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0 | 0 | Epsin-mediated degradation of IP3R1 fuels atherosclerosis | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
In this study by Dong and colleagues, the role of endothelial Epsin-1 in the development of
atherosclerosis was investigated. The authors identified an interaction of Epsin-1 with the
endoplasmatic reticulum protein IP3R1, which regulates calcium release i... | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
In this study by Dong and colleagues, the role of endothelial Epsin-1 in the development of
atherosclerosis was investigated. The authors identified an interaction of Epsin-1 with the
endoplasmatic reticulum protein IP3R1, which regulates calcium release i... | TPR | NC_BS_CBIO_011_RR1.txt | {
"criticism": 11,
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0 | 0 | Epsin-mediated degradation of IP3R1 fuels atherosclerosis | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
The authors have sufficiently revised the manuscript and I have no further comments.
Reviewer #2:
Remarks to the Author:
My main concern was the absence of direct evidence for the molecular mechanism mediating the
degradation of a multi-pass chann... | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
The authors have sufficiently revised the manuscript and I have no further comments.
Reviewer #2:
Remarks to the Author:
My main concern was the absence of direct evidence for the molecular mechanism mediating the
degradation of a multi-pass chann... | TPR | NC_BS_CBIO_011_RR2.txt | {
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0 | 0 | Persistent telomere cohesion protects aged cells from premature senescence | Response to Reviewer 2
Reviewer #2 (Remarks to the Author):
The authors have made efforts to address some of the concerns raised previously, however several
main issues remain outstanding. This dampens one’s enthusiasm to endorse it for publication as it
currently stands.
1. The TRF1AA work cited by the... | Response to Reviewer 2
Reviewer #2 (Remarks to the Author):
The authors have made efforts to address some of the concerns raised previously, however several
main issues remain outstanding. This dampens one’s enthusiasm to endorse it for publication as it
currently stands.
1. The TRF1AA work cited by the... | TPR | NC_BS_CBIO_012_RR3.txt | {
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0 | 0 | Persistent telomere cohesion protects aged cells from premature senescence |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
This manuscript details a robust study by the Smith lab focusing on the intersection between telomere
length and telomere cohesion in aging and ALT cells. The presented experimentation probes how
altering telomere cohesion through multiple methods leads t... |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
This manuscript details a robust study by the Smith lab focusing on the intersection between telomere
length and telomere cohesion in aging and ALT cells. The presented experimentation probes how
altering telomere cohesion through multiple methods leads t... | TPR | NC_BS_CBIO_012_RR1.txt | {
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0 | 0 | Persistent telomere cohesion protects aged cells from premature senescence |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
Thank you to the authors for effectively addressing all my queries. I support publication of the revised
manuscript.
Reviewer #2 (Remarks to the Author):
The authors have made efforts to address some of the concerns raised previously, however severa... |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
Thank you to the authors for effectively addressing all my queries. I support publication of the revised
manuscript.
Reviewer #2 (Remarks to the Author):
The authors have made efforts to address some of the concerns raised previously, however severa... | TPR | NC_BS_CBIO_012_RR2.txt | {
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0 | 0 | Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
In this manuscript, Promonet, Padioleau, Liu et al use ChIP-seq to map the distribution of R-loops,
phospho-RPA (pRPA) and γ-H2AX around transcribed genes in HeLa cells, both under normal
conditions and during mild depletion of Top1. Interestingly, the a... | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
In this manuscript, Promonet, Padioleau, Liu et al use ChIP-seq to map the distribution of R-loops,
phospho-RPA (pRPA) and γ-H2AX around transcribed genes in HeLa cells, both under normal
conditions and during mild depletion of Top1. Interestingly, the a... | TPR | NC_BS_CBIO_013_RR1.txt | {
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0 | 0 | Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination |
Reviewers' Comments:
Reviewer #2:
Remarks to the Author:
The authors have done a wonderful job addressing my concerns and I think this is really a
beautiful paper - congrats to them.
A few minor points for the final version
- in the abstract, I think the worked "accumulated" instead of "cumulated" is more... |
Reviewers' Comments:
Reviewer #2:
Remarks to the Author:
The authors have done a wonderful job addressing my concerns and I think this is really a
beautiful paper - congrats to them.
A few minor points for the final version
- in the abstract, I think the worked "accumulated" instead of "cumulated" is more... | TPR | NC_BS_CBIO_013_RR2.txt | {
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0 | 0 | Mammalian histones facilitate antimicrobial synergy by disrupting the bacterial proton |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The authors answered my questions to my satisfaction.
The only point I want to posit is a comment in support of the authors on the relation between
synergy/self-amplification and the role of NETs and citrullination, in questions raised by one... |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The authors answered my questions to my satisfaction.
The only point I want to posit is a comment in support of the authors on the relation between
synergy/self-amplification and the role of NETs and citrullination, in questions raised by one... | TPR | NC_BS_CBIO_014_RR2.txt | {
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0 | 0 | Mammalian histones facilitate antimicrobial synergy by disrupting the bacterial proton | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
This manuscript examines the antimicrobial activity of histones, which are now better known for
their ability to organize DNA in mammalian chromosomes. Specifically, the authors investigate how
histones can work together with membrane permeating anti... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
This manuscript examines the antimicrobial activity of histones, which are now better known for
their ability to organize DNA in mammalian chromosomes. Specifically, the authors investigate how
histones can work together with membrane permeating anti... | TPR | NC_BS_CBIO_014_RR1.txt | {
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"content": "Reviewers' comments: \n\n \n\nReviewer #1 (Remarks to the Author): \n\n \n\nThis manuscript examines the antimicrobial activity of histones, which are now better known for \ntheir ability to organize DNA in mammalian chromosom... | 2,020 | |||
0 | 0 | Mammalian histones facilitate antimicrobial synergy by disrupting the bacterial proton |
REVIEWERS' COMMENTS:
Reviewer #2 (Remarks to the Author):
The authors have sufficiently answered all my questions. While I still do not agree that the resolution
of images is very good, they do support what the authors want to show. Thus, I recommend
publication in Nature Communications without furthe... |
REVIEWERS' COMMENTS:
Reviewer #2 (Remarks to the Author):
The authors have sufficiently answered all my questions. While I still do not agree that the resolution
of images is very good, they do support what the authors want to show. Thus, I recommend
publication in Nature Communications without furthe... | TPR | NC_BS_CBIO_014_RR3.txt | {
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0 | 0 | Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of | Reviewer #1 (Remarks to the Author):
While there are many structures of mitochondrial ribosomes, the majority have been of isolated
subunits or vacant ribosomes. Very few have reported defined functional states and insights into
mitochondrial translocation catalyzed by EF-G1 have been lacking. The manuscript of Kor... | Reviewer #1 (Remarks to the Author):
While there are many structures of mitochondrial ribosomes, the majority have been of isolated
subunits or vacant ribosomes. Very few have reported defined functional states and insights into
mitochondrial translocation catalyzed by EF-G1 have been lacking. The manuscript of Kor... | TPR | NC_BS_CBIO_015_RR1.txt | {
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0 | 0 | Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors have made an excellent effort to address all my comments. I would like to thank them for
highlighting the changes in the text which makes it easier to find the sections (except for the FSC
criteria which they didn't highlight unfortunately).... |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors have made an excellent effort to address all my comments. I would like to thank them for
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criteria which they didn't highlight unfortunately).... | TPR | NC_BS_CBIO_015_RR2.txt | {
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0 | 0 | Chimeric design of pyrrolysyl-tRNA synthetase/tRNA pairs and canonical synthetase/tRNA |
Reviewers' Comments:
Reviewer #2:
Remarks to the Author:
All concerns from this reviewer have been addressed. It is ready for acceptance.
|
Reviewers' Comments:
Reviewer #2:
Remarks to the Author:
All concerns from this reviewer have been addressed. It is ready for acceptance.
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0 | 0 | Chimeric design of pyrrolysyl-tRNA synthetase/tRNA pairs and canonical synthetase/tRNA |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
The re-revised manuscript from Ding et. al has addressed many of the concerns that reviewers had
but requires some additional modifications before publication. The manuscript has a better flow and
the ideas are more clearly laid out than previous version... |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
The re-revised manuscript from Ding et. al has addressed many of the concerns that reviewers had
but requires some additional modifications before publication. The manuscript has a better flow and
the ideas are more clearly laid out than previous version... | TPR | NC_BS_CHBIO_001_RR1.txt | {
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0 | 0 | Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
I am a computational chemist by training and have focused in my evaluation on the computational
aspects. Nonetheless, I have some questions to the experimental parts as well.
