Datasets:
row_id
string | series_id
string | timepoint_h
int64 | host_model
string | abx_drug
string | abx_dose_mg
int64 | abx_conc_ng_mL
int64 | expected_abx_conc_ng_mL
int64 | abx_conc_deviation
int64 | concomitant_drug
string | concomitant_exposure_index
float64 | expected_interaction_shift
int64 | interaction_shift_deviation
int64 | ddi_coherence_index
float64 | host_stress_index
float64 | later_adverse_ddi_flag
int64 | assay_method
string | source_type
string | ddi_emergence_signal
int64 | earliest_ddi_emergence
int64 | notes
string |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ABXHT010-TR-0001
|
S1
| 0
|
human_sim
|
clarithromycin
| 500
| 120
| 120
| 0
|
simvastatin
| 0.1
| 0
| 0
| 0.9
| 0.1
| 0
|
pk_ddi_panel
|
simulated
| 0
| 0
|
baseline
|
ABXHT010-TR-0002
|
S1
| 12
|
human_sim
|
clarithromycin
| 500
| 140
| 140
| 0
|
simvastatin
| 0.9
| 25
| -25
| 0.6
| 0.9
| 0
|
pk_ddi_panel
|
simulated
| 0
| 0
|
expected shift present
|
ABXHT010-TR-0003
|
S1
| 24
|
human_sim
|
clarithromycin
| 500
| 220
| 140
| 80
|
simvastatin
| 0.9
| 25
| 55
| 0.35
| 0.9
| 0
|
pk_ddi_panel
|
simulated
| 0
| 0
|
first emergence
|
ABXHT010-TR-0004
|
S1
| 36
|
human_sim
|
clarithromycin
| 500
| 230
| 140
| 90
|
simvastatin
| 0.9
| 25
| 65
| 0.3
| 0.9
| 0
|
pk_ddi_panel
|
simulated
| 1
| 1
|
onset
|
ABXHT010-TR-0005
|
S1
| 72
|
human_sim
|
clarithromycin
| 500
| 260
| 140
| 120
|
simvastatin
| 0.9
| 25
| 95
| 0.2
| 0.9
| 1
|
pk_ddi_panel
|
simulated
| 1
| 0
|
adverse later
|
ABXHT010-TR-0006
|
S2
| 0
|
human_sim
|
amoxicillin
| 500
| 110
| 110
| 0
|
metformin
| 0.1
| 0
| 0
| 0.9
| 0.1
| 0
|
pk_ddi_panel
|
simulated
| 0
| 0
|
baseline
|
ABXHT010-TR-0007
|
S2
| 24
|
human_sim
|
amoxicillin
| 500
| 112
| 110
| 2
|
metformin
| 0.9
| 0
| 2
| 0.86
| 0.9
| 0
|
pk_ddi_panel
|
simulated
| 0
| 0
|
no interaction
|
ABXHT010-TR-0008
|
S2
| 48
|
human_sim
|
amoxicillin
| 500
| 108
| 110
| -2
|
metformin
| 0.9
| 0
| -2
| 0.84
| 0.9
| 0
|
pk_ddi_panel
|
simulated
| 0
| 0
|
no interaction
|
ABXHT010-TR-0009
|
S3
| 0
|
human_sim
|
clarithromycin
| 500
| 230
| 140
| 90
|
none
| 0
| 0
| 90
| 0.3
| 0.9
| 1
|
pk_ddi_panel
|
simulated
| 0
| 0
|
no concomitant
|
ABXHT010-TR-0010
|
S4
| 36
|
human_sim
|
clarithromycin
| 500
| 230
| 140
| 90
|
simvastatin
| 0.9
| 25
| 65
| 0.3
| 0.3
| 1
|
pk_ddi_panel
|
simulated
| 0
| 0
|
stress low
|
ABX-HT-010 Drug-Drug Interaction Emergence
Purpose
Detect early interaction emergence when antibiotic exposure stops tracking expected interaction shift with concomitant medications.
Core pattern
- host_stress_index high
- concomitant_exposure_index high
- ddi_coherence_index drops
- interaction_shift_deviation stays high
- later_adverse_ddi_flag appears
Files
- data/train.csv
- data/test.csv
- scorer.py
Schema
Each row is one timepoint in a within series PK and medication exposure course.
Required columns
- row_id
- series_id
- timepoint_h
- host_model
- abx_drug
- abx_dose_mg
- abx_conc_ng_mL
- expected_abx_conc_ng_mL
- abx_conc_deviation
- concomitant_drug
- concomitant_exposure_index
- expected_interaction_shift
- interaction_shift_deviation
- ddi_coherence_index
- host_stress_index
- later_adverse_ddi_flag
- assay_method
- source_type
- ddi_emergence_signal
- earliest_ddi_emergence
Labels
ddi_emergence_signal
- 1 for rows at or after first confirmed emergence onset
earliest_ddi_emergence
- 1 only for the first onset row in that series
Scorer logic in v1
- require a concomitant medication signal in the series
- candidate onset point
- host_stress_index at least 0.80
- concomitant_exposure_index at least 0.80
- ddi_coherence_index at most 0.40
- absolute interaction_shift_deviation at least 40 for two consecutive points
- ignore one point deviation spike then recovery artifacts
- confirmation
- later_adverse_ddi_flag equals 1 later in series
Evaluation
Run
- python scorer.py --path data/test.csv
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