orden para , y . Los resultados para la regresión lineal muestran una tendencia negativa P < 0.05, sin embargo el coeficiente de variación señala una tendencia positiva P < 0.05, lo que es contradictorio. También se realizaron análisis similares usando el logaritmo natural de P130. Posteriormente se dividió la base en dos grupos de años, uno del 2003 al 2006 y otro del 2007 al 2010, intentando buscar una tendencia en los estimados, se analizó la , y graficando los intervalos para , (Figuras 1, 2), de igual forma se analizaron los datos transformados a logaritmo natural (Figuras 3, 4). Los coeficientes de variación calculados para cada grupo se presentan en el cuadro 1. Conclusión Los resultados obtenidos de los análisis para y usando los datos originales y transformados a logaritmo natural de P130 no indican cambios significativos a través del tiempo para ninguno de los dos parámetros, lo que coincide con los resultados de y sugiere que hay efectos importantes de escala que deben tomarse en cuenta para analizar este tipo de datos , por lo cual no podemos afirmar estadísticamente que para los datos utilizados en éste estudio haya habido una pérdida significativa de la variabilidad genética aditiva en respuesta al proceso de selección en el transcurso de los años posteriores al 2005. Todavía otra posibilidad es qu	poster
Data from OSM has been automatically categorised in several accessibility classes, in accordance with the national and regional legislation. Two different types of maps have been produced: current status, with footways, crossings, kerbs and obstacles represented, and project status, with modiﬁed elements included in the plan. 1000 kerbs mapped 400 crossings mapped 31% inaccessible kerbs 10000 images uploaded in Mapillary 60000 €/km costs estimated 155 buildings assessed 12 recurring situations 37 standard intervention typologies 10 meetings were organised in 10 different locations, corresponding to the 10 sub-departments of the city. The aim was to present the project and collaboratively decide the areas/paths to be mapped and where to assess accessibility during the following mappings events. 10 mapping events were organised with citizens and local organizations both as demonstration and training for the use of mapping tools (FieldPapers, Mapillary, OSMAnd), and for collection of local expertise on accessibility. Then expert mappers ﬁnalized the collection in information and the upload on OpenStreetMap. Various open tools have been used: FieldPapers during mapping events; OsmAnd during technical mapping; Mapillary for collection of street-level pictures; JOSM for editing OpenStreetMap data; QGIS for the production of ﬁnal cartographic maps of the ofﬁcial plan. PARTICIPATORY MEETINGS MAPPING The "PEBA - Piano per l'Eliminazione delle Barriere architettoniche" (Plan for the elimination of architectural barriers) is a legislative tool aiming at ensuring full accessibility of urban paths, spaces and buildings for all the people. The local administration of Padua ﬁnanced the creation of the PEBA of the city, with the brand "Padova + Accessibile" (Padua more accessible). More information at http://www.comune.padova.it/ peba. The two main criteria for the development of the plan have been a wide participatory vision and the use of open geospatial tools for analysis. OpenStreetMap has been selected as the core tool for mapping accessibility. elements. 10 meetings with citizens and associations 66 invited associations 40 km of footways/paths mapped 137 disabled designated parking spaces 370 geolocated +reports 229 obstacles observed 1.5 km of non-accessible sidewalks 17 km of sidewalks with limited accessibility OUTPUT MAPS CREDITS The local administration of Padua (Comune di Padova) funded the realization of the PEBA, including participatory meetings and mapping events and activities (contact person arch. Alberto Marescotti). Wikimedia Italia provided free patronage for mapping events; various Wikimedia Italia volunteers contributed to the mapping and editing activities. Image “Padova+accessibile” by arch. Alberto Marescotti. Font OpenDyslexic ®. Background image ©OpenStreetMap contributors. Project manager Elena De Toni. The PEBA (Plan for the elimination of architectural barriers) of the city of Padua has been the ﬁrst example in Italy of the direct use of OpenStreetMap as main tool to collect information and derive decisions for the characterization of accessibility of public areas and paths. In the area of Padua, data in OSM have been improved in relation to information on accessibility of public areas and path, especially for disabled people; in addition to this, through the involvement of citizens and local organizations, the use of open source technology and the revision and application of a tagging scheme for OpenStreetMap, accessibility information will be easily updated and extended in the future. CONCLUSIONS TAGGING SCHEME PEBA IN NUMBERS PEBA During the activities of the PEBA, a short guide on how to map parkings for people with disabilities was produced and then shared and promoted to a few associations working on disabilities. In 4 months the number of these parking spaces increased from 0 to ~140, allowing the production of a dynamic map that is being continuosly updated. PARKING SPACES This work is available at http:/	poster
Are Physicians Ready to Take up Leadership Roles in Planetary Health? Suraj Bhattarai1,2; Omary Chillo3; Biljana Gjoneska4; Dipendra Khatiwada5; Jaifred Christian F. Lopez6; Atiya Mosam7; Juan Carlos Núñez Enríquez8; Duha Shellah9; Nora Grasselli10 1Global Health Research & Medical Interventions for Development, Nepal; 2London School of Hygiene & Tropical Medicine, UK; 3Muhimbili University of Health and Allied Sciences, Tanzania; 4Macedonian Academy of Sciences and Arts, North Macedonia; 5College of Medical Sciences, Nepal; 6Duke University, USA; 7Mayibuye Health and University of the Witwatersrand, South Africa; 8UMAE Hospital de Pediatría CMN Siglo XXI, IMSS, Mexico; 9Palestine Academy for Science & Technology, Palestine; 10European School of Management and Technology, Germany. INTRODUCTION • Physicians’ role is primarily thought to provide patient care. • They also contribute to improve healthcare systems & health indicators.a • However, their role in planetary health has not been established nor defined yet. • Young Physician Leaders Programme (YPL) is a flagship training programme of the InterAcademy Partnership (IAP) – the parent academy of 149 national science academies worldwide.b • IAP has a mission to “foster the next generation of research and science policy leaders” by strengthening critical capacities for leadership.b REFERENCES aInstitute of Medicine (US) Division of Health Sciences Policy. Medical Education and Societal Needs: A Planning Report for the Health Professions. National Academies Press (US); 1983. Chapter 4, The Physicians’ Role in a Changing Health Care System. bThe InterAcademy Partnership. www.interacademies.org cMyers SS, Potter T, Wagner J and Xie M. Clinicians for Planetary Health. One Earth; 2022. dMoser AM, Stigler FL and Haditsch B. Physicians’ responsibility for planetary health. The Lancet Planetary Health; 2017. METHODS • A semi-structured questionnaire was developed based on literature review and distributed electronically to the 10-year YPL cohorts (2011- 2022), with assistance from the IAP Secretariat. • The 8-member YPL Alumni Steering Committee coordinated the study, in collaboration with the ESMT. • EMST ethics committee provided ethical clearance to the survey. • Descriptive statistics was used to analyse the data. RESULTS • Out of 235 physicians approached, 77 (33%) completed the survey. • 51% were female. Majority (73%) represented LMICs. • 52% of the respondents were engaged in clinical practice, 60% in research, 29% in strategic and policymaking roles, 14% in bureaucracy. CONCLUSIONS • Physicians are extending their work area beyond curative medicine, embracing upstream approaches to impact population health. • Therefore, it is important to acknowledge physicians as key stakeholders of planetary health and engage them in global initiatives. OBJECTIVE To explore the engagement of YPL alumni in health sector in the context of emerging global discourse on planetary health. Young Physician Leaders (YPL) at a glance • YPL programme is running since 2011. • It has 21 new members and 231 Alumni across 5 continents. • Each year, national academies send their nominations to IAP and its expert medical panel selects the new cohort (~20 members). • World Health Summit, M8 Alliance and European School of Management and Technology (ESMT) are main programme partners, among others. • While 30% of the respondents worked from central or federal level, the majority (58%) worked from local level (district or community facilities). DISCUSSION • Physicians’ community represent highly educated and respected professionals and apt science communicators, so they could be the most suitable messengers/ debaters/ negotiators for planetary health.c • Next generation physicians should be educated to recognize planetary health as the foundation for any efforts to improve human health.d May 27-29, 2024 Geneva, Switzerland Contact: Dr. Suraj BHATTARAI Director and Investigator GLOHMED, Nepal E: surajbhattarai.m	poster
X-ARAPUCA as photon detection system of SBND Ana Machado for SBND Collaboration NEUTRINO 2024 June 16-22, 2024 – Milan, Italy Three LArTPC detector to study short range neutrino oscillation • Neutrino-argon interactions at GeV energy scale. Millions of nµ and thousands of ne from two neutrino beams • Verify the “low-energy excess” anomaly Investigate the excess of ne observed by MiniBooNE experiments • Search for sterile neutrino Discover or exclusion of 1 eV-scale sterile neutrino mass region • Beyond Standard Model Physics 192 X-ARAPUCA 176 ARARA readout SensL - 3x3m2 SiPM. (C-series 30050-A1) 88 VUV OPTO 400nm PTP coating EJ286 88 Visible OPTO 450nm EJ280 16 APSAIA readout Hamamatsu - 6x6m2 SiPM. (S13360-6050 VE & HS) 8 VUV OPTO 400nm PTP coating Glass to Power 8 Visible OPTO 450nm Glass to Power FILTER (400nm cutoff) PTP (emission 350nm) SiPM WLS plate LAr scintillation light FILTER (450nm cutoff) SiPM WLS plate Visible light Photon Detection System Active elements: on the PD-BOX, behind the anode. • 120 8” Hamamatsu Cryogenic PMT’s (96 TPB coated + 24 uncoated) • 192 X-ARAPUCA (96 VIS + 96 VUV) Passive element: at the cathode. Wavelength-Shifting Reflective plates (TPB coated) 64 double-sided Short Baseline Near Detector TPC Cathode Plane at -100 kV divides the detector into 2 drift volumes. Drift distance is 2 m, drift time is 1.28ms Anode Plane on either side. Each consists of 3 planes of wires with 3 mm spacing and different angle per plane. Total of 11,260 wires Cold (89K) Electronics to pre-amplify and digitize signals Field Cage that wraps around the 2 LArTPCs to step down the voltage & ensure uniform electric field of 500 V/cm. Cosmic Ray Tagger (CRT) Scintillator strips with SiPM readout 142x32 channels X-TDB X-ASB All PCB boards were tested in cryogenic temperature 60 SiPMs was tested - 48 6050-VE (VBr = +53V @RT) - 12 6050-HS (VBr = +38V @RT) A total of 777 X-TDBs were tested at the LN2 temperatures and able to see light. 704 were required. Only 1 “bad” board was identified Digitized signal from the HS test – APSAIA – ARAPUCA POWER SUPPLY AND INPUT AMPLIFIER – ARARA – ARAPUCA ANALOG READOUT AMPLIFIER Readout Electronics The APSAIA will power the SiPMs and amplify their 32 output signals. It is hosted in the outer flange of SBND. Each board has 8 channels with input connectors. The power supplies are designed to meet the SiPMs' requirements, and the amplifiers process the SiPMs' output signals. Each channel has an MCX output connector. The power supply and serial port connector use a standard DB15 connector. The supply voltage for the SiPMs is remotely adjustable up to 60 V with a resolution of less than 100mV. The power supplies and amplifiers are controlled by a microcontroller connected to an RS232C port. RJ45 à DB37, cold side view The preamplifier board conditions and biases the signal between the X-ARAPUCA light collection hardware and the signal capture hardware The bias voltage must be programmed remotely using an RS232c. The power supply is available via a cable with a DSUB9 connector. The 352 signals for flange are inputs for ARARA board. Into the ARARA board the signals are ganged by 4. RAVANA board convert signals from the ARARA to the CAEN 1740 digitizers Single-channel prototype of the pre-amplifier by AGE scientific These preamp modules are: - Double width 6U VME cards in custom crate. - Powered by externally provided 8V DC - 64 input channels for 16 output channels - Compliant with FNAL Electrical Design Standards for Electronics The amplifier characteristics are as follows: - Minimum gain of 20, adjustable via microcontroller if other gain values are needed. - Sufficient bandwidth for processing 30 ns rise-time signals, DC-coupled. - Output impedance of 50 Ω. ASSEMBLY & INSTALLATION 1o step: The assembly of the mechanical and optical parts (dichroic filters and light guide) was done at Unicamp 2 o step : The PCB board installation in each X- ARAPUCA was carried out at Fermilab. Finally, 4 VUV X-A	poster
Comparison of fatty acid composition in grass-fed and grain-fed horse meat Aidyn Igenbayev, Shyngys Amirkhanov, Muhtarbek Kakimov, Alida Kanabekova S. Seifullin Kazakh Agrotechnical University, Astana, Kazakhstan Reference: Igenbayev, A., Amirkhanov, S., Ospankulova, G., Kardenov, S., Baytukenova, S., & Ali Shariati, M. (2022). Determination of the fatty acid composition and fatty acids trans-isomers in the horse, stall horse, mutton, beef and pork meat. Potravinarstvo Slovak Journal of Food Sciences, 16, 800–809. https://doi.org/10.5219/1799 The objective of this research was to analyze the fatty acid composition of horse meat. The study involved the selection of two distinct groups of horses: 1) horses that were raised and fed in a pasture; 2) horses that were kept in stalls. For the analysis, pasture horse meat (Kazakh horse breed), and stall horse meat (Kazakh horse breed) were purchased from meat markets and supermarkets in Astana, Kazakhstan. Samples were obtained from four diﬀerent carcass muscles (back muscles, thigh muscles, rib muscles, neck muscles) of each animal, an average of 500 grams of sample. The samples obtained were stored at a temperature of - 18 ºC. Horse meat for pasture and stall keeping was supplied from farms engaged in horse breeding in an appropriate way of feeding. This analysis compares the fatty acid composition of grass-fed and grain-fed horse meat, speciﬁcally in the loin cut. The data shows that grain-fed horse meat has a higher percentage of saturated fatty acids (SFA) compared to grass-fed horse meat, with the content being 40.32% and 37.43% respectively. Conversely, grass-fed horse meat has a higher percentage of monounsaturated fatty acids (MUFA) compared to grain-fed horse meat, with the content being 48.12% and 40.36% r e s p e c t i v e l y. T h e p e r c e n t a g e o f polyunsaturated fatty acids (PUFA) is also higher in grain-fed horse meat compared to grass-fed horse meat, with the content being 19.31% and 14.44% respectively. Table 1. Fatty acid content in muscle lipid fraction of grass fed horse meat, % of total fatty acids Table 2. The fatty acid content in the muscle lipid fraction of grain-fed horse meat, % of total fatty acids This study reports the levels of trans fatty acids (TFAs) in diﬀerent cuts of grass-fed horsemeat, revealing that the TFA content varies across cuts with the highest level in loin (1.85%) and the lowest in round (1.66%). The levels of TFAs in rib (1.68%) and neck (1.70%) are similar to each other and fall in between the levels observed in loin and round. This study presents data on the levels of trans fatty acids (TFAs) in various cuts of grain-fed horsemeat, revealing that the TFA content is markedly higher in round (5.54%) and neck (5.52%) than in loin (2.75%) and rib (3.56%). These ﬁndings suggest that the TFA content in horsemeat can be inﬂuenced by the type of feed given to the animals. As high intake of TFAs has been linked to increased risk of cardiovascular disease, these results provide important information for assessing the potential health risks associated with the consumption of grain-fed horsemeat. This comparison suggests that the type of diet fed to horses can have a signiﬁcant impact on the fatty acid composition of their meat. The higher content of SFAs in grain-fed horse meat may increase the risk of cardiovascular disease, while the higher content of MUFAs in grass-fed horse meat may have potential health beneﬁts. The higher content of PUFAs in grain-fed horse meat may also be beneﬁcial, as PUFAs are essential fatty acids that have been linked to a reduced risk of cardiovascular disease. However, the speciﬁc types of PUFAs present in grain-fed horse meat should be taken into consideration, as some types of PUFAs may be more beneﬁcial than others. Further studies are needed to explore the health implications of consuming grass-fed vs. grain- This research is funded by the Ministry of Agriculture of the Republic of Kazakhstan (BR1076499	poster
Analysis 大質量星 Telescope Resolution Reference !"CO(2 −1) ALMA 1.12” (53 pc) Leroy et al. (2021) Hα VLT 0.92” (44 pc) Emsellem et al. (2022) Giant molecular clouds and their Type classification in M74 Fumika Demachi 1, Yasuo Fukui 1, Kengo Tachihara 1, Rin Yamada 1, Kazuki Tokuda 2,3, Shinji Fujita 4, Masato Kobayashi 5 Kazuyuki Muraoka 6, Ayu Konishi 6, Tsuge Kisetsu 4, Toshikazu Onishi 6, Akiko Kawamura 3 (Nagoya university 1, Kyushu university 2, National Astronomical Observatory of Japan 3, University of Tokyo 4, University of Cologne5, Osaka Metropolitan university 6 ) 1. 3. Need to expand samples to establish a general picture of GMC evolution. [ The goal of this study ] Establish the method of Type classification based on 𝐿!" Suitable for resolving GMCs without contamination in a line of sight Distance: 9.7 Mpc (Anand et al. 2021) Inclination: 8.9° (Lang et al. 2020) 𝑀()+ = 10,-./0𝑀⊙, 𝑀23 = 104.5-𝑀⊙ (Leroy et al. 2021) M74 Giant molecular clouds (GMCs) are the main star formation sites and their evolutions are important to understand galaxy evolution. In this poster, we discuss GMC evolution in nearby spiral galaxy M74 by using spatially resolved GMC samples. We classified GMCs into 3 types based on Hα luminosity (𝐿67) of HII regions with GMCs, and Type I (without star formation) are 58, Type II (with 𝐿67 < 10/5.8 erg s9,) are 202, and Type III (𝐿67 > 10/5.8 erg s9,) are 172, then obtained these results, (1) the young star clusters clearly associated with Type II and III GMCs, and 𝐿67 and cluster mass show tight correlation for Type III (2) massive Type I GMCs show the sign of embedded star formation and Type II GMCs are affected by extinction more than Type III, and (3) Type III are the most virialized state. For these results, we interpreted GMC Type classification as GMC evolutionary sequence from Type I to III with active star formation. In this study, Type classification are applied in grand design spiral galaxy out of the local group for the first time. 1. Identify GMC by PYCPROPS1 and HII region by Astrodendro2. 2. Determine the association between GMC and HII region if their boundaries are overlapped, and classify GMCs based on 𝐿2:. 3. Compare Type GMCs with clusters3 obtained by HST and 21 µm emissions4 obtained by JWST to check consistency with results of LMC and the effects of Hα extinction, respectively. → Classify GMCs based on Hα luminosity (𝐿67) 10/5.8 erg s9, of associated HII regions because Hα is more uniformly surveyed Results 4. We identified 58 Type I, 202 Type II, 172 Type III (Fig.1). The median of GMC mass and radius increase Type I<II<III. Type III GMCs are in the most virialized states (Fig.2). 1-4 Myr clusters are located closer to GMCs than typical GMCs separation (Fig. 3). GMC evolution 5. Fig.2 → Type III GMCs are most gravitationally relaxed. Conclusions 6Type classification base on 𝐿2: is useful method to distinguish different evolutionary phases as tested in M74, out of the Local group, for the first time. Extend into other galaxies to validate the universality and for the future work. Assume GMCs evolve steadily and the timescale of Type III is 4 Myr based on associated cluster age. Estimate the timescale of Type I and II by the ratio with Type III statistically → Type I: 1Myr, Type II: 5Myr, Type III: 4Myr [Problem] GMC [Type I ] No star formation [Type II ] With HII region (𝐿!" < 10#$.&) [Type III ] With HII region (𝐿!" > 10#$.&) HII region 1: Rosolowsky et al. 2021, 2: Rosolowsky et al. 2008, 3: Adamo et al. 2017, *4: Lee et al. 2023 Fig.3) Histogram of separation between nearest GMCs and clusters. The orange line indicates typical GMC-GMC separation. Fig.4) Scatter plot between total cluster mass and Hα luminosity associated common GMCs. The size of marker indicate the number of clusters with each GMC. The cluster mass increase with 𝐿2: especially for Type III (Fig. 4). 35% of Type I and more than 80% of Type II and III are associated with 21 µm emission. Correct Hα extinct lu	poster
Ergebnisse • Diskriminanzfähigkeit zw. Bildern η2T1 = .28, η2T2 = .33 • Inter-Rater-Reliabilität ICCT1 = .81, ICCT2 = .84 • Test-Retest-Reliabilität r = .93 • Hauptkomponentenanalyse 8-Faktorenlösung • Tucker-Korrelationskoeffizient rT1 = \|0.82\|, rT2 \|1.00\| Empirische Bildanalyse Validierung von RizbA an bildnerischen Arbeiten erwachsener Laiinnen Schoch K.1,2 & Ostermann T.1 1 Universität Witten/Herdecke, Fakultät für Gesundheit, Department Psychologie und Psychotherapie 2 Hochschule für Künste im Sozialen, Ottersberg, Institut für Kunsttherapie und Forschung Hintergrund Literatur Epstein, C. (2019, 22. März). Bildlicher Ausdruck von Depression: Erprobung des Ratinginstruments RizbA an Bildstichproben aus dem klinischen Kunsttherapiesetting. Zenodo. https://doi.org/10.5281/zenodo.3365921 Janßen, B. (2018, 31. August). Erprobung des Ratinginstruments für zweidimensionale bildnerische Arbeiten (RizbA): Ansatz zu einer möglichen Untersuchung des bildnerischen Ausdrucks von Schmerz in gemalten Bildern von Menschen mit chronischer Schmerzsymptomatik. Zenodo. https://doi.org/10.5281/zenodo.3407808 Schoch, K., & Ostermann T. (under review). Psychometrics of art: Validation of RizbA, a quantitative rating instrument for pictorial expression. Psychology of Aesthetics, Creativity and the Arts. Schoch, K. (2018). Ratinginstrument für zweidimensionale bildnerische Arbeiten (RizbA): Fragebogen in deutscher Sprache. Zenodo. DOI:10.5281/zenodo.2530858 Schoch, K. (2018). Jenseits von gut und schön: Entwicklung eines quantitativen Ratinginstruments für zweidimensionale bildnerische Arbeiten (RizbA). Musik-, Tanz- und Kunsttherapie: Zeitschrift für Künstlerische Therapien im Bildungs-, Sozial- und Gesundheitswesen. 28(2), 131-138. https://doi.org/10.5281/zenodo.1479716 Schoch. K., Gruber. H., & Ostermann, T. (2017). Measuring art: Methodical development of a quantitative rating instrument measuring pictorial expression. The Arts in Psychotherapy, 55, 73-79. https://doi.org/10.5281/zenodo.1479694 Diskussion • Reliabel und generalisierbar auf Bildmaterial von Laiinnen • Praxisdokumentation, Grundlagen- und Anwendungsforschung Dokumentation und Analyse von Bildern und Prozessen Korrelationen mit anderen Konstrukten Gruppenvergleiche • Abgeschlossen Dritte Validierungsstudie an Gegenwartskunst • Durchgeführt Pilotstudien zu spezifischen Populationen Chronische Schmerzsymptomatik (Janßen, 2018) Rezidivierende Depression (Epstein, 2019) • In Entwicklung Manual • In Planung Machine Learning-Ansätze kerstin.schoch@hks-ottersberg.de www.kunsthochzwei.com/forschung Tab.1. Antwortformat: Sechsstufige Likert-Skala trifft überhaupt nicht zu trifft nicht zu trifft eher nicht zu trifft eher zu trifft zu trifft voll- kommen zu ✘ Limitierung Weitere Validierung Faktorenstruktur CFA, SEM Weitere Populationen Bildmaterial und Rater*innen Tab.2. Fragebogen: Items und deren Gütekriterien (T1) Nr. Itembeschreibung pi si2 𝛈2 ICC 1 Das Bild enthält zeichnerische Elemente .58 1.31 .52 .96 2 Das Bild enthält malerische Elemente .61 0.92 .41 .93 3 Die Darstellungsweise ist gegenständlich .43 1.67 .63 .97 4 Die Darstellungsweise ist abstrakt .61 1.19 .52 .96 5 Der Farbauftrag ist pastos .33 0.63 .31 .90 6 Die vorherrschende Farbgebung ist leuchtend .58 1.08 .52 .96 7 Im Bild befinden sich vorwiegend reine Farben .47 0.52 .28 .88 8 Im Bild befinden sich vorwiegend Mischfarben (Sekundärfarben) .50 0.72 .36 .92 9 Im Bild sind Komplementärkontraste vorhanden .51 1.34 .51 .96 10 Im Bild enthaltene Formen sind vorwiegend organisch .52 0.65 .34 .92 11 Im Bild enthaltene Formen sind vorwiegend geometrisch .39 0.98 .46 .94 12 Die Linienführung verläuft vorwiegend gebogen .55 1.07 .50 .95 13 Die Linienführung verläuft vorwiegend eckig .30 0.90 .49 .95 14 Das Bild enthält unbearbeitete Flächen .53 1.72 .51 .96 15 Das Bild wirkt tief .32 0.44 .29 .88 16 Das Bild ist perspektivisch .33 0.62 .34 .91 17 Das Bild ist frei von Perspektive (aperspektivisch) .60 0.71 .31 .90 18 Das Bil	poster