The manuscript describes the determination of a structure of an N-termi... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
I am a computational chemist by training and have focused in my evaluation on the computational
aspects. Nonetheless, I have some questions to the experimental parts as well.
The manuscript describes the determination of a structure of an N-termi... | TPR | NC_BS_CHBIO_002_RR1.txt | {
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0 | 0 | Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors have addressed most of my comments satisfactorily. Two minor issues remain:
I my first point, I had indicated that in order to accommodate the substrate, the Ct-extension must
already have moved in the simulation in which on... |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors have addressed most of my comments satisfactorily. Two minor issues remain:
I my first point, I had indicated that in order to accommodate the substrate, the Ct-extension must
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"content": "\n\n \n\n\n \n\n\fREVIEWERS' COMMENTS: \n\n \n\nReviewer #1 (Remarks to the Author): \n\n \n\nThe authors have addressed most of my comments satisfactorily. Two minor issues remain: \n\n \n\nI my first point, I had indicated t... | 2,020 | |||
0 | 0 | Multi-layered proteomic analyses decode compositional and functional effects of cancer | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
Mehnert et al. use a series of proteomics approaches (AP-MS, BioID-MS, crosslinking-MS,
proteomics, and phosphoproteomics) to investigate the impact of mutations of the DYRK2 kinase on
its interactome, topology, and downstream signaling. They describ... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
Mehnert et al. use a series of proteomics approaches (AP-MS, BioID-MS, crosslinking-MS,
proteomics, and phosphoproteomics) to investigate the impact of mutations of the DYRK2 kinase on
its interactome, topology, and downstream signaling. They describ... | TPR | NC_BS_CHBIO_003_RR1.txt | {
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"content": "Reviewers' comments: \n\n \n\nReviewer #1 (Remarks to the Author): \n\n \n\nMehnert et al. use a series of proteomics approaches (AP-MS, BioID-MS, crosslinking-MS, \nproteomics, and phosphoproteomics) to investigate the impact... | 2,020 | |||
0 | 0 | Multi-layered proteomic analyses decode compositional and functional effects of cancer |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors have addressed my concerns. I support the publication of the manuscript.
|
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors have addressed my concerns. I support the publication of the manuscript.
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0 | 0 | Quantifying CDK inhibitor selectivity in live cells | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
Wells and Vasta et al., describe new assays for quantifying in vivo target engagement on CDK-cyclin
complexes. For these studies, they have extended their development of BRET-based assays,
previously developed for other enzymes or kinases (178 of the 500+)... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
Wells and Vasta et al., describe new assays for quantifying in vivo target engagement on CDK-cyclin
complexes. For these studies, they have extended their development of BRET-based assays,
previously developed for other enzymes or kinases (178 of the 500+)... | TPR | NC_BS_CHBIO_004_RR1.txt | {
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"content": "Reviewers' comments: \n\nReviewer #1 (Remarks to the Author): \n\nWells and Vasta et al., describe new assays for quantifying in vivo target engagement on CDK-cyclin \ncomplexes. For these studies, they have extended their dev... | 2,020 | |||
0 | 0 | Quantifying CDK inhibitor selectivity in live cells |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors have done a very nice job addressing concerns from the first submission. In particular,
the addition of Nanobit is quite nice.
Minor correction: line 35 has a grammatical error with a period followed by a comma.
Optional issue to add... |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors have done a very nice job addressing concerns from the first submission. In particular,
the addition of Nanobit is quite nice.
Minor correction: line 35 has a grammatical error with a period followed by a comma.
Optional issue to add... | TPR | NC_BS_CHBIO_004_RR2.txt | {
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0 | 0 | Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their |
Reviewers' Comments:
Reviewer #2:
Remarks to the Author:
This is a re-revised manuscript that now deals with a few of the concerns of the original review,
rather than pointing out that those concerns were unwarranted. The revision represents at least an
initial effort to establish some degree o... |
Reviewers' Comments:
Reviewer #2:
Remarks to the Author:
This is a re-revised manuscript that now deals with a few of the concerns of the original review,
rather than pointing out that those concerns were unwarranted. The revision represents at least an
initial effort to establish some degree o... | TPR | NC_BS_CHBIO_005_RR3.txt | {
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0 | 0 | Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
I thank the authors for the thorough explanations that have dissipated my concerns. I think the
manuscript is much improved and deserves publication. A side note: recently, a different method,
also based on split inteins, has been published that has pr... |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
I thank the authors for the thorough explanations that have dissipated my concerns. I think the
manuscript is much improved and deserves publication. A side note: recently, a different method,
also based on split inteins, has been published that has pr... | TPR | NC_BS_CHBIO_005_RR2.txt | {
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"content": "\n \n\fReviewers' Comments: \n \nReviewer #1: \nRemarks to the Author: \nI thank the authors for the thorough explanations that have dissipated my concerns. I think the \nmanuscript is much improved and deserves publication. A... | 2,020 | |||
0 | 0 | Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
In this paper, Yao and colleagues report the development of a method to detect protein-protein
interactions (PPIs) based on the trans-splicing reaction mediated by the split intein gp41-1. The
authors justify why they decided to develop such method saying ... | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
In this paper, Yao and colleagues report the development of a method to detect protein-protein
interactions (PPIs) based on the trans-splicing reaction mediated by the split intein gp41-1. The
authors justify why they decided to develop such method saying ... | TPR | NC_BS_CHBIO_005_RR1.txt | {
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"content": "Reviewers' Comments: \n \nReviewer #1: \nRemarks to the Author: \nIn this paper, Yao and colleagues report the development of a method to detect protein-protein \ninteractions (PPIs) based on the trans-splicing reaction mediat... | 2,020 | |||
0 | 0 | Prominent members of the human gut microbiota express endo-acting O-glycanases to |
REVIEWERS' COMMENTS:
Reviewer #2 (Remarks to the Author):
This revised manuscript by Crouch et al. is significantly better than the original submission. The
significance and discussion is now much better conveyed, and the conclusions are appropriate for
the study. The authors have also sufficiently addressed ... |
REVIEWERS' COMMENTS:
Reviewer #2 (Remarks to the Author):
This revised manuscript by Crouch et al. is significantly better than the original submission. The
significance and discussion is now much better conveyed, and the conclusions are appropriate for
the study. The authors have also sufficiently addressed ... | TPR | NC_BS_CHBIO_006_RR2.txt | {
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"content": "\n\n\n\fREVIEWERS' COMMENTS: \n\nReviewer #2 (Remarks to the Author): \n\nThis revised manuscript by Crouch et al. is significantly better than the original submission. The \nsignificance and discussion is now much better conv... | 2,020 | |||
0 | 0 | Prominent members of the human gut microbiota express endo-acting O-glycanases to | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The colonic mucus barrier separates the human gut microbiome (both commensals and pathogens)
from the epithelium and plays a vital role as primary defense against the enteric pathogens.
Recent literature underscores the importance of this barrier for the h... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The colonic mucus barrier separates the human gut microbiome (both commensals and pathogens)
from the epithelium and plays a vital role as primary defense against the enteric pathogens.
Recent literature underscores the importance of this barrier for the h... | TPR | NC_BS_CHBIO_006_RR1.txt | {
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"content": "Reviewers' comments: \n\nReviewer #1 (Remarks to the Author): \n\nThe colonic mucus barrier separates the human gut microbiome (both commensals and pathogens) \nfrom the epithelium and plays a vital role as primary defense aga... | 2,020 | |||
0 | 0 | Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact | REVIEWERS' COMMENTS:
Reviewer #3 (Remarks to the Author):
Fei Dong, MD
The authors have addressed my concerns. This article is a useful analysis of mutations identified in
a large cohort of colorectal cancers | REVIEWERS' COMMENTS:
Reviewer #3 (Remarks to the Author):
Fei Dong, MD
The authors have addressed my concerns. This article is a useful analysis of mutations identified in
a large cohort of colorectal cancers | TPR | NC_BS_CHBIO_007_RR4.txt | {
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"content": "REVIEWERS' COMMENTS:\nReviewer #3 (Remarks to the Author):\nFei Dong, MD\n The authors have addressed my concerns. This article is a useful analysis of mutations identified in\n a large cohort of colorectal cancers",
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0 | 0 | Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
In this study, Zaidi et al. performed deep targeted sequencing using a custom 205 gene AmpliSeq
assay, including MSI status, in 2105 CRC cases with matched normals. The clinical annotation of
the cases includes disease-specific survival data. Their main fi... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
In this study, Zaidi et al. performed deep targeted sequencing using a custom 205 gene AmpliSeq
assay, including MSI status, in 2105 CRC cases with matched normals. The clinical annotation of
the cases includes disease-specific survival data. Their main fi... | TPR | NC_BS_CHBIO_007_RR1.txt | {
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0 | 0 | Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
In their revised manuscript, Zaidi et al. have now provided the underlying mutational and clinical
data and have clarified some aspects of their analysis.
