id
stringclasses 8
values | drug_name
stringclasses 8
values | condition_context
stringclasses 8
values | pre_coupling_summary
stringclasses 8
values | on_drug_coupling_summary
stringclasses 8
values | post_drug_coupling_summary
stringclasses 8
values | observation_window
stringclasses 6
values | coupling_change_matrix
stringclasses 8
values | newly_synchronized_pairs
stringclasses 8
values | newly_desynchronized_pairs
stringclasses 8
values | instability_flags
stringclasses 8
values | net_coupling_integrity_score
stringclasses 3
values | monitoring_targets
stringclasses 8
values | notes
stringclasses 8
values | constraints
stringclasses 1
value | gold_checklist
stringclasses 1
value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CCDM-001
|
SSRI
|
depression
|
Sleep and mood tightly coupled; HRV tracks sleep
|
Mood improves while HRV remains low; sleep improves
|
Coupling returns toward baseline; GI effects resolve
|
9 months
|
sleep–mood: weaken; sleep–HRV: weaken; mood–HRV: weaken
|
mood–sleep (improves)
|
sleep–HRV; mood–HRV
|
low autonomic recovery
|
Medium
|
HRV; sleep staging; GI motility
|
Neural gain with autonomic lag
|
Under 240 words.
|
matrix+pairs+flags+score
|
CCDM-002
|
steroid
|
autoimmune_flare
|
Pain tracks inflammation; glucose stable
|
Pain decouples from inflammation markers; glucose rises
|
Rebound pain with persistent metabolic shift
|
6 months
|
immune–pain: distort; immune–glucose: new coupling; sleep–glucose: strengthen
|
immune–glucose
|
immune–pain
|
metabolic drift; rebound risk
|
Low
|
glucose; sleep; infection markers
|
Suppression creates distortion
|
Under 240 words.
|
matrix+pairs+flags+score
|
CCDM-003
|
metformin
|
type2_diabetes
|
Glucose variance tracks sleep and activity
|
Glucose variance drops; GI upset decouples activity from appetite
|
GI resolves; glucose-sleep coupling strengthens
|
12 months
|
glucose–sleep: strengthen; glucose–activity: strengthen; gut–appetite: transient strengthen
|
glucose–sleep; glucose–activity
|
activity–appetite
|
transient GI destabilization
|
High
|
sleep; activity; GI symptoms
|
Net coupling improvement
|
Under 240 words.
|
matrix+pairs+flags+score
|
CCDM-004
|
beta_blocker
|
arrhythmia
|
Anxiety spikes track palpitations; HRV low
|
Palpitations reduce; fatigue rises; activity decouples from mood
|
Fatigue resolves; palpitations return
|
8 months
|
palpitations–anxiety: weaken; activity–mood: weaken; HRV–fatigue: strengthen
|
fatigue–HRV
|
activity–mood
|
functional suppression
|
Medium
|
activity; fatigue; HRV
|
Control with functional cost
|
Under 240 words.
|
matrix+pairs+flags+score
|
CCDM-005
|
GLP1
|
obesity
|
Appetite and glucose tightly coupled
|
Appetite suppressed; nausea couples intake to dehydration risk
|
Nausea resolves; appetite–glucose coupling resets
|
10 months
|
appetite–glucose: reset; nausea–hydration: strengthen; sleep–appetite: strengthen
|
sleep–appetite
|
appetite–glucose (old pattern)
|
dehydration sensitivity
|
Medium
|
hydration; renal labs; nausea
|
Conditional coupling shifts
|
Under 240 words.
|
matrix+pairs+flags+score
|
CCDM-006
|
benzodiazepine
|
anxiety
|
Anxiety and sleep weakly coupled; daytime function variable
|
Sleep improves but daytime function drops; missed dose triggers rebound anxiety
|
Rebound couples anxiety to sleep collapse
|
7 months
|
sleep–anxiety: distort; dose–function: strengthen; anxiety–sleep: strengthen (rebound)
|
dose–function
|
sleep–restoration
|
dependence; rebound cascade
|
Low
|
adherence; rebound severity; falls risk
|
Fragility signature in coupling
|
Under 240 words.
|
matrix+pairs+flags+score
|
CCDM-007
|
stimulant
|
adhd
|
Focus and sleep inversely coupled
|
Focus up; sleep fragmentation rises; appetite drops
|
Sleep recovers; focus baseline returns
|
6 months
|
focus–sleep: strengthen inverse; sleep–mood: weaken; appetite–sleep: weaken
|
focus–sleep (inverse)
|
sleep–mood
|
sleep debt drift
|
Medium
|
sleep; mood; appetite
|
Tradeoff coupling
|
Under 240 words.
|
matrix+pairs+flags+score
|
CCDM-008
|
diuretic
|
heart_failure
|
Weight and edema track symptoms
|
Edema down; renal markers become sensitive to intake
|
Stabilizes with titration
|
9 months
|
volume–renal: strengthen; symptoms–weight: weaken; BP–renal: strengthen
|
volume–renal; BP–renal
|
symptoms–weight
|
AKI sensitivity
|
Medium
|
creatinine; electrolytes; intake
|
Narrowed operating range
|
Under 240 words.
|
matrix+pairs+flags+score
|
What this dataset tests
How a single drug
changes coupling between systems.
Required outputs
- coupling change matrix
- newly synchronized pairs
- newly desynchronized pairs
- instability flags
- net coupling integrity score
- monitoring targets
Use case
Second layer of the Drug-Induced System Drift Library.
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