El riesgo CV , se define como la probabilidad de un individuo de tener un evento cardiovascular en un período de tiempo determinado (por ejemplo, en los próximos 5 o 10 años). La ecuación de riesgo de Framinghan define como un primer evento CV al IAM, angina de pecho, ataque cerebral isquémico, enfermedad vascular periférica, insuficiencia cardíaca congestiva o una muerte cardiovascular. El objetivo de hacer una evaluación del riesgo CV es identificar los factores de riesgo, estimar el riesgo de hacer un evento CV y utilizar este cálculo para hacer un manejo terapéutico apropiado de aquellos factores. El presente estudio se llevo a efecto en los CS. San Lorenzo , Pile , El Aromo , Manantiales , San Mateo , con una población de 32 personas , de las cuales se evidencia que 27/32 presenta un RCV bajo , 2/32 presenta un riesgo MUY ALTO , por ser diabéticos , y de riesgo moderado 3/32. Lo que llamo la atención fue que de los 32 evaluados 22 presentan SOBREPESO y 4 con OBESIDAD , además que el 100% del grupo es SEDENTARIO . Al momento no se encuentra implementado un programa de salud preventiva en nuestro distrito de salud , cosa alarmante , por eso la pregunta ¿ Se preocupa la salud por nuestra salud?? Quien se preocupa por que los funcionarios tengan SALUD ¿?.Los múltiples requerimientos no solo en el trabajo clínico si no administrativo absorbe de forma casi total el tiempo de los trabajadores , dando lugar al desarrollo de patologías que silenciosamente evolucionan tanto en la salud cardiovascular como HTA, DM , DLP , OBESIDAD , Problemas de salud mental como trastornos ansiosos , depresión etc . Es necesario la implementación de medidas que nos protejan , asegurando bienestar SALUD a los trabajadores del área de la salud , en aras de mejor atención a nuestros usuarios y al mejoramiento de el sistema de salud del país. RIESGO CARDIOVASCULAR EN EL PERSONAL DEL DISTRITO DE SALUD NUMERO DOS SECTOR RURAL SCORE DE FRAMINGHAN UNIVERSIDAD DE PIURA MAESTRIA EN SALUD OCUPACIONAL ¿ Hay salud en la salud? Distribución del Personal de salud del área rural , distrito 2 BAJO 5% MODERADO 5-9% ALTO 10-19% MUY ALTO 20 o > 0 2 4 6 8 10 Serie1 0 5 10 15 20 25 SOBREPESO BIBLIOGRAFIA . 1.Programa de Salud Cardiovascular. Reorientación de los Programas de Hipertensión y Diabetes. Ministerio de Salud de Chile. 2002 . Prevención Primaria de Enfermedad Coronaria. Tablas de Framingham para la estimación de riesgo coronario a 10 años adaptadas a la población chilena. Programa de Investigación de Factores de Riesgo de Enfermedad Cardiovascular. 2007. Universidad de Talca. http://pifrecv.utalca.cl . Determinación y Prevalencia de Factores de Riesgo Cardiovascular en el Personal de la Brigada de Caballería Blindada No 11 Galápagos, Riobamba ELABORADO POR: DRA SUSANA JASMIN CABRERA MERO MANTA OCTUBRE 2014 RIESGO CARDIOVASCULAR 22 PCTES CON SOBREPESO 4 CON OBESIDAD	poster
We wish to thank the Allen Institute founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. An integrated imaging and staining platform for cubic millimeter scale array tomography Forrest Collman, Robert Seraﬁn, Sarah Davis, Olga Gliko, Tom M Keenan, Kristy Parker, Linnaea E Ostroﬀ, Stephen J Smith Synapse Biology Department, Allen Institute for Brain Science, Seattle WA 98103 Array tomography (AT) involves reconstruction of images acquired from arrays of serial ultrathin sections, which can be imaged by fluorescence microscopy (FM-AT) for proteometric analysis, or by scanning electron microscopy (EM-AT) for higher resolution. Axial resolution is defined by the thickness of physical sections (50-200 nm); the lateral resolution of FM imaging is optimal given the direct adhesion of sections to an optical coverslip. However, the throughput of data acquisition is slowed by the image acquisition time, and the need for human intervention to stain and set up samples on the microscope. The first AT systems acquired data at a throughput of ~16 seconds per 4 channel image (Micheva 2007). Recent work incorporated a hardware-based autofocus technology that improved throughput to 5-12 sec per 4 channel image (Rah 2013), achieving 0.1 mm3 in 878 imaging hours with 200 nm-thick sections. Data acquisition throughput is further impaired by the overhead involved in staining and setting the sample up for imaging. As part of the Open Synaptome Project (http://opensynapto.me) effort to improve all aspects of ATomo based synaptic analysis, we are developing a next-generation system to achieve imaging throughput on the order of 0.2mm3 per day per microscope. We will describe the design of the imaging system, which include hardware-based autofocus, large format sCMOS sensors, motionless high intensity wide-field laser illumination, and a custom open-source software solution. We will also describe our efforts to construct a robofluidic staining solution fully integrated with the microscope. Our goal is to enable continual staining and imaging without human intervention, thus increasing both throughput and consistency of results ultrathin section onto coverglass IF stain IF imaging poststain FESEM elution ABSTRACT ARRAY TOMOGRAPHY IMAGING brain-map.org alleninstitute.org y (mm) 0 ul 50 ul 100 ul 150 ul 200 ul 250 ul 300ul Fluorescein Intensity (AU) 0 500 100 200 300 400 Wash In x (mm) y (mm) Wash Out 0 ul 50 ul 100 ul 150 ul 200 ul 250 ul 300ul Fluorescein Intensity (AU) 0 500 100 200 300 400 x (mm) 300ul 0 10 x (mm) >95% washin with 200-250ul >99% washout with 300 ul Non-saturating/quenching concentration of fluoroscein 10x air objective, median intensity of field, 50μl increments Fully automated pipetting and image acquisition across x,y grid Pipette In Pipette Out 1.5 mm 3.25 mm pipetting robot inverted microscope 96-well chiller tips 45 mm 3D printed mold PDMS (Sylgard) poured mold Passive pumping design allows simple unpowered flow-cell compatible with vertical pipetting robot (Walker 2002) PASSIVE PUMPING FLOW CELL PROTOTYPE MOSAIC PLANNER - OPEN SOURCE ARRAY TOMOGRAPHY SOFTWARE REFERENCES AND GRANT SUPPORT COVERSLIP FLATNESS LASER ILLUMINATION time per 4 channel frame (sec) auto-focus filter-change exposure stage move Standard Upright Automated Microscope Zeiss Observer Z.1, 4 filter cubes, x-cite mercury halide liquid light guide IMAGING SPEED IMPROVEMENTS Improvement 16.1 sec per 4 images 892 images/hour hardware auto-focus (Rah et al. 2015) 100-400ms focus time ~2000 images/hour Estimated Speed Increase ~10-50 ms change time ~4000 images/hour quad band dichroic illumination switching sCMOS field size 4.2 vs 1.4 megapixels effectively 2.9x faster laser illumination ~5x power density ~12,000 images/hour NET IMPROVEMENT ~40x faster net imaging 500 nm X Y XY PSF 500 nm Z Y YZ PSF 50 100 1 nm/μm across 200 μm 500μm μmanager Core API hardware agnostic microscope commands images/status Camera Illumination Stage Microsc	poster
ZENTRUM Für nachhaltiges Forschungsdatenmanagement Literatur Huschka, Denis et al. (Hg.) (2013): Forschungsinfrastrukturen für die qualitative Sozialforschung. Berlin: Scivero. RatSWD (Hg.) (2018): Archivierung und Zugang zu qualitativen Daten. RatSWD Working Paper 267/2018. Berlin: Rat für Sozial- und Wirtschaftsdaten (RatSWD). https://doi.org/10.17620/02671.35 Steinhardt, Isabel et al. (2020): Das Öffnen und Teilen von Daten qualitativer Forschung. Ergebnisse eines Workshops der Forschungsgruppe „Digitalisierung der Wissenschaft“. Weizenbaum Series 6. Berlin: Weizenbaum Institute for the Networked Society. https://doi.org/10.34669/wi.ws/6 POSTER Möllenkamp, Andreas (2020): Öffnen und Teilen von Interviews. Ein Leitfaden. Zenodo. DOI: https://doi.org/10.5281/zenodo.3925304 Lizenz Dieses Werk ist lizensiert unter der Lizenz Creative Commons Attribution 4.0 International (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ PROJEKT Das Poster ist entstanden im Rahmen des Projekts Open Interviews. Auf dem Weg zur Öffnung qualitativer Interviewforschung. Weitere Informationen: https://w.wiki/Vkp Das Projekt wurde das 2018/2019 im Rahmen des Fellow-Programm Freies Wissen von Wikimedia Deutschland, dem Stifterverband für die Deutsche Wissenschaft und der VolkswagenStiftung gefördert. KONTAKT Andreas Möllenkamp Universität Hamburg Zentrum für nachhaltiges Forschungsdatenmanagement Monetastr. 4 20146 Hamburg Tel.: +49 40 42838-7231 andreas.moellenkamp@uni-hamburg.de www.fdm.uni-hamburg.de https://orcid.org/0000-0002-5750-0220 https://twitter.com/andreasmoellen21 Vorbereitung und Planung Bei Qualifikationsarbeiten: Sprechen Sie mit Ihren Betreuerinnen über das Archivieren, Öffnen und Teilen von Interviews. Einen Überblick über das Öffnen und Teilen von Daten qualitativer Forschung bietet Steinhardt et al. (2020). Reflektieren Sie, ob in Ihrem Projekt durch das Öffnen und Teilen ein Eingriff in den Forschungsprozess entstehen würde. Eine Beeinflussung der Interviewsituation können Sie umgehen, indem Sie Fragen der Archivierung und Zugänglichmachung erst nach dem Interview besprechen, beispielsweise auf Grundlage des Interviewtranskripts.3 ÖFFNEN und Teilen von Interviews Ein Leitfaden Informieren Sie sich über geeignete Forschungsdaten-Repositorien. Der Rat für Sozial- und Wirtschaftsdaten akkreditiert Forschungsdatenzentren: www.ratswd.de/forschungsdaten/fdz/ qualitativ Das Forschungsdatenzentrum Qualiservice hat sich auf die Archivierung und Bereitstellung von Interviews und anderen qualitativen Daten aus der Sozialforschung spezialisiert. Lassen Sie sich dort beraten und planen Sie Zeit und Kosten für die Archivierung ggf. in Ihrem Förderantrag mit ein. www.qualiservice.org/ Illustrationen: digitalbevaring.dk (CC-BY 2.5 DK) Durchführung Dokumentation und Kontextualisierung: Für eine gute Nachvollziehbarkeit und Nachnutzbarkeit ist eine möglichst umfassende und prozessbegleitende Dokumentation und Kontextualisierung Ihrer Interviews wichtig. Dazu gehören die Mitglieder Ihres Forschungsteams, die Erläuterung der Auswahl Ihrer Interviewpartnerinnen, die Kommunikation vor dem Interview, der Kontext der Interviewsituation sowie die weiteren Bearbeitungs- und Auswertungsschritte. Datenschutz: Als Forscherin sind Sie verpflichtet, verantwortungsvoll mit den personenbezogenen Daten Ihrer Interviewpartnerinnen umzugehen. Nach der Datenschutz-Grundverordnung (DSGVO) dürfen personenbezogene Daten nur für festgelegte, eindeutige und legitime Zwecke erhoben und verarbeitet werden. Darüber hinaus sind die Landesdatenschutzgesetze für öffentliche Hochschulen in Deutschland einschlägig. Die Erhebung, Verarbeitung und Archivierung von personenbezogenen Daten bedarf daher der informierten Einwilligung Ihrer Interviewpartnerinnen. Informierte Einwilligung: Die Einwilligungserklärung einer Interviewpartnerin setzt voraus, dass Sie sie über Ihre Forschungsabsicht, das Vorgehen, die konkrete Nutzung der Daten und die Rechte der beforscht	poster
Collaborative Research: Elements: ROCCI: Integrated Cyberinfrastructure for In Situ Lossy Compression Optimization Based on Post Hoc Analysis Requirements PIs: Sheng Di1,2, Franck Cappello1,2, Dingwen Tao3 1University of Chicago, 2Argonne National Laboratory 3 Indiana University Motivation Libpressio Z-Checker/QCAT Objectives This project aims to develop a Requirement-Oriented Compression Cyber-Infrastructure (ROCCI) for data-intensive domains such as astrophysics and materials science. The core purpose is practicality, enabling scientists to efficiently assess and/or optimize the lossy compression quality based on their post hoc analysis requirements. This project advances knowledge with three key thrusts: • It builds an efficient layer to interoperate with different lossy compressors and diverse post hoc analysis requirements on data fidelity by leveraging our developed compression adaptor library (LibPressio) and compression assessment library (Z-checker). • It develops an efficient engine to determine the best compressor with automatically tuned optimized settings. • It develops a user-friendly infrastructure integrating compression optimization and execution via HDF5 dynamic filter mechanism. Acknowledgement Z-checker is a parallel framework for assessing lossy compression of scientific data efficiently. QCAT is the corresponding lightweight utility library and toolkit. This research is supported by NSF OAC # 2104023 and 2104024. We acknowledge the computing resources provided on Bebop (operated by Argonne Laboratory Computing Resource Center and on Theta and JLSE (operated by Argonne Leadership Computing Facility). Publications Estimation error and cost of SECRE for SZx: When using a large sampling stride such as 40 (sampling rate would be 1/41≈2.43%), the estimation error is still very low less than 1% in the worst case). System Architecture of ROCCI with improved & innovative modules. We are towards the end of the second year of the project. In the first two years, we have 20+ papers published in top conference/journal papers, including SC, ICDCS, ICDE, IPDPS, HPDC, ICS, VLDB, EuroSys, IJHPCA, HiPC, etc.. Major Accomplishments First year: We improved Libpressio to support 30+ compressors (both lossy and lossless, both CPU and GPU) and Z-checker/QCAT to support 40+ compression assessment metrics (including ratio, speed, max error, PSNR, SSIM, derivatives, distribution of errors, auto- correlation of errors, visualization, etc.) Second Year: We explored a series compression quality estimation methods, by leveraging machine learning (ML), statistical analysis, compression-principle analysis (surrogate), sampling method, etc. We also improved the performance for Libpressio, Z-checker/QCAT, SZ3, SZx, and developed new capabilities such as QoZ, FAZ. Libpressio-Predict Compression Ratio Estimation Evaluation using 4 real-world science datasets including climate simulation, cosmology research, large-eddy simulation, etc. LibPressio provides a productive interface for integrating compression. It eases experiment with new compressors with less code and complexity. Compression developers benefit from using a common implementation for a parallel compression; a CLI; Python, Rust, Julia, C, C++ bindings; and HDF5, ADIOS2, and other integrations that are complete and consistent with just 1 C++ class. 1 API 32+ compressors Builtin Provenance Support Optional Automatic Configuration and Optimization CPU Parallel and GPU Parallel Compressors Non-measurable overhead CLI, Python, Rust, Julia, C, and C++ bindings LibPressio addresses all these issues by providing a unifying interface with advanced engines for provenance and configuration optimization. LibPressio-predict integrates quite a few compression ratio and metric estimation algorithms for error-bounded lossy compression, including FXRZ, SECRE, Stats-based compresibility estimation method, etc. We have developed multiple efficient compression quality estimation methods and error-con	poster
Innovative Research for a Sustainable Future www.epa.gov/research Keith Houck \| houck.keith@epa.gov \| 919-541-5519 Predicting Toxic and Therapeutic Mechanisms of the ToxCast Chemical Library by Phenotypic Screening Houck K1, Kleinstreuer N2, Yang J3, Berg E3, Knudsen T1, Richard A1, Martin M1, Reif D4, Judson R1, Polokoff M3 1 National Center for Computational Toxicology, Office of Research and Development, US EPA, Research Triangle Park, NC; 2ILS, Inc., Research Triangle Park, NC; 3BioSeek, a Division of DiscoveRx, South San Francisco, CA; 4NCSU, Raleigh, NC Abstract Summary Results The ToxCast Phase II library was screened in 8 complex cell culture systems measuring endpoints relevant to inflammatory signaling and vascular biology. Assays showed strong reproducibility across technical replicates and built-in test compounds. The BioMAP system identified potential targets, modes of action, and clinical side effects for compounds based on the reference database. Assays provided coverage of mechanisms/targets not directly represented in assay endpoints, e.g. AhR Phenotypic screening and computational analysis provides a unique opportunity to survey environmental chemicals for potential human bioactivity Methods Addressing safety aspects of drugs and environmental chemicals relies extensively on animal testing. However the quantity of chemicals needing assessment and challenges of species extrapolation require development of alternative approaches. Using 8 primary human cell systems (BioMAP), we screened in concentration-response format 776 chemicals from the ToxCast Phase II library (http://epa.gov/ncct/toxcast/chemicals.html) for perturbation of physiologically important pathways. Cell systems consisted of combinations of endothelial, peripheral blood mononuclear, bronchial epithelial and coronary artery smooth muscle cells; fibroblasts and keratinocytes. Chemical-response signatures from 87 endpoints covering molecular functions relevant to toxic and therapeutic pathways were generated. Assessment of profiling data by unsupervised clustering using Self Organizing Maps and supervised analysis using Support Vector Machine algorithms grouped chemical/concentration by potential mechanism class providing insight into polypharmacology and potential off-target effects of drugs. Clusters contained diverse mechanistic activity including kinase, TNFα, phosphodiesterase and Hsp90 inhibitors; Ah, estrogen and glucocorticoid receptor modulators; disruptors of mitochondrial and tubulin function; histamine antagonists; and statins. Novel associations identified included induction of tissue factor in endothelial cells by ER antagonists, AhR agonists and mTOR inhibitors, all chemical classes with susceptibility to venous thrombosis. Further, structure-based analysis demonstrated associations between chemical categories and mechanism class predictions. Our results yielded an extensive list of potential toxicological targets and biological pathways that we are incorporating into a chemical prioritization strategy for chemicals of concern to the Agency. Objective Use primary human cell phenotypic responses to classify and predict compound mechanisms of action and potential toxicities Primary Cell Systems Used SVM Models and Top Scoring Compounds • Compounds were tested at 4 (or 8) concentrations in duplicate, 200 mM high concentration with half-log dilutions. • Cells treated with compounds followed at one hr by stimulation of signaling pathways • Cells harvested at 24 hr and endpoints measured by ELISA or staining (SRB) • Data normalized to log10 Fold Change over DMSO controls • AC50 values calculated using 4-parameter Hill model • Compounds tested in blinded fashion and included internal replicates • Predictive models for 28 mechanism classes were built using a two class approach with SVM using R SVM package e1071 (Berg et al., JBS 18:1260, 2013). • Unsupervised clustering of all compounds at the individual concentration level was conducted	poster
Key partners: Sewer Mining (SM) technology is a mobile wastewater treatment system in containers able to extract wastewater from local sewers, treat it directly and reuse at the point of demand in dense urban environments. The unit consists of a membrane bioreactor unit (MBR) and a UV disinfection component and produces high quality reclaimed water for irrigation and for aquifer recharge during the winter. The SM unit has an annual capacity of about 9.000 m3 of reclaimed water Treatment residuals are collected, treated locally in the site and are transformed to an eco-friendly fertilizer (compost), when merged with green waste from pruning. Implemented technology The technology has been tested for over 1.5 year. Sampling and analysis activities have been implemented at a weekly basis and the main results that are illustrated in the table and the diagrams are summarized below: • SM produces water of a quality that meets all national and international criteria for unrestricted irrigation and urban use • Achieves complete elimination of organic carbon and pathogenic content • Provides reduction of pathogens due to MBR filtration process (without addition of chemicals avoiding production of secondary pollutants) • UV disinfection unit showed great performance • System works automatically and is remotely monitored in terms of operation and quality performance. Parameters Influent Effluent after UV disinfection Legislation Limits TSS 253± 97 ≤ 2 for 80% of samples ≤2 for 80% of samples ≤10 for 80% of samples BOD5 216 ± 64 8,6 ± 2,4 3 ≤10 for 87% of samples ≤10 for 80% of samples COD 695 ± 97 24,2 ± 4,1 3 - TN 81 (average) 5,5 ± 1,4 3 ≤ 15 NH4-N 5 ± 3 0,2 ± 0,19 3 ≤ 2 TP 10 ± 1.4 1,57 (average) - Turbidity - 2 (median) ≤ 2 (median) Conductivity 1,109 ± 75 1,067 ± 0 - pH 7.1 ± 0,2 7.5 ± 0,3 - TC >10 2 for 80% of samples 9 for 95% of samples ≤2 for 80% of samples ≤20 for 95% of samples FC >10 ≤3 - EC >10 ≤ 3 for 95% of samples ≤5 for 80% of samples ≤50 for 95% of samples Sewer Mining (SM) technology as a Distributed Intervention for Water-Energy-Materials in the Circular Economy: A Real World Demonstration in the Athens Plant Nursery Klio Monokrousou1, Christos Makropoulos1, Konstantinos Tsimnadis2, Georgios Katsouras3, Nikolaos Tsalas3 1. Department of Water Resources and Environmental Engineering, School of Civil Engineering, National Technical University of Athens, Heroon Polytechneiou 5, Zografou, 15780, Greece, kmonokrousou@gmail.com; cmakro@mail.ntua.gr 2. City of Athens, Department of Greenery and Urban Fauna, 5 Panag. Kanellopoulou, 11525 Athens, Greece, tsimnad@yahoo.gr 3. Athens Water Supply and Sewerage Company S. A (E.YD.A.P.) – Research and Development – 156 Oropou 11 str., 11146, Galatsi, Athens, Greece, gekats@eydap.gr; ntsal@eydap.gr Methodology Results The sewerage is extracted through two pumps that work alternately, from about four meters below the surface to fill in a buffer tank. The process starts when filtered wastewater enters a denitrification tank, where anaerobic microorganisms turn nitrates to nitrogen gas which naturally leaves the system. The denitrification tank communicates with a nitrification or aeration tank, where aerobic microorganisms turn reduced nitrogen compounds to nitrates. Subsequently, the biologically treated wastewater is transferred to the membrane tank and then the permeate passes through the UV disinfection unit and the final disinfected product flows naturally toward a storage tank to be reused mainly for irrigation purposes. The whole process is fully monitored through sensors and is automated using pneumatic actuated valves controlled by a PLC unit. The excess sludge produced from the SM unit along with the green and wood waste of the urban green spaces that end up in the Nursery, goes through a rapid composting process to produce on-site fertiliser. A heat exchanger and heat pump system recovers thermal energy from the wastewater to be reused for the technological processes of the c	poster
Ruta alternativa Barranco Jabalí Ruta alternativa Trincheras Sendero Acequias de Paulo y El Coto Usted está aquí Mapa propiedad del Instituto Geográfico Nacional El municipio alpujarreño de Pórtugos, ubicado en el macizo granadino de Sierra Nevada, destaca por sus diversas fuentes y manantiales que abastecen de agua una importante red de acequias históricas. Estos nacimientos de agua se enriquecen con los aportes nivales y permiten dotar al municipio de abundante agua. Estos sistemas de riego existen, al menos, desde época andalusí y han generado numerosos espacios de cultivo, pastos y han modelado el paisaje, haciendo de este, un espacio singular. En En el caso del sendero Acequias de Paulo y El Coto, podremos apreciar, transitando por el camino de servidumbre de paso de la acequia, parte de un sistema ancestral de manejo de agua. Estas acequias, toman las aguas del río Jabalí y recorren zonas de alta montaña, guiándola hasta puntos muy concretos donde se “carea”. Esto, signiöca la inöltración del agua en la tierra de manera artiöcial, para recogerla, en zonas más bajas, un tiempo después. A través de diferentes puntos de interés, podremos aprender sobre estos regadíos de alta montaña: la gestión y mantenimiento por parte de las comunidades de regantes, sus beneöcios ambientales, infraestructuras asociadas a estas y otros elementos con los que nos encontraremos a lo largo del recorrido (más información en el código QR). Visitaremos un espacio alterado por el ser humano tradicionalmente, pero que respeta de manera equilibrada y eöciente el medio en el que se encuentra. RECUERDE: Manténgase Evite hacer ruido Respete los bienes y Mantenga limpio No se permite No se permite la No se permite la No se permite la en los caminos propiedades privadas este entorno encender fuego recolección de plantas captura de animales recolección de fósiles 2 2 2 3 DATOS TÉCNICOS: Tipo de sendero: Semi-circular Distancia del recorrido: 7,3 km Desnivel acumulado de subida: 503 m Desnivel acumulado de bajada: 503 m Tiempo estimado del recorrido: 3 h y 10 min. Señalización de Sendero Local (SL) Acequia El Coto I Acequia de Paulo Panorámica de Pórtugos Sendero ACEQUIAS DE PAULO Y EL COTO (PÓRTUGOS) SL-A 386 Ayuntamiento de Pórtugos https://regadiohistorico.es	poster
