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@@ -6,8 +6,8 @@ tags:
6
  - genomics
7
  - single-cell
8
  - model_cls_name:SCANVI
9
- - scvi_version:1.2.0
10
- - anndata_version:0.11.1
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  - modality:rna
12
  - tissue:various
13
  - annotated:True
@@ -23,7 +23,7 @@ clustering.
23
 
24
  scANVI takes as input a scRNA-seq gene expression matrix with cells and genes as well as a
25
  cell-type annotation for a subset of cells.
26
- We provide an extensive [user guide](https://docs.scvi-tools.org/en/1.2.0/user_guide/models/scanvi.html).
27
 
28
  - See our original manuscript for further details of the model:
29
  [scANVI manuscript](https://www.embopress.org/doi/full/10.15252/msb.20209620).
@@ -31,7 +31,7 @@ We provide an extensive [user guide](https://docs.scvi-tools.org/en/1.2.0/user_g
31
  how to leverage pre-trained models.
32
 
33
  This model can be used for fine tuning on new data using our Arches framework:
34
- [Arches tutorial](https://docs.scvi-tools.org/en/1.0.0/tutorials/notebooks/scarches_scvi_tools.html).
35
 
36
 
37
  # Model Description
@@ -52,24 +52,14 @@ space might still be useful for analysis.
52
 
53
  **Cell-wise Coefficient of Variation**:
54
 
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- | Metric | Training Value | Validation Value |
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- |-------------------------|----------------|------------------|
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- | Mean Absolute Error | 2.14 | 2.16 |
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- | Pearson Correlation | 0.77 | 0.78 |
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- | Spearman Correlation | 0.78 | 0.79 |
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- | R² (R-Squared) | 0.50 | 0.55 |
61
 
62
  The gene-wise coefficient of variation summarizes how well variation between different genes is
63
  preserved by the generated model expression. This value is usually quite high.
64
 
65
  **Gene-wise Coefficient of Variation**:
66
 
67
- | Metric | Training Value |
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- |-------------------------|----------------|
69
- | Mean Absolute Error | 10.85 |
70
- | Pearson Correlation | 0.61 |
71
- | Spearman Correlation | 0.62 |
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- | R² (R-Squared) | -1.01 |
73
 
74
  </details>
75
 
@@ -84,21 +74,7 @@ cell-type.
84
 
85
  **Differential expression**:
86
 
87
- | Index | gene_f1 | lfc_mae | lfc_pearson | lfc_spearman | roc_auc | pr_auc | n_cells |
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- | --- | --- | --- | --- | --- | --- | --- | --- |
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- | fibroblast | 0.96 | 0.40 | 0.80 | 0.95 | 0.40 | 0.85 | 3014.00 |
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- | endothelial cell | 0.94 | 1.25 | 0.73 | 0.96 | 0.27 | 0.89 | 2077.00 |
91
- | T cell | 0.91 | 2.30 | 0.67 | 0.88 | 0.35 | 0.82 | 546.00 |
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- | vascular associated smooth muscle cell | 0.92 | 3.14 | 0.69 | 0.83 | 0.21 | 0.82 | 390.00 |
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- | macrophage | 0.84 | 2.16 | 0.59 | 0.86 | 0.38 | 0.84 | 344.00 |
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- | myometrial cell | 0.87 | 3.53 | 0.65 | 0.76 | 0.25 | 0.72 | 199.00 |
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- | epithelial cell of uterus | 0.83 | 1.80 | 0.64 | 0.89 | 0.47 | 0.80 | 194.00 |
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- | pericyte | 0.87 | 4.07 | 0.61 | 0.67 | 0.31 | 0.62 | 95.00 |
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- | endothelial cell of lymphatic vessel | 0.76 | 3.31 | 0.59 | 0.76 | 0.53 | 0.79 | 86.00 |
98
- | epithelial cell | 0.66 | 2.24 | 0.63 | 0.89 | 0.58 | 0.87 | 68.00 |
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- | mature NK T cell | 0.77 | 5.10 | 0.62 | 0.69 | 0.37 | 0.67 | 53.00 |
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- | ciliated epithelial cell | 0.56 | 3.58 | 0.64 | 0.82 | 0.51 | 0.78 | 31.00 |
101
- | leukocyte | 0.49 | 4.21 | 0.66 | 0.70 | 0.46 | 0.69 | 17.00 |
102
 
103
  </details>
104
 
@@ -118,7 +94,9 @@ These provide the settings to setup the original model:
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  "dropout_rate": 0.05,
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  "dispersion": "gene",
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  "gene_likelihood": "nb",
 
121
  "linear_classifier": false,
 
122
  "latent_distribution": "normal",
123
  "use_batch_norm": "none",
124
  "use_layer_norm": "both",
@@ -134,9 +112,9 @@ These provide the settings to setup the original model:
134
  Arguments passed to setup_anndata of the original model:
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  ```json
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  {
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- "labels_key": "cell_ontology_class",
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  "unlabeled_category": "unknown",
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- "layer": null,
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  "batch_key": "donor_assay",
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  "size_factor_key": null,
142
  "categorical_covariate_keys": null,
@@ -151,15 +129,15 @@ Arguments passed to setup_anndata of the original model:
151
  <summary><strong>Data Registry</strong></summary>
152
 