The main concern of this reviewer remains: In their cohort, they find that about 5% of tumors are ... |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
In their revised manuscript, Zaidi et al. have now provided the underlying mutational and clinical
data and have clarified some aspects of their analysis.
The main concern of this reviewer remains: In their cohort, they find that about 5% of tumors are ... | TPR | NC_BS_CHBIO_007_RR2.txt | {
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0 | 0 | Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
In this revision, Zaidi et al. have looked more closely at the potentially novel subtype of CRC that
is hypermutated, MSS, but not explained by any obvious mechanism.
While it is interesting to see that the mutations in the hypermutated MSS cases that do not ... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
In this revision, Zaidi et al. have looked more closely at the potentially novel subtype of CRC that
is hypermutated, MSS, but not explained by any obvious mechanism.
While it is interesting to see that the mutations in the hypermutated MSS cases that do not ... | TPR | NC_BS_CHBIO_007_RR3.txt | {
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0 | 0 | Light-triggered switching of liposome surface charge directs delivery of membrane |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
I thank the authors for addressing my questions and concerns adequately. I recommend
publication. I have no further requests.
Reviewer #2:
Remarks to the Author:
The manuscript has been improved.
Reviewer #3:
Remarks to the Author:
In m... |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
I thank the authors for addressing my questions and concerns adequately. I recommend
publication. I have no further requests.
Reviewer #2:
Remarks to the Author:
The manuscript has been improved.
Reviewer #3:
Remarks to the Author:
In m... | TPR | NC_BS_CHBIO_008_RR2.txt | {
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0 | 0 | Light-triggered switching of liposome surface charge directs delivery of membrane | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
The manuscript entitled "Light-triggered switching of liposome surface chargedirects
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describes light-induced switching of surface charges of liposomal carriers ... | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
The manuscript entitled "Light-triggered switching of liposome surface chargedirects
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"content": "Reviewers' Comments: \n \nReviewer #1: \nRemarks to the Author: \nThe manuscript entitled \"Light-triggered switching of liposome surface chargedirects \ntheintracellular delivery of membrane impermeable payloads in vivo\" by ... | 2,020 | |||
0 | 0 | INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
In this revised manuscript, Sabath and colleagues have refined their analysis on a newly identified
structural/functional module of the Integrator complex.
In its original version, this manuscript presented compelling biochemical and structural evidence... |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
In this revised manuscript, Sabath and colleagues have refined their analysis on a newly identified
structural/functional module of the Integrator complex.
In its original version, this manuscript presented compelling biochemical and structural evidence... | TPR | NC_BS_CHBIO_009_RR1.txt | {
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0 | 0 | Multiplexed Optical Sensors in Arrayed Islands of Cells for multimodal recordings of cellular | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
I enjoyed reading this manuscript, which describes a smart technical approach to simultaneously
apply different genetically encoded probes in a microarray assay. The authors used defined
lentivirus particles that were blotted on a microarray to infect cell... | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
I enjoyed reading this manuscript, which describes a smart technical approach to simultaneously
apply different genetically encoded probes in a microarray assay. The authors used defined
lentivirus particles that were blotted on a microarray to infect cell... | TPR | NC_BS_CHBIO_012_RR1.txt | {
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0 | 0 | Multiplexed Optical Sensors in Arrayed Islands of Cells for multimodal recordings of cellular |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
Dear Authors,
Congratulations to this beautiful work. All my comments have been addressed satisfactorily.
Sincerely,
Roland Malli
Reviewer #2:
Remarks to the Author:
The authors have addressed most points adequately. It is regrettable they wer... |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
Dear Authors,
Congratulations to this beautiful work. All my comments have been addressed satisfactorily.
Sincerely,
Roland Malli
Reviewer #2:
Remarks to the Author:
The authors have addressed most points adequately. It is regrettable they wer... | TPR | NC_BS_CHBIO_012_RR.txt | {
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0 | 0 | Mapping allosteric communications within individual proteins | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The authors propose a structure-based stochastic computational method to map allosteric sites,
pathways and networks based on the hypothesis that packing heterogeneities serve as a mechanism
to relay allosteric perturbations. The proposed software wa... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The authors propose a structure-based stochastic computational method to map allosteric sites,
pathways and networks based on the hypothesis that packing heterogeneities serve as a mechanism
to relay allosteric perturbations. The proposed software wa... | TPR | NC_BS_CHBIO_013_RR1.txt | {
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0 | 0 | Mapping allosteric communications within individual proteins |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors have adequately addressed our previous comments. Just a couple of very minor
suggestions to enhance clarity:
p. 7 of merged PDF, lines 165-166: “These results indicate that the allosteric correlation between the
allosteric site... |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors have adequately addressed our previous comments. Just a couple of very minor
suggestions to enhance clarity:
p. 7 of merged PDF, lines 165-166: “These results indicate that the allosteric correlation between the
allosteric site... | TPR | NC_BS_CHBIO_013_RR2.txt | {
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0 | 0 | The receptor PTPRU is a redox sensitive pseudophosphatase |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors have done a largely admirable job at addressing the concerns of the reviewers and
especially, through editing changes and changes to the figures, made the results considerably more
clear.
I have only a final concern, which arises, ... |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors have done a largely admirable job at addressing the concerns of the reviewers and
especially, through editing changes and changes to the figures, made the results considerably more
clear.
I have only a final concern, which arises, ... | TPR | NC_BS_CHBIO_014_RR2.txt | {
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0 | 0 | The receptor PTPRU is a redox sensitive pseudophosphatase | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
NCOMMS-19-37816
The manuscript by Hay et al describes the structure and characterization of the PTPRU
pseudophosphatase, a receptor tyrosine phosphatase that is proposed to be proto-oncogenic,
although its true function is still not fully establish... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
NCOMMS-19-37816
The manuscript by Hay et al describes the structure and characterization of the PTPRU
pseudophosphatase, a receptor tyrosine phosphatase that is proposed to be proto-oncogenic,
although its true function is still not fully establish... | TPR | NC_BS_CHBIO_014_RR1.txt | {
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0 | 0 | Generation, localization and functions of macrophages during the development of testis |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
While this referee based on own but not published experiments respectfully disagrees on the lack of
bioavailability of TAM at later time points of development when administered at E13.5 the new labeling
experiments performed at E8.5 answer my questions.... |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
While this referee based on own but not published experiments respectfully disagrees on the lack of
bioavailability of TAM at later time points of development when administered at E13.5 the new labeling
experiments performed at E8.5 answer my questions.... | TPR | NC_BS_DBIO_001_RR2.txt | {
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0 | 0 | Generation, localization and functions of macrophages during the development of testis | Reviewers' comments:
Reviewer #1 (Hematopoiesis, tissue-resident macrophage)(Remarks to the Author):
Lokka et al. present data on the heterogeneity and origin of testes-resident macrophages and their
role in spermatogenesis. Using high dimensional single cell mass cytometry, alterations in macrophage
populations ... | Reviewers' comments:
Reviewer #1 (Hematopoiesis, tissue-resident macrophage)(Remarks to the Author):
Lokka et al. present data on the heterogeneity and origin of testes-resident macrophages and their
role in spermatogenesis. Using high dimensional single cell mass cytometry, alterations in macrophage
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0 | 0 | ATAC-seq footprinting unravels kinetics of transcription factor binding during zygotic | REVIEWER COMMENTS
Reviewer #1 (Remarks to the Author):
In this study, Bentsen and colleagues introduce a new strategy (called TOBIAS) aimed at
identifying footprints of chromatin-associated proteins from ATAC-seq accessibility profiles. They
propose a data-driven correction of Tn5 bias and show that this is ind... | REVIEWER COMMENTS
Reviewer #1 (Remarks to the Author):
In this study, Bentsen and colleagues introduce a new strategy (called TOBIAS) aimed at
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propose a data-driven correction of Tn5 bias and show that this is ind... | TPR | NC_BS_DBIO_002_RR1.txt | {
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0 | 0 | ATAC-seq footprinting unravels kinetics of transcription factor binding during zygotic |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors addressed all the relevant concerns raised by the reviewers. Notably, the availability
to the community of the results shown in the manuscript has also been improved. I think this
newer version of the manuscript is suitable for publicatio... |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors addressed all the relevant concerns raised by the reviewers. Notably, the availability
to the community of the results shown in the manuscript has also been improved. I think this
newer version of the manuscript is suitable for publicatio... | TPR | NC_BS_DBIO_002_RR2.txt | {
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0 | 0 | Dynamic changes in the epigenomic landscape regulate human organogenesis and link to |
Reviewers' Comments:
Reviewer #2:
Remarks to the Author:
In this revised version of their manuscript, the authors:
1. Add more in-depth analyses to support their claim regarding the absence of promoter bivalency
in cell-fate determining genes in human organogenesis.