U.S. Environmental Protection Agency Office of Research and Development EPA www.epa.gov ►Comparison of the HT-H295R screening data analyzed by ANOVA with the summary results available from the OECD validation study suggests that the HT-H295R assay predicted T and E2 effects well. ►The maxmMd is a reproducible and quantitative metric to determine the magnitude of chemical perturbation of steroidogenesis in HT-H295R, representing a data-driven option for evaluating lists of chemicals. ►The number of steroid hormone significantly perturbed in the HT-H295R assay does not indicate the magnitude of effect on steroidogenesis, whereas the maxmMd can differentiate strong and weak modulators of steroidogenesis. ►Selectivity scoring is a useful method to filter HT-H295R pathway positives for additional screening. ►Future work will include more comprehensive benchmarking of the maxmMd metric, and further adapting the HT- H295R kinetic model based on time-course experiments. We use Mahalanobis distance to quantify disruption of steroidogenesis across 11 steroid hormone measurements. Mahalanobis distance incorporates the effect size for each steroid hormone measure after adjusting for covariance between the steroid hormone measures. Evaluating Perturbation of In Vitro Steroidogenesis Using a High-throughput H295R Assay Derik E. Haggard1,2, Agnes L. Karmaus1,2,3, Matt T. Martin2,4, Richard S. Judson2, R. Woodrow Setzer2, Katie Paul Friedman2 1ORISE Postdoctoral Research Participant 2National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency 3Currently at Integrated Laboratory Systems, Inc 4Currently at Drug Safety Research and Development, Global Investigative Toxicology, Pfizer Derik E. Haggard l haggard.derik@epa.gov l 919-541-0745 Background: Endocrine disruption is a toxicity of both physiological and regulatory importance; as steroid hormones regulate reproduction, development, and other biological processes, it is a priority to identify chemicals that may interact with production of these hormones. A high-throughput H295R assay (HT-H295R) was developed as part of the U.S. EPA’s ToxCast program that includes measurement of 11 hormones across the steroid hormone biosynthesis pathway expressed in H295R cells, including progestagens, corticosteroids, androgens, and estrogens. HT-H295R Screening: 2012 chemicals in single concentration screening, 656 in concentration-response. Objectives: ►Demonstrate that the HT-H295R assay may be used to predict testosterone (T) and estradiol (E2) production via comparison of the 25 reference chemicals in the OECD-validated H295R assay. ►Develop a statistical analysis that integrates data from 11 steroid hormones into a single numeric value that indicates the magnitude of effect on steroidogenesis in the HT-H295R assay. ►Begin development of a pathway-based kinetic model of steroidogenesis in HT-H295R. This poster does not reflect US EPA policy. D.E.H. was supported by appointment to the Research Participation Program of the U.S. Environmental Protection Agency, Office of Research and Development, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. EPA. ►A total of 107 chemicals were replicated across multiple blocks; of these, 94 chemicals (87.9%) had concordant maxmMd pathway responses. ►maxmMd values were compared to the sum of steroid hormone hit counts, as measured by ANOVA. ►The maxmMd provides a quantitative indicator of activity that can distinguish chemicals that exert different magnitudes of effect on steroidogenesis but have the same hit count. Effect Sensitivity Specificity Accuracy Testosterone up 1.00 0.89 0.90 Testosterone dn 0.67 0.92 0.83 Estradiol up 0.75 0.83 0.80 Estradiol dn 0.80 1.00 0.95 Left: The residual covariances of many hormone measures in HT-H295R are highly correlated. Middle: Example of Euclidean distance for correlated	poster
Towards cell-inspired particle-based microrobots: Optimisation of the encapsulation of microparticles in lipid membranes Eugenia De Remigis1, Gaia Petrucci1, Elisa Roberti1, Dario Cecchi1, Hilda Gomez Bernal1, Elisa L. Petrocelli2, Jyoti Sharma1 , Francesco Bianciardi1 and Stefano Palagi1 1) The Biorobotics Institute, Scuola Superiore Sant’Anna, Pontedera (Pisa), Italy 2) Sapienza University of Rome (Rome), Italy Confinement of active matter can lead to the emergence of peculiar collective behaviour and interaction with the confining structure1,2. Encapsulating microscale active particles in flexible vesicles can be the basis for artificial active systems to study or emulate complex biological phenomena. ERC project CELLOIDS aims to employ this concept to fabricate soft, deformable and intelligent microrobots for medical applications, inspired by the amoeboid migration strategy of human leukocytes. Particle density has been shown to be crucial for the emergence of collective behaviour3,4. 1. Song, S. et al., J. Am. Chem. Soc. 144, 2022. 2. Vutukuri, H. R. et al., Nature 586, 2020. 3. Bricard, A. et al., Nature 503, 2013. 4. Buttinoni, I. et al., Phys. Rev. Lett. 110, 2013. 5. Pautot, S. et al., Langmuir 19, 2003. 6. Moga, A. et al., ChemBioChem 20, 2019. 7. Ghellab, S. E. et al., Biophys Chem 253, 2019. 8. NIST/SEMATECH e-Handbook of Statistical Methods, http://www.itl.nist.gov/div898/handbook/, accessed April 11, 2023. 9. Sakamoto, R. et al., Proceedings of the National Academy of Sciences 119, 2022. Icons from: Bioicons - high quality science illustrations Data analysis: ImageJ, Rstudio References Acknowledgements This work has been supported by the European Research Council under Grant Agreement No. 948590, project “CELLOIDS”. Further information Do not hesitate to contact us! eugenia.deremigis@santannapisa.it PI: stefano.palagi@santannapisa.it @MicroRobotLab @microrobot.lab Microscale Robotics Laboratory Optimization of microparticle encapsulation Objective 1: obtain controllable particle density Goal: design a bioinspired strategy to employ active microparticles as a propulsion system for ultra-deformable, autonomous microrobots. flexible membrane active core gives ultra- deformability and responsiveness allows for self- propulsion Fabrication of particle-loaded, phospholipid-based giant unilamellar vesicles (GUVs) by inverted emulsion method5,6 Critical process parameters • particle concentration in inner suspension • centrifugation acceleration and time Major issue: polydispersity in vesicle size and particle density Future directions Analysis: response surfaces7,8 Phase-contrast microscopy Motility of amoeboid model systems derives from the interaction with a confining environment9. Fabrication of GUVs encapsulating PS@Pt Janus microparticles A B Infiltration of empty/full GUVs in restrictive chambers Particle-loaded GUVs in confinement Objective 2: verify activity and stability GUVs + PS@Pt Janus microparticles in unconfined environment GUVs in hypertonic solution form protrusions, where active particles can move. Confinement of the GUV in an asymmetric restrictive environment Functionalisation of membrane phospholipids and Janus microparticles to induce contraction-based propulsion How to obtain directional movement of the GUV by exploiting the spontaneous behaviour of Janus microparticles? Activity Stability & Deformability contraction-based extension-based Response parameters • vesicle size • particle density combined Conclusions Objective 1: Results suggest that high particle concentration in the inner suspension helps obtain bigger and fuller GUVs. Long centrifugation time and high acceleration seem necessary to maximise GUV dimension; on the other hand, very high acceleration values could prove counterproductive for an efficient encapsulation. The optimal trade-off point is likely still outside the tested domain. hypertonic glucose solution 3% H2O2 in hypertonic glucose solution GUV suspension 1 2 3 no confineme	poster
• Internationale Konferenzen zu historischer Datenkritik • Blog "Historical method under digital conditions" • Epochenspezifische Lehrpläne • Buch "Historical Data Criticism and Sustainable RDM" • Rechtliche Empfehlungen • Informationsdienst zu technischen Trends und Normen in anderen Ländern • Empfehlungen zu Datenkritik und FDM • White Paper zu ethischen Dimensionen in den Area Histories im digitalen Raum The Future of the Past Task Area "Data Literacy" • Data Literacy Bedarfserhebung • Regional Training Centers • Virtueller Beratungsservice • Virtuelle Trainingskurse • Data Literacy Schulungskatalog • Modell Curriculum • Lernmodule & Schulungsmaterialien • Pilotprogramm für Multiplikator:innen • Governance-Modell für Data Literacy Material-Akkreditierung Unsere Arbeitsfelder Data Literacy Bedarfserhebung Start "von Büchern zu Bytes" Publikation Fragebogendesign Internationale Konferenz "Epistemic Virtues in Digital History and Humanities" Start der Blogreihe "Was Historiker:innen und historisch Arbeitende ihrem jüngeren Ich raten würden" Publikation „Digital Monolingualism, Archives at Risk, and Global Views on Open Access“ Bereitstellung Data Literacy Bibliographie Gründung AG "Regional Training Centers" Kooperationsworkshop zu OER Sammlung von Data Literacy Lern- und Lehrmaterialien Mitwirkung Konzeption NFDI-Workinggroup "Helpdesks" Publikation Umfragebericht Data Literacy Bedarfe Veröffentlichung Data Literacy Trainingskatalog Publikation Whitepaper Data Literacy Kompetenzprofil Gründung AG "Data Literacy in der Lehre" Roundtable auf der CrossArea-Tagung zum Thema "The Future of the Archive(s)" 4memory.de \| @NFDI4memory \| 4memory@ieg-mainz.de gefördert durch Projektnummer 501609550 Mailingliste: E-Mail: contact@4memory-dataliteracy.de Wir sind eng vernetzt Auf dem Laufenden bleiben Veröffentlichungen auf Zenodo "Von Büchern zu Bytes" Veranstaltungsreihe auf YouTube Data Literacy Data Literacy Ausbildung Ausbildung Historische Historische Quellenkritik Quellenkritik & FDM & FDM Digitale Area Digitale Area Histories Histories 2023 2024 Dienste für Dienste für digitale digitale Forschung Forschung Workshop & Publikation "Area Histories und die NFDI4Memory: Zur Rolle der FID"	poster
1 Online supplement for integrated production-transportation planning for supply chain with perishable food and shared returnable transport items APPENDIX A: THE FRAMEWORK OF THE DIFFERENTIAL EVOLUTIONARY ALGORITHM The framework of the differential evolutionary algorithm (DEA) is shown in Fig 1. The basic iteration process of the DEA is similar to other evolutionary algorithms, such as genetic algorithms. It starts with a randomly generated population of candidate solutions and iteratively improves these solutions through mutation, crossover, and selection operations, aiming to converge toward the global optimal solution. The main steps of the DEA are as follows: first, we randomly generate enough individuals as an initial population; second, in mutation operation, two individuals are randomly selected from the current population. A weighted difference vector is calculated between these individuals and added to a third individual to create a new individual; third, the crossover operation crosses the original individual and the mutated individual to generate a new individual; then, in the selection operation, individuals with better fitness values are selected for the next-generation population. For more details on the DEA, please refer to Kumar et al. [1]. Population initialization Stopping condition is satisfied No Mutation Crossover Selection Output the best optimal solution Yes Fig. 1. The framework of differential evolutionary algorithm. APPENDIX B: THE FRAMEWORK OF THE COLUMN GENERATION The framework of the column generation (CG) algorithm is represented in Fig 2. To apply the CG to our problem P1, we reformulate it appropriately into a set partitioning model (master problem MP) and \|M\| subproblems. At the initial iteration of the CG, we solve a smaller-scale restricted master problem RMP (i.e., with fewer variables than the original problem MP). Then, we solve the relaxation of RMP, calculate the dual value (i.e., shadow price) for each constraint, and input dual values into subproblems. Subsequently, subproblems are solved to check the variables that are not currently considered in the RMP to see if there are any variables that can reduce the total cost (i.e., their reduced cost, denoted as RC, is less than zero). If such variables are found, we add them to the RMP and return to solve RMP. This process is repeated until no new variables can enter the RMP to reduce the total cost (i.e., the RC is non-negative). For more details on the CG, please refer to Tempelmeier [2].	poster
ANÁLISE GEOESPACIAL E TEMPORAL DOS INDICADORES DE ALTA COMPLEXIDADE EM SAÚDE NO ESTADO DE SÃO PAULO Breno Bologna, Laura Lopes Amaral, Ana Paula Romani, Larissa Mayumi Yokoi, Tiago Ribeiro de Oliveira, Harki Tanaka, Priscyla Waleska Simões Curso de Engenharia Biomédica, Programa de Pós-Graduação em Engenharia Biomédica Centro de Engenharia, Modelagem e Ciências Sociais Aplicadas Universidade Federal do ABC / Santo André, Brazil 1. INTRODUÇÃO Procedimentos de alta complexidade são destinados a situações específicas e mais raras, entretanto o impacto financeiro desse tipo de procedimento é alto. Assim, essa pesquisa visa apresentar a taxa de internações de alta complexidade no Estado de São Paulo de forma a prover informações importantes para a gestão de saúde pública. 2. METODOLOGIA Estudo descritivo que utilizou dados secundários do Sistema de Informações Hospitalares (SIH/SUS), extraídos do TabNet/DATASUS distinguindo entre as macrorregiões e microrregiões do Estado de São Paulo, e entre os municípios da microrregião de São Paulo. Foram obtidas as internações de alta complexidade de 2008 a 2016, por local de residência e por grupos de procedimentos. Além disso a população de cada uma dessas regiões foi extraída do IBGE. Determinou-se assim a taxa bruta de internações de alta complexidade a cada mil habitantes para cada região. A partir deste indicador foi estimada a média, o desvio padrão e foram realizadas análises da evolução histórica. Além disso foram realizados cálculos de regressão linear, e estimados o coeficiente angular, o nível de significância e o coeficiente de determinação. Em todas as análises, considerou-se como estatisticamente significativo p<0,05. 3. RESULTADOS A série histórica evidencia que a média do Estado de SP aumentou nesses últimos anos, e ao observar as microrregiões com maiores e menores taxas, Barretos e Franco da Rocha, nota-se que o aumento foi distribuído entre as regiões (Figura 1 e Figura 2). O procedimento que resultou em maiores taxas de internação de alta complexidade foi a Cirurgia, com taxa média bruta de 2,8 e aumento ao longo dos anos. Os procedimentos clínicos, transplantes e procedimentos com finalidade diagnóstica revelaram taxas de 0,6; 0,4 e 0,1 internações a cada 1.000 habitantes, respectivamente, com poucas oscilações no período. 4. CONCLUSÃO O presente estudo resultou em indicadores que servem de insumo para decisões dentro da gestão pública baseada em evidências principalmente quanto à distribuição espacial de quem usa esse tipo de serviço. Futuras pesquisas devem investigar os indicadores e estatísticas associadas. Figura 1. Evolução Temporal das Taxas de Internação por Microrregião/SP No período entre 2008 a 2016, foram realizadas 1.537.476 internações de alta complexidade no Estado de SP, o que equivale a uma taxa bruta média de 4,0 internações a cada 1.000 habitantes CONTATO Profa Dra Priscyla Waleska Simões - pritsimoes@gmail.com Curso de Engenharia Biomédica / Programa de Pós-Graduação em Engenharia Biomédica / Centro de Engenharia, Modelagem e Ciências Sociais Aplicadas/ Universidade Federal do ABC / São Bernardo do Campo (SP) / Brasil Figura 2. Distribuição Geográfica das Taxas de Internação (p/ 1.000 hab) por Microrregião/SP (a) e Macrorregião/SP (b)	poster
RESEARCH POSTER PRESENTATION DESIGN © 2015 www.PosterPresentations.com Studied areas in coastal zone for SST and the preparation of the TRISHNA mission: The Mediterranean sea along the coast from the Bay of Banyuls/Mer up to Marseille : → Submesoscale processes (~ 1-10km) (link with the SWOT mission) up to the scale of mixing/dissipation (100 m-1km): → Diurnal cycle, mixing after a wind event, river discharge and plumes, groundwater discharges especially around the in situ observations for the SST: moorings (LF/HF) examples: in the Bay of Banyuls/Mer (this poster), lagoons • Côte Sud-Nord avec un canyon → difference (Airborne SST/Landsat SST – HF in situ SST) = - 0.5°C (POEM Station) And = -1°C (SOLA Station) → Difference (satellite SST at 9:20am – Airborne SST at 10am) = - 0.1°C Laboratoire d’Etudes en Géophysique et Océanographie Spatiales – Toulouse – F - France I. Dadou, B. Pagli, M. Kaouah (LEGOS, Toulouse, F)M. Irvine (INRAE, Bordeaux, F) B. Coudert, V. Rivalland (CESBIO, Toulouse, F) R. Villemain, L. Zudaire (LOMIC/OOB, Banyuls/Mer, F) F. Bourrin (CEFREM, Perpignan, F) Sea surface temperature (SST) in coastal ocean with different data: application for the TRISHNA mission Scientific context Scientific context Study thermal infrared signals (TIR) for the determination of sea surface temperature (SST) in the coastal environment (Mediterranean Sea) by different data (airborne, satellite, in situ data, model outputs) and methods, complementary in their spatio-temporal resolutions and coverage in order to prepare the TRISHNA mission (CNES/ISRO - 2025) (algorithm, products and expectations in coastal environment) Main scientific question Main scientific question Studied Area: Mediterranean Sea Studied Area: Mediterranean Sea SST data and models used with different spatial resolution SST data and models used with different spatial resolution Conclusion & perspectives Conclusion & perspectives References References Results Results Berk, A. et al. MODTRAN 5: a reformulated atmospheric band model with auxiliary species and practical multiple scattering options: update. In Proceedings of the Algorithms and Technologies for Multispectral, Hyperspectral, and Ultraspectral Imagery XI ; International Society for Optics and Photonics, 2005; Vol. 5806, pp. 662–667.Estournel, C., Marsaleix, P., & Ulses, C. (2021). A new assessment of the circulation of Atlantic and Intermediate Waters in the Eastern Mediterranean. Progress in Oceanography, 198, 102673. Estournel, C., X. Durrieu de Madron, P. Marsaleix, F. Auclair, C. Julliand, and R. Vehil (2003) Observation and modeling of the winter coastal oceanic circulation in the Gulf of Lion under wind conditions influenced by the continental orography, (FETCH experiment), J. Geophys. Res., 108(C3), 8059, doi:10.1029/2001JC000825, 2003 Feuilloley G. , Fromentin J-M, Stemmann L., Demarcq H, Estournel C, Saraux C. (2006), Concomitant changes in the environment and small pelagic fish community of the Gulf of Lions, Progress in Oceanography, Volume 186, 2020 Gatti, J., Petrenko, A., Devenon, J. L., Leredde, Y., & Ulses, C. (2006). The Rhone river dilution zone present in the northeastern shelf of the Gulf of Lion in December 2003. Continental Shelf Research, 26(15), 1794-1805. Lagouarde, J.-P., M. Bach, J.A. Sobrino, G. Boulet, X. Briottet, S. Cherchali, B. Coudert, I. Dadou, G. Dedieu, P. Gamet, O. Hagolle, F. Jacob, F. Nerry, A. Olioso, C. Ottlé, (2013). The MISTIGRI thermal infrared project: scientific objectives and mission specifications. International Journal of Remote Sensing. Volume 34, Issue 9-10, pages 3437-3466 O’Carroll, A. G., Armstrong, E. M., Beggs, H. M., Bouali, M., Casey, K. S., Corlett, G. K., ... & Wimmer, W. (2019). Observational needs of sea surface temperature. Frontiers in Marine Science, 6, 420. Schaeffer, A., Garreau, P., Molcard, A., Fraunié, P., & Seity, Y. (2011). Influence of high-resolution wind forcing on hydrodynamic modeling of the Gulf of Lions. Ocean Dynamics, 61(11)	poster
Introduction Chronic hepatitis B infection (CHB) has diverse disease phenotypes, ranging from minimal hepatic fibrosis, to cirrhosis and hepatocellular carcinoma (HCC)1. Serum viral markers are currently measured to inform clinical management, however none directly detect the covalently closed circular DNA (cccDNA) hepatocyte reservoir. Serum hepatitis B core related antigen (HBcrAg) has been correlated with cccDNA levels, and may predict HCC development2,3, but most studies are from Asia where genotypes B and C predominate4-6, so wider utility of HBcrAg is unknown. Serum Hepatitis B core-related antigen in a diverse UK cohort of patients with Chronic Hepatitis B infection Louise O Downs1,2, Tingyan Wang1,3, Marion Delphin4, Elizabeth Waddilove4, Monique Andersson2, Geoffrey Dusheiko5, Kosh Agarwal5, Eleanor Barnes1,2 Ivana Carey5, and Philippa C Matthews1,4,6,7 1 Nuffield Department of Medicine, University of Oxford, UK, 2 Department of Infectious Diseases and Microbiology, John Radcliffe Hospital, Oxford, UK, 3 NIHR Oxford Biomedical Research Centre, University of Oxford, UK, 4 The Francis Crick Institute, London, UK, 5 Institute of Liver Studies, King’s College Hospital, London, UK, 6 Division of Infection and Immunity, University College London, UK, 7 Department of Infectious Diseases, University College London Hospital, London, UK Contact Informations: Louise Downs: louise.downs@exeter.ox.ac.uk @lou_downs Philippa Matthews: philippa.matthews@crick.ac.uk @pippa_matt References 1 GBD 2019 Hepatitis B Collaborators, 2022 (PMID: 35738290) 2 Testoni et al, 2019 (PMID:30529504) 3 Carey et al, 2020 (PMID: 31701544) 4 Tada et al, 2018 (PMID: 28914957) 5 Tada et al, 2016 (PMID: 27034253) 6 Shimakawa et al, 2020 (PMID: 31102406) Aims We measured HBcrAg in a cross-sectional cohort of 143 ethnically diverse adults with CHB from a UK teaching hospital to understand how HBcrAg varies or is associated with: Patient demographics. Liver disease. Treatment Its use as a surrogate HBV DNA marker will also be investigated and whether this applies in all subgroups. Methods Clinical Metadata Patient data were collected in outpatient clinics and from Oxford University Hospitals Electronic Patient Records (EPR). 143 patients infected with HBV enrolled in the Oxford University Hospitals NHS Foundation with broad Viral Loads (VL). Participants provided written informed consent. Serum samples Liver Biomarkers (Alanine Transferase - ALT) HBV Biomarkers (HBeAg, HBsAg, VL) HBcrAg: chemiluminescent assay (Lumipulse G HBcrAg assay, Fujirebo) Statistical analysis was conducted in R (version 4.1.1) using the ‘ggplot2’ package (version 3.3.6). Correlations were all done using Pearson’s coefficient. Acknowledgments: Oxford University Hospitals laboratories NIHR Health Informatics Collaborative Kinga A Várnai and Oliver Freeman Results Figure 1: HBcrAg correlation with patients metadata HBcrAg was significantly correlated with HBsAg (A-B) and HBV DNA levels (D-E), however this was lost with HBeAg negativity (C,F). HBcrAg was still detected in those with undetectable HBV DNA. HBcrAg did not correlate with ethnicity (A), biological sex (B) or treatment (C) but is positively correlated with serum ALT (D) and decline significantly with age (E). 2 4 6 8 0 100 200 300 ALT (IU/L) HBcrAg (U/mL) 2 4 6 8 20 40 60 Age (years) HBcrAg (U/mL) E D 2 4 6 8 Arab Asian Black African Chinese European Other Asian Unknown HBcrAg (U/ml) A Ethnic group 2 4 6 8 Female Male HBcrAg (U/ml) B Biological Sex Figure 2: HBcrAg correlation with viral parameters in patients 4 6 8 0 2000 4000 HBsAg (IU/ml) HBeAg positive patients B 2 3 4 5 0 2000 4000 6000 HBeAg negative patients C A 2 4 6 8 0.0 2.5 5.0 7.5 HBcrAg (U/mL) All Patients D 4 6 8 0.0 2.5 5.0 7.5 HBV DNA (log IU/mL) HBeAg positive patients E 2 3 4 5 0 2 4 HBeAg negative patients F HBcrAg (U/mL) All Patients 2 4 6 8 No Yes HBcrAg (U/ml) Treatment status C 0.0 2.5 5.0 7.5 0 2000 4000 6000 R = - 0.19 p = 0.023 R = - 0.42 p = 0.047 R =	poster
