GENERanno-prokaryote-0.5b-cds-annotator model

Abouts

In this repository, we present GENERanno-cds-annotator, which is meticulously finetuned on GENERanno-prokaryote-0.5b-base for metagenomic annotation tasks. Through comprehensive evaluations, GENERanno-cds-annotator achieves superior accuracy compared to traditional HMM-based methods (e.g., GLIMMER3, GeneMarkS2, Prodigal) and recent LLM-based approaches (e.g., GeneLM), while demonstrating exceptional generalization ability on archaeal genomes.

Python scripts for end-to-end genome annotation is avaliable on GitHub: GenerTeam

Citation

@article{li2025generanno,
    author = {Li, Qiuyi and Wu, Wei and Zhu, Yiheng and Feng, Fuli and Ye, Jieping and Wang, Zheng},
    title = {GENERanno: A Genomic Foundation Model for Metagenomic Annotation},
    elocation-id = {2025.06.04.656517},
    year = {2025},
    doi = {10.1101/2025.06.04.656517},
    publisher = {Cold Spring Harbor Laboratory},
    URL = {https://www.biorxiv.org/content/early/2025/06/05/2025.06.04.656517},
    journal = {bioRxiv}
}