2. Include sufficient details on how com... |
Reviewers' Comments:
Reviewer #2:
Remarks to the Author:
In this revised version of their manuscript, the authors:
1. Add more in-depth analyses to support their claim regarding the absence of promoter bivalency
in cell-fate determining genes in human organogenesis.
2. Include sufficient details on how com... | TPR | NC_BS_DBIO_003_RR2.txt | {
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0 | 0 | Dynamic changes in the epigenomic landscape regulate human organogenesis and link to | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
Dear authors,
The manuscript “The epigenomic landscape regulating organogenesis in human embryos linked to
developmental disorders” by Gerrard et al. provides unique insight regarding epigenetic landscape
dynamics of H3K27Ac, H3K4me3 and H3K27me3 during a... | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
Dear authors,
The manuscript “The epigenomic landscape regulating organogenesis in human embryos linked to
developmental disorders” by Gerrard et al. provides unique insight regarding epigenetic landscape
dynamics of H3K27Ac, H3K4me3 and H3K27me3 during a... | TPR | NC_BS_DBIO_003_RR1.txt | {
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0 | 0 | Mutations in FAM50A suggest that Armfield XLID syndrome is a spliceosomopathy |
Reviewer #3 (Remarks to the Author):
The authors have addressed all of my concerns.
Reviewer #4 (Remarks to the Author):
The revisions added to the manuscript have clarified and enhanced the examination of Fam50A.
The new data indicating a role of Fam50A in spliceosomopathy is compelling, and has
stren... |
Reviewer #3 (Remarks to the Author):
The authors have addressed all of my concerns.
Reviewer #4 (Remarks to the Author):
The revisions added to the manuscript have clarified and enhanced the examination of Fam50A.
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0 | 0 | Mutations in FAM50A suggest that Armfield XLID syndrome is a spliceosomopathy | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
This is a thoroughly studied, well described and well written paper reporting 20 years of study
leading to the identification of hypomorphic hemizygous variants in FAM50A as disease-causing in
Armfield syndrome, an X-linked recessive syndromic form of ID. ... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
This is a thoroughly studied, well described and well written paper reporting 20 years of study
leading to the identification of hypomorphic hemizygous variants in FAM50A as disease-causing in
Armfield syndrome, an X-linked recessive syndromic form of ID. ... | TPR | NC_BS_DBIO_004_RR1.txt | {
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0 | 0 | Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
The authors show that prime to naive transition in human ES cells is associated with methylation
of CpG islands for a group of developmental genes that are also methylated in cancers. The
authors suggest this hypermethyaltion is potentially mediated by DNM... | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
The authors show that prime to naive transition in human ES cells is associated with methylation
of CpG islands for a group of developmental genes that are also methylated in cancers. The
authors suggest this hypermethyaltion is potentially mediated by DNM... | TPR | NC_BS_DBIO_005_RR1.txt | {
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"content": "Reviewers' Comments: \n \nReviewer #1: \nRemarks to the Author: \nThe authors show that prime to naive transition in human ES cells is associated with methylation \nof CpG islands for a group of developmental genes that are al... | 2,020 | |||
0 | 0 | Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
The authors have addressed various questions raised in response to the 1st submission. Some of
the remaining concerns are listed below which can be addressed through discussions in the paper
and figure edits where required. Barring these changes, th... |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
The authors have addressed various questions raised in response to the 1st submission. Some of
the remaining concerns are listed below which can be addressed through discussions in the paper
and figure edits where required. Barring these changes, th... | TPR | NC_BS_DBIO_005_RR2.txt | {
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"content": "\n \n \n\n\fReviewers' Comments: \n \nReviewer #1: \nRemarks to the Author: \nThe authors have addressed various questions raised in response to the 1st submission. Some of \nthe remaining concerns are listed below which can b... | 2,020 | |||
0 | 0 | Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
The authors have satisfactorily addressed all concerns. The manuscript looks good and addresses
the critical caveats of the model and mechanisms.
Reviewer #2:
Remarks to the Author:
The authors have resolved almost all the remaining questions ... |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
The authors have satisfactorily addressed all concerns. The manuscript looks good and addresses
the critical caveats of the model and mechanisms.
Reviewer #2:
Remarks to the Author:
The authors have resolved almost all the remaining questions ... | TPR | NC_BS_DBIO_005_RR3.txt | {
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0 | 0 | Global translation during early development depends on the essential transcription factor |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The authors have done an excellent job at addressing our comments. However, there are still a few
issues with the manuscript that should addressed.
In supplemental Fig 1E, they show the expression of Nanog and Oct4 in the trophoblast of PDRM10
mutants... |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The authors have done an excellent job at addressing our comments. However, there are still a few
issues with the manuscript that should addressed.
In supplemental Fig 1E, they show the expression of Nanog and Oct4 in the trophoblast of PDRM10
mutants... | TPR | NC_BS_DBIO_006_RR2.txt | {
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"role": "user"
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"content": "\n\n\fReviewers' comments: \n\nReviewer #1 (Remarks to the Author): \n\nThe authors have done an excellent job at addressing our comments. However, there are still a few \nissues with the manuscript that should addressed. \n\n... | 2,020 | |||
0 | 0 | Global translation during early development depends on the essential transcription factor | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
In this article the authors describe and characterise the role of Prdm10 in early murine development,
both in vivo and in vitro. They found that homozygous embryos are lethal post implantation and E4.5
embryos demonstrate a growth phenotype. To better unde... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
In this article the authors describe and characterise the role of Prdm10 in early murine development,
both in vivo and in vitro. They found that homozygous embryos are lethal post implantation and E4.5
embryos demonstrate a growth phenotype. To better unde... | TPR | NC_BS_DBIO_006_RR1.txt | {
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"role": "user"
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"content": "Reviewers' comments: \n\nReviewer #1 (Remarks to the Author): \n\nIn this article the authors describe and characterise the role of Prdm10 in early murine development, \nboth in vivo and in vitro. They found that homozygous em... | 2,020 | |||
0 | 0 | Global translation during early development depends on the essential transcription factor |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors have addressed the comments we raised.
|
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors have addressed the comments we raised.
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"role": "assistant"
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] | 2,020 | |||
0 | 0 | The mutational impact of culturing human pluripotent and adult stem cells |
REVIEWERS' COMMENTS:
Reviewer #3 (Remarks to the Author):
The authors adequately addressed my concern.
|
REVIEWERS' COMMENTS:
Reviewer #3 (Remarks to the Author):
The authors adequately addressed my concern.
| TPR | NC_BS_DBIO_007_RR3.txt | {
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0 | 0 | The mutational impact of culturing human pluripotent and adult stem cells | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
Kuijk et al. quantified and characterized genetic aberrations in human iPSCs and adult stem cells
during in vitro cell culture. They further compared in vitro and in vivo mutation data, revealing several
novel and important insights. Detailed analysis of... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
Kuijk et al. quantified and characterized genetic aberrations in human iPSCs and adult stem cells
during in vitro cell culture. They further compared in vitro and in vivo mutation data, revealing several
novel and important insights. Detailed analysis of... | TPR | NC_BS_DBIO_007_RR1.txt | {
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"role": "user"
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"content": "Reviewers' comments: \n \nReviewer #1 (Remarks to the Author): \n \nKuijk et al. quantified and characterized genetic aberrations in human iPSCs and adult stem cells \nduring in vitro cell culture. They further compared in vit... | 2,018 | |||
0 | 0 | The mutational impact of culturing human pluripotent and adult stem cells |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
I thank the authors for thoroughly revising the manuscript. My concerns are fully addressed.