hhu.de Cyanobacteria as platform organisms for biotechnology Cyanobacteria are photoautotrophic bacteria capable of photosynthesis and high rates of CO2 fixation. Their metabolic potential makes them promising candidates for biotechnological production of industrially relevant compounds such as plant secondary metabolites. Valencene - an important aroma and more Valencene is a sesquiterpene that can be found in many citrus fruits. While it can be used in various applications in industry, including cosmetics and flavor, it also serves as a precursor for nootkatone, which has been shown to act as a powerful insect repellant, but can also inhibit growth of cancer cells. ValenCell: Large-scale production of sesquiterpenes from microalgae Anna Behle1, Ilka Axmann1, Lars Bähr2, Arne Wüstenberg2 CO2BioTech Kick-Off Meeting Lars Bähr (CellDEG) Anna Behle (HHU) Heinrich-Heine-Universität Düsseldorf Institute for Synthetic Microbiology 1 Institute for Synthetic Microbiology, HHU Düsseldorf; 2 CellDEG GmbH Berlin synmikrobiologie.hhu.de CO2 CO2 CO2 NADPH Valencene A WP1: Engineering the bacterial metabolism We previously showed that increasing metabolic flux through the terpenoid biosynthesis pathway had positive effects on strain productivity. Since sesquiterpene production competes with pigment biosynthesis, it is important to supply the cell with sufficient precursor molecules, as well as cofactors. We were able to achieve, rerouting carbon supply from pigment biosynthesis towards product formation with inducible systems1. We aim to build a stable production strain without costly inducers using the following strategies. Titration of expression strength by testing multiple genetic cassettes Testing different sesquiterpene synthases Variation of cultivation conditions Reinforcement of carbon and cofactor supply by rerouting the metabolism (Fig. 1) WP3: Scaling up with CellDEG One main challenge when scaling up the cultivation volume of cyanobacterial strains is ensuring a sufficient availability of nutrients such as light and CO2. The CellDEG technology is specifically designed to enable fast growth of photoautotrophic organisms to a high cell density (Fig. 2B). To identify strains that perform best in such reactors, promising strains will be screened in HD10 reactors early on. Upscaling of the best production strains will take place in the HD1500 production platform (Fig. 2A). The final aim of this project is to achieve a strain with a growth rate of 2.5 g DCW/L/day while maintaining a production rate of 200 mg valencene / g DCW. WP2: Alternative extraction methods Valencene, along with many sesqui- and monoterpenes, is a volatile compound. This is especially advantageous for downstream processing, as it eliminates the need for expensive and time- consuming extraction from the biomass. The current state-of-the-art for quantification of valencene production makes use of a thin layer of dodecane on top of the culture, which captures the volatile product (Fig. 2C). This is favorable for analysis, as dodecane can be analyzed via GC/MS directly. In terms of cost, scalability and sustainability it is of high interest to find alternative extraction- or capturing methods for valencene. A B C Figure 1: Relevant metabolic pathways in the cyanobacterium Synechocystis sp. PCC 6803. Relevant genes for overexpression or deletion are boxed. Involvement of ATP and NADPH is shown in red and blue, respectively. Figure 2 A. From left to right: HD10, HD100, HD1500 reactor setup. B. Growth curves of Synechocystis sp. PCC 6803 WT in the three different reactors. C. Schematic setup for growth of production strains to high cell densities using the HD10 screening platform (image modified from2 Scientific reports, 10(1), 5932 https://doi.org/10.1038/s41598-020-62681-w) 1 OD₇₅₀ = 0,322 gDW L⁻¹ 1Dietsch, Behle et al.: Metabolic engineering of Synechocystis sp. PCC 6803 for the photoproduction of the sesquiterpene valencene. Metab. Eng. Commun. 2021 Aug 13	poster
U.S. Environmental Protection Agency Office of Research and Development Building an Adverse Outcome Pathway Framework through HTS Data and Literature Mining Integration Nancy C. Baker1, Nisha S. Sipes2, M. Shane Hutson3, Thomas B. Knudsen2 1Lockheed Martin, RTP, NC, 2U.S. EPA, ORD, National Center for Computational Toxicology, 3Departments of Physics and Biological Sciences, Vanderbilt University, Nashville, TN Footnotes Go Here Footnotes Go Here Footnotes Go Here Footnotes Go Here Footnotes Go Here Footnotes Go Here Footnotes Go Here Footnotes Go Here Footnotes Go Here Footnotes Go Here Footnotes Go Here Overview Literature Data Nancy Baker l baker.nancy@epa.gov l 919-541-2680 Interpreting EPA’s ToxCast in vitro assay data in the context of Adverse Outcome Pathway (AOP) development is a significant challenge. While chemical activation in these assays may shed light on the molecular initiating event, it can be difficult to identify the downstream effect of these activities at higher levels of biological organization (e.g., cellular, tissue, organ) that could potentially lead to a toxicity endpoint. In this research, we explore applications of literature mining techniques that can be readily used to build and evaluate an AOP framework from in vitro data. We use cleft palate as a prototype and focus on the ToxCast assay targets that were found to have a significant univariate association with cleft palate / cleft lip (CLP) in ToxRefDB and the literature. DISCLAIMER: does not reflect EPA policy Proteins Chemicals Effects 51 million annotations 24 million annotations 18 million annotations >22 million articles A connection Analyze the EPA’s ToxCast HTS dataset containing > 1,000 unique chemicals tested across >500 in vitro assays to identify the assays with the most significant univariate association with chemicals that cause cleft palate or cleft lip. Find the literature connections between ToxCast targets and cell-level activity/entities and tissue-level activity and entities. Connections are defined as an article co-annotation between a target protein and the cell/tissue entity. Strategy Target Tissue Level CLP Organ Cell Level Option 1. Binary relationships Option 2. Expand relationships Option 3. Bidirectional relationships Results Target Tissue Level CLP Organ Cell Level ToxCast: 56 chemicals in the ToxCast libraries were identified as CLP actives by reviewing data in ToxRefDB and the biomedical literature. A statistical analysis of the assay data identified 29 assays that correlated significantly with the CLP endpoints. (Student’s T-test (p<=0.05)) A subset of those assays with the corresponding Medical Subject Heading (MeSH) term for the target protein is found in Table 1. These statistical correlations represent potential molecular targets that have been assayed in the ToxCast portfolio and serve as a potential entry point for AOPs leading to a cleft palate/cleft lip phenotype in pregnant rats and/or rabbits. Literature: The search of EPA’s biomedical literature database using the term Cleft Palate retrieved 36 unique tissue MeSH terms, 37 cell types, 34 cellular processes, and 54 non-cellular processes. Co-annotations of these tissue or cell types and any of the MeSH terms for the ToxCast targets (Table 1) were also retrieved. The articles were counted and the results output to the database and extracted (with hyperlinks) into the spreadsheets show below. Observations deduced from the subject categories serve as a starting point to fill in the biological space between the assays and the endpoint based on what is known in the literature. Target Cell Level Tissue Level Tissue Level Tissue Level Tissue Level CLP Organ CLP Organ CLP Organ Organ CLP Organ CLP Organ Organ AOP Framework: Table 1. Selected assays with significant univariate association with cleft lip / cleft palate; Blue: nuclear receptors; Gray: GPCRs; Green: other ToxCast Assay Target - selected MeSH term NVS_ENZ_oCOX1 Cyclooxygenase 1 NVS_ENZ_hElastase Leukoc	poster
There is increasing recognition of the scope of cultural change needed to realize the European vision for Open Science policy. Key challenges include contemporary modes of recognition and reward that are out of step with principles of open science[1] and identi@ication of numerous disincentives, at the individual level, regarding adoption of new openness practices[2]. These obstacles raise questions about implementation of top-down policy in general, and the European Commission's open science policy in particular. (mock-up) x-xxxx-xxxx-xxxx Contributor Contributions, Open Scholarship •————— •——- •————— •———— •————— •————— Openness Proﬁle (individual) Openness Proﬁle (group) Contributor x-xxxx-xxxx-xxxx Repository, (e.g. Zenodo or RAiD) individual group Research and Innovation – a vision for Europe Open Innovation Open Science Open to the World In what ways is open science policy informed by the science of science? Although evaluation of open science is gaining traction as an important dimension for implementation of open science policy, there is not yet much in the way of empirical analysis. To address this question, we begin with a targeted search in the Web of Science bibliographic database (WoS), which yields three citation networks associated with: open access, open data, and open science[3]. With a combined total of approximately @ive-thousand publication records, published between 1958 and 2018, we then use VOSviewer for analysis and visualization of keyword terms at an aggregate level. Keyword mapping illustrates the relatedness of research topics on the bases of keyword co-occurrence. —> economics of academic publishing —> transparency and accountability —> aﬀordances of digital media and computa8onal resources —> technical integrity of scien8ﬁc processes and outputs —> rapid dissemina8on of medically relevant knowledge In our analysis of the combined keyword datasets, the three queried topics largely retain their individual structures with some interlinking across networks. The keyword map also identi@ies sub-networks that reveal motivating factors associated with the broader openness movement, such as: economics of academic publishing, transparency and accountability, affordances of digital media and computational resources, technical integrity of scienti@ic processes and outputs, and rapid dissemination of medically relevant knowledge. While we identify some common ground between the European notion of open science and the keyword networks, the research topics identi@ied shed light on a more complex relationship between research practice and increased openness. In other words, the European notion of open science appears to draw on particular understandings of the sciences system, characterized by close alignment with economic activity and a clear, albeit linear, view of how science bene;its society. Open science is seen as a natural extension of existing research practices. Missing from this vision is attention to research practices that do not align so easily with economic activity and research @ields that hold a more indirect relationship with society. Within the community of policy makers and advocates of open Science, there is increasing consensus that (a) better recognition and reward of openness practices is a necessary condition for broad adoption of open scholarship, (b) top-down guidance, which is aimed at a wide range of disciplinary practices, will require substantial cultural change to shift the priority of research evaluation toward principles of open scholarship and (c) bottom-up openness initiatives and practices must emerge from local contexts to enable relevant, sustainable change [1, 2]. The Knowledge Exchange working group addressing this issue[4], proposes an Openness Proﬁle for making visible and being recognized for one’s contribu?ons to open scholarship. The aim in this endeavor is to provide complementary, boFom-up resources linked to contemporary Research Informa8on infrastructure. There are	poster
LA CIENCIA ABIERTA EN LA UNIVERSIDAD DE PUERTO RICO OBJETIVO DE LA INVESTIGACIÓN Explorar la apertura y el intercambio de los procesos, herramientas y resultados de investigación en la Universidad de Puerto Rico (UPR), en cuatro dimensiones de la Ciencia Abierta: (I) Acceso abierto (Open Access) (II) Revisión por pares abierta (Open Peer review) (III) Recursos educativos abiertos (Open Educational Resources) (IV) Código Abierto (Open Source) METODOLOGÍA • Estudio inicial de carácter exploratorio y fundamentalmente descriptivo • Fuentes para la recogida de la información: - Política de Acceso Abierto a los resultados de la labor creativa e investigaciones producidas en la Universidad de Puerto Rico (Certificación 113, 2019-2020) - Portal de Revistas Académicas de la Universidad de Puerto Rico - Estadísticas de acceso y uso de los repositorios institucionales de la UPR - Scopus® (Elsevier's abstract and citation database) CONCLUSIONES Los resultados preliminares de este trabajo reflejan que, indudablemente, el movimiento de la ciencia abierta viene impactando notable en las políticas institucionales de la Universidad de Puerto Rico, que en los últimos años ha puesto en marcha distintas iniciativas para favorecer el proceso de apertura e intercambio de sus resultados de investigación. RESULTADOS PRELIMINARES: acceso abierto Dra. Cláudia De Souza claudia.souza@upr.edu Profesora Catedrática Auxiliar Dr. Carlos A. Suárez Balseiro carlos.suarez5@upr.edu Profesor Catedrático Universidad de Puerto Rico, Recinto de Río Piedras (UPRRP) Facultad de Comunicación e Información (FaCI) https://faci.uprrp.edu/ Programa Graduado en Ciencias de la Información 443 436 490 643 592 714 902 906 969 986 1070 974 1001 944 1017 1032 1048 1091 1071 1010 1084 13,32 60,42 0,00 5,00 10,00 15,00 20,00 25,00 30,00 35,00 40,00 45,00 50,00 55,00 60,00 65,00 70,00 75,00 80,00 85,00 90,00 95,00 100,00 0 100 200 300 400 500 600 700 800 900 1000 1100 N. docs UPR % All Open Access 28 revistas editadas o coeditadas en 5 recintos de la UPR Más de 9000 documentos disponibles a texto completo	poster
Summarized findings Two candidate effectors, PM02_g378 and PM02_g2610, localize to the cell periphery while the remaining putative effectors localize to both the nucleus and cell periphery PM02_g1115, PM02_g7882 and PM02_g8240 consistently suppress chitin-dependent ROS production when transiently expressed in N. benthamiana PM02_g1115 suppresses Pseudomonas syringae DC3000-mediated cell death in maize \ Acknowledgments and Funding We thank Dr. Tesfaye Mengiste (Purdue University) for access to the microplate reader for ROS suppression assays, Dr. Rachel Hiles and Dr. Terri Cameron for their technical assistance, and the Purdue University Imaging Facility for access to the Zeiss LSM880 Axio Examiner upright confocal microscope. This research was funded by the USDA-ARS research project 5020-21220-014-00D. USDA is an equal opportunity provider and employer. Candidate effector proteins from from the maize tar spot pathogen Phyllachora maydis suppress immune responses Abigail Rogers1†,Namrata Jaiswal2 †, Emily Roggenkamp3, Hye-Seon Kim4, Joshua S. MacCready3, Martin Chilvers3, Steven R. Scofield2, Anjali Iyer-Pascuzzi1, and Matthew Helm2 * † these authors contributed equally to this work 1 Department of Botany and Plant Pathology, Purdue University West Lafayette, IN 47907, U.S.A. 2 Crop Production and Pest Control Research Unit, U.S. Department of Agriculture-Agricultural Research Service (USDA-ARS), West Lafayette, IN 47907, U.S.A., 3 Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, MI, 48824 4 Mycotoxin Prevention and Applied Microbiology Research Unit, USDA-ARS, Peoria, IL, U.S.A. * Corresponding author: M. Helm; Email: Matthew.Helm@usda.gov Significance @LabAbbie27 To better understand the molecular mechanisms underlying the P. maydis – maize interaction, we investigated how P. maydis utilizes effectors to induce disease. Leveraging the most recent genome annotation, we identified eighteen candidate virulence (effector) proteins that are expressed during disease development and assessed whether these putative effectors suppress immune responses using heterologous expression systems, including Nicotiana benthamiana and the bacterial type III secretion system from Pseudomonas syringae DC3000. Three P. maydis effector candidates suppress chitin-mediated ROS production in N. benthamiana Figure 5. Protein structures were predicted with ColabFold v1.5.2: AlphaFold2 and visualized using the ChimeraX-1.5 modeler package. Here we present the predicted structures of three PmECs which have cell surface-triggered immune suppression activities. The coloring of the models depicts the predicted local distance different test (pLDDT) which indicates the per-residue confidence score. Higher confidence scores are depicted in cool colors while low confidence scores are depicted in warmer colors. Figure 2. Transient expression assays were performed at 48 hours post infiltration. The sub-cellular localizations of PmEC-sYFP fusions were determined by laser scanning confocal microscopy (A). Expression of full-length PmEC-sYFP fusions in N. benthamiana leaves was confirmed by western blot analysis (B). Figure 3. Transient expression of candidate effector- fluorescent protein fusions suppress reactive oxygen species (ROS) burst triggered by chitin in N. benthamiana. The indicated constructs were expressed in N. benthamiana. Forty-eight hours post-agroinfiltration, N. benthamiana leaf disks were collected, challenged with chitin, and relative luminescence was monitored for 40 minutes using a luminol-based assay. Free sYFP (3xHA:sYFP) was used as a reference control P. maydis effector candidates localize primarily to the nucleus and cell periphery Predicted protein structures of the candidate effectors as determined by AlphaFold2 An introduction to Phyllachora maydis The fungal phytopathogen Phyllachora maydis is an obligate pathogen of maize and is the causal agent of tar spot disease. It was first identifie	poster
1. Inhibition and processing speed impaired in MCI and AD groups • Standardised tests detect cognitive changes in impaired groups, and more so in inhibition than processing speed 2. WM fibre density (FD) in SLF differed between groups, but not FC, and little for FDC • Density, rather than volume of the fibre, steadily decreased between groups • While C and SCD groups had similar cognitive performance, the SLF FD differed. The C group had greater SLF FD, while the SCD group’s SLF FD was more similar to the MCI and AD groups 3. Inhibition, and not processing speed significantly correlated with FD in the left SLF 2 and 3 • The SLF plays a critical role in inhibition processes in AD risk cohorts Funding from Brain Research New Zealand (BRNZ) We thank the participants and DPRC staff for giving their time for this study. SCD n = 60 C n = 35 mMCI n = 52 AD n = 27 aMCI n = 55 Lenore T Tahara-Eckl1,2, Reece Roberts1,2, Catherine Morgan1,2, Flavio Dell’Acqua3, Ian Kirk1,2, Tracy R Melzer4,6, John C Dalrymple-Alford4,5, Tim J Anderson4,6, Nicholas J Cutfield7, Lynette Tippett1,2 1School of Psychology, University of Auckland, New Zealand; 2Centre for Brain Research, University of Auckland, New Zealand; 3Forensic and Neurodevelopmental Sciences, King’s College, London, England; 4NZ Brain Research Institute, Christchurch, New Zealand; 5School of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand; 6Department of Medicine, University of Otago, Christchurch, New Zealand; 7Department of Medicine, University of Otago, Dunedin, New Zealand Participants. n = 229 (122 F, 69.75 ± 8.25 years), recruited from the Dementia Prevention Research Clinic (DPRC) over three sites: Auckland, Christchurch, Dunedin Neuropsychological assessment. Normal Fibre Bundle Reduced FD Reduced FC Reduced FDC Fixel-based analysis (FBA) for FD, FC, and FDC5 1. Rabin, L. A., Smart, C. M., and Amariglio, R. E. 2017. Annual Review of Clinical Psychology, 13(1), 369–396. 2. Lockhart, S. N., & DeCarli, C. 2014. Neuropsychology Review, 24(3), 271–289. 3. Perry, R. J., & Hodges, J. R. 1999. Brain, 122(3), 383–404. 4. Bennett, I. J., & Madden, D. J. 2014. Neuroscience, 12(276), 187–205. 5. Sasson, E., Doniger, G. M., Pasternak, O., Tarrasch, R., and Assaf, Y. 2013. Frontiers in Neuroscience, 7(7 MAR), 1–13. 6. Cremers, L. G. M., de Groot, M., Hofman, A., Krestin, G. P., van der Lugt, A., Niessen, W. J., Vernooij, M. W., and Ikram, M. A. 2016. Neurobiology of Aging, 39, 108–117. 7. Raffelt, D. A., Tournier, J. D., Smith, R. E., Vaughan, D. N., Jackson, G., Ridgway, G. R., and Connelly, A. 2017. NeuroImage, 144, 58–73. 8. Tournier, J. D., Smith, R., Raffelt, D., Tabbara, R., Dhollander, T., Pietsch, M., Christiaens, D., Jeurissen, B., Yeh, C. H., and Connelly, A. 2019. NeuroImage, 202(August), 116137. Five participant groups (total n = 229) Poorer executive function is associated with lower white matter fibre density in the superior longitudinal fasciculus in groups at risk of Alzheimer’s disease Diffusion FOD Image acquisition and preprocessing. Diffusion-weighted MRI (100 directions, b = 1000, 2000 s/mm2). FOD estimation with multi-tissue constrained spherical deconvolution and FBA processed with MRtrix38 Six SLF tracts of interest. Left: SLF tracts coloured by direction (red = right-left, blue = superior-inferior, green = anterior- posterior). Right: SLF tracts segmented by number (SLF1, SLF2, SLF3) In groups at different levels of risk of AD… 1. Do measures of processing speed and inhibition differ? 2. Do SLF fibre properties differ? 3. Do the SLF tracts correlate with processing speed and inhibition measures? Research Questions Background Methods Processing Speed Hayling’s Congruent Sentence Set 1 Stroop Colour Naming Stroop Word Reading Trail Making Test A Inhibition Hayling’s Incongruent Sentence Set 2 Hayling Category A Error Hayling Category B Error Stroop Inhibition Category Switching Trail Making Test B Our findings suggest that specific mi	poster
Commissariat à l’énergie atomique et aux énergies alternatives INES \| 50 avenue du lac Léman \| 73375 Le Bourget-du-Lac www-liten.cea.fr / www.ines-solaire.org DEVELOPMENT AND IMPROVEMENT OF METHODS FOR REDUCING CONTAMINATION OF SILICON-KERF FROM WAFER SLICING Roland RIVA, Margot LANDA-PLIQUET, Fabrice COUSTIER UNIVERSITÉ GRENOBLE ALPES, CEA, LITEN, CAMPUS INES, 73375 LE BOURGET DU LAC, FRANCE CONTACT : Roland RIVA, roland.riva@cea.fr This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 958365 CONTEXT 35% silicon-kerf loss during wafer slicing (diamond wire) recycling desirable Silicon contamination from cutting liquid (water + additives), brick holder (beam) and diamond wire CONTAMINATION REDUCTION OF SILICON-KERF 1) DURING WAFER SLICING Low concentration (Carbon Oxygen Demand) coolant decrease of carbon Beam composition (silicon-based filler) aluminum reduction 2) ON DRY RECOVERED SILICON-KERF Soft chemical treatment (HCl) followed by thermal treatment (2 hours @ 500°C) Main residual contaminant = nickel (from cutting wire coating) CONCLUSION • Raw silicon-kerf purity can be enhanced to 3N (99.9%, excluding light elements) without industrial cutting process modification thanks to cutting liquid and beam composition change • Additional soft chemical treatment, followed by thermal treatment can drastically reduce carbon concentration and increase silicon-kerf purity to 4N (99.99%) References • H. Hajjaji, F. Coustier, V. Brizé, A. Benayad, M. Benmansour, A. Chabli, “Recycling of Kerf-Loss Silicon Powder from Diamond-Wire Cutting Without Chemical Treatment”, EU PVSEC 33, 2017. • M. Vazquez-Pufleau, T.S. Chadha, G. Yablonsky, P. Biswas, “ Carbon elimination from silicon kerf: Thermogravimetric analysis and mechanistic considerations”, Scientific Reports, Volume 7, 2017. • F. Coustier, V. Brizé, H. Hajjaji, “Wire cutting support for bonded abrasives comprising an assembly of different materials, system comprising such a support and wire cutting methods”, European Patent EP 3 424 663 A1, 2017. • X. Li, G. Lv, W. Ma, T. Li, R. Zhang, J. Zhang, S. Li, Y. Lei, “Review of resource and recycling of silicon powder from diamond-wire sawing silicon waste”, Journal of Hazardous Materials, Volume 424, Part A, 2022. • Z. Hu, G. Wang, J. Li, Y. Tan, Y. liu, P. Li, “Recycling of diamond-wire sawing silicon powder by direct current assisted directional solidification”, Waste Management, Volume 157, 2023. Metals divided by 3 and carbon by 6 from raw Si-kerf 1BV.5.5	poster
Hochschule für Gesundheit · University of Applied Sciences · Gesundheitscampus 8 · 44801 Bochum Raising awareness for RDM: The importance of multipliers within the institution anke.osterhoff@hs-gesundheit.de Osterhoff, Anke & Koch, Katharina Hochschule für Gesundheit, Bochum, Germany State of RDM at UAS Professional research data management (RDM) is becoming increasingly important not only at universities but also at universities of applied sciences (UAS). This is partly due to DFG and other authorities’ regulations regarding RDM, which means that more and more third-party funding bodies require RDM for funding. Additionally, research at UAS is often practical and application-oriented, which means that the findings and results can quickly flow into different areas of society, the economy, and culture to create innovation and transformation. Research data at UAS therefore has yet rather underutilized scientific, cultural, and economic potential, especially in terms of its subsequent applied use. Professional RDM is essential for realizing these opportunities. Researchers and institutions are becoming increasingly sensitive to its potential. Yet, UAS are burdened with high teaching loads and relatively little funds for research, while RDM is often not funded at all. Starting points Bringing RDM into practice at the institutional level and raising awareness among researchers, administrative and infrastructural stakeholders is challenging. Thus, we placed special focus on the role of voluntary multipliers within the institution. These voluntary multipliers are also referred to as “data champions” [1] and can be considered key actors for raising awareness for RDM among researchers as their peers and can serve to complement the work of professional RDM staff (such as data stewards). In our example, RDM as a concept was initially introduced by the Research and Transfer Office with the support of university leadership, which recognized RDM as strategically important. The initial situation was as follows: • no professional RDM staff • all efforts to establish RDM took place on a voluntary basis • consultation with RDM-initiatives • contacting associated working groups for guidance Strategies for increased institutional RDM awareness Our first goal was to create a trickle-down effect by making RDM a topic of discussion in several institutional committees, starting with UAS leadership. This includes regular reporting about RDM and linking RDM with other current topics, e.g. the institution's digitization strategy or establishing a local repository. Furthermore, specific measures have been initiated to establish services related to RDM, e.g. by acquiring third-party funding for RDM- related research. Thanks to said funding, a data steward (0,5 FTE) is currently developing subject-specific RDM services and providing practical support for researchers. Another important step to make RDM visible in the institution was to appoint a professorial, voluntary RDM representative. Said professor serves as an important multiplier due to their RDM-related expertise and research interests. They can be considered a sort of data champion due to their specific RDM-knowledge [2]. We selected them since they have a comprehensive understanding of the importance of well-planned research data management practice and are passionate about sharing discipline-specific expertise and advancing FAIR principles and good scientific/RDM practice [1]. In doing so, the RDM representative is one of our institution’s key actors in promoting changes in research culture towards RDM and Open Science. They work in close collaboration with the Research and Transfer Office and data steward. Additionally, their feedback and assessment have been crucial to improving our RDM services. As a long-standing professor, they are experienced, trusted, and well known at the institution. The role benefits greatly from selecting a low-threshold contact person for academic peers to ask about R	poster