153
  Registry elements for AnnData manager:
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- | Registry Key | scvi-tools Location |
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- |-------------------|--------------------------------------|
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- | X | adata.X |
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- | batch | adata.obs['_scvi_batch'] |
158
- | labels | adata.obs['_scvi_labels'] |
159
- | latent_qzm | adata.obsm['scanvi_latent_qzm'] |
160
- | latent_qzv | adata.obsm['scanvi_latent_qzv'] |
161
- | minify_type | adata.uns['_scvi_adata_minify_type'] |
162
- | observed_lib_size | adata.obs['observed_lib_size'] |
163
 
164
  - **Data is Minified**: False
165
 
@@ -168,16 +146,16 @@ Registry elements for AnnData manager:
168
  <details>
169
  <summary><strong>Summary Statistics</strong></summary>
170
 
171
- | Summary Stat Key | Value |
172
  |--------------------------|-------|
173
- | n_batch | 2 |
174
- | n_cells | 7114 |
175
- | n_extra_categorical_covs | 0 |
176
- | n_extra_continuous_covs | 0 |
177
- | n_labels | 14 |
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- | n_latent_qzm | 20 |
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- | n_latent_qzv | 20 |
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- | n_vars | 3000 |
181
 
182
  </details>
183
 
 
6
  - genomics
7
  - single-cell
8
  - model_cls_name:SCANVI
9
+ - scvi_version:1.4.2
10
+ - anndata_version:0.12.7
11
  - modality:rna
12
  - tissue:various
13
  - annotated:True
 
23
 
24
  scANVI takes as input a scRNA-seq gene expression matrix with cells and genes as well as a
25
  cell-type annotation for a subset of cells.
26
+ We provide an extensive [user guide](https://docs.scvi-tools.org/en/stable/user_guide/models/scanvi.html).
27
 
28
  - See our original manuscript for further details of the model:
29
  [scANVI manuscript](https://www.embopress.org/doi/full/10.15252/msb.20209620).
 
31
  how to leverage pre-trained models.
32
 
33
  This model can be used for fine tuning on new data using our Arches framework:
34
+ [Arches tutorial](https://docs.scvi-tools.org/en/stable/tutorials/notebooks/scrna/scarches_scvi_tools.html).
35
 
36
 
37
  # Model Description
 
52
 
53
  **Cell-wise Coefficient of Variation**:
54
 
55
+ Not provided by uploader
 
 
 
 
 
56
 
57
  The gene-wise coefficient of variation summarizes how well variation between different genes is
58
  preserved by the generated model expression. This value is usually quite high.
59
 
60
  **Gene-wise Coefficient of Variation**:
61
 
62
+ Not provided by uploader
 
 
 
 
 
63
 
64
  </details>
65
 
 
74
 
75
  **Differential expression**:
76
 
77
+ Not provided by uploader
 
 
 
 
 
 
 
 
 
 
 
 
 
 
78
 
79
  </details>
80
 
 
94
  "dropout_rate": 0.05,
95
  "dispersion": "gene",
96
  "gene_likelihood": "nb",
97
+ "use_observed_lib_size": true,
98
  "linear_classifier": false,
99
+ "datamodule": null,
100
  "latent_distribution": "normal",
101
  "use_batch_norm": "none",
102
  "use_layer_norm": "both",
 
112
  Arguments passed to setup_anndata of the original model:
113
  ```json
114
  {
115
+ "labels_key": "cell_type",
116
  "unlabeled_category": "unknown",
117
+ "layer": "counts",
118
  "batch_key": "donor_assay",
119
  "size_factor_key": null,
120
  "categorical_covariate_keys": null,
 
129
  <summary><strong>Data Registry</strong></summary>
130
 
131
  Registry elements for AnnData manager:
132
+ | Registry Key | scvi-tools Location |
133
+ |--------------------------|--------------------------------------|
134
+ | X | adata.layers['counts'] |
135
+ | batch | adata.obs['_scvi_batch'] |
136
+ | labels | adata.obs['_scvi_labels'] |
137
+ | latent_qzm | adata.obsm['scanvi_latent_qzm'] |
138
+ | latent_qzv | adata.obsm['scanvi_latent_qzv'] |
139
+ | minify_type | adata.uns['_scvi_adata_minify_type'] |
140
+ | observed_lib_size | adata.obs['observed_lib_size'] |
141
 
142
  - **Data is Minified**: False
143
 
 
146
  <details>
147
  <summary><strong>Summary Statistics</strong></summary>
148
 
149
+ | Summary Stat Key | Value |
150
  |--------------------------|-------|
151
+ | n_batch | 3 |
152
+ | n_cells | 22029 |
153
+ | n_extra_categorical_covs | 0 |
154
+ | n_extra_continuous_covs | 0 |
155
+ | n_labels | 29 |
156
+ | n_latent_qzm | 20 |
157
+ | n_latent_qzv | 20 |
158
+ | n_vars | 3000 |
159
 
160
  </details>
161