Reviewer #2 (Remarks to the Author):
In their revised manuscript “The mutational impact of culturing human pluripotent and adult stem cells”
Kuijk ... |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
I thank the authors for thoroughly revising the manuscript. My concerns are fully addressed.
Reviewer #2 (Remarks to the Author):
In their revised manuscript “The mutational impact of culturing human pluripotent and adult stem cells”
Kuijk ... | TPR | NC_BS_DBIO_007_RR2.txt | {
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"content": " \n\n \n\n\fReviewers' comments: \n \nReviewer #1 (Remarks to the Author): \n \nI thank the authors for thoroughly revising the manuscript. My concerns are fully addressed. \n \n \nReviewer #2 (Remarks to the Author): \n \nIn ... | 2,018 | |||
0 | 0 | Unique properties of a subset of human pluripotent stem cells with high capacity for self- |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The authors have now addressed most previous criticism. Fig.2 however needs further work. The
Germline differentiation potential data of hPSC are described in line 168-191 and show increased PGC-
like cell differentiation capacity in the HHH group. Howeve... |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The authors have now addressed most previous criticism. Fig.2 however needs further work. The
Germline differentiation potential data of hPSC are described in line 168-191 and show increased PGC-
like cell differentiation capacity in the HHH group. Howeve... | TPR | NC_BS_DBIO_008_RR1.txt | {
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"role": "user"
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"content": "\n\nReviewers' comments: \n\nReviewer #1 (Remarks to the Author): \n\nThe authors have now addressed most previous criticism. Fig.2 however needs further work. The \nGermline differentiation potential data of hPSC are describe... | 2,020 | |||
0 | 0 | Unique properties of a subset of human pluripotent stem cells with high capacity for self- |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The authors have now adequately addressed the reviewer comments.
Reviewer #2 (Remarks to the Author):
I don't think the characterization of differentiation potential into the three germ layers is sufficient to
address the question raised (revis... |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The authors have now adequately addressed the reviewer comments.
Reviewer #2 (Remarks to the Author):
I don't think the characterization of differentiation potential into the three germ layers is sufficient to
address the question raised (revis... | TPR | NC_BS_DBIO_008_RR2.txt | {
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0 | 0 | Long-term culture of human pancreatic slices as a model to study real-time islet | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
This paper is a major breakthrough in pancreatic tissue long term culture of up to a remarkable 10
days, which is of sufficient duration for numerous applications in pancreatic islet and exocrine
biology, but here it was applied to understanding neogenesis... | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
This paper is a major breakthrough in pancreatic tissue long term culture of up to a remarkable 10
days, which is of sufficient duration for numerous applications in pancreatic islet and exocrine
biology, but here it was applied to understanding neogenesis... | TPR | NC_BS_DBIO_010_RR1.txt | {
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"content": "Reviewers' Comments: \n \nReviewer #1: \nRemarks to the Author: \nThis paper is a major breakthrough in pancreatic tissue long term culture of up to a remarkable 10 \ndays, which is of sufficient duration for numerous applicat... | 2,020 | |||
0 | 0 | Long-term culture of human pancreatic slices as a model to study real-time islet |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
To reiterate, I do think that this paper is a major breakthrough in pancreatic tissue long term
culture of up to a remarkable 10 days, which is of sufficient duration for numerous applications in
pancreatic islet and exocrine biology, and here the isl... |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
To reiterate, I do think that this paper is a major breakthrough in pancreatic tissue long term
culture of up to a remarkable 10 days, which is of sufficient duration for numerous applications in
pancreatic islet and exocrine biology, and here the isl... | TPR | NC_BS_DBIO_010_RR2.txt | {
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0 | 0 | LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
The work by Vinckier et al. examines the role of LDS1 in enhancer decommissioning during
endodermal (gut/pancreas) embryonic development. The authors show that LSD1 binding to
enhancers induces demethylation of H3K4 and promotes enhancer decommissioning. I... | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
The work by Vinckier et al. examines the role of LDS1 in enhancer decommissioning during
endodermal (gut/pancreas) embryonic development. The authors show that LSD1 binding to
enhancers induces demethylation of H3K4 and promotes enhancer decommissioning. I... | TPR | NC_BS_DBIO_011_RR1.txt | {
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"content": "Reviewers' Comments: \n \nReviewer #1: \nRemarks to the Author: \nThe work by Vinckier et al. examines the role of LDS1 in enhancer decommissioning during \nendodermal (gut/pancreas) embryonic development. The authors show tha... | 2,020 | |||
0 | 0 | LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
We are pleased to see that the authors have addressed all comments very well. There are a couple
of points where the authors are not sure whether to include or not the data. We would
recommend:
1) to keep out the short-term YFP tracing, as suggested b... |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
We are pleased to see that the authors have addressed all comments very well. There are a couple
of points where the authors are not sure whether to include or not the data. We would
recommend:
1) to keep out the short-term YFP tracing, as suggested b... | TPR | NC_BS_DBIO_011_RR2txt.txt | {
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"content": " \n\n\fReviewers' Comments: \n \nReviewer #1: \nRemarks to the Author: \nWe are pleased to see that the authors have addressed all comments very well. There are a couple \nof points where the authors are not sure whether to in... | 2,020 | |||
0 | 0 | Impaired peroxisomal import in Drosophila oenocytes causes cardiac dysfunction by |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The authors have responded appropriately to my comments and have added new relevant data that
strengthen the manuscript. I believe the manuscript can now be recommended for publication.
Reviewer #2 (Remarks to the Author):
The au... |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The authors have responded appropriately to my comments and have added new relevant data that
strengthen the manuscript. I believe the manuscript can now be recommended for publication.
Reviewer #2 (Remarks to the Author):
The au... | TPR | NC_BS_DBIO_013_RR2.txt | {
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"content": " \n \n \n\n\fReviewers' comments: \n\n \n\nReviewer #1 (Remarks to the Author): \n\n \n\nThe authors have responded appropriately to my comments and have added new relevant data that \nstrengthen the manuscript. I believe the... | 2,020 | |||
0 | 0 | Impaired peroxisomal import in Drosophila oenocytes causes cardiac dysfunction by | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
Huang and colleagues present compelling and interesting data exploring the effects of Oenocyte- mediated inflammation in the age-related decline of cardiac function in Drosophila. The authors show that increased oxidative stress in aging oenocytes results in the... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
Huang and colleagues present compelling and interesting data exploring the effects of Oenocyte- mediated inflammation in the age-related decline of cardiac function in Drosophila. The authors show that increased oxidative stress in aging oenocytes results in the... | TPR | NC_BS_DBIO_013_RR1.txt | {
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"content": "Reviewers' comments:\nReviewer #1 (Remarks to the Author):\nHuang and colleagues present compelling and interesting data exploring the effects of Oenocyte- mediated inflammation in the age-related decline of cardiac function i... | 2,020 | |||
0 | 0 | Impaired peroxisomal import in Drosophila oenocytes causes cardiac dysfunction by |
REVIEWERS' COMMENTS:
Reviewer #3 (Remarks to the Author):
By performing additional validation experiments of the Pex19 knockdown, which I suggested, the
anomalies with the Pex5/Pex14 depleted cells could now be clarified.
The other issues were also satisfactorily dealt with by the authors.
|
REVIEWERS' COMMENTS:
Reviewer #3 (Remarks to the Author):
By performing additional validation experiments of the Pex19 knockdown, which I suggested, the
anomalies with the Pex5/Pex14 depleted cells could now be clarified.
The other issues were also satisfactorily dealt with by the authors.
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0 | 0 | CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
Review Hagey et al.
The paper by Hagey et al performs single cell RNA-seq to characterize the cell populations using
cluster analysis. Bulk RNA-seq was used to determine how cell cycle phases might be involved in the
regulation of cell fate in the dev... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
Review Hagey et al.