Barriers & Enablers of Intercropping and Enhanced Crop Diversification in the UK Trivett E.E¹ Bates L¹ Drummond C.J¹ ¹ LEAF (Linking Environment And Farming) CV8 2LG, UK ABSTRACT Increasingly volatile weather conditions and extreme weather events have increased challenges in pest management in single variety cropping. A need to enhance Integrated Pest Management (IPM) has led to the use of plant species mixtures or ‘plant teams’ to optimise performance, improve yield stability, reduce pest and disease damage and enhance stress resilience in agricultural systems. Combined with supporting Integrated Farm Management (IFM) practices, intercropping, in field crop mixtures and other examples of enhanced crop diversification have gained attention in recent years due to the beneficial effects of soil fertility, nutrient recycling and pest, weed and disease management. However, uptake remains limited in the UK. Barriers to and opportunities presented by enhanced crop diversification are illustrated through a series of case studies from across three projects LEAF collaborated on between 2017 and 2020. Enablers and barriers to adoption of enhanced crop diversification are illustrated, concluding that a range of approaches will be necessary to support upscaling of these practices in the UK. We are grateful to of received the support and funding from the following projects to make this study possible. The project DiverIMPACTS - "Diversification through Rotation, Intercropping, Multiple Cropping, Promoted with Actors and value-Chains towards Sustainability" is supported by the European Union's HORIZON 2020 research and innovation programme under Grant Agreement no 727482 and by the Swiss State Secretariat for Education, Research and Innovation (SERI) under contract number 17.00092. The DIVERSify project has received funding from the European Union’s Horizon 2020 research and innovation programme under agreement No. 727284. The SEAMS project Funded by the Esmée Fairbairn Foundation, and coordinated by the James Hutton Institute. Enablers Barriers • Soil health and fertility • Integrated Pest Management • Mixed farming systems lend themselves well to enhanced crop diversification • Investment and availability of machinery • Seed separation • Establishment • Lack of knowledge exchange Outcomes Through H2020 projects DIVERSify , DiverIMPACTS and Esmee Fairbairn Foundation project SEAMS, LEAF has been working with a range of UK farmers and stakeholders since 2017 on enhanced crop diversification projects. A farmer engagement workshop ‘Experiences, barriers and opportunities in plant teams’ was carried out at West Gilson Mains, Fife as part of the SEAMS project. The outcome of this event was a summary of plenary discussions between farmers, agronomists and industry representatives. Two farmer led case studies were delivered as part of LEAF’s contribution to the H2020 project cluster ‘Crop Diversification’ which includes the DIVERSify and DiverIMPACTS projects. Enablers of barriers to the uptake of enhanced crop diversification approaches such as intercropping , companion cropping and rotation extension were the focus of all three outputs. Enablers were classified as site specific farm business approaches which improved access, incentive or motivation to employ enhanced crop diversification strategies. Barriers were categorised as unresolved challenges or perceived risks in the adoption of such approaches. Companion, cover and intercropping and extended rotations all have potential to enhance sustainability in UK cropping. An increase in effective knowledge exchange to highlight opportunities, and advice and support to help overcome barriers will be required. Where the balance between risks against benefits is seen to pay off, an increase in the adoption of enhanced crop diversification is more likely. Farming 300ha’s of arable ground, intercropping trials have been a particular interest in the farms diverse 9 crop wide rotation. Seed separation i	poster
Diameters Star Sp Type (mas) 1 Diameter ( )2 NR Vul K3 I (L05) 3.04 0.1 4.12 BD+354077 M2.5 I (L05) 3.18 0.13 5.45 BI Cyg M3-M4 I (L05) 5.16 0.34 9.21 RW Cyg M3 I (L05) 5.09 0.36 11.8 AZ Cyg M3 Iab (M19) 3.74 0.18 8.41 V424 Lac M0 I (L05) 3.77 0.08 12.6 V 336 And M2Ib (KM89) 2.46 0.05 3.08 AD Per M2.5 Iab (M19) 2.39 0.15 8.39 BU Per M3 I (L05) 2.27 0.29 21.0 FZ Per M1.5 (M19) 1.8 0.24 13.7 KK Per M2 Iab-Ib (M19) 2.27 0.10 2.17 SU Per M3-M4 I (L 05) 3.20 0.21 10.9 RS Per M4 I (L 05) 2.96 0.13 5.13 S Per M4.5 I (L 05) 4.08 0.36 6.91 W Per M4.5 I (L05) 2.93 0.12 6.14 XX Per M4 Ib (M19) 2.77 0.16 5.90 6 Gem M1-M2 Ia-Iab (KM89) 4.11 0.48 49.3 TV Gem M1 I (L 05) 3.41 0.53 37.5 WY Gem M2 Iabep+ (M19) 2.68 0.03 3.96 An Interferometric Imaging Survey of Red Supergiant Stars Ryan P. Norris (New Mexico Tech) Abstract Red supergiant stars (RSGs) are an end stage of massive star evolution. Among the notable behaviors of stars during this stage are their irregular and semi- regular variability and mass-loss. In order to better understand the sources of these phenomena, we collected high resolution optical interferometric observations of 17 RSGs using the Center for High Angular Resolution Astronomy (CHARA) Array at Mount Wilson between 2015 and 2016. Here, we present stellar diameters derived from these data. We comment on evidence of surface asymmetries on those stars for which we were able to obtain closure phases and present an example image for one of these objects. In addition, we have obtained near-contemporaneous spectroscopy of these stars using SpeX on the NASA InfraRed Telescope Facility (IRTF). We have developed libraries of synthetic spectra derived from spherical MARCS, PHOENIX, and SATLAS stellar atmospheres, and are currently working to derive fundamental stellar parameters with these data. Diameter Fitting We used the OITOOLS.jl1 package to run a grid search for fitting model limb-darkened disks to the squared visibilities. Future efforts will resistrict the fit to the first two lobes of the visibility curve in order to avoid effects from large surface features. 1:https://github.com/fabienbaron/OITOOLS.jl Figure 1: Example χ2 surface for the linearally limb-darkened disk of RS Per. 1: Linear limb-darkening coefficent. 2: Using Gaia parallaxes as reported in Bailer-Jones et al. 2018 References 1)Bailer-Jones, C. A. L., Rybizki, J., Fouesneau, M.,Mantelet, G., & Andrae, R. 2018, AJ, 156, 58 2)Keenan P. C., McNeil R. C., 1989,ApJS, 71, 245 (KM89) 3)Levesque, E. M., Massey, P., Olsen, K. A. G., et al. 2005,ApJ,628, 973 (L05) 4) Norris et al. 2021. Submitted.. 5)Messineo, M., & Brown, A. G. A. 2019,AJ,158, 20 (M19) Example Imaging Image Reconstruction Of the 17 stars observed 10 have enough (u, v) coverage for image reconstruction and have closure phases suggesting surface assymetries. In Figure 2, we present an example image for RS Per. Details of the reconstruction process can be found in Norris et al. 2021. We used SQUEEZE1 and the OITOOLS.jl package to reconstruct images. 1:https://github.com/fabienbaron/squeeze Figure 2: Image reconstruction of RS Per (top) and corresponding uv coverage (bottom). Beam size is depicted in the lower right corner of the image. Image was reconstructed using SQUEEZE and total variation and Laplacian regularizers.	poster
using the QR-Code and: your training. gaps or needs for further training and your training. Get your training if you meet at least 80% of the principles recommended by the research community. your badged training to the OS Learning Gate. reach out: buchheit@paedagogik.uni-kiel.de alavi@zke-kiel.de Help us to create an intersection of high-quality and reliable OS training in line with principles of Research Integrity, Research Ethics and Ethics of AI operating with OS tailored according to the needs of various OS learning groups. Join us in the OPEN SCIENCE LEARNING GATE 3 2 1 4 SCREEN IDENTIFY & COMMUNICATE BADGED CONNECT AMEND QUESTIONNAIRE Starting at the beginning of June 2024 ENTER NERQ_OS QUESTIONNAIRE for Julia Priess-Buchheit, Joeri K. Tijdink, Katharina Miller, Sean Lacey, Peter Eduard, Marie Alavi (and more from NERQ_OS Group)Julia Priess-Buchheit, Joeri K. Tijdink, Katharina Miller, Sean Lacey, Peter Eduard, Marie Alavi (and more from NERQ_OS Group) OPEN SCIENCE Learning Gate tailored capacity building for OS training Authors: Julia Priess-Buchheit, Marie Alavi With contribution of: Joeri K. Tijdink, Katharina Miller, Ruth Moran, Varga Orsolya, Maruxa Martinez, Ulf Tölch, Sean Lacey , Peter Eduard, Anita Lunić (and more from NERQ_OS Group)With contribution of: Joeri K. Tijdink, Katharina Miller, Ruth Moran, Varga Orsolya, Maruxa Martinez, Ulf Tölch, Sean Lacey, Peter Eduard, Anita Lunić (and more from NERQ_OS Group) SIG_OS	poster
A Model for Interpretable High Dimensional Interactions Bhatnagar SR1,2, Yang Y3, Blanchette M4, Greenwood CMT1,2 1Department of Epidemiology, Biostatistics and Occupational Health, McGill University 2Lady Davis Institute, Jewish General Hospital, Montreal, QC 3Department of Mathematics and Statistics, McGill University, QC 4School of Computer Science, McGill University Summary • Environmental exposures may induce subtle system-wide changes in high- dimensional genomic data such as gene expression or epigenetic measures – Can such situations be exploited to improve prediction models? • Large system-wide changes are observed in many environments and hence this assumption can possibly be exploited to aid analysis of high dimensional data • We develop and implement a multivariate penalization procedure for predict- ing a continuous or binary disease outcome while detecting interactions between high dimensional data (p >> n) and an environmental factor. R software: http://sahirbhatnagar.com/eclust/ – Dimension reduction is achieved through leveraging the environmental-class- conditional correlations – Also, we develop and implement a strong heredity framework within the penal- ized model Motivation Figure 1: Microarray study of COPD. Top: Heatmap of Pearson correlations. Bottom: Heatmap of gene expression data (2,900 genes) rows are genes and columns are subjects. There are 7 subjects in each group, matched on COPD case status, gender and age. Methods Figure 3: Method overview. First step involves measuring gene similarity in both exposure groups. We then cluster these and create a cluster representation. The last step involves entering these terms in a penalization model that follows the strong heredity principle [1] Figure 4: Clustering based on Fisher’s Z transformation of exposure dependent correla- tions. Let ρijk be the correlation between genes i and j in class k. Transform the corre- lations into z values: zijk = 0.5log\|(1 + ρijk)/(1 −ρijk)\|. The Z-test statistic is given by \|zij0 −zij1\|/ p 1/(n0 −3) + 1/(n1 −3) ∼N(0, 1) • Model: g(µ) = β0 + β1X1 + · · · + βpXp + βEE \| {z } main eﬀects + α1E(X1E) + · · · + αpE(XpE) \| {z } interactions • Strong Hierarchy Principle [1]: ˆαjE ̸= 0 ⇒ ˆβj ̸= 0 and ˆβE ̸= 0 • Reparametrization [2]: αjE = γjEβjβE. • Variable Selection: arg minβ0,β,γ 1 2 ∥Y −g(µ)∥2 + λβ w1β1 + · · · + wqβq + wEβE + λγ w1Eγ1E + · · · + wqEγqE • Adaptive weights: wj = 1 ˆβj , wjE = ˆβj ˆβE ˆαjE • Why strong heredity? – Statistical Power: large main eﬀects are more likely to lead to detectable interactions than small ones – Interpretability: Assuming a model with interaction only is generally not biologically plausible – Practical Sparsity: X1, E, X1 · E (2 variables to measure) vs. X1, E, X2 · E (3 variables to measure). Simulation Study Results Figure 5: Stability of results: Average Jaccard distance from 10-fold cross validation. A Jaccard distance of 1 indicates perfect agreement between two sets while no agreement will result in a distance of 0. Figure 6: Prediction accuracy: Test set mean squared error This work was supported by the Ludmer Centre for Neuroinformatics and Mental Health. Software available at http://sahirbhatnagar.com/eclust/. References [1] Hugh Chipman. Bayesian variable selection with related predictors. Canadian Journal of Statis- tics, 24(1):17–36, 1996. [2] Nam Hee Choi, William Li, and Ji Zhu. Variable selection with the strong heredity constraint and its oracle property. Journal of the American Statistical Association, 105(489):354–364, 2010.	poster
INCIPIT-CSIC Monte Gaias s/n, Edificio Fontán, bloque 4, 15707, Santiago de Compostela, Galicia, Spain leticia.tobalina-pulido@incipit.csic.es A thorough recording and collection of archaeological finds allows the detection of errors in the field and later on. FROM FIELD TO GIS Intensive archaeological pedestrian survey in the characterisation of Roman rural settlements BIBLIOGRAFÍA Leticia TOBALINA-PULIDO (Institute of Heritage Sciences, CSIC) The use of archaeological survey for the characterisation of Roman sites and their surroundings is not a new topic. We present here the theoretical proposal that we have carried out in recent months, emphasising an exhaustive record that allows us to assess the quality of the archaeological survey. SURVEY APPROACH It is also significant that some imported materials were found, such as a fragment of an amphora made of paste from the Lower Guadalquivir. It is curious that neither Terra Sigillata nor other fine pottery is recorded. Many loom weights were recovered too. Only common pottery and dolia were recorded. The concentration of material, moreover, shows the three concentration patches, possibly corresponding to those indicated in the literature as three archaeological sites. The distribution of archaeological material extends over almost 2ha, making it a settlement of significant size. Considering the classification of L.G. Pérez-Aguilar (2018) for the southwest of Spain, we can consider that we are dealing with a large farm-type site. Perhaps, in the event that future interventions extend the area of distribution of materials, we may be looking at a small settlement. There is very limited datable artefacts, although a fragment of a highly eroded amphora dates to the 1st century AD. The use of intensive archaeological prospection with the systematic collection of archaeological material has allowed us to characterise archaeological sites from the Roman period of lesser importance and with a complicated materiality (a lot of constructive material and little datable material). PERSPECTIVES CONTACT @dynatinc @dynatinc Firstly, we opted for an intensive archaeological survey with a spacing between surveyors of 5 metres. The intensity changes depending on the terrain. In our case, the two types of land we prospect are pasture and vineyard. In cases of poor visibility in dehesa, we choose to reduce the intensity to 3 metres. Secondly, all archaeological finds are geo-referenced in the field. In addition, all non-constructive archaeological material is collected (also from other chronologies), with the aim of being able to detect identification errors in the field due to poor visibility, for example. In the case of doubts or significant constructive material, it is also collected. Thridly, for each surveyed plot, each prospector has to fill in a sheet indicating issues such as GPS used, visibility, GPS error or field experience. Each of these factors must be indicated on the sheet with a number according to the criteria specified in the sheet's instructions. This allows for a better homogenisation of the data afterwards. APPLICATION EXAMPLE The sheet allows us to know which areas each prospector has surveyed, the previous experience he/she has in the field and the characteristics of the area he/she surveyed. A case study of an application in the municipality of Fronteira, Portugal, is presented here. It is an area previously extensively surveyed and recorded on the archaeological chart as 3 settlements. In addition, one of the problems archaeologists encountered when prospecting it was the difficulty of characterising it. The aim was to characterise the area and determine whether there are three areas of the same site or three separate sites and to characterise it LOCATION OF THE SURVEYED AREA SURVEYED AREA DISPERSION OF ARCHAEOLOGICAL FINDS During the survey we located a large amount of laterite building material. There was also a significant concentration of scoria and dolia. The collecti	poster
In order to assess the relationship between ﬂowering time control and roots, ﬂowering time mutants and mu- tants isolated from the reverse genetic approach presented above were characterized for root architecture (ﬁg. 3a). Unexpectedly, we observed that the late ﬂowering constans (co) mutant had a striking root phenotype (ﬁg. 3b) although we did not detect expression of the CO gene in the root (data not shown). By contrast, the svp mutant did not display any root phenotype albeit the gene was highly expressed throughout the roots (ﬁg. 2c). The dormancy asso- ciated2 mutant had a signiﬁcant phenotype, including longer primary and secondary roots and an increased lateral root density. The same observations stand for the ipt3;5;7 triple mutant but not for the ipt3 single mutant. Because many ﬂowering time genes were found to be expressed in the roots, we analyzed the changes in gene expression occurring in the roots during the induction of ﬂowering. To do so, 7-week old vegetative plants grown in short days (SD) were induced to ﬂower by exposure to a single 22-h long day (LD). Roots were harvested during the photoperiod extension for transcriptomic analysis. We found that hundreds of genes were diﬀerentially expressed in the roots in LD vs SD (ﬁg. 2a). The biological signiﬁcance of these changes was addressed by recording whether loss of function mutants had a ﬂowering phenotype. Interestingly the cytokinin-biosynthesis genes IPT3, 5 & 7 (IPT; ISOPENTENYL TRANSFERASE) were all up-regulated in the roots during the during the induction of ﬂowering (ﬁg. 2b). According to the root map published by Brady et al. (2007), the expression of IPT3 and IPT5 is restricted to some tissues of the roots (ﬁg. 2c). We also looked at the expression pattern of well-characterized ﬂowering time genes detected in roots (ﬁg. 1b,c). Among them, we ob- served that SHORT VEGETATIVE PHASE (SVP) is expressed throughout the roots (ﬁg. 2c). FLORAL INDUCTION IMPACTS THE ROOT TRANSCRIPTOME FLOWERING TIME GENES ARE EXPRESSED IN ROOTS Plant Physiology ULg FLOWERING GOES UNDERGROUND F. Bouché, G. Lobet, M. D’Aloia, N. Detry, P. Tocquin, C. Périlleux. Laboratory of Plant Physiology, University of Liège, B22, Sart Tilman, B-4000 Liège, Belgium Corresponding author: f.bouche@ulg.ac.be In conclusion, complementary approaches based on published expression data, transcriptomic experiments and genetic analyses indicate that genes involved in ﬂowering time control are expressed in the roots and/or aﬀect root architecture. Further experiments are on the way to downregulate ﬂowering time genes in the roots by overexpressing artiﬁcial microRNAs in an organ-targeted manner. Acknowledgements : FB is grateful to the F.R.S.-FNRS for the award of a PhD fellowship. We thank Pr. Tatsuo Kakimoto (Osaka University, Japan) who kindly provided us with ipt3 and ipt3;5;7 seeds. This research is funded by the Interuniversity Attraction Poles Programme P7/29 initiated by the Belgian Science Policy Oﬃce. The genetic control of ﬂowering is complex : deepest knowledge has been accumulated on Arabidopsis where we identiﬁed 278 ﬂowering time genes from a littera- ture survey. We then crossed the list with transcriptomic data obtained from roots and found that 98 ﬂowering time genes were expressed in the roots of Arabidopsis plants grown in hydroponics, on soil, or in vitro (ﬁg. 1a,b). Among them, genes involved in photoperiodism or light perception were well represented whereas others – e.g. genes involved in ﬂower development - were not (ﬁg. 1c). References : Brady, S.M. et al., 2007. A high-resolution root spatiotemporal map reveals dominant expression patterns. Science, 318 ( 5851), 801-6. Lobet, G. et al., 2011. Novel Image Analysis Toolbox Enabling Quantitative Analysis of Root System Architecture. Plant Physiology,157, 29-39. AT5G18840 Figure 1. Genes controlling ﬂowering time in Arabidopsis are expressed in the roots. (a) Root transcriptomic data were obtained from plants grown in hydropo	poster
PhD Library Course Topics I´m a virtual librarian, ready to assist you with your PhD Library Course questions! Available 24/7 to assist PhD candidates with their coursework and research. Provides personalized feedback and real-time support. Helps students brainstorm keywords and formulate effective search queries. Guides users through citation styles and reference management using tools like Zotero. Facilitates understanding and implementation of Open Science practices. Enhances the overall research and learning experience for PhD candidates. Promotes engagement and active learning through interactive assistance. Demonstrates the potential of AI in transforming academic support services. 0% 10% 20% 30% 40% 50% I don't have access to full version of ChatGPT Consult dates and conditions of course Consult for deeper understanding of subject I don't like vi̶tual assistance Consult the assignments Archie Bookworm: Virtual Librarian for Advancing PhD Education PhD Library Course in Nutshell Blended learning format combining webinars, in-person workshops, e-learning, and practical assignments. Provides a platform for networking among PhD from different fields (over 90 participants attended this year). Focuses on developing core research competencies and practical skills. Encourages interdisciplinary collaboration and knowledge sharing. Regular feedback and personalized guidance enhance the learning experience (real-time support from the AI virtual librarian). Meet Archie Bookworm Feedback Highlights: How Archie Transformed Learning “Archie helped me formulate effective search queries, making my research process much smoother and more efficient.” “I found the use of AI in teaching through Archie inspiring. I'll be incorporating similar AI tools in my own teaching methods." “I'm not a fan of virtual assistants; I prefer human interaction. However, I can see the potential benefits for those who like using AI” Tereza Šímová Czech University of Life Sciences Prague www.terezasimova.com, simovat@lib.czu.cz	poster
