zhouyw/PolyXpert

Model Card for Model ID

PolyXpert：Sequence-Based Therapeutic Antibody Polyreactivity Prediction

Model Details

A fine-tuned ESM-2 model for predicting polyreactivity of antibody candidates using scFv sequence data.

Model Description

• **Developed by: [Yuwei Zhou]
• **Model type: [Classification]
• **Finetuned from model: [facebook/esm2_t30_150M_UR50D]

Model Sources

• **Repository: https://github.com/zzyywww/PolyXpert

Citation

[Yuwei Zhou,Haoxiang Tang, Changchun Wu, Zixuan Zhang, Jinyi Wei, Rong Gong, Samarappuli Mudiyanselage Savini Gunarathne, Changcheng Xiang, Jian Huang.Enhancing polyreactivity prediction of preclinical antibodies through fine-tuned protein language models. Journal of Pharmaceutical Analysis, 2025,101448. DOI: 10.1016/j.jpha.2025.101448]