The paper by Hagey et al performs single cell RNA-seq to characterize the cell populations using
cluster analysis. Bulk RNA-seq was used to determine how cell cycle phases might be involved in the
regulation of cell fate in the dev... | TPR | NC_BS_DBIO_014_RR1.txt | {
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0 | 0 | CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors have addressed my concerns. I am happy with the revised manuscript.
Reviewer #2 (Remarks to the Author):
I find it strange that the authors could not cluster rare populations (interneurons, astrocytes and
microglia) using top variabl... |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors have addressed my concerns. I am happy with the revised manuscript.
Reviewer #2 (Remarks to the Author):
I find it strange that the authors could not cluster rare populations (interneurons, astrocytes and
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0 | 0 | Synergistic gene editing in human iPS cells via cell cycle and DNA repair modulation |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
Summary:
The authors have submitted a very commendable rebuttal to the Referee comments from their original
submission, with satisfactory responses to most concerns. Most importantly, the authors have added
additional data on endogenous sites, which... |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
Summary:
The authors have submitted a very commendable rebuttal to the Referee comments from their original
submission, with satisfactory responses to most concerns. Most importantly, the authors have added
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0 | 0 | Context specificity of the EMT transcriptional response | Reviewers' comments:
Reviewer #1 (Remarks to the Author): Expertise in ATAC-seq and EMT
This article entitled « Context specificity of the EMT transcriptional response” is proposed by David
P. Cook & Barbara C. Vanderhyden and is interested in the identification of robust/universal
transcriptional signature of ... | Reviewers' comments:
Reviewer #1 (Remarks to the Author): Expertise in ATAC-seq and EMT
This article entitled « Context specificity of the EMT transcriptional response” is proposed by David
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0 | 0 | Context specificity of the EMT transcriptional response |
REVIEWERS' COMMENTS:
Reviewer #3 (Remarks to the Author):
The authors have provided a rebuttal solely based on rewording some paragraphs. Although they
have somewhat clarified some of the criticisms raised by the reviewer, it is clear that the present
study is facing the same issues regarding the het... |
REVIEWERS' COMMENTS:
Reviewer #3 (Remarks to the Author):
The authors have provided a rebuttal solely based on rewording some paragraphs. Although they
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0 | 0 | A broad-spectrum virus- and host-targeting peptide against respiratory viruses including | Peer Review File - Reviewers' comments first round
Reviewer #1 (Remarks to the Author):
Zhao and co-workers show data on the alkaline peptide P9R with broad antiviral activity against
the novel SARS-CoV-2, two other highly pathogenic CoV (MERS-CoV and SARS-CoV), influenza
viruses and non-enveloped rhinovirus. O... | Peer Review File - Reviewers' comments first round
Reviewer #1 (Remarks to the Author):
Zhao and co-workers show data on the alkaline peptide P9R with broad antiviral activity against
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0 | 0 | A broad-spectrum virus- and host-targeting peptide against respiratory viruses including |
Peer Review File - Reviewers' comments second round
Reviewer #2 (Remarks to the Author):
The authors improved the manuscript from Yuen et al. significantly and addressed all questions
and comments with intensive efforts. From my view this article is now suitable for publication in
nature communication... |
Peer Review File - Reviewers' comments second round
Reviewer #2 (Remarks to the Author):
The authors improved the manuscript from Yuen et al. significantly and addressed all questions
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0 | 0 | Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
Using phage display the authors have developed a peptide inhibitor to FXIIa that excels, existing
protein-based inhibitors, in its specificity, selectivity and half-life. Much of the manuscript focuses
on improving another inhibitor from the same group (FX... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
Using phage display the authors have developed a peptide inhibitor to FXIIa that excels, existing
protein-based inhibitors, in its specificity, selectivity and half-life. Much of the manuscript focuses
on improving another inhibitor from the same group (FX... | TPR | NC_BS_DDIS_003_RR1.txt | {
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0 | 0 | Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
None
Reviewer #2 (Remarks to the Author):
All issues raised were very well-addressed. Additional data are provided that further strengthen
the work. No further comments
|
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
None
Reviewer #2 (Remarks to the Author):
All issues raised were very well-addressed. Additional data are provided that further strengthen
the work. No further comments
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0 | 0 | Molecular engineering of safe and efficacious oral basal insulin |
Reviewers' Comments:
Reviewer #3:
Remarks to the Author:
No further comments
Reviewers' Comments:
Reviewer #3:
Remarks to the Author:
No further comments
|
Reviewers' Comments:
Reviewer #3:
Remarks to the Author:
No further comments
Reviewers' Comments:
Reviewer #3:
Remarks to the Author:
No further comments
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... | 2,020 | |||
0 | 0 | Molecular engineering of safe and efficacious oral basal insulin | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
In the communication from Kjeldsen’s group, the development of ultra-long acting insulin analogs
for the use of oral insulin therapy for diabetic patients has been reported. This is achieved by the
combination of the pertinent mutations on the amino acid s... | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
In the communication from Kjeldsen’s group, the development of ultra-long acting insulin analogs
for the use of oral insulin therapy for diabetic patients has been reported. This is achieved by the
combination of the pertinent mutations on the amino acid s... | TPR | NC_BS_DDIS_004_RR1.txt | {
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"content": "Reviewers' Comments: \n \nReviewer #1: \nRemarks to the Author: \nIn the communication from Kjeldsen’s group, the development of ultra-long acting insulin analogs \nfor the use of oral insulin therapy for diabetic patients has... | 2,020 | |||
0 | 0 | Protein–ligand binding with the coarse-grained Martini model |
Peer Review File: Reviewers' comments first round:
Reviewer #1 (Remarks to the Author):
Review of NCOMMS-19-28960
This is an interesting study of the use of Martini (version 3) coarse-grained molecular dynamics
simulations to explore millisec timescale sampling of ligand/drug binding to 3 protein targets. T... |
Peer Review File: Reviewers' comments first round:
Reviewer #1 (Remarks to the Author):
Review of NCOMMS-19-28960
This is an interesting study of the use of Martini (version 3) coarse-grained molecular dynamics
simulations to explore millisec timescale sampling of ligand/drug binding to 3 protein targets. T... | TPR | NC_BS_DDIS_005_RR1.txt | {
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0 | 0 | Protein–ligand binding with the coarse-grained Martini model |
REVIEWERS' COMMENTS second round:
Reviewer #1 (Remarks to the Author):
Review of NCOMMS-19-28960A Revised Paper
The authors have responded to nearly all of my comments satisfactorily in the rebuttal and revised
manuscript.
In particular, they have expanded the range of their study which helps to convi... |
REVIEWERS' COMMENTS second round:
Reviewer #1 (Remarks to the Author):
Review of NCOMMS-19-28960A Revised Paper
The authors have responded to nearly all of my comments satisfactorily in the rebuttal and revised
manuscript.
In particular, they have expanded the range of their study which helps to convi... | TPR | NC_BS_DDIS_005_RR2.txt | {
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"content": "\n \n\n\fREVIEWERS' COMMENTS second round: \n \nReviewer #1 (Remarks to the Author): \n \nReview of NCOMMS-19-28960A Revised Paper \n \nThe authors have responded to nearly all of my comments satisfactorily in the rebuttal and... | 2,014 | |||
0 | 0 | Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors have addressed all of my comments in full, and I thank them for taking the time to
provide a comprehensive rebuttal to each of my points. No further comments other than to
complement them on an excellent paper!
Reviewer #2 (Remarks to the A... |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
The authors have addressed all of my comments in full, and I thank them for taking the time to
provide a comprehensive rebuttal to each of my points. No further comments other than to
complement them on an excellent paper!
Reviewer #2 (Remarks to the A... | TPR | NC_BS_DDIS_006_RR2.txt | {
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0 | 0 | Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
In this paper, the authors examine tau reduction via inhibition of mTOR signalling as a potential
tau therapeutic in iPSC-neurons. The authors show that a single dose can lower tau protein levels
for up to 12 days following treatment, and this reduces the ... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
In this paper, the authors examine tau reduction via inhibition of mTOR signalling as a potential
tau therapeutic in iPSC-neurons. The authors show that a single dose can lower tau protein levels
for up to 12 days following treatment, and this reduces the ... | TPR | NC_BS_DDIS_006_RR1.txt | {
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0 | 0 | Representation of molecular structures with persistent homology for machine learning |
REVIEWERS' COMMENTS:
Reviewer #3 (Remarks to the Author):
In the revised manuscript the authors provided a nice proof of the advantage of their unique method
over other existing machine learning approaches for the high-throughput screening of molecules
binding stronger to CO2 than to N2.
|
REVIEWERS' COMMENTS:
Reviewer #3 (Remarks to the Author):
In the revised manuscript the authors provided a nice proof of the advantage of their unique method
over other existing machine learning approaches for the high-throughput screening of molecules
binding stronger to CO2 than to N2.