A Mixed-Mode Simulation Framework to Investigate Neuronal Signal Transduction and Sensing at Nanoelectrodes Federico Leva1, Pierpaolo Palestri2, Luca Selmi1 1Dipartimento di Ingegneria ‘‘Enzo Ferrari’’, Università di Modena e Reggio Emilia, Modena, Italy 2Polytechnic department of Engineering and Architecture University of Udine, Udine, Italy Corresponding author: federico.leva@unimore.it Overview Figure 1: Schematic representation of an intracellular (a) and extracellular (b) FET-based nanoelectrode integrated in CMOS technology, interfaced with a neuron and connected to a transimpedance readout circuit. Accurate physics-based numerical models of coupled neuron-sensor-readout CMOS-based systems are useful to: • design and optimize the sensing device and the readout, • interpret the measurements, • derive lumped-element descriptions of the recording systems related to geometrical and physical properties. A semiconductor-TCAD-based mixed-mode modeling environment is suited for such purposes. We exemplify its capabilities by analyzing relevant figures of merit (including SNR) for an active FET-based nanoelectrode envisioned for intra- and extracellular coupling to neurons (Fig. 1). This work has been financially supported by the European Union’s Horizon 2020 project “IN-FET” (Grant Agreement n. 862882) via the IUNET consortium. Methods The modelling framework consists of a FEM TCAD for semiconductors [1], which supports: • Mixed device-circuit simulations with user-defined physics and lumped-elements via PMI and CMI, respectively [1]. • Drift-diffusion transport in the intra- and extracellular electrolyte regions, implemented by mimicking anions and cations with electrons and holes, and suitably adjusting the semiconductor properties [2,3,4]. • Combined DC steady state, transient, AC small signal, and noise analysis. • Cellular membrane compartment description as (i) lossless insulator in TCAD (with parameters consistent to [5]), or (ii) lumped capacitor in the circuit portion. • Action potentials (APs) incorporation onto each membrane’s compartment as either: (i) voltage generator (Fig. 2.b), (ii) current generator (Fig. 2.c), or (iii) Hodgkin- Huxley (HH) [5] circuit model (Fig. 2.a), implemented via custom multi-port memristors described by CMIs. The CMIs set the (de)activation state-variables for the non- linear conductances of the K+ and Na+ ion-channels [5]. Results • Fig. 3 shows that our mixed-mode approach predicts the expected monophasic (a) and biphasic (b) waveforms of lumped-element circuit models (not shown) derived from state-of-art results [6] for intra- and extracellular contact. • Fig. 4 reports the neuron-to-readout transfer function (TF1) computed with AC small signal analysis. A band-pass behavior is observed for intracellular contact, whereas a derivative behavior for the extracellular case on the frequency range of the AP spectrum. The TF shapes are consistent with the time-domain profiles of Fig. 3. • Fig. 5 shows that the active FET-sensor SNR2 is not affected by the presence of the readout noise and only slightly affected by the coupling condition with the neuron, overall achieving adequately large values. • Extended results can be found in [7]. Figure 2: Different equivalent circuits to include the generation of action potentials across the passive neuron membrane: (a) Hodgkin-Huxley model; (b) external voltage boundary; (c) external current boundary. Figure 3: AP waveform comparison for TCAD and full L.E. Circuit descriptions of an active nanoelectrode in (a) intracellular and (b) extracellular contact (Fig. 1). Vm is the intracellular neuron signal, Vout is the output signal of the readout. Figure 4: Modulus of the system transfer function of the active intracellular and extracellular sensing systems (Fig. 1). Figure 5: SNR for the different access types, and in presence or absence of the readout noise. The readout gain has been set to provide recorded signals with 1 Vpp. References [1] Synopsys, I	poster
Henrietta Swan Leavitt (7/4/1868 – 12/12/1921) 1 2 5 6 8 9 10 3 4 7 11 1) Henrietta Leavitt working at HCO, circa 1900. Measuring Variable Stars 2) Plate a2969. Leavitt studied changes in variable stars by inspecting photos of the same section of sky taken on different dates. Photos were imaged through tele scopes onto glass plate negatives coated in light-sensitive chemicals. (The bright er a star, the more photons reached the plate and the larger its dark dot.) She labeled each star, measuring diameters through a loupe (magnifying glass). 3) Leavitt kept her analyses in handwrit ten notebooks. For each plate, she would draw a detailed chart of the stars she was exam- ining as they appeared in the sky. (Mirror image to her markings on the back of the plate. See circled “u” and “v”.) 4) List of magnitudes for each labeled star on plate a2969. Stars were sometimes recalibrated. See 8. Comparing Plates 5) Detail from Plate b20650, exposed for 4 hours on October 20, 1897. Henrietta Swan Leavitt, a deaf American astronomer and graduate of Radcliffe College, worked at the Harvard College Observatory (HCO) as a “computer”, examining glass photographic plates in order to measure and catalog the bright- ness of stars. This work led her to discover the relation between the luminosity and the period of Cepheid variables. Though she received little recognition in her lifetime, Leavitt’s discovery later provided astronomers with the first “stand- ard candle” with which to measure the distance to faraway galaxies. 1 2 Williamina Fleming (5/15/1857 – 5/21/1911) c e a d f 4 5 6 8 9 7 new variable 10 11a 11b 1) Portrait, circa 1890s. Fleming orga nized the Draper Catalogue, classifying 10,498 stars, based on 28,266 spectra on 633 plates. By 1910, she had examined ~200,000 HCO photographic plates. 2) Orion Nebula in Glass Plate b10250 (de tail), September 8, 1893 with markings by Fleming. 3) b10250 (detail), in which Fleming dis covered the Horsehead Nebula. Fleming discovered 10 novae, 59 gaseous nebulae, ~ 300 variable stars, and was the first to recog nize the existence of white dwarfs. 4) Photo of Horsehead Nebula; Ken Craw ford, Rancho Del Sol Observatory. Note nebula color and position are reversed from negative in 3). Work With Variable Stars 5) Fleming’s notes. She would draw a chart with the new variable, as well as stars near it (red box), then document positions & known magni tudes (green). 6) Determining magnitude of new star (Plate i10491) using the “Pickering-Fleming Method” (cyan box): Compare variable star “v” with a known, slightly dimmer star. Note how many Williamina Patton Fleming was the most famous woman astronomer in America during her lifetime. She helped develop a common designation system for stars and showed that variable stars and novae could be identified by their spectra, discovering many. A founding member of the Harvard Computers, a group of female astronomers and analysts at Har vard College Observatory (HCO), she supervised other women astronomers and managed publications issued during her time there. A charter member of the Astronomical and Astrophysical Society, she advocated for women in astronomy. Read more about Williamina Fleming at https://library.cfa.harvard.edu/phaedra/fleming 3 The Project PHaEDRA Collection: An Anchor to Connect Modern Science With Historical Data Poster by: Peggy Wargelin, Project PHaEDRA, Wolbach Library, Center for Astrophysics \| Harvard & Smithsonian Presented by: Edward Los, Harvard College Observatory, AAVSO Member ABSTRACT Project PHaEDRA (Preserving Harvard's Early Data and Research in Astronomy) is an initiative by the Wolbach Library, in collaboration with many partners, to catalog, digitize, transcribe, and enrich the metadata of over 2500 logbooks and notebooks produced by the Harvard Computers and early Harvard astronomers. Our goal is to ensure that this remarkable set of items, created by a remarkable group of people, is as accessible and useful as possi bl	poster
On behalf of PID Network Germany Felix Burger (TIB), Andreas Czerniak (UB Bielefeld), Barbara Fischer (DNB), Stephanie Glagla-Dietz (DNB), Lena Messerschmidt (Helmholtz Open Science Office), Heinz Pampel (Helmholtz Open Science Office / Humboldt-Universität zu Berlin, IBI), Jochen Schirrwagen (UB Bielefeld), Antonia C. Schrader (Helmholtz Open Science Office), Paul Vierkant (DataCite), Frauke Ziedorn (TIB) This work, excluding logos, is licensed under a Creative Commons Attribution 4.0 International. Funder: Authors & license: Project partners: 10 PID use cases in the project’s focus About the project The goal of the project “PID Network Germany” is to build a network of existing and currently forming actors around Persistent Identifiers (short PIDs) in science and culture. The aim is to promote the application, implementation, standardization and interoperability of PID systems on a local, national and international level. The findings from the project will lead to recommendations in a national PID roadmap for Germany. The project started on March 01, 2023, and is funded by the German Research Foundation (DFG) scheduled to run for 36 months. The project website provides further insight into the goals of the project. Support & Contact • Website: www.pid-network.de • Contact: info.pidnetwork@listserv.dfn.de • Mailing list: PID Dialog Follow us on Social Media: • Mastodon: @PIDNetworkDE@openbiblio.social • Twitter: @PIDNetworkDE e. g. DataCite DOI, URN, Archival Resource Key (ARK) e. g. DataCite DOI, based on the metadata schema by the RDA WG PIDINST e. g. GND Why do we need PIDs? PIDs... • offer unique, universal, and permanent references to potentially any type of digital or non-digital entities in the research process. • enable linkage between entities. • contribute to the integrity of scholarly communication, its reusability and their reproducibility. • play a crucial role to make data FAIR. • provide a comprehensive overview of all entities in the research process. Netzwerk für die Förderung von persistenten Identifikatoren in Wissenschaft und Kultur e. g. ROR ID, ISNI, GND, or for funding information (Gepris or Crossref Funder Registry), and for projects RAiD e. g. ORCID iD and Integrated Authority File (GND) e. g. Research Resource Identifier (RRID) for biological and the International Generic Sample Number (IGSN) for samples from all scientific fields e. g. DOI using the Citation File Format (CFF) e. g. DOI and URN service of the German National Library e. g. DataCite DOI, as suggested by ConfIDent (DFG-funded project in Germany) Logos by Julian Kücklich (https://doi.org/10.5281/zenodo.5608845), licensed under CC 0 So far only few initiatives, such as re3data and FAIRsharing, are providing DOIs for research data repositories.	poster
Lotte Wilms, Andreas Degkwitz, Caleb Derven, Marian Lefferts, Kirsty Lingstadt, Liam O’Dwyer, Demmy Verbeke & Digital Humanities and Digital Cultural Heritage WG Participants 56 participants - 54 institiutions - 20 countries Full report available at doi.org/10.5281/zenodo.3247286 3. Select youractivitieswisely Libraries are most active in data capture, creation and storage. Build on your (collection) strengths to decide what works best for you. 1. Createa goal or visionforyourlibrary A defined framework clarifies your goal and manages expectations of partners. Set up your organisation with enough resources to make sure you can also reach this goal. 2. Measureyourimpact Identify early on how you will measure your achievements and impact. This will help you define what works well and what needs to be re-evaluated. 4. Reflectthefull breadthof yourcollections By broadening your scope to the full width of your collection your DH offering can be strengthened. Work from your strenghts and make access as easy as possible. 5. Have confidencein yourexpertise As the creator of your digital collections, you are the expert. Your are therefore the ideal partner, as you know what has been digitised, how it’s been digitised, what licenses apply, what works well and what probably wouldn’t. Strengthening the position of libraries as partner in DH will be a a core theme for the WG for the next two years. 6. Involveallyourcolleagues, notjusttheobviousones DH activities are most succesful if they are supported by a large number of library staff. Work together to build your skills and ideas. 7. Collaborate, collaborate, collaborate! Building your network in DH is crucial, as collaboration is key. Once you have defined your goals and activities go out and disseminate your data, your team and you ideas. Special thanks to Friedel Grant for the design of all graphs, tables and the word cloud. We also wish to thank all contributors and our WG’s members for their input.	poster
Genome Annotation using Nanopublications: An Approach to Interoperability of Genetic Data Rajaram Kaliyaperumal1, Peter A.C. ‘t Hoen1, Zuotian Tatum1, Mark Thompson1, Erik Schultes1, Andrew Gibson1, Ivo F.A. C. Fokkema1, Johan T. den Dunnen1, Jeroen F.J. Laros1, José Luis Oliveira2, Pedro Lopes2, Pedro Sernadela2, Marco Roos1 1 Department of Human and Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands, 2 DETI/IEETA, University of Aveiro, Aveiro, Portugal Nucleotide change Substitutions Deletions Duplications Indels Single 22 2 - - Multiple - 6 4 1 Variant DB-ID gChange No.of TSS deleted SGCB_00043 g. 52886872_52904485del 1 DYSF_00176 g.71707370_71838047del 9 LMNA_00209 g.156052975_156100408del 12 promoter TSS exon inton CAGE cluster peaks	poster
HELSINGIN YLIOPISTO HELSINGFORS UNIVERSITET UNIVERSITY OF HELSINKI DMP PROCESS AT THE UNIVERSITY OF HELSINKI HELSINKI UNIVERSITY LIBRARY In 2020, the Research Council of Finland changed its DMP submission process: 1) The DMP has to be submitted only by those applicants who receive a positive funding decision. 2) The RPO is responsible for ensuring that the DMP can be implemented and that the measures taken are in line with good data management practice. The UH receives approximately 100-130 positive funding decisions in relation to the largest funding call of the year - how do we manage the DMP review process at the university level? Tuija Korhonen tuija.korhonen@helsinki.fi Soile Manninen soile.manninen@helsinki.fi HULib Data Team/UH Data Support 25 86 216 165 0 50 100 150 200 250 2016 2017 2018 2019 Year of the call Number of DMPs, RCF’s September call 2016– 2019 (DMPs in the application phase) 137 112 103 0 50 100 150 200 250 2020 2021 2022 Year of the call Number of DMPs, RCF’s September call 2020–2022 (DMPs after pos. funding decision)	poster
Comparing two ways of generating 328 nm laser light for high-resolution spectroscopy of the S1/2 P3/2 transition in Ag Julius Wessolek1,2, Mitzi Urquiza3, Bram van den Borne4, Ruben de Groote4, Katerina Chrysalidis5, Kieran Flanagan1 and the CRIS Collaboration5 1) University of Manchester, 2) M Squared Lasers, 3) HÜBNER Photonics GmbH, 4) KU Leuven, 5) CERN Spectra of the 532 nm, 856 nm and 656 nm pulses were taken with a scanning FPI (Toptica FPI-100) and the linewidths extracted. The linewidths of the 328 nm beams can be calculated as quadratic sums of the components: ∆𝜈328𝑛𝑚 𝑠𝑢𝑚 𝑓𝑟𝑒𝑞𝑢𝑒𝑛𝑐𝑦= 177 𝑀𝐻𝑧 ∆𝜈328𝑛𝑚 𝑑𝑜𝑢𝑏𝑙𝑒𝑑 𝑃𝐷𝐴= 387 𝑀𝐻𝑧 High resolution spectroscopy of Ag has been conducted at the Collinear Resonance Ionization Spectroscopy (CRIS) experiment at CERN ISOLDE to measure nuclear properties of the ground- and isomeric states. For spectroscopy of the S1/2 -> P3/2 transition in Ag, nano-second pulsed narrow-band 328 nm laser light has been produced in two different ways: Fig. 1: Sum frequency generation of narrow-band Ti:sapphire light with pulsed 532 nm light to generate 328 nm. Fig. 2: Second harmonic generation of pulsed amplified light from a cw OPO to generate 328 nm. Fig. 3: Ionisation scheme of Ag. The measured pulse lengths show that the pulses are in no case Fourier limited. This is expected for the 532 nm laser which is only actively temperature stabilized against drifts down to minute timescales. The PDA was pumped by that same laser and showed a shorter pulse length. The pulses from an injection-locked Ti:sapphire laser are usually broadened by cavity mode pulling and refractive index variation of the active medium. This leads to an instantaneous frequency shift and chirp and the pulse is not Fourier limited. ∆𝜈𝑚𝑖𝑛= 90𝑀𝐻𝑧≪274𝑀𝐻𝑧 ∆𝜈𝑚𝑖𝑛= 51𝑀𝐻𝑧≪176𝑀𝐻𝑧 ∆𝜈𝑚𝑖𝑛= 9.7𝑀𝐻𝑧≪17.2𝑀𝐻𝑧 Fig. 5: Pulse lengths measured with a biased Si photodetector. The minimum spectral linewidths were calculated assuming Gaussian pulses and are all significantly smaller than the measured linewidths. Fig. 7: Spectra of the S1/2 -> P3/2 transition in 109Ag with 328 nm laser light produced in two different ways. The linewidths extracted from the spectra are ~ 250 MHz in both cases, contrary to the linewidths measured with the FPI. Figure from private communication with B. v. d. Borne. Spectra of stable 109Ag were taken with with both versions of the 328nm laser light at 6µW to minimize power broadening effects. The FWHM of the peaks is in the order of 250 MHz for both cases. This is contrary to the linewidth extracted from the FPI scans. For the summed light, small side peaks started to occur, suggesting not fully single mode operation. This could be caused by the implemented stabilization but it has to be investigated further. 109Ag with doubled PDA 109Ag with sum frequency generation Fig. 6: Scan of 109Ag with the 328 nm light from sum frequency generation. The regular side peaks are possibly from multimode operation. Fig. 4: Spectra of the different pulses, taken with a scanning FPI. The linewidth was extracted by fitting a Voigt profile to the peaks.	poster
Drones above, Currents below: Using unmanned aerial systems for aerial systems to observe ocean surface current Take a closer look! Find supplementary details inside and a full copy of the poster on the back! The ocean surface measurement technique: UAS wave-based current mapping CONTACT INFO Vivek Bheeroo \| Vbheeroo09@tamu.edu (603) 866-9406 A Mavic 2 Pro is deployed over the ocean surface. The drone is stabilized at an altitude of 120 m. The camera mounted to the drone records with a field of view of 55o. The resulting spatial dimensions of the acquired image sequence have approximate dimensions of 100 m x 75m. The image stack is divided into sub-windows of about 6 x 6 m. This procedure is shown in Fig. 1. A 3-dimensional Fast Fourier Transform (3D-FFT) is applied to the raw pixel intensities of the image stack in each sub-window. The 3D-FFT procedure is given by (1). Where I(x,y,t) is the intensity value at the point (x,y,t) in the spatio-temporal domain, F(kx,ky,ω) is the complex value at the point (kx,ky,ω) in the frequency-wavenumber domain, Nx, Ny, Nt are the dimensions of the 3D image data, kx and ky are the wavenumber vectors and ω is the angular wave frequency. The dispersion relation of a surface gravity wave describes the relationship between the wavenumber vector, k, and the angular wave frequency. This is shown in (2). For water waves that are influenced by an underlying current, U, the dispersion relation is expressed by (3). Fig. 1: Image acquisition and workflow breakdown Where h is the water depth and g is the acceleration due to gravity constant. For a wave field that does not experience interactions with an underlying current, (2) will form the dominant signal observed in the 3D FFT output in each sub- window. Typically, surface currents are present and influence the wave propagation. In these instances, (3) will manifest as the dominant signal in the 3D FFT output. To recover the ambient current in each sub-window, a fitting procedure is performed by applying a spectral energy-based maximization technique in the wavenumber-frequency domain. This is shown with a signal to noise ratio (SNR) optimization procedure in (4). Where Pw is the power related to surface waves, Pn is the power related to background noise, nw is the number of bins belonging to waves and nn is the number of bins belonging to noise. (1) 𝐹൫𝑘𝑥, 𝑘𝑦, ω൯= ෍෍෍𝐼(𝑥, 𝑦, 𝑡) ⋅e −2πi(𝑘𝑥𝑥 𝑁𝑥+𝑘𝑦𝑦 𝑁𝑦+𝜔𝑡 𝑁𝑡) 𝑁𝑡−1 𝑡=0 𝑁𝑦−1 𝑦=0 𝑁𝑥−1 𝑥=0 (2) 𝜔= ඥ𝑔𝒌𝑡𝑎𝑛ℎ(𝒌ℎ) (3) 𝜔= ඥ𝑔𝒌𝑡𝑎𝑛ℎ(𝒌ℎ) + 𝒌⋅𝐔 (4) 𝑆𝑁𝑅൫𝑈𝑥, 𝑈𝑦൯= ∑𝑃൫𝑘𝑥, 𝑘𝑦, 𝜔൯𝑤 ∑𝑃൫𝑘𝑥, 𝑘𝑦, 𝜔൯𝑛 𝑛𝑛 𝑛𝑤	poster
KARMAN-HOWARTH-MONIN EQUATION FOR COMPRESSIBLE HALL MHD TURBULENCE VICTOR MONTAGUD-CAMPS1, PETR HELLINGER1, ANDREA VERDINI2, SIMONE LANDI2, LUCA FRANCI3, EMANUELE PAPINI2, LORENZO MATTEINI4 1Astronomical Institute , CAS, Prague, Czech Republic, 2Università di Firenze, Italy, 3Queen Mary University of London, UK, 4Imperial College, London, UK Contact e-mail: victor.montagud-camps@asu.cas.cz INTRODUCTION • The rate at which solar wind protons temperature decreases with heliospheric distance (Tp ∝ R−0.9[1]) is slower than the prediction for an ideal gas that expands adiabatically (Tp ∝R−4/3). • The energy from large scale ﬂuctuations driven by plasma turbulence towards smaller scales is one of the proposed mechanisms that could have a heating rate adequate to explain this difference. • The heating rate associated to turbulence is computed as the energy cascade rate, Q, that is, the net energy transfer rate between the scales at which turbulent non-linear interactions take place. • The Kármán-Howarth-Monin (KHM) equation is an accurate estimation of the energy cascade rate that can be directly derived from the compressible MHD equations using structure functions. • Our objective is to extend the estimation of the energy cascade rate given by the KHM equations to scales below the proton inertial length, di and assess the effect of turbulence anisotropy on the energy cascade rate estimation. VERIFICATION OF KHM FOR 2D COMPRESSIBLE HALL-MHD 10-1 100 101 102 -1.0 -0.5 0.0 0.5 1.0 l/di O = −∂S/∂t/4+KMHD+KHall+Ψ−D [Q] • Initial simulation set-up: Simulation box of size 2562d2 i , and 20482 grid-points resolution. B0 along z. Alfvénic ﬂuctuations δBrms/B0 = 0.17 for kdi < 0.2. Zero cross-helicity, turbulent Mach M = 0.26 and η = µ = 10−3. • KHM equations terms are normalized to Hall- MHD heating rate Q ≡⟨η∇B : ∇B + τ : ∇u⟩. • KHM equation holds, but non-linear terms do not show a clear inertial range, i.e., they are not con- stant over an extended range of scales. KHM ANISOTROPY ON 3D COMPRESSIBLE HALL-MHD • Initial simulations set-up: two simulation boxes of size 323d3 i , and 5123 grid-points resolution. B0 along x. One demagnetized \|B0\| = 0 (3D Iso) and the other one magnetized (3D ani) with B0 along z and Alfvénic ﬂuctuations δBrms/B0 = 0.2. Zero cross-helicity, turbulent Mach M = 0.1 and η = µ = 6 10−4. • Top row: averaging over all increments (top row), demagnetized case is qualitatively similar to the 2D magnetized one. Non constant contribution from non-linear terms. • Bottom row: KMHD and KHall gyrotropized about B0 axis and 1D cuts θ = 0o, 30o, 60o and 90o with respect to B0. Anisotropic behaviour of both terms for \|B0\| ̸= 0 run. REFERENCES [1] M. et al. Maksimovic. Anticorrelation between the Bulk Speed and the Electron Temperature in the Pristine Solar Wind: First Results from the Parker Solar Probe and Comparison with Helios. ApJS, 246(2):62, February 2020. [2] Petr Hellinger, Andrea Verdini, Simone Landi, Luca Franci, and Lorenzo Matteini. von Kármán-Howarth Equation for Hall Magnetohydrodynamics: Hybrid Simulations. ApJL, 857(2):L19, April 2018. [3] R. Ferrand, S. Galtier, F. Sahraoui, R. Meyrand, N. Andrés, and S. Banerjee. On Exact Laws in Incompressible Hall Magnetohydrodynamic Turbulence. ApJ, 881(1):50, August 2019. DISCUSSION AND CONCLUSIONS • KHM equation for compressible Hall-MHD holds true for 2D and 3D simulations. • Magnetized plasma and 3D non-linear interactions were necessary to develop clear range for constant KMHD. For the same case, B0-aligned KHall contribution is observed above di. Box size effect or inverse cascade? • Higher resolution and smaller dissipation are still needed to show signiﬁcant Hall contributions below di KHM EQUATION FOR COMPRESSIBLE HALL-MHD Derivation of KHM equation[2,3]: evaluate Hall-MHD equations at two different points x′ = x + l and x separated by an increment l. Subtract them and average over all possible increments. Hence, −1 4 ∂S ∂t + KMHD + KH + C + Ψ −D = 0 Second order st	poster
Control of clathrin-mediated endocytosis by NIMA family kinases Braveen B. Joseph, Yu Wang+, Phil Edeen, Vladimir Lažetić, Barth D. Grant+ and David S. Fay *Department of Molecular Biology, College of Agriculture and Natural Resources, University of Wyoming, Laramie, WY 82071 +Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854 Abstract Suppressor screen NEKL kinases are highly conserved members of the NIMA-kinase family, which have been predominantly implicated in cell division and ciliogenesis. We previously reported, that NEKL-2/NEK8/9 and NEKL-3/NEK6/7 are required within the C. elegans epidermis, and that their knockdown causes molting defects that results in larval lethality. In addition, we discovered a conserved set of ankyrin repeat proteins, MLT-2/ANKS6, MLT-3/ANKS3, and MLT-4/INVS, that partner with the NEKLs to regulate their intracellular localization. To better understand the mechanistic functions of NEKL-MLTs we obtained genetic suppressors of molting defects in nekl-2; nekl-3 double mutants. Strikingly, our screen identified several mutations that directly affect the activity of AP2, a conserved heterotetrametric adaptor complex required for clathrin mediated endocytosis. Knockdown of individual AP2 subunits, or an allosteric activator of AP2, FCHO-1, strongly suppress molting defects in nekl mutants. Conversely, mutations that increase the levels of active AP2 strongly enhance nekl molting defects. In addition, inhibition of nekls suppress morphological defects associated with reduced AP2 function, attesting to the tight functional connection between the NEKLs and AP2. To determine the functions of NEKLs in endocytosis, while avoiding potential confounding effects caused by nekl- mutant larval arrest, we used auxin inducible degradation methods to deplete NEKLs specifically at the adult stage. Loss of NEKLs led to greatly elevated levels of clathrin at the epidermal apical membrane and to a profound reduction in apical clathrin mobility. Adult NEKL depletion also adversely affected uptake of LRP-1, an epidermal cargo critical for molting. These results are consistent with depletion of NEKLs leading to a defect in the ability of vesicles to release clathrin after scission and suggest that NEKLs promote clathrin uncoating. Notably, both defects were largely alleviated by a reduction in AP2 or FCHO-1 activities. These findings suggest that reduced AP2 activity may facilitate clathrin uncoating and indicate that reduced AP2 activity suppresses nekl molting defects through the restoration of normal trafficking. Lastly, we show that human NEK6 and NEK7, orthologs of NEKL-3, can rescue both molting and trafficking defects in NEKL-3 depleted strains, suggesting that the control of intracellular trafficking is an evolutionarily conserved function of NEK family kinases. Individual knock down of µ, a, and d subunits Model that NEKLs may promote closed AP2 Loss of NEKL changes epidermal clathrin localization Cargo trafficking is disrupted in NEKL-depleted adults ⍺-Flag ⍺-actin + + – – NEKL-2 ::AID NEKL-3 ::AID Auxin (20h) Auxin- Inducible Degron NEKL Auxin NEKL NEKL Ub Poly- ubiquitin TIR1 SCF Ub Ub Several suppressors connected to clathrin mediated endocytosis Dynamin Closed AP2 Open AP2 Cargo Clathrin Actin Auxilin Hsc70 Uncoating Plasma Membrane FCHO-1 FCHO-1 σ nekl-2; nekl-3; fcho-1(fd131) nekl-2; nekl-3; dpy-23(fd155) nekl-2(fd81); nekl-3(gk894345); Ex nekl-3+, GFP+ Allele nekl-2(fd81) nekl-2(fd90) nekl-2(fd91) nekl-2(gk839) nekl-3(gk894345) nekl-3(sv3) nekl-3(gk506) mlt-3(fd72) mlt-4(sv9) Change Y84L G88A Y84L G87A G88A Y84L G87A Deletion D228N P194L Deletion Deletion Splice Loss of function Weak Strong Moderate Null Weak Moderate Null Null Moderate MLT-4 Larval Molting MLT-3 NEKL-3 NEKL-2 MLT-2 Old Cuticle New Cuticle Shed Cuticle Synthesis α β σ μ NEKL-3 NEKL-2 NEKL-3 NEKL-2 μ α σ nekl molting defects are suppressed by decreased function of the AP2 clathrin-adapter comple	poster
6th International Conference on Recent Trends in Bioengineering (ICRTB 2023), 20th January 2023 MIT School of Bioengineering Science and Research Molecular Docking and Dynamics Studies of CDK1 against Epithelial Ovarian Cancer Drugs Asmita Jagadale, Shama Mujawar and K. Venkateswara Swamy* *Corresponding author : venkateswara.swamy@mituniversity.edu.in Epithelial ovarian cancer has been researched to be the most common and an aggressive form of cancer. Owing to its ability to evade detection until stage 3, when the cancer has metastasized extensively, it is important and crucial to find an effective treatment. Keeping this concept in mind, we implemented in silico analyses in the form of molecular docking and dynamics. The gene CDK1, the encoder of the protein that is a member if the Ser/Thr protein kinase family, is a catalytic subunit of the M-phase promoting factor (MPF), and a key player in the eukaryotic cell cycle. The protein encoded by CDK1 was chosen as a target for molecular docking, due to its existence as a significant hub gene from literature reviews. The ligands chosen were imipramine, trazodone, propafenone, resveratrol, alpha estradiol, levonorgestrel, apigenine, doxazosin, rottlerin, nortriptyline, prochlorprazine, noretynodrel, chlomipramine, fluphenazine, amiodarone, medrysone, piperlongumine, daunorubicin, vironostat, methotrexate and scriptaid, based on their potential evaluated by drug databases. The active sites of the protein were analysed using PDBSUM, and their neighboring amino acids were evaluated. The amino acids were observed to be Tyrosine 15A, Glutamine 81, Isoleucine 10A and Leucine 83A. The grid was calculated based on the coordinates of isoleucine, glutamine and tyrosine residues. Grid formation was done based on this location of the active site, and molecular docking was carried out using AutoDock Vina. The highest docking score observed was the protein against Doxazosin, showing a binding affinity of -10.4 kcal/mol. The interactions within the complex were observed using ProteinsPlus and Discovery Studio, and the interactions seen were among The results will be analysed and the best docked complexes were chosen to carry out molecular dynamics simulations using DESMOND. Molecular Dynamics CDK1 Retrieval of protein structure Retrieval of receptor structure Molecular Docking and analysis Result and analysis Virtual Screening Abstract Methodology Result: M o l e c u l a r D o c k i n g Molecular Dynamics Doxazosin Fluphenazine Medrysone Background Conclusion: Acknowledgement: We would like to thank to our honorable director Prof. Vinayak Ghaisas and our HOD Dr. Renu Vyas for their guidance and infrastructure support. • Ovarian cancer caused by stromal or germ cell tumors have high survival rates as compared to epithelial ovarian cancer. • Ovarian cancer rates are highest in woman aged 55-64. 3,13,000 New cases per year 2,00,000 Deaths per year 2D view of the docked complex 3D view of the docked complex The molecular docking and dynamics studies of CDK1 and FDA approved 21 drugs reveals that doxazosin against ovarian cancer is more effective. The present research work supports doxazosin usage is more effective as compared to other 20 drugs as it has lowest binding energy with -10.4 kcal/mol against CDK1. The C-alpha backbone of CDK is more stable through out 100ns within range of RMSD 1.6 to 2.2 A0 in additional doxazosin ranging from 1.62 to 2.0 A0 also stable at TIP3P water model constructed with cubic box 10 A0 at NPT conditions with 300K with Desmond, Schrodinger software.	poster
Liu-Liu Shen, Gui-Rong Zhang, Wei Li, Markus Biesalski, Bastian J.M. Etzold 50. Jahrestreffen Deutscher Katalytiker, 15th – 17th Mar. 2017, Weimar, Germany References: [1] P. Lodeiro, J. Barriada, R. Herrero, M.S. De Vicente, Environ. Pollut. 2006, 142, 264. [2] P. Apostoli, J. Chromatogr. B 2002, 778, 63. [3] Table of regulated drinking water contaminants. https://www.epa.gov/ [4] Guidelines for drinking water quality, 4th ed. World Health Organization: Geneva, 2011. [5] L. Shen, G. Zhang, W. Li, M. Biesalsiki, B. J. M. Etzold, ACS Omega in submission. Device fabrication: Modifier-Free Microfluidic Electrochemical Sensor for Heavy Metal Detection Heavy metals are hazard pollutants to the environment and impose severe risks to human health. Therefore, heavy metal detection is playing important role in environmental and clinical analysis. In this work, a simple, cost- effective and portable miniaturized electrochemical carbon-based sensor (µCS) is designed and proved to be highly sensitive towards Cd2+ and Pb2+ detection in aqueous solution. The µCS possess a novel 3D structure with working and reference electrodes directly facing each other but separated by the microfluidic paper channel. The electrodes in µCS are inexpensive graphite foil without any additional surface modifier such as mercury or bismuth. It is found that impressive low detection limits of 1.2 µg/L for Cd2+ and 1.8 µg/L for Pb2+ can be achieved on the µCS. The µCS also exhibits stable sensing performance up to 10 repetitive measurements, demonstrating the robustness of a sensing device for heavy metal detections. We believe that a proper design in the device configuration can completely eliminate the necessity to modify the working electrode by using additional surface modifier, which could provide new ideas for portable electroanalytical/sensing systems. Electrolyte: 0.1 M acetate buffer, pH=4.6 Individual detection of Cd2+ and Pb2+ § Deposition condition: Cd2+: -1.2 V, 60 s Pb2+: -1.1 V, 180 s § The limit of detection (LOD) are below the allowable limits in drinking water proposed by US Environmental Protection Agency (Cd: 5 µg/L, Pb: 15 µg/L) and World Health Organization (Cd: 3 µg/L, Pb: 10 µg/L). Stability and reproducibility of the µCS § The deposition condition for simultaneous detection is (-1.2 V, 180 s). § The detection limit is 6 µg/L for both Cd2+ and Pb2+. Conclusions: § A modifier-free, low cost, reusable, electrochemical microfluidic carbon-based sensor was developed for heavy metal detection. § High sensitivity and low detection limit at short detection time are obtained on the sensor during individual detection for Cd2+ and Pb2+. § The high sensitivity may originate from the combined microfluidic configuration and novel 3D electrode layout, which may provide some new ideas for other portable electroanalytical/sensing systems. Structure analysis of the graphite foil Simultaneous detection of Cd2+ and Pb2+ § Very good electrocatalytic stability was observed on µCS. Prof. Bastian J.M. Etzold (etzold@tc1.tu-darmstadt.de) Ernst-Berl-Institut für Technische und Makromolekulare Chemie Technische Universität Darmstadt 64287 Darmstadt Correspondence: This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement n° 681719) Electrochemical measurements 1. Metal deposition; 2. Square wave voltammetry Experimental Section Cd2+ Pb2+ LOD = 1.2 µg/L LOD = 1.8 µg/L § The electrodeposited Cd species are selectively located at the edge positions of graphite flakes. WE, CE & RE: graphite foil Paper channel: filter paper, pore size 15 µm	poster
The Library Treasure Hunt – Reach for the Stars! Introducing first-year students to the landscape of scientific information Eva Jurlander, Lund Observatory and Carina Enestarre, Physics and Astronomy Library Cajsa Andersson, Library of Chemistry and Chemical Engineering, Kristina Holmin Verdozzi, Physics and Astronomy Library, Nina Reistad, Department of Physics The students gather in the library and meet the library staff. The librarians give a quick presentation of the library and an introduction to the treasure hunt. The students receive a stamp on the treasure map from the librarian. They get their next assignment and continue on with their quest. Mission accomplished! Each student evaluates the hunt via a short poll and receives a treasure. The librarians thank the students and hope to see them soon again in the library. The students are divided into smaller groups and given their first assignment and a treasure map. OBJECTIVE • To make the first encounter with the library useful, fun and memorable for the students • To provide all students with a minimum level of information literacy CHALLENGES • The library competes with many other introductory activities for the first-year student. • To find an amusing way to introduce the library. METHOD • Learning by doing • Hands-on excercises • On the spot assessment and evaluation • Reward system OUTCOME • All students receive a positive first encounter with the library. • They get to know essential aspects of the library resources. • It opens up for further development of the student’s information literacy. • The librarians get immediate input from the students. SUCCESS FACTORS • Close collaboration between librarians and teachers supported by the management • Making the library introduction an integrated and compulsory part of the course programme ADDED VALUE • Students practice team work • Interlibrary staff cooperation • Subject library profiling DEVELOPMENTS • Present new technology for example Ipads and e-readers to enhance the use of the digital collection. • The library should be an integrated part of all teachers’ planning at all levels. The students carry out the missions together in groups and discover the physical and digital library collections and services. The students communicate their findings directly to the librarian who gives instant feedback. . 1 Photo: Francois Polito CC BY-SA 3.0 4 4 4 3 2 5 6 Highlight of the hunt! A view from top of the Observatory tower Sweden www.fysik.lu.se/english/library/treasure	poster
MIT Open Access Articles FEDERATED LEARNING FRAMEWORK FOR NLP IN HEALTHCARE: ASSESSING HOSPITAL READMISSION USING ELECTRONIC HEALTH RECORDS The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation: Nalawade, Sahil, Samineni, Soujanya, Chowdhury, Alex, Feng, Ling, Umeton, Renato et al. 2023. "FEDERATED LEARNING FRAMEWORK FOR NLP IN HEALTHCARE: ASSESSING HOSPITAL READMISSION USING ELECTRONIC HEALTH RECORDS." Conference Poster at Bio-IT World, Boston, 2023 (May). As Published: https://www.bio-itworldexpo.com/poster-presentations Persistent URL: https://hdl.handle.net/1721.1/151725 Version: Author's final manuscript: final author's manuscript post peer review, without publisher's formatting or copy editing Terms of Use: Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.	poster
Enabling open research practices - connecting Octopus with research repositories Dr Agustina Martínez García, John Kaye, Dr Alexandra Freeman Open practices § The research landscape is evolving rapidly, with a wide range of tools and platforms being developed to enable open research practices, and increased expectations from funders to openly share research outputs. § Repositories play a critical role to ensure discoverability, access and long-term preservation of research outputs Using open and well-adopted standards, this collaborative project aims to increase interoperability between innovative research publishing tools like Octopus and remove barriers to depositing research outputs into research repositories. The project uses the DSpace platform as the case study. Octopus overview § Octopus is a new scholarly publishing platform designed to incentivise best practices in research § Open and free to use: all publications and the source code itself are available under open access licenses § Its unit of publication is not a traditional ‘paper’ but instead one of eight constituent units supporting the research lifecycle stages § Open, post-publication peer review, with red- flagging capabilities, to assess quality and integrity What we will do § The project will produce an implementation case study using Apollo repository (DSpace) § Develop deposit mechanisms into repositories via Jisc Publications Router native API § Align with COAR guidelines by implementing a Resourcesync endpoint - Users will be able to view Octopus outputs via repositories or content aggregators Key benefits § Reassure researchers of their outputs being available and preserved for the long-term § Facilitate tracking of research impact through linking outputs together § Support institutions with funder compliance and reporting CRIS integrations via Jisc Publications Router Apollo (DSpace), Cambridge’s trustworthy repository Figure placeholder References 1) Octopus, https://www.octopus.ac/ 2) JISC Publications Router, https://pubrouter.jisc.ac.uk/ 3) DSpace Repository Platform, https://dspace.lyrasis.org/ 4) UK Reproducibility Network, https://www.ukrn.org/ Octopus Apollo Scan the QR code to download the poster Dr. Agustina Martínez García am857@cam.ac.uk John Kaye John.kaye@jisc.ac.uk Dr. Alexandra Freeman Alex.freeman@maths.cam.ac.uk	poster
334 G077 European consumers’ purchase intentions towards plant-based meat products: the mediation effect of social media involvement. Listia Rini1, Simoun Bayudan1, Ilona Faber2, Michael Bom Frøst2, Federico J. A. Perez-Cueto3, Joachim Schouteten1, Hans De Steur1 1Ghent University, Belgium. 2University of Copenhagen, Denmark. 3Umeå University, Sweden Abstract The OECD projects that by 2031, meat supplies will elevate to almost 400 MT to meet global demands, correspondingly increasing total greenhouse gas (GHG) emissions by 9%. Meat consumption has been associated with many health adversities, such as diabetes and cardiovascular disease. The environmental and health challenges related to meat production and consumption have thus contributed to the rise of new plant-based food (PBF) products. In Europe, the market growth of PBF products is encouraging, with a total sales value of around EUR 3.6 billion in 2020. Plant-based meats (PBM) are some of the most popularly developed PBF products, with countries such as France, Germany, the Netherlands and Sweden already producing and marketing their own PBM products to European consumers. However, European consumers’ acceptance of PBM products is generally lower than conventional meat. One of the barriers to PBF consumption is related to consumers’ information needs, but social media (SM) can nowadays help alleviate these needs through information dissemination. Therefore, the objective of this study is to investigate whether consumers’ SM involvement mediates the relationship between consumers’ pro-meat-reduction attitudes and their PBM purchase intention. Data were collected from European countries (AT, DK, FR, DE, IT, NL, PL, RO, ES, UK), with a total of 4589 omnivore respondents. Linear regression with mediation analyses was conducted via SPSS PROCESS v4.2 with pro-meat reduction attitudes as the independent variable and PBM purchase intention as the dependent variable. Two SM-related variables, namely likelihood to use SM to find PBF information and trust towards PBF information from SM were utilized as the mediators. Preliminary analyses showed that SM-related variables partially mediated the pro-meat reduction attitudes towards PBM purchase intention. The result suggests SM can be a driver to satisfy consumers’ need of information regarding PBF products and increase their purchase intentions. Keywords Social media, Plant-based meat, Meat reduction, Purchase intention	poster
Copyright 2019. The Trustees of Columbia University in the City of New York. This work is licensed under a Creative Commons Attribution 4.0 International License. Meeting the Challenges of the TRUST Principles for Digital Repositories Robert R. Downs 1 NASA Socioeconomic Data and Applications Center (SEDAC) Center for International Earth Science Information Network (CIESIN), Columbia University, 1 rdowns@ciesin.columbia.edu Prepared for Presentation to the 2020 ESIP Summer Meeting July 14-24, 2020, Virtual Event July 17, 2020 Poster Session The work reported here has been supported by the National Aeronautics and Space Administration under Contract 80GSFC18C0111 for the Socioeconomic Data and Applications Distributed Active Archive Center (DAAC). Endorsement of the TRUST Principles for Digital Repositories TRUST Principles for Digital Repositories* References Certification Programs CoreTrustSeal (2020) Nestor (2013) Audit and Certification of Trustworthy Digital Repositories. ISO 16363/CCSDS 652.0-M-1, https://public.ccsds.org/Pubs/652x0m1.pdf (2011). CoreTrustSeal Trustworthy Data Repositories Requirements. 2020. https://www.coretrustseal.org/why-certification/requirements/ ESIP Data Management Training Clearinghouse. 2020. https://dmtclearinghouse.esipfed.org/ Lehnert et al. 2019. Building Resilience by Sharing Infrastructure Among Data Facilities: An Initiative of the EarthCube Council of Data Facilities. https://agu2019fallmeeting-agu.ipostersessions.com/default.aspx?s=A6-0C-96-FA-24-07-F6-36-77-00-78-35-E6-7C-AC-51 Lin, D., et al. The TRUST Principles for digital repositories. Sci Data 7, 144 (2020). https://doi.org/10.1038/s41597-020-0486-7 Harmsen, H. et al. Explanatory notes on the Nestor seal for trustworthy digital archives. Nestor Certification Working Group, http://nbn- resolving.de/urn:nbn:de:0008-2013100901 (2013). Wilkinson, MD. et al. The FAIR Guiding Principles for scientific data management and stewardship. Sci. Data 3, 160018 (2016). https://doi.org/10.1038%2Fsdata.2016.18 Transparency To be transparent about specific repository services and data holdings that are verifiable by publicly accessible evidence. Responsibility To be responsible for ensuring the authenticity and integrity of data holdings and for the reliability and persistence of its service. User Focus To ensure that the data management norms and expectations of target user communities are met. Sustainability To sustain services and preserve data holdings for the long-term. Technology To provide infrastructure and capabilities to support secure, persistent, and reliable services. *Reproduced from Lin, et al., 2020. The TRUST Principles for Digital Repositories. Digital repositories, including scientific data centers, archives, and other data facilities must provide stewardship for the resources that they have been entrusted to manage and disseminate for their user communities. The tenets of transparency, responsibility, user focus, sustainability, and technology that are described in the TRUST Principles for Digital Repositories offer guidance for meeting the needs of users who can use research data, today, as well as succeeding generations of users (Lin, et al., 2020). Developed by several stakeholders from across the digital preservation and research data stewardship community, the TRUST Principles for Digital Repositories can be built upon by the broader community of data stewards to ensure that the data that are being collected now and in the future will be treated as valuable intellectual assets so that they are findable, accessible, interoperable, and reusable, as articulated in the FAIR Principles (Wilkinson, et al., 2016). Diligent digital curation and stewardship efforts will help to ensure that research data products and services can be used to continue scientific progress and achieve the societal benefits that such research can provide. Along with future stewards of research data and related resources, the digital repository professio	poster
Continuing Large-Scale Global Trade and Illegal Trade of Highly Hazardous Chemicals Zhanyun Wang1,2, Hongyan Zou3, Tao Wang3, Zhong-Liang Wang3 1. EMPA – Swiss Federal Laboratories for Materials Science and Technology, 9014 St. Gallen, Switzerland, zhanyun.wang@empa.ch 2. Chair of Ecological Systems Design, Institute of Environmental Engineering, ETH Zürich, 8093 Zürich, Swtizerland 3. Tianjin Key Laboratory of Water Resources and Environment, Tianjin Normal University, Tianjin, P.R. China Methods Introduction ü Chemical pollution, along with climate change and biodiversity loss, is causing in the triple planetary crisis. ü To complement national/regional frameworks on chemicals, the Rotterdam Convention on the Prior Informed Consent Procedure for Certain Hazardous Chemicals and Pesticides in International Trade has been established. ü For each listed chemical, all parties are required to make a decision as to whether they will allow future import of the chemical. Then, it is illegal to export the chemicals to a party that has decided not to further import them. However, the Convention does not have a formal mechanism to evaluate its effectiveness. ü This study aims to capture an up-to-date, accurate, comprehensive overview of the global trade of highly hazardous chemicals listed under the Convention from 2004, when it entered into force, to 2019, to shed light on the Convention’s impacts on the global trade of hazardous chemicals and provide insights on areas for improvement. Acknowledgements H.Z. acknowledges funding from the National Natural Science Foundation of China (NSFC grant no. 21906118), and Z.W. acknowledges funding from the European Union under the Horizon 2020 Research and Innovation Programme (project ZeroPM; grant agreement no. 101036756). View full article Continuing large-scale global trade of hazardous chemicals ü The cumulative global trade of the 46 listed chemicals among all countries reached 64.5 megatonnes in 2004–2019. The highly hazardous pesticides and formulations had lower trade volumes (2.4 megatonnes), dominated by pentachlorophenol and its salts and esters (see Fig. 1, left). ü It is an especially pressing problem for developing countries and countries with economies in transition (see Fig. 1, right). Main Findings ü We develop and use a novel workflow of analysing trade records from the UN Comtrade database (79,194 entries), providing a minimum scenario of the global trade and illegal trade of 46 highly hazardous chemicals listed under the Convention. The workflow included: ü an outlier analysis using clustering and statistical methods to identify erroneous trade records, and ü a subsequent mirror analysis to reconcile asymmetric bilateral transactions. Complex geographical distributions of the global trade (see Figure 2) ü Most of Asia were the major importers of pesticides chemicals, while U.S. and Middle East were the major exporters. Central and Western Europe were not only major importers but also big exporters of industrial chemicals. Prevalent illegal trade of hazardous chemicals (see Figure 3) ü Defaulting was prevalent all over the world, especially in Central, Western and Southern Europe, South and Southeast Asia, and the Middle East. ü In total, they accounted for 40% of the total trade volume (25.7 of 64.5 megatonnes), underlining insufficient effectiveness of the Convention. ü The defaulting counts are seemingly on the rise over time. Tackling the global trade of highly hazardous chemicals ü expanding the Convention’s geographical coverage ü enabling swifter listing of chemicals under the Convention ü enhancing data availability, quality and accessibility ü Understanding and addressing the “lock-in” of hazardous chemicals Fig. 1 Trade volumes by chemical (a) and net imports by geographic region (b) of highly hazardous chemicals Fig. 2 Global transfer of the listed highly hazardous chemicals Fig. 3 Defaulting counts of the trade for exporting parties (countries) and counts of being	poster