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0 | 0 | Representation of molecular structures with persistent homology for machine learning |
Reviewers' comments:
Reviewer #2 (Remarks to the Author):
The authors have provided substantive changes to the manuscript and addressed most of the raised
points in detail, which I appreciate. This certainly helps to alleviate any concerns on the validity and
significance of the performance of the method and... |
Reviewers' comments:
Reviewer #2 (Remarks to the Author):
The authors have provided substantive changes to the manuscript and addressed most of the raised
points in detail, which I appreciate. This certainly helps to alleviate any concerns on the validity and
significance of the performance of the method and... | TPR | NC_BS_DDIS_007_RR2.txt | {
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0 | 0 | Representation of molecular structures with persistent homology for machine learning | Reviewers' comments:
Reviewer #2 (Remarks to the Author):
The authors present a molecular representation, which they consider to be easy to calculate and of the
same size across all molecules (size-consistent). The authors apply it to train the CO2/N2 interaction
energies of organic molecules within the GDB-9 set... | Reviewers' comments:
Reviewer #2 (Remarks to the Author):
The authors present a molecular representation, which they consider to be easy to calculate and of the
same size across all molecules (size-consistent). The authors apply it to train the CO2/N2 interaction
energies of organic molecules within the GDB-9 set... | TPR | NC_BS_DDIS_007_RR1.txt | {
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0 | 0 | Multiplex secretome engineering enhances recombinant protein production and purity | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
Thank you for giving me tho opportunity to review this manuscript by Kol et al. This is a very
interesting, well designed and comprehensive study that will undoubtedly be of high interest to the
bioprocessing community. I only have three questions for clar... | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
Thank you for giving me tho opportunity to review this manuscript by Kol et al. This is a very
interesting, well designed and comprehensive study that will undoubtedly be of high interest to the
bioprocessing community. I only have three questions for clar... | TPR | NC_BS_DDIS_008_RR1.txt | {
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"content": "Reviewers' Comments: \n \nReviewer #1: \nRemarks to the Author: \nThank you for giving me tho opportunity to review this manuscript by Kol et al. This is a very \ninteresting, well designed and comprehensive study that will un... | 2,019 | |||
0 | 0 | Multiplex secretome engineering enhances recombinant protein production and purity |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
The revised manuscript is improved in terms of clarity and accuracy. I particularly appreciate the
acknowledgment of limitations of the experimental design/study as well as the additional work that
has been carried out to provide evidence of reproducibil... |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
The revised manuscript is improved in terms of clarity and accuracy. I particularly appreciate the
acknowledgment of limitations of the experimental design/study as well as the additional work that
has been carried out to provide evidence of reproducibil... | TPR | NC_BS_DDIS_008_RR2.txt | {
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0 | 0 | Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein |
Reviewers' Comments:
Reviewer #2:
Remarks to the Author:
The authors have thoroughly and precisely addressed the concerns of this reviewer. I would
publish this interesting paper.
|
Reviewers' Comments:
Reviewer #2:
Remarks to the Author:
The authors have thoroughly and precisely addressed the concerns of this reviewer. I would
publish this interesting paper.
| TPR | NC_BS_DDIS_009_RR2.txt | {
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0 | 0 | Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
In their manuscript entitled ”The blood circulation of soft nanomaterials in vivo is governed by
dynamic remodeling of protein opsonins at the nano-biointerface” Abbina et al. investigate protein
corona formation on a small panel of three differently sized... | Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
In their manuscript entitled ”The blood circulation of soft nanomaterials in vivo is governed by
dynamic remodeling of protein opsonins at the nano-biointerface” Abbina et al. investigate protein
corona formation on a small panel of three differently sized... | TPR | NC_BS_DDIS_009_RR1.txt | {
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"content": "Reviewers' Comments: \n \nReviewer #1: \nRemarks to the Author: \nIn their manuscript entitled ”The blood circulation of soft nanomaterials in vivo is governed by \ndynamic remodeling of protein opsonins at the nano-biointerfa... | 2,020 | |||
0 | 0 | Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat |
Reviewers' Comments:
Reviewer #2:
Remarks to the Author:
The manuscript is improved with the inclusion of further data. The interpretation of the data is willfully
simplistic in this reviewer's opinion, but enough data are included for readers to decide for
themselves.
Reviewer #4:
Remarks to the Au... |
Reviewers' Comments:
Reviewer #2:
Remarks to the Author:
The manuscript is improved with the inclusion of further data. The interpretation of the data is willfully
simplistic in this reviewer's opinion, but enough data are included for readers to decide for
themselves.
Reviewer #4:
Remarks to the Au... | TPR | NC_BS_DDIS_010_RR2.txt | {
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0 | 0 | Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
The authors have adequately addressed all of my prior concerns. The paper is much improved and will
be a valuable contribution to the field.
Reviewer #2:
Remarks to the Author:
The manuscript is very much improved in the current form, especially ... |
Reviewers' Comments:
Reviewer #1:
Remarks to the Author:
The authors have adequately addressed all of my prior concerns. The paper is much improved and will
be a valuable contribution to the field.
Reviewer #2:
Remarks to the Author:
The manuscript is very much improved in the current form, especially ... | TPR | NC_BS_DDIS_010_RR1.txt | {
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0 | 0 | Stereospecific Si-C coupling and remote control of axial chirality by enantioselective |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The revised version of the paper is in my personal opinion lacking some important aspects. First of
all, the assignment of the absolute configuration to the stereogenic axis is not correct. The authors
report that compounds 5 have the M absolute configur... |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The revised version of the paper is in my personal opinion lacking some important aspects. First of
all, the assignment of the absolute configuration to the stereogenic axis is not correct. The authors
report that compounds 5 have the M absolute configur... | TPR | NC_BS_DDIS_011_RR2.txt | {
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0 | 0 | Stereospecific Si-C coupling and remote control of axial chirality by enantioselective |
REVIEWERS' COMMENTS:
Reviewer #3 (Remarks to the Author):
Hydrosilylation of unsaturated carbon-carbon bonds with hydrosilanes is one of the most important
processes and can rank one of the most fundamental reactions in organsilicon chemistry. In this
manuscript, Xu and co-workers reported a highly enantiosele... |
REVIEWERS' COMMENTS:
Reviewer #3 (Remarks to the Author):
Hydrosilylation of unsaturated carbon-carbon bonds with hydrosilanes is one of the most important
processes and can rank one of the most fundamental reactions in organsilicon chemistry. In this
manuscript, Xu and co-workers reported a highly enantiosele... | TPR | NC_BS_DDIS_011_RR3.txt | {
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"content": "\n\n\fREVIEWERS' COMMENTS: \n\nReviewer #3 (Remarks to the Author): \n\nHydrosilylation of unsaturated carbon-carbon bonds with hydrosilanes is one of the most important \nprocesses and can rank one of the most fundamental rea... | 2,020 | |||
0 | 0 | Stereospecific Si-C coupling and remote control of axial chirality by enantioselective | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The manuscript by Xu and collaborators is an interesting example of a Pd catalyzed hydrosilylation
of activated maleimides. The synthesis of novel organosilicon compounds is realized in an
enantioselective fashion. The optimization is well performed and al... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The manuscript by Xu and collaborators is an interesting example of a Pd catalyzed hydrosilylation
of activated maleimides. The synthesis of novel organosilicon compounds is realized in an
enantioselective fashion. The optimization is well performed and al... | TPR | NC_BS_DDIS_011_RR1.txt | {
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0 | 0 | Dicer-like 5 deficiency confers temperature-sensitive male sterility in maize | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The exact functions of DCL5 and 24nt-phasiRNAs in reproductive organs of monocots have been a
mystery since their discoveries. In this paper, the authors confirmed the involvement of DCL5 in
24-nt phasiRNA biogenesis and showed that DCL5 and 24-nt phasiRNA... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The exact functions of DCL5 and 24nt-phasiRNAs in reproductive organs of monocots have been a
mystery since their discoveries. In this paper, the authors confirmed the involvement of DCL5 in
24-nt phasiRNA biogenesis and showed that DCL5 and 24-nt phasiRNA... | TPR | NC_BS_DDIS_012_RR1.txt | {
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"content": "Reviewers' comments: \n\nReviewer #1 (Remarks to the Author): \n\nThe exact functions of DCL5 and 24nt-phasiRNAs in reproductive organs of monocots have been a \nmystery since their discoveries. In this paper, the authors conf... | 2,018 | |||
0 | 0 | Dicer-like 5 deficiency confers temperature-sensitive male sterility in maize |
REVIEWERS' COMMENTS:
Reviewer #3 (Remarks to the Author):
Dear Authors,
Compared to the manuscript a year ago, a lot of supplementary data have been added, making
the revise version an attractive article.
1) Quantitative data for fertility/sterility (Fig4, SupFig16 and Sup Table1)
I’m interested in the swa... |
REVIEWERS' COMMENTS:
Reviewer #3 (Remarks to the Author):
Dear Authors,
Compared to the manuscript a year ago, a lot of supplementary data have been added, making
the revise version an attractive article.
1) Quantitative data for fertility/sterility (Fig4, SupFig16 and Sup Table1)
I’m interested in the swa... | TPR | NC_BS_DDIS_012_RR3.txt | {
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0 | 0 | Dicer-like 5 deficiency confers temperature-sensitive male sterility in maize |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
This manuscript, entitled "Dicer-like 5 deficiency confers temperature-sensitive male sterility in
maize" reports the involvement of DCL5 in 24-nt phasiRNA biogenesis in maize and shows that
DCL5 and 24-nt phasiRNAs play vital roles in tapetal functions... |
Reviewers' comments:
Reviewer #1 (Remarks to the Author):
This manuscript, entitled "Dicer-like 5 deficiency confers temperature-sensitive male sterility in
maize" reports the involvement of DCL5 in 24-nt phasiRNA biogenesis in maize and shows that
DCL5 and 24-nt phasiRNAs play vital roles in tapetal functions... | TPR | NC_BS_DDIS_012_RR2.txt | {
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"content": "\n\n\fReviewers' comments: \n\nReviewer #1 (Remarks to the Author): \n\nThis manuscript, entitled \"Dicer-like 5 deficiency confers temperature-sensitive male sterility in \nmaize\" reports the involvement of DCL5 in 24-nt pha... | 2,018 | |||
0 | 0 | Mode of action of teixobactins in cellular membranes | Peer Review File
Reviewers' comments first round:
Reviewer #1 (Remarks to the Author):
This is an impressive paper that should be published after revision. The authors perform detailed
NMR-based structural studies of a teixobactin analogue (Arg4,Leu10-teixobactin) and characterize
its interactions with lipid ... | Peer Review File
Reviewers' comments first round:
Reviewer #1 (Remarks to the Author):
This is an impressive paper that should be published after revision. The authors perform detailed
NMR-based structural studies of a teixobactin analogue (Arg4,Leu10-teixobactin) and characterize
its interactions with lipid ... | TPR | NC_BS_DDIS_013_RR1.txt | {
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"suggestion_a... | 1.928571 | 0 | [
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"content": "Peer Review File \n\nReviewers' comments first round: \n \nReviewer #1 (Remarks to the Author): \n \nThis is an impressive paper that should be published after revision. The authors perform detailed \nNMR-based structural stud... | 2,020 | |||
0 | 0 | Mode of action of teixobactins in cellular membranes |
REVIEWERS' COMMENTS second round:
Reviewer #1 (Remarks to the Author):
I am satisfied with the authors' thoughtful efforts to address our concerns and those of the other
reviewer, particularly in light of the COVID-19 shutdown, and recommend publication as is. The
PDB structure will be a particularly valu... |
REVIEWERS' COMMENTS second round:
Reviewer #1 (Remarks to the Author):
I am satisfied with the authors' thoughtful efforts to address our concerns and those of the other
reviewer, particularly in light of the COVID-19 shutdown, and recommend publication as is. The
PDB structure will be a particularly valu... | TPR | NC_BS_DDIS_013_RR2.txt | {
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"content": "\n \n\n\fREVIEWERS' COMMENTS second round: \n \nReviewer #1 (Remarks to the Author): \n \nI am satisfied with the authors' thoughtful efforts to address our concerns and those of the other \nreviewer, particularly in light of... | 2,020 | |||
0 | 0 | Labeled oxytocin administered via the intranasal route reaches the brain in rhesus |
Reviewer #1 (Remarks to the Author):
The manuscript has been significantly improved and deserves publication.
Reviewer #2 (Remarks to the Author):
The authors have addressed many of our concerns in this revised manuscript. The data are important to
present since this is the first measurement and comparison of ... |
Reviewer #1 (Remarks to the Author):
The manuscript has been significantly improved and deserves publication.
Reviewer #2 (Remarks to the Author):
The authors have addressed many of our concerns in this revised manuscript. The data are important to
present since this is the first measurement and comparison of ... | TPR | NC_BS_DDIS_014_RR2.txt | {
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"suggestion... | 1.074074 | 0 | [
{
"content": "Please review this paper.",
"role": "user"
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{
"content": "\n\fReviewer #1 (Remarks to the Author): \n\nThe manuscript has been significantly improved and deserves publication. \n\nReviewer #2 (Remarks to the Author): \n\nThe authors have addressed many of our concerns in this revised... | 2,020 | |||
0 | 0 | Labeled oxytocin administered via the intranasal route reaches the brain in rhesus | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The study of Lee and co-authors, addressing permeability of neuropeptide oxytocin to the brain tissue of
monkeys, is very timely and important for translational application of OT in human. Furthermore, the
strength of the study is that it goes beyond oxyt... | Reviewers' comments:
Reviewer #1 (Remarks to the Author):
The study of Lee and co-authors, addressing permeability of neuropeptide oxytocin to the brain tissue of
monkeys, is very timely and important for translational application of OT in human. Furthermore, the
strength of the study is that it goes beyond oxyt... | TPR | NC_BS_DDIS_014_RR1.txt | {
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"suggestion_and_solution": 0.... | 1.590476 | 0 | [
{
"content": "Please review this paper.",
"role": "user"
},
{
"content": "Reviewers' comments: \n\nReviewer #1 (Remarks to the Author): \n\nThe study of Lee and co-authors, addressing permeability of neuropeptide oxytocin to the brain tissue of \nmonkeys, is very timely and important for translation... | 2,020 | |||
0 | 0 | Labeled oxytocin administered via the intranasal route reaches the brain in rhesus |
Reviewer #2 (Remarks to the Author):
The authors have responded to my concerns. In particular, the figures are much better. The paper
reaches my threshold for publication.
|
Reviewer #2 (Remarks to the Author):
The authors have responded to my concerns. In particular, the figures are much better. The paper
reaches my threshold for publication.
| TPR | NC_BS_DDIS_014_RR3.txt | {
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"role": "user"
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{
"content": " \n\n\fReviewer #2 (Remarks to the Author): \n\nThe authors have responded to my concerns. In particular, the figures are much better. The paper \nreaches my threshold for publication. \n\n\f\n",
"role": "assistant"
}
] | 2,020 | |||
0 | 0 | A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
In this revised version and/or in their rebuttal letter, authors meet all comments and critics raised
by reviewers.
Reviewer #2 (Remarks to the Author):
Thank you for the clarification re what forms of aSyn the reporter recognizes. This is an i... |
REVIEWERS' COMMENTS:
Reviewer #1 (Remarks to the Author):
In this revised version and/or in their rebuttal letter, authors meet all comments and critics raised
by reviewers.
Reviewer #2 (Remarks to the Author):
Thank you for the clarification re what forms of aSyn the reporter recognizes. This is an i... | TPR | NC_BS_DDIS_015_RR2.txt | {
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"content": "Please review this paper.",
"role": "user"
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"content": "\n\n\fREVIEWERS' COMMENTS: \n \nReviewer #1 (Remarks to the Author): \n \nIn this revised version and/or in their rebuttal letter, authors meet all comments and critics raised \nby reviewers. \n \n \nReviewer #2 (Remarks to th... | 2,019 |
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