Energy Reconstruction with Autoencoders for Dual-Phase Time Projection Chambers Ivy Li, Aarón Higuera, Shixiao Liang, Christopher Tunnell \| CHEP 2023 Energy Reconstruction for XENONnT References Weight Layer ELU(𝛼=1) x Weight Layer F(x) F(x) + x x identity Residual Block (ResBlock) ELU(𝛼=1) Input Hit Pattern (494,) Reconstructed Hit Pattern (494,) Latent Space Representation (50,) 5 ResBlocks (494,494) 1 LinBlock (494,50) 1 LinBlock (50,494) 1 LinBlock (494,494) ENCODER DECODER 5 ResBlocks (494,494) Inferring Number of Electrons in the Gas Gap Example Reconstruction of Top Array Hit Pattern , , Input Hit Pattern (494,) Reconstructed Hit Pattern (494,) Inferred ne True ne Loss = (1 - 𝛽) MSE + 𝛽 MSE Loss Function with Cyclic Annealing Inferred ne True ne ENCODER: encodes input into a lower dimensional latent space↑ LATENT SPACE REPRESENTATION: constrains one value as the number of electrons in the gas gap but allows the others to evolve freely ↗ DECODER: decodes input from latent space representation ↑ LOSS FUNCTION: weighted sum of the mean squared error (MSE) losses below ↓ CYCLIC ANNEALING: 𝛽 evolves from 𝛽=0 (prioritize reconstruction) to 𝛽=1 (prioritize latent space constraint) Weight Layer Linear Block (LinBlock) x ELECTRIC FIELD DRIFTS ELECTRONS TO GAS GAP: not all of the freed electrons from the interaction point reach the gas gap SCINTILLATION SIGNAL (S1): incoming particle interacts with xenon and causes a scintillation signal with energy which is proportional to the initial signal’s number of photons IONIZATION SIGNAL (S2): electrons which reach the gas gap cause a brighter ionization signal with energy which is proportional to the number of electrons at the interaction point XENONnT has a detector target of 6 tonnes of ultra-pure liquid xenon [1] ↗ HIT PATTERNS: Photosensors above and below measure signals → Future Work TOTAL ENERGY 6163194 trainable parameters Adam optimizer, starting learning rate 5e-4 Reduce learning rate by factor of 0.1 if loss does not decrease after 5 epochs Semi-Supervised Autoencoder DATASET: simulated hit patterns from a given [0, 2000] ne INPUT SIZE: 494 photosensors total TRAIN/VALIDATION/TEST SPLIT: 447500/447500/100000 hit patterns NUMBER OF ELECTRONS IN GAS GAP Inference Difference Normalized Difference DYNAMIC RANGE: autoencoder can reconstruct hit patterns well without normalizing or log-scaling hit patterns due to skip connections [3] ENERGY RESOLUTION: precise reconstruction is critical for rare event searches such as the search for dark matter evidence [2] INTERPRETABILITY: constraining the latent space to be physically meaningful e.g. a variational autoencoder constrains latent parameters as probability distributions → meaningful parameter uncertainties COMPUTATIONAL EFFICIENCY: simulating data through Monte Carlo methods is computationally expensive and time-consuming → ongoing efforts to create more efﬁcient machine-learning algorithms for fast simulation [0] Check out our experiment! xenonexperiment.org [1] Aprile, E., et al. "Search for new physics in electronic recoil data from XENONnT." Physical Review Letters 129.16 (2022): 161805. [2] Billard, Julien, et al. "Direct detection of dark matter—APPEC committee report." Reports on Progress in Physics 85.5 (2022): 056201. [3] Dieng, Adji B., et al. "Avoiding latent variable collapse with generative skip models." The 22nd International Conference on Artiﬁcial Intelligence and Statistics. PMLR, (2019). GOAL TO IMPROVE RESOLUTION: the spread of the inferred number of electrons in the gas gap decreases as the inverse square root for increasing number of electrons ← UNDERPREDICTION: WHY? currently the autoencoder underpredicts the number of electrons in the gas gap ↑ Ground Truth Gas Gap Reconstructed True ne Inferred ne True ne (X) Inferred ne (Y) Counts	poster
Spectral Model Components › KERRBB [4]: The thermal spectrum of the accretion disc around a Kerr (rotating) black hole. › SIMPL [5]: Converts soft disc photons to hard X-ray photons with a power-law spectrum expected for the disc corona. › RelXill [6]: The ionised disc reflection, with relativistic effects. › ISMabs [7]: Galactic absorption. Observations We use observations from March & September 2019: › 3 from XMM-Newton (blue): › rev3531, rev3533, rev3623 › 8.5 ks, 11.3 ks, 56.3 ks exposure times. › 2 from NuSTAR (orange): › Simultaneous with rev3533, rev3623 › 57.3 ks and 94.9 ks exposure times. rev3531 rev3533 rev3623 Fig 3. The Swift/BAT & XRT light curve of MAXI J1820+070. Fig 6. Mass posterior (grey) and prior (red). The Current Debate Different groups have reached very different conclusions, sometimes from the same data. These often correspond to the extreme cases: Model 1: › Zero or low spin and/or › A truncated disc (Rin ≥ 6 rg) Model 2: › High (near maximal) spin (a > 0.9) › Rin ~ 1 rg Fig 2. An overview of the two different, but extreme XRB models. Models like these are common in the literature, they all make implicit assumptions. Black hole Black hole Disc Disc Rin ≥ 6 rg Rin ~ 1 rg Where is the Inner Edge of the Accretion Disc? The location of the inner edge of the disc effects the spectrum in various ways: › The luminosity and temperature profile of the thermal emission from the disc. › The relativistic distortion on discrete features in the X-ray reflection spectrum, especially the Fe-Kline. It is theoretically possible to use the detailed shape of the spectrum to infer the location of the inner edge of the accretion disc. These spectral effects are subtle and modelling them is subject to several assumptions. A Bayesian analysis of X-ray spectra from the black hole LMXB MAXI J1820+070 using XMM-Newton and NuSTAR. Abstract We adopt a fully Bayesian approach with the best available prior information, making use of the latest spectral models and the most accurate models of ISM absorption, using XMM-Newton RGS data. Our test case is the recently confirmed black hole LMXB MAXI J1820+070. We fit data over the 0.8 – 70 keV range using XMM-Newton and NuSTAR observations. Fig 1. Structure of a low-mass X-ray Binary [1]. Sachin Dias, Simon Vaughan sdd9@leicester.ac.uk System Parameters Our modelling of MAXI J1820+070 includes proper priors on system parameters based on the best available radio through UV observations. System parameters are typically frozen or left entirely free, permitting other parameters to find unphysical values. › Distance: A gamma prior based on VLBI measurements [2]. › Inclination: A Gaussian prior from proper motion of ejecta [2] [3]. › Mass: The mass function (𝑓(𝑀)), mass ratio (𝑞) and inclination (𝑖) combine to give a shifted log-normal prior on the mass. 𝑴𝑩𝑯= 𝒇𝑴 𝟏+ 𝒒𝟐 𝒔𝒊𝒏𝟑(𝒊) › Mass Accretion Rate: A Jeffreys prior between 10−6 ṀEdd and ṀEdd, calculated based on the 10th and 90th percentile masses respectively, assuming a standard accretion disc. References: 1. Image Credit: NASA/R. Hynes 2. Atri et al., 2020, MNRAS, 493, 81 Fig 4. Distance posterior (black) and prior (red). Priors are broader due to effects of unknown errors. Additional Priors We adopt additional priors for the parameters: › Disc Colour Correction Factor (fcol): fcol is typically fixed at 1.7 [8]. Others argue the range could be broader [9] [10]. We assigned a gamma prior over the range [1, 10] with the highest density over [1.4, 2] [9]. › Reflection Emissivity Indices: A gamma prior over the range [0, 10] with a mode at 3 (near Euclidean case) and 10-6 lower density at 10. Ne K-edge Fe L2-edge Oi K-edge Fe L3-edge Fig 10. XMM-Newton RGS spectrum for rev3531 (black) and rev3533 (red). › ISM Column Densities: We fit XMM-Newton RGS spectra using ISMabs. H, O, Ne and Fe column densities were free parameters (having the largest effect in the 11 – 24 Å range) with other column densities fixed (relative to H) to the values given in	poster
Introduction Permaculture is an agricultural system, intended to be sustainable and self- sufficient, that uses natural ecosystems as a model. Permaculture is relevant on a global stage as the world’s population is expected to grow to 10.5 billion people by 2050 (Reid 2017), creating an urgency for effective and sustainable agriculture. Beyond investigating how The Island School produces its food, this Permaculture study concentrates on food insecurity in the immediate vicinity of the Island School campus. At present, The Island School imports about 89% of the food. Permaculture practices seek to address the economic, environmental, and social issues prevalent in South Eleuthera and Small Island Developing States (SIDS). By finding possible solutions to Food insecurity and instability within The Island School’s campus, Permaculture feeds into the larger global conversation regarding the negative environmental impacts of the global food system, the widespread food insecurity and instability, and the future of food in society. Permaculture: Planting Seeds of Sustainability on The Island School Campus Susanna Cabot, Isabel Cullen, Maeve Goodrich, Kelvin Monje, Kate Pausic, Ezra Stern, Nora Verdier Research Advisors: Joseph Plant, Leigh Schmitt Citations Garnett, T. 2013. Food Sustainability: problems perspectives and solutions. Proceedings of the nutrition society. 72,29- 39. Reid, J. 2017. Carbon Narrative. Waterfield Farms. Robards, C. 2017. Survey outlines food insecurity on Eleuthera. The Nassau Guardian. Tilman, D & Balzer, C & Hill, J & Befort, B. 2011. Global food demand and the sustainable intensification of agriculture. Proceedings of the National Academy of Sciences. 108; 50. Viviano, F. 2017. “This Tiny Country Feeds the World.” National Geographic. http://www.nationalgeographic.com/magazine/2017/09/ho lland-agriculture-sustainable-farming.html. Methods The semester’s research is focused around campus design and planning. The Permaculture Research Cohort cultivated and planted crops, added soil amendments, conducted animal husbandry, and informed the outside community through social media and a research blog. The Permaculture Team also collaborated with the dining hall and the Aquaponics team to prepare and serve a local meal for Parent’s Weekend. Data and Results Throughout the semester, the Permaculture research cohort studied how to best communicate their scientific findings through social outreach. In addition, the group has been working on harvesting crops on the Island School farm that was then a part of the “locavore” Parent’s Weekend meal. Campus Planning: Local Meal: Social Media and Outreach: Acknowledgements: We would like to acknowledge all those who have assisted us in our research, mainly the Permaculture research advisors: Leigh Schmitt and Joseph Plant, as well as the Farm Team, the Kitchen Team, and the Communications Team. We would also like to acknowledge the Aquaponics Research Group. Figure 8: A map of the United States shows the frequency of visits from each state to the Permaculture blog. Figure 4: Permaculture students clear a plot of land for agricultural use. Figure 6: The aquaponics system on campus produces leafy greens throughout the year for The Island School dinning services. Figure 1: The Island School has a model farm on campus designed with permaculture principles. Figure 3: The orchard near the CSD will be split up into sectors for a crop rotation. Figure 5: Radishes collected from Permaculture Research farm plots harvested in preparation for the Parents Weekend local meal. Figure 7: This graph shows the daily views of the Permaculture Research blog throughout the course of a week. Figure 2: Students filet tilapia from the Aquaponics system in preparation for the local meal. Permaculture Essential Questions • How do we feed ourselves? • What are the true costs (economic, social, environmental) to successfully growing food on campus? • For the long-term, what are the best and most logi	poster
Last Year Before Death: Observations of SN 2020fqv by TESS and Friends Kaew Samaporn Tinyanont (UCSC), Ryan Ridden-Harper (JHU), Ryan Foley (UCSC), Viktoriya Morozova (PSU), Charlie Kilpatrick (Northwestern) Georgios Dimitriadis (Trinity), Armin Rest (STScI), Qinan Wang (JHU) on behalf of the Young Supernova Experiment (YSE) Collaboration. Early observations are key to understanding what happened in the last year prior to the star’s death. SN 2020fqv was discovered within a day and we obtained the first spectrum 26 hr post-explosion. SN 2020fqv shows signs of interaction and is within an active TESS sector prompting us to trigger the first ultra-rapid HST program ever to obtain early-time UV-optical spectra with STIS and COS. The earliest STIS spectrum was obtained only 79 hr post-explosion. TESS captures the rise of this SN, allowing us to model it to constrain the explosion time and other properties of the explosion. SN 2020fqv comes from a red supergiant with a dense circumstellar environment. From the light curve fitting, pre- explosion image from HST (non-detection, F606W, shown on left), and late-time nebular spectroscopy (see different ranges of mass below), we are able to constrain that SN 2020fqv is an explosion of a red supergiant (RSG) with a zero-age main sequence mass (ZAMS) of 13.5-15 M⊙. Further, the fast rise time and the early-time excess flux of SN 2020fqv, along with narrow emission lines in the spectra, point to a dense circumstellar medium (CSM) immediately outside of the progenitor star of SN 2020fqv. Circumstellar Medium of SN 2020fqv We find 0.23 M⊙of CSM within 1450 R⊙from the star. Modelling our observations shows that the density profile of the RSG progenitor of SN 2020fqv does not just drop off like normal at about 1000 R⊙, but has a CSM component extending out to ~1450 R⊙, containing ~0.23 M⊙of material. The density and optical depth is so large that the SN shock only breaks out at the edge of this CSM, marked with a red cross in the bottom left figure. These CSM properties are not unusual among the population of SNe II (Morozova+ 2018). Our models show that the CSM is a result of an energy injection of 5x1046 erg into the envelope about 300 days before the explosion, which may be related to instability in late-stage nuclear burning (e.g., Quataert & Shiode 2012, Fuller 2017, Wu & Fuller 2021). The inner part of the CSM leaves an imprint on the SN’s early light curve. Middle right figure compares the light curve models with and without the CSM. The data points are binned TESS light curve with uncertainty. The solid line model shows the light curve expected with the CSM component; it matches the data best. Bare RSG models (dashed and dotted-dash lines) cannot explain the entire light curve. This light curve is affected most by the bulk of the CSM inward of the shock breakout point. The outer part of the CSM forms narrow emission lines. Lower right figure shows the early-time spectra of SN 2020fqv both from the ground and from HST/STIS. They show the emission features around 4600 Åfrom high-ionization metal species like N III and C III. They originate from the outer CSM getting radiatively ionized by the shock breakout. These features have been observed in a growing number of CCSNe with early-time spectra, e.g. SN 2013cu shown here (Gal-Yam+ 2014). Select References: Morozova+ 2015, 2018, 2020; Vallely+ 2021; Jerkstrand+ 2014, 2018; Gal-Yam+ 2014, Wu&Fuller 2021, Fuller 2017, Quataert&Shiode 2012, Bowen 1935. SN shock breaks out from here Inner, optically thick, CSM Outer, optically thin, CSM	poster
“THE SPINE” “THE TORSO” “THE ARMS” “THE LEGS" THE ANATOMY BEHIND TASK DESIGN WITHIN HIGHER EDUCATION Within the fundamentals of lesson planning in Higher Education, task design is vital to support student learning. The aim of the infographic is to provide "THE SKELETON" to assist the task design process for new academics. Claire Farquharson & Sarah Sandford, Hartpury University How does the task link to the lesson plan? Communicate this to the group. What Learning Outcomes does the task map too? Which transferable skills are embedded in the task? Think about how you can develop a range of skills across different tasks! For example working with others, presentation skills, team work. Do you need to "scaffold skills" for task success? For example if they are required to present information to a full group, have previous tasks assist them in presenting to to each other in pairs, then smaller groups first Identify any pre-task activities or previous learning that will assist students in completion of the task Do you need a ice breaker to help group dynamics? What are the clears aims of the task and it’s duration? Is the task emphasising the level of study and expected skills? What’s your exit task - take home messages! What type of task do you want to do? Is it a closed, structured task to identify key concepts? If it is a larger task, can this be split into smaller tasks first Is it more open, unstructured for students to apply their understanding of the concept in a wider environment and to create discussion? Through the group or individual task: How can we reinforce the concept? How can we get students to verify their understanding of the concept? How can we consolidate the concept, with context and relevance, to the group? How can you assist the student engagement? Can you get students to think individually, discuss in pairs and then share with a wider group. THINK - PAIR- SHARE. How can you assist group dynamics? Do you allocate groups? Choose groups? How do you identify roles within the tasks? How can they work with each other for a common goal? Consider the environment you are delivering the session in. Is it online or face to face? How does the environment work for you and them? Don’t feel that you need to provide a variety of activities. Focus on the aim of the task and how it assists the lesson/module/unit more widely. What resources can you use to facilitate the task? Can this resource be collated for all the group to share and access after completion? Can you direct students for further resources and reading to support the task? “THE FINGERS & TOES" Be innovative! Try different approaches! How did it go? Reflect on; Did the task achieve what you wanted? Were students engaged? Did you achieve the session aims? Did students improve their understanding? How did the task work within the session? What would you change or do differently next time?	poster
Improved enhancer discovery in Drosophila and other insects Hasiba Asma1, Chad M. Jaenke2, Michael L. Weinstein2, Thomas M. Williams2 and Marc S. Halfon1 Introduction Transcriptional enhancers, or more broadly, cis- regulatory modules (CRMs), are essential building blocks of gene regulatory networks. We previously developed the SCRMshaw method for computational CRM discovery[1,2,3]. SCRMshaw uses the wealth of known D. melanogaster CRMs as training data to facilitate CRM discovery in not just Drosophila but in diverse holometabolous insects including mosquitoes, beetles, and bees. Here we present three approaches for increasing SCRMshaw’s effectiveness. SCRMshaw: predicting CRMs (a) SCRMshaw takes a training set of similar CRMs and a set of similarly-sized non- CRMs as a background (BKG) set, (b) builds up kmer profiles of the sequence sets, (c) generates scores using statistical models , and (d) searches the genome for high scoring windows (predicted CRMs). 1. pCRM_eval: A comprehensive pipeline for in silico evaluation of CRM prediction approaches[4] 3. Iterative searching can serve to augment weak training sets to improve true-positive : false-positive ratios We used SCRMshaw on a small training set of 7 CRMs to identify CRMs within a gene regulatory network for Drosophila abdominal pigmentation. 1. Kantorovitz, Miriam R., et al.. Developmental cell 17.4 (2009): 568-79. 1. 2. Kazemian, M., et al. Nucleic Acids Res 39.22 (2011): 9463-72. 2. 3. Kazemian M, Halfon MS: CRM Discovery Beyond Model Insects.: Insect Genomics: Methods and Protocols; 2019: 117 3. 4. Asma H, Halfon MS:. BMC Bioinformatics 2019, 20(1):174. 4. 5. Suryamohan K, Halfon MS:. Wiley interdisciplinary reviews Developmental biology 2015, 4(2):59-84 1University at Buffalo-State University of New York, Buffalo, NY 2University of Dayton, Dayton, OH ~24000 CRMs pCRMeval compares prediction results with the existing extensive corpus of validated Drosophila CRMs to calculate recovery of true CRMs and estimate the specificity of a given method. pCRMeval can also assess the performance of a specific training set in terms of both sensitivity and specificity. 0 20 40 60 80 100 Training set sensistivity REDfly recovery Expression pattern specificity Percent Percent Percent Percent Training Set Sensitivity REDfly recovery Expression Pattern Specificity True Expectation True Expectation True Random Random Random Expectation Expectation Expectation True True A B C D 0 25 0 20 40 60 0 20 40 60 50 75 100 True Expectation Three measures of Assessment pCRM_eval demonstrates that SCRMshaw performs better than random expectations (A) Aggregate performance for 29 true training sets, 62 random training sets, and random expectation. Comparison of training set sensitivity (B), REDfly recovery (C), and expression pattern specificity (D) for true versus random expectations for each of the 29 training sets. 2. Toward individual prediction confidence scores A true CRM might be predicted in multiple related species. We are developing a “weighted comparative confidence” score to identify such conserved CRMs, even in the absence of sequence alignment. SCRMshaw Prediction SCRMshaw Prediction < 10kb SCRMshaw Prediction < 10kb Reference Species Genome Target Species 1 Genome Target Species 2 Genome [5] Assessment measures These 10 new validated CRMs were combined with the original 7 and the 2.5-fold expanded training set used for a new round of SCRMshaw prediction. Following is the summary of the results after getting predictions from updated training set. *Notably prediction results from updated training set contain all the previous true positives and only one false positive demonstrating a marked improvement in prediction specificity using the updated training data. Empirical testing of 18 SCRMshaw predictions revealed 10 true (e.g. Kr-h1) and 8 false positive (e.g. Pdp1) prediction results. Assessment measures In vivo validation Total No. of CRMs No. of CRMs predicted by original Training s	poster
Planet gap opening across stellar masses Cat Sinclair (Cambridge), Giovanni Rosotti (Leiden), Cathie Clarke (Cambridge) Motivation and questions Many discs have rings and they may be due to planets. • How massive must a planet be to create a ring? • How does this vary with the distance from the star? • How does this vary with the host stellar mass? Theoretical expectation Depends on disc aspect ratio, i.e. temper- ature. Therefore varies with distance from the star and stellar luminosity Methods To verify the prediction, we do: • Dust and gas hydro simulations • Radiative transfer • CASA simulations to include ALMA observational effects Results Possible to use stellar mass with average luminosity, but keep in mind there is large spread in luminosities for any stellar mass. Luminosity spread in Lupus Theoretical expectations matched. Gap opening more difficult far from the star and for high stellar luminosities Conclusions • Gap opening more difficult far from the star and for high stellar lu- minosities. Quantitative expressions in the paper (QR code on the right) • Stellar luminosity crucial parameter for gap opening mass	poster
Practice Abstracts Series BRANCHES #28 28 Monte Holiday Ecoturismo+Bosque - Regenerative tourism to prevent forest fires The company Monte Holiday Ecotourism has developed a set of coordinated actions in the tourist complex located in a privately owned holm oak forest in the mountainous area Sierra de Madrid, whose objective is to establish an adaptive forest management that allows both the prevention of forest fires and the energy recovery of the biomass obtained by means of the heating network of the campsite. In this way a double benefit is achieved, on the one hand the preservation and protection of the surrounding forest and people and on the other hand it contributes to achieve a neutral carbon footprint. The proposed forest management focuses on the selection and conservation of the trees that present best condition, including silvicultural treatments such as pruning and cutting to reduce the trees’ density and the introduction of extensive livestock. The biomass obtained is used to produce renewable thermal energy for the comfort of visitors staying at the campsite. The "MHE+Forest" project aimed at energy self-sufficiency started 10 years ago with a hybrid solar/biomass heat network. Now, the installation has been expanded with a 99 kW photovoltaic plant and a 500 kW high-efficiency ETA boiler, which enables the recovery of biomass from forest management and ensures virtually zero emissions of particulate matter. In 2023, the first silvicultural intervention was carried out in the holm oak forest, obtaining 200 tonnes of green biomass. In the coming years, the adaptive management work will continue in accordance with the provisions of the forest management plan and higher volumes will be obtained. Part of the biomass will also come from nearby woodlands identified as being at high risk of fire spread by the campsite's self-protection plan. Monte Holiday Ecotourism aims to serve as an example of adaptive forest management that contributes to increase the resilience of the forest to climate change and forest fires while enabling the development of the local and circular bioeconomy and the production of renewable energy in the tourism sector, which also leads to savings in the campsite's energy bill (in 2022 over 30,000 € for an average consumption of 500 MWh of thermal energy per year, which implies a saving of over 50%). KEY WORDS Bioenergy, sustainable forest management, biomass, ecotourism COUNTRY Spain DISCLAIMER This Practice Abstract reflects only the author’s view and the Branches project is not responsible for any use that may be made of the information it contains. LINKS www.intercambiom.org www.branchesproject.eu AUTHORS Maider Gómez Daniel García Pablo Rodero Alicia Mira